Mr George Christopoulos - Researcher Profile

Biography

Position

Senior Research Assistant
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

BACHELOR OF SCIENCE (HONS)

Institution: Monash University

Year awarded: 1991

Publications

Journal Articles

Qi, T., Ly, K., Poyner, D.R., Christopoulos, G., Sexton, P., Hay, D.L., 2011, Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors, Peptides [P], vol 32, issue 5, Elsevier Inc., USA, pp. 1060-1067.

Qi, T., Christopoulos, G., Bailey, R.J., Christopoulos, A., Sexton, P., Hay, D.L., 2008, Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function, Molecular Pharmacology, vol 74, issue 4, American Society for Pharmacology and Experimental Therapeutics, United States, pp. 1059-1071.

Sexton, P., Christopoulos, G., Christopoulos, A., Nylen, E.S., Snider Jr., R.H., Becker, K.L., 2008, Procalcitonin has bioactivity at calcitonin receptor family complexes: Potential mediator implications in sepsis, Critical Care Medicine, vol 36, issue 5, Lippincott Williams & Wilkins, United Stastes, pp. 1637-1640.

Morfis, M., Tilakaratne, N., Furness, S.G.B., Christopoulos, G., Werry, T.D., Christopoulos, A., Sexton, P., 2008, Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors, Endocrinology, vol 149, issue 11, The Endocrine Society, United States, pp. 5423-5431.

Udawela, M., Christopoulos, G., Morfis, M., Tilakaratne, N., Christopoulos, A., Sexton, P., 2008, The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors, Regulatory Peptides, vol 145, Elsevier Science BV, Amsterdam The Netherlands, pp. 65-71.

Udawela, M., Christopoulos, G., Morfis, M., Christopoulos, A., Ye, S., Tilakaratne, N., Sexton, P.M., 2006, A critical role for the short intracellular C terminus in receptor activity-modifying protein function, Molecular Pharmacology, vol 70, issue 5, American Society for Pharmacology and Experimental Therapeutics, Bethesda Maryland USA, pp. 1750-1760.

Sexton, P., Morfis, M., Tilakaratne, N., Hay, D.L., Udawela, M., Christopoulos, G., Christopoulos, A., 2006, Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs, Annals of the New York Academy of Sciences, vol 1070, New York Acad. Sciences, New York USA, pp. 90-104.

Hay, D.L., Christopoulos, G., Christopoulos, A., Sexton, P.M., 2006, Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-, Molecular Pharmacology, vol 70, issue 6, American Society for Pharmacology and Experimental Therapeutics, Bethesda Maryland USA, pp. 1984-1991.

Udawela, M., Christopoulos, G., Tilakaratne, N., Christopoulos, A., Albiston, A.L., Sexton, P.M., 2006, Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors, Molecular Pharmacology, vol 69, issue 6, The American Society for Pharmacology and Experimental Therapeutics, Bethesda USA, pp. 1984-1989.

Hay, D.L., Christopoulos, G., Christopoulos, A., Poyner, D.D., Sexton, P.M., 2005, Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes, Molecular Pharmacology, vol 67, issue 5, American Society for Pharmacology and Experimental Therapeutics, Bethesda MD USA, pp. 1655-1665.

Hay, D.L., Christopoulos, G., Christopoulos, A., Sexton, P., 2004, Amylin receptors: Molecular composition and pharmacology, Biochemical Society Transactions [P], vol 32, issue Pt 5, Portland Press Ltd, UK, pp. 865-867.

Paxinos, G., Chai, S.Y., Christopoulos, G., Huang, X., Toga, A.W., Wang, H.Q., Sexton, P.M., 2004, In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain, Journal of Chemical Neuroanatomy, vol 27, issue 4, Elsevier Science BV, The Netherlands, pp. 217-236.

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N., Sexton, P.M., 2003, Novel receptor partners and function of receptor activity-modifying proteins, Journal of Biological Chemistry, vol 278, issue 5, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 3293-3297.

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences