Adj Assoc Prof Cristina Morganti-Kossmann - Researcher Profile

Biography

Cristina works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

BIOLOGY/ BIOCHEMISTRY

Institution: italy/rome

Year awarded: 1984

Publications

Books

Morganti-Kossmann, M., Semple, B., Yan, E., Ziebell, J., Bye, N., Kossmann, T., 2010, Neuroimmune Biology: The Brain and host defense., Elsevier, Manitoba, Canada.

Book Chapters

Semple, B.D., Morganti-Kossmann, M.C., 2012, Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both?, in Traumatic Brain and Spinal Cord Injury: Challenges and Developments, eds Cristina Morganti-Kossmann, Ramesh Raghupathi, Andrew Maas, Cambridge University Press, New York, USA, pp. 155-168.

Morganti-Kossmann, M.C., Semple, B.D., Ziebell, J.M., Yan, E.B., Bye, N., Kossmann, T., 2010, Modulation of immune response by head injury, in New Insights to Neuroimmune Biology, eds Istvan Berczi, Elsevier, USA, pp. 193-220.

Morganti-Kossmann, M.C., satgunaseelan, L., Bye, N., Nguyen, P., Kossmann, T., 2009, Role of the inflammatory process in traumatic brain damage, in Inflammatory Diseases of the Central Nervous System, eds Trevor Kilpatrick, Richard M Ransohoff and Steven L Wesselingh, Cambridge University Press, USA, pp. 185-200.

Morganti-Kossmann, M.C., 2006, Spinal Trauma, in Neurology:Basic and Clinical Neurosciences, eds Anthony H Schapira, Elsevier, Philadelphia, pp. 1397-1408.

Morganti-Kossmann, M.C., Bye, N., Nguyen, P., Kossmann, T., 2005, Influence of brain trauma on blood - Brain barrier properties, in The Blood-Brain Barrier and Its Microenvironment - Basic Physiology to Neurological Disease, eds Elga de Vries and Alexandre Prat, Informa Healthcare, UK, pp. 457-479.

Morganti-Kossmann, M.C., Rancan, M., Stahel, P.F., Kossmann, T., 2002, Inflammatory responses to traumatic brain injury: An overview for the new millenium, in Search inside another edition of this book Immune and Inflammatory Responses in the Nervous System, eds Nancy Rotherwell and Sarah Lodick, Oxford University Press, UK, pp. 106-126.

Journal Articles

Ng, S.Y., Semple, B.D., Morganti-Kossmann, M.C., Bye, N., 2012, Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice, Journal of Neurotrauma [P], vol 29, issue 7, Mary ann liebert INC, Australia, pp. 1410-1425.

Rosenfeld, J.V., Bragge, P., Morganti-Kossmann, M.C., Gruen, R.L., 2012, Early management iof servere traumatic brain injury, Lancet [P], vol 380, issue 9847, The Lancet Publishing Group, United Kingdom, pp. 1088-1098.

Rosenfeld, J.V., Maas, A.I., Morganti-Kossmann, M.C., Manley, G.T., Gruen, R.L., 2012, Early management of severe traumatic brain injury, Lancet [P], vol 380, issue 9847, The Lancet publishing group, United Kingdom, pp. 1088-1098.

Hellewell, S., Morganti-Kossmann, M.C., 2012, Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury, Mediators of Inflammation [E], vol 2012, issue Art. ID: 356494, Hindawi Publishing Corporation, USA, pp. 1-18.

Bye, N., Turnley, A.M., Morganti-Kossmann, M.C., 2012, Inflammatory regulators of redirected neural migration in the injured brain, Neurosignals [P], vol 20, issue 3, S. Karger AG, Switzerland, pp. 132-146.

Bye, N., Turnley, A., Morganti-Kossmann, M.C., 2012, Inflammatory regulators of redirected neural migration in the injured brain, Neurosignals [P], vol 20, issue 3, Karger, Australia, pp. 132-146.

Alwis, D.D.S., Yan, E.B., Morganti-Kossmann, M.C., Rajan, R., 2012, Sensory cortex underpinnings of traumatic brain injury deficits, PLoS ONE [P], vol 7, issue 12 (Art. No.: e52169), Public Library of Science, USA, pp. 1-19.

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A.L., Cops, E., Beckham, S.A., Galle, A.A., McLean, C., Morganti-Kossmann, M.C., Rosenfeld, J.V., Madani, R., Vassalli, J., Su, E.J., Lawrence, D.A., Medcalf, R.L., 2012, The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans, Brain [P], vol 135, issue Part 11, Oxford University Press, United Kingdom, pp. 3251-3264.

Ziebell, J., Bye, N., Semple, B.D., Kossman, T., Morganti-Kossmann, M., 2011, Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury, Brain Research [P], vol 1414, Elsevier BV, Netherlands, pp. 94-105.

Bye, N., Carron, S., Han, X., Agyapomaa, D., Ng, S., Yan, E., Rosenfeld, J., Morganti-Kossmann, M., 2011, Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats, Journal Of Neuroscience Research [P], vol 89, issue 7, John wiley & Sons Inc., USA, pp. 986-1000.

Yan, E., Hellewell, S., Bellander, B., Agyapomaa, D., Morganti-Kossmann, M., 2011, Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury, Journal of Neuroinflammation [P], vol 8, issue 147, BioMed Central Ltd, UK, pp. 1-16.

Morganti-Kossmann, M.C., Yan, E.B., Bye, N., 2010, Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory?, Injury-International Journal Of The Care Of The Injured [P], vol 41, issue Suppl 1, Elsevier Ltd, UK, pp. 10-13.

Semple, B., Frugier, T.J., Morganti-Kossmann, M.C., 2010, CCL2 modulates cytokine production in cultured mouse astrocytes, Journal of Neuroinflammation [P], vol 7, issue 67, BioMed Central Ltd, United Kingdom, pp. 1-11.

Semple, B.D., Bye, N., Ziebell, J.M., Morganti-Kossmann, M.C., 2010, Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury, Neurobiology Of Disease [P], vol 40, issue 2, Academic Press, USA, pp. 394-403.

Frugier, T.J., Morganti-Kossmann, M., O'Reilly, D., McLean, C., 2010, In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury, Journal of Neurotrauma [P], vol 27, issue 3, Mary Ann Liebert, Inc. Publishers, USA, pp. 497-507.

Ziebell, J., Morganti-Kossmann, M., 2010, Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury, Neurotherapeutics [P], vol 7, Springer, Germany, pp. 22-30.

Ziebell, J., Morganti-Kossmann, M., 2010, Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury, Neurotherapeutics [P], vol 7, issue 1, Springer new York LLC, United States, pp. 22-30.

Hellewell, S., Yan, E.B., Agyapomaa, D., Bye, N., Morganti-Kossmann, M., 2010, Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses, Journal of Neurotrauma [P], vol 27, issue 11, Mary Ann Liebert, Inc. Publishers, USA, pp. 1997-2010.

Semple, B., Bye, N., Rancan, M., Ziebell, J.M., Morganti-Kossmann, M.C., 2010, Role of CCL2 (MCP-1) in traumatic brain injury (TBI): Evidence from severe TBI patients and CCL2-/- mice, Journal of Cerebral Blood Flow and Metabolism [P], vol 30, issue 4, Nature Publishing Group, United States, pp. 769-782.

Semple, B.D., Kossmann, T., Morganti-Kossmann, M.C., 2010, Role of chemokines in CNS health and pathology: A focus on the CCL2/CCR2 and CXCL8/CXCR2 networks, Journal of Cerebral Blood Flow and Metabolism [P], vol 30, issue 3, Nature Publishing Group, US, pp. 459-473.

Crack, P.J., Gould, J.A., Bye, N., Ross, S., Ali, U., Habgood, M., Morganti-Kossmann, M.C., Saunders, N.R., Hertzog, P.J., 2009, The genomic profile of the cerebral cortex after closed head injury in mice: Effects of minocycline, Journal of Neural Transmission, vol 116, issue -, Springer Wien, Austria, pp. 1-12.

Seifman, M.A., Adamides, A., Nguyen, P., Vallance, S., Cooper, D.J., Kossmann, T., Rosenfeld, J.V., Morganti-Kossmann, M.C., 2008, Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray, Journal of Cerebral Blood Flow & Metabolism, vol 28, issue 4, Nature Publishing Group, United States, pp. 684-696.

Gantois, I., Fang, K., Jiang, L., Babovic, D., Lawrence, A.J., Ferreri, V., Teper, Y., Jupp, B., Ziebell, J.M., Morganti-Kossmann, M.C., O'Brien, T.J., Nally, R., Schutz, G., Waddington, J., Egan, G.F., Drago, J., 2007, Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior, Proceedings of the National Academy of Sciences of the United States of America, vol 104, issue 10, National Academy of Sciences, USA, pp. 4182-4187.

Habgood, M., Bye, N., Dziegielewska, K.M., Ek, C.J., Lane, M.A., Potter, A., Morganti-Kossmann, M.C., Saunders, N.R., 2007, Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice, European Journal of Neuroscience, vol 25, issue 1, Wiley-Blackwell Publishing Ltd, Oxford, England, pp. 231-238.

Grosjean, M., Lenzlinger, P., Stahel, P., Yatsiv, I., Shohami, E., Tentz, O., Kossman, T., Morganti-Kossmann, M., 2007, Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: Relationship with neuronal cell death and inflammatory mediators, Histology and Histopathology [P], vol 22, issue 3, Histology and Histopathology, Spain, pp. 235-250.

Grosjean, M.B., Lenzlinger, P.M., Stahel, P.F., Yatsiv, I., Shohami, E., Trentz, O., Kossmann, T.K., Morganti-Kossmann, M.C., 2007, Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: Relationship with neuronal cell death and inflammatory mediators, Histology and, vol 22, issue 3, Histology and Histopathology, Spain, pp. 235-250.

Morganti-Kossmann, M.C., satgunaseelan, L., Bye, N., Kossmann, T.K., 2007, Modulation of immune response by head injury, Injury-International Journal of the Care of the Injured, vol 38, issue 12, Elsevier Science Ltd, Oxford, England, pp. 1392-1400.

Bye, N., Habgood, M., Callaway, J.K., Malakooti, N., Potter, A., Kossmann, T.K., Morganti-Kossmann, M.C., 2007, Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration, Experimental Neurology, vol 204, issue Dec 2006, Academic Press, US, pp. 220-233.

Phillips, D.J., Nguyen, P., Adamides, A.A., Bye, N., Rosenfeld, J.V., Kossmann, T.K., Vallance, S., Murray, L.J., Morganti-Kossmann, M.C., 2006, Activin A release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury, Journal of Neurotrauma, vol 23, issue 9, Mary Ann Liebert Inc., New York USA, pp. 1283-1294.

Sang, Q., Kim, M., Kumar, S., Bye, N., Morganti-Kossmann, M.C., Gunnersen, J., Fuller, S.J., Howitt, J., Hyde, L., Beissbarth, T., Scott, H.S., Silke, J., Tan, S., 2006, Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury., Journal of Neuroscience, vol 26, issue 27, Society for Neuroscience, USA, pp. 7234-7244.

Lenzlinger, P.M., Shimizu, S., Marklund, N., Thompson, H.J., Schwab, M.E., Saatman, K.E., Hoover, R.C., Bareyre, F.M., Motta, M., Luginbuhl, A., Pape, R., Clouse, A.K., Morganti-Kossmann, M.C., McIntosh, T.K., 2005, Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats, Neuroscience, vol 134, issue 3, Elsevier, Oxford UK, pp. 1047-1056.

Hans, V.H., Lenzlinger, P.M., Joller-Jemelka, H.I., Morganti-Kossmann, M.C., 2005, Low T3 syndrome in head-injured patients is associated with prolonged suppression of markers of cell-mediated immune response, European Journal of Trauma and Emergency Surgery [P], vol 31, issue 4, Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH, Germany, Austria, pp. 359-368.

Rancan, M., Bye, N., Otto, V.I., Trentz, O., Kossmann, T.K., Frentzel, S., Morganti-Kossmann, M.C., 2004, The Chemokine Fractalkine in Patients with Severe Traumatic Brain Injury and a Mouse Model of Closed Head Injury, Journal of Cerebral Blood Flow and Metabolism, vol 24, issue 10, Lippincott Williams & Wilkins, USA, pp. 1110-1118.

Schmidt, O.I., Morganti-Kossmann, M.C., Heyde, C.E., Perez, D., Yatsiv, I., Shohami, E., Ertel, W., Stahel, P.F., 2004, Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury, Journal of Neuroinflammation, vol 1, issue 13, BioMed Central Ltd, UK, pp. 1-6.

Rancan, M., Morganti-Kossmann, M.C., Barnum, S.R., Saft, S., Schmidt, O.I., Ertel, W., Stahel, P.F., 2003, Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice, Journal of Cerebral Blood Flow & Metabolism, vol 23, issue 9, Lippincott Williams & Wilkins, Baltimore USA, pp. 1070-1074.

Kossmann, T.K., Morganti-Kossmann, M., Orenstein, J.M., Britt, W.J., Wahl, S.M., Smith, P.D., 2003, Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release, The Journal of Infectious Diseases, vol 187, issue 4, University of Chicago Press, Chicago USA, pp. 534-541.

Yatsiv, I., Morganti-Kossmann, M.C., Perez, D., Dinarello, C.A., Novick, D., Rubinstein, M., Otto, V.I., Rancan, M., Kossmann, T.K., Redaelli, C.A., Trentz, O., Shohami, E., Stahel, P.F., 2002, Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury, Journal of Cerebral Blood Flow & Metabolism, vol 22, issue 8, Nature Publishing Group, New York USA, pp. 971-978.

Morganti-Kossmann, M.C., Rancan, M., Stahel, P.F., Kossmann, T., 2002, Inflammatory response in acute traumatic brain injury: A double-edged sword, Current Opinion In Critical Care [P], vol 8, issue 2, Lippincott Williams & Wilkins, USA, pp. 101-105.

Lenzlinger, P.M., Marx, A., Trentz, O., Kossmann, T., Morganti-Kossmann, M., 2002, Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans, Journal of Neuroimmunology, vol 122, issue 1-2, Elsevier, Amsterdam The Netherlands, pp. 167-174.

Otto, V.I., Gloor, S.M., Frentzel, S., Gilli, U., Ammann, E., Hein, A.E., Folkers, G., Trentz, O., Kossmann, T., Morganti-Kossmann, M.C., 2002, The production of macrophage inflammatory protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase, Journal of Neurochemistry, vol 80, issue 5, Blackwell Publishing, Oxford England, pp. 824-834.

Stahel, P.F., Morganti-Kossmann, M.C., Perez, D., Redaelli, C., Gloor, B., Trentz, O., Kossmann, T., 2001, Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury, Journal of Neurotrauma, vol 18, issue 8, Mary Ann Liebert Inc., New Rochelle USA, pp. 773-781.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Oligodendrocytes derived from pluripotent stem cells: Myelination potential following injury.

Supervisors:

Azari, M (Main), Petratos, S (Associate), Boyd, R (Associate), Morganti-Kossmann, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Traumatic brain injury & the barrel cortex; Using a novel sensory system to understand functional changes in the brain..

Supervisors:

Rajan, R (Main), Coleman, H (Associate), Morganti-Kossmann, M (Associate), Yan, E (Associate).

Completed Supervision

Student:

Semple, B.

Program of Study:

Chemokines networks in neuroinflammation following focal traumatic brain injury. (PHD) 2010.

Supervisors:

Morganti-Kossmann, M (Main).

Student:

Ziebell, J.

Program of Study:

. 2004.

Supervisors:

Kelly, L (Main), Morganti-Kossmann, M (Associate), Bye, N (Associate), Alderuccio, F (Associate).

Student:

Ziebell, J.

Program of Study:

The role of FasL and TNF in cell apoptosis following focal traumatic brain injury. (PHD) 2008.

Supervisors:

Morganti-Kossmann, M (Main).