Dr Anthony Sadler - Researcher Profile

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Address

Monash Institute of Medical Research
Monash Medical Centre, Clayton

Biography

Anthony works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY
Institution: University of Otago - New Zealand
Year awarded: 2000

Publications

Journal Articles

Beckham, S.A., Brouwer, J.M., Roth, A., Wang, D., Sadler, A.J., John, M., Jahn-Hofmann, K., Williams, B.R.G., Wilce, J.A., Wilce, M.C.J., 2013, Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly, Nucleic Acids Research [P], vol 41, issue 5, Oxford University Press, UK, pp. 3436-3445.

Irving, A., Wang, D., Vasilevski, O., Latchoumanin, O., Kozer, N., Clayton, A., Szczepny, A., Morimoto, H., Xu, D., Williams, B., Sadler, A., 2012, Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense, Immunity [P], vol 36, issue 5, Cell Press, United States, pp. 795-806.

Sadler, A., Williams, B., 2011, Dynamiting Viruses with MxA, Immunity [P], vol 35, issue 4, Cell Press, United States, pp. 491-493.

Pindel, A., Sadler, A., 2011, The role of protein kinase R in the interferon response, Journal of Interferon and Cytokine Research [P], vol 31, issue 1, Mary Ann Liebert, Inc. Publishers, United States, pp. 59-70.

Wei, J., Waithman, J., Lata, R., Mifsud, N., Cebon, J., Kay, T., Smyth, M., Sadler, A., Chen, W., 2010, Influenza a infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7-and type I IFN-dependent fashion, Journal Of Immunology [P], vol 185, issue 10, American Association of Immunologists, USA, pp. 6013-6022.

Sadler, A.J., 2010, Orchestration of the activation of protein kinase R by the RNA-binding motif, Journal of Interferon and Cytokine Research [P], vol 30, issue 4, Mary Ann Liebert, Inc. Publishers, USA, pp. 195-203.

Sadler, A.J., Latchoumanin, O.A.L., Hawkes, D.J., Mak, J., Williams, B.R.G., 2009, An antiviral response directed by PKR phosphorylation of the RNA helicase A, Plos Pathogens [P], vol 5, issue 2 (e1000311), Public Library of Science, USA, pp. 1-11.

Lynch, H., Ray, C.A., Oie, K.L., Pollara, J.J., Petty, I.T.D., Sadler, A.J., Williams, B.R.G., Pickup, D.J., 2009, Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication, Virology [P], vol 391, issue 2, Academic Press, USA, pp. 177-186.

Xu, D., Holko, M., Sadler, A.J., Scott, B.M., Higashiyama, S., Berkofsky-Fessler, W., McConnell, M.J., Pandolfi, P.P., Licht, J.D., Williams, B.R.G., 2009, Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 802-816.

Sadler, A.J., Williams, B.R.G., 2008, Interferon-inducible antiviral effectors, Nature Reviews, Immunology, vol 8, issue 7, Nature Publishing Group, UK, pp. 559-568.

Chakrabarti, A., Sadler, A.J., Kar, N., Young, H.A., Silverman, R.H., Williams, B.R.G., 2008, Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA, Journal of Biological Chemistry, vol 283, issue 37, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 25132-25139.

Lim, W., Timmins, J.M., Seimon, T.A., Sadler, A.J., Kolodgie, F.D., Virmani, R., Tabas, I., 2008, Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo, Circulation, vol 117, issue 7, Lippincott Williams & Wilkins, USA, pp. 940-951.

Gantier, M.P.M., Sadler, A.J., Williams, B.R.G., 2007, Fine-tuning of the innate immune response by microRNAs, Immunology and Cell Biology, vol 85, issue 6, Nature Publishing Group, New York, NY, USA, pp. 458-462.

Sadler, A.J., Williams, B.R.G., 2007, Structure and function of the protein kinase R, Current Topics in Microbiology and Immunology, vol 316, Springer-Verlag Berlin, Berlin, Germany, pp. 253-292.

Gabel, F., Wang, D., Madern, D., Sadler, A.J., Dayie, K., Daryoush, M.Z., Schwahn, D., Zaccai, G., Lee, X., Williams, B.R.G., 2006, Dynamic flexibility of double-stranded RNA activated PKR in solution, Journal of Molecular Biology, vol 359, issue 3, Academic Press Ltd Elsevier Science Ltd, London England, pp. 610-623.

Other

Williams, B.R.G., Sadler, A.J., 2006, PKR, UCSD-Nature Molecule Pages: a comprehensive signalling database., Nature Publishing Group, http://www.signaling-gateway.org/molecule/query?afcsid=A000792&mpv=1.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigation of role for PKR in obesity related diseases.
Supervisors:
Sadler, A (Joint), Williams, B (Joint-co).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigation of role for PKR in obesity related diseases .
Supervisors:
Sadler, A (Main), Tipping, P (Associate), Williams, B (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigation of the role of IFIH-1 and the effect of rotavirus in Type 1 Diabetes.
Supervisors:
Sadler, A (Joint), Williams, B (Joint-co).