Dr Geoffrey Kelso - Researcher Profile

Biography

Geoffrey works in the Centre for Green Chemistry at Monash University as a Research Fellow. His research interests include catalysis in synthesis and medicinal chemistry.

Keywords

Green chemistry, organic synthesis, catalysis, , Medicinal chemistry, targeted drug delivery

Qualifications

PHD - CHEMISTRY

Institution: University of Otago

Year awarded: 2005

BACHELOR OF SCIENCE (HONOURS)

Institution: University of Otago

Year awarded: 1999

Publications

Journal Articles

Kelso, G., Maroz, A., Cocheme, H.M., Logan, A., Prime, T.A., Peskin, A.V., Winterbourn, C.C., James, A.M., Ross, M.F., Brooker, S., Porteous, C.M., Anderson, R.F., Murphy, M.P., Smith, R.A., 2012, A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic, Chemistry & Biology [E], vol 19, issue 10, Cell Press, USA, pp. 1237-1246.

Do Pham, D.D., Kelso, G., Yang, Y., Hearn, M.T.W., 2012, One-pot oxidative N-demethylation of tropane alkaloids with hydrogen peroxide and a Fe-III-TAML catalyst, Green Chemistry [P], vol 14, issue 4, Royal Society of Chemistry, Cambs England, pp. 1189-1195.

Ciayadi, R., Potdar, M., Walton, K., Harrison, G., Kelso, G., Harris, S., Hearn, M., 2011, 2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-B1 and activin A signalling, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 18, Pergamon-Elsevier Science Ltd, Oxford England, pp. 5642-5645.

Kazi, S., Kelso, G., Harris, S., Boysen, R., Chowdhury, J., Hearn, M., 2010, Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture, Tetrahedron [P], vol 66, issue 48, Pergamon Elsevier Science Ltd, Oxford England, pp. 9461-9467.

Maroz, A., Kelso, G., Smith, R.A., Ware, D., Anderson, R., 2008, Pulse radiolysis investigation on the mechanism of the catalytic action of Mn(II)-Pentaazamacrocycle compounds as superoxide dismutase mimetics, Journal Of Physical Chemistry A [P], vol 112, issue 22, American Chemical Society, USA, pp. 4929-4935.

Cocheme, H.M., Kelso, G., James, A.M., Ross, M.F., Trnka, J., Mahendiran, T., Asin-Cayuela, J., Blaikie, F.H., Manas, A.B., Porteous, C.M., Adlam, V.J., Smith, R.A.J., Murphy, M.P., 2007, Mitochondrial targeting of quinones: Therapeutic implications, Mitochondrion [P], vol 7, Elsevier BV, Netherlands, United States, pp. 94-102.

Ross, M.F., Kelso, G., Blaikie, F.H., James, A.M., Cocheme, H.M., Filipovska, A., Ros, T.D., Hurd, T.R., Smith, R.A.J., Murphy, M.P., 2005, Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology, Biochemistry-Moscow [P], vol 70, issue 2, MAIK Nauka - Interperiodica, Russian Federation, pp. 222-230.

Filipovska, A., Kelso, G., Brown, S.E., Beer, S.M., Smith, R.A.J., Murphy, M.P., 2005, Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: Insights into the interaction of ebselen with mitochondria, Journal Of Biological Chemistry [P], vol 280, issue 25, The American Society for Biochemistry and Molecular Biology, USA, pp. 24113-24126.

Smith, R., Kelso, G., James, A., Murphy, M., 2004, Targeting coenzyme Q derivatives to mitochondria, Methods in Enzymology [P], vol 382, Elsevier, Amersterdam, pp. 45-67.

Smith, R.A.J., Kelso, G., Blaikie, F.H., Porteoust, C.M., Ledgerwood, E.C., Hughes, G., James, A.M., Ross, M.F., Asin-Cayuela, J., Cocheme, H.M., Filipovska, A., Murphy, M.P., 2003, Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences, Biochemical Society Transactions [P], vol 31, issue 6, Portland Press Ltd., United Kingdom, pp. 1295-1299.

Conference Proceedings

Do Pham, D., Kelso, G., Yang, Y., Hearn, M., 2011, Investigation of FeIII-tamil catalyst in oxidative organic synthesis, Green Chemistry 2011 Innovations, 4-7 December, Royal Australian Chemistry Institute, Australia.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

One-Pot Oxidative N-Demethylation of Tropane Alkaloids with Hydrogen Peroxide and Fe III - TAML Catalyst.

Supervisors:

Hearn, M (Joint-co), Kelso, G (Joint).

Completed Supervision

Student:

Ciayadi, R.

Program of Study:

The synthesis of inhibitors of TGF-beta cytokine signalling and identification of their protein binding partners. (PHD) 2012.

Supervisors:

Hearn, M (Main), Harris, S (Associate), Kelso, G (Associate).