Dr Katie Leach - Researcher Profile

Biography

Position

Postdoctoral Scientist
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Reading - United Kingdom

Year awarded: 2006

BACHELOR OF SCIENCE WITH HONOURS - BIOLOGICAL SC

Institution: University of Reading - United Kingdom

Year awarded: 2001

Publications

Book Chapters

Leach, K., Simms, J., Sexton, P.M., Christopoulos, A., 2012, Structure-function studies of muscarinic acetylcholine receptors, in Muscarinic Receptors - Handbook of Experimental Pharmacology 208, eds AD Fryer, A Christopoulos, & NM Nathanson, Springer Science+Business Media, USA, pp. 29-48.

Journal Articles

Leach, K., Wen, C., Davey, A.E., Sexton, P.M., Conigrave, A.D., Christopoulos, A., 2012, Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor , Endocrinology [P], vol 153, issue 9, The Endocrine Society, USA, pp. 4304-4316.

Davey, A.E., Leach, K., Valant, C., Conigrave, A.D., Sexton, P.M., Christopoulos, A., 2012, Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor, Endocrinology [P], vol 153, issue 3, The Endocrine Society, USA, pp. 1232-1241.

Suratman, N.S., Leach, K., Sexton, P., Felder, C.C., Loiacono, R., Christopoulos, A., 2011, Impact of species variability and "probe-dependence" on the detection and in vivo validation of allosteric modulation at the M(4) muscarinic acetylcholine receptor, British Journal of Pharmacology [P], vol 162, issue 7, John Wiley & Sons Ltd, UK, pp. 1659-1670.

Leach, K., Sexton, P., Christopoulos, A., 2011, Quantification of allosteric interactions at G protein-coupled receptors using radioligand binding assays, Current Protocols in Pharmacology [P], vol 1, issue Supp 52 (Unit 1.22), John Wiley & Sons, Inc., USA, pp. 1-41.

Leach, K., Davey, A.E., Felder, C.C., Sexton, P., Christopoulos, A., 2011, The role of transmembrane domain 3 (Tmiii) in the actions of orthosteric, allosteric and atypical agonists of the M4 muscarinic acetylcholine receptor, Molecular Pharmacology [P], vol 79, issue 5, American Society for Pharmacology & Experimental Therapeutics, USA, pp. 855-865.

Leach, K., Loiacono, R.E., Felder, C.C., McKinzie, D.L., Mogg, A., Shaw, D.B., Sexton, P.M., Christopoulos, A., 2010, Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties, Neuropsychopharmacology [P], vol 35, issue 4, Nature Publishing Group, UK & USA, pp. 855-869.

Nawaratne, V., Leach, K., Felder, C.C., Sexton, P.M., Christopoulos, A., 2010, Structural determinants of allosteric agonism and modulation at the M 4 muscarinic acetylcholine receptor: Identification of ligand-specific and global activation mechanisms, Journal Of Biological Chemistry [P], vol 285, issue 25, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 19012-19021.

Nawaratne, O.V., Leach, K., Suratman, S., Loiacono, R., Felder, C.C., Armbruster, B.N., Roth, B.L., Sexton, P., Christopoulos, A., 2008, New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug), Molecular Pharmacology, vol 74, issue 4, American Society for Pharmacology & Experimental Therapeutics, United States, pp. 1119-1131.

Leach, K., Sexton, P., Christopoulos, A., 2007, Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology, Trends in Pharmacological Sciences, vol 28, issue 8, Elsevier Science London, London England UK, pp. 382-389.

May, L.T., Leach, K., Sexton, P.M., Christopoulos, A., 2007, Allosteric modulation of G protein-coupled receptors, The Annual Review of Pharmacology and Toxicology, vol 47, Annual Reviews, Palo Alto USA, pp. 1-51.

Leach, K., Charlton, S.J., Strange, P.G., 2007, Analysis of second messenger pathways stimulated by different chemokines acting at the chemokine receptor CCR5, Biochemical Pharmacology [P], vol 74, issue 6, Elsevier Inc., USA, pp. 881-890.

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences