Assoc Prof Brendan Jenkins - Researcher Profile

Biography

Brendan works in the Faculty of Medicine, Nursing & Health Sciences at Monash University. He is a Senior Scientist and Head of the Cytokine Signalling Laboratory in the Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, and currently holds a prestigious Sylvia and Charles Viertel Senior Medical Research Fellowship. His research laboratory has a strong focus on cancer and inflammatory diseases.

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Keywords

Cancer, Cancer/Carcinogenesis, Inflammation, Inflammatory diseases, animals cell division cell movement/immunology cytokine receptor gp130/genetics disease models, , cytokine signalling cellular homeostasis stats interleukin 6 cytokine family cell biology , cytokine signalling, animal disease models, pathoegn recognition receptors, cytokine; t-cell regulation; inflammation , gastritis; gastric cancer; gp130; il-6; il-17a; stat3 , gp130; receptor; il-6; cytokines; apoptosis

Qualifications

MEDICINE

Institution: The University of Adelaide

Year awarded: 1998

Publications

Journal Articles

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., Longano, A., Bardin, P., Bozinovski, S., Anderson, G., Jenkins, B., 2012, Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 32, issue 7, American Physiological Society, Untied States, pp. L627-L639.

GreenHill, C., Gould, J.A., Ernst, M.R., Jarnicki, A.G., Hertzog, P.J., Mansell, A.S., Jenkins, B.J., 2012, LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling, Immunology And Cell Biology [P], vol 90, issue 5, Nature Publishing Group, United Kingdom, pp. 559-563.

Tye, Y.M.H., Kennedy, C.L., Najdovska, M., McLeod, L., McCormack, W., Hughes, N.R., Dev, A.T., Sievert, W., Ooi, C., Ishikawa, T., Oshima, H., Bhathal, P.S., Parker, A.E., Oshima, M., Tan, P., Jenkins, B.J., 2012, STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation, Cancer Cell [P], vol 22, issue 4, Cell Press, United States, pp. 466-478.

McCormack, W., Oshima, M., Tan, P., Jenkins, B.J., 2012, Toll-like receptor 2: therapeutic target for gastric carcinogenesis, OncoTarget [E}, vol 3, issue 11, Impact Journals LLC, United States, pp. 1260-1261.

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., Ernst, M., Armes, J., Bardin, P., Anderson, G., Jenkins, B., 2011, Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice, American Journal Of Respiratory Cell And Molecular Biology [P], vol 45, issue 4, American Thoracic Society, United States, pp. 720-730.

Kennedy, C., Najdovska, M., Jones, G., McLeod, L., Hughes, N., Allison, C., Ooi, C., Tan, P., Ferrero, R., Jones, S., Dev, A., Sievert, W., Bhathal, P., Jenkins, B., 2011, The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17, Journal Of Pathology [P], vol 225, issue 2, John Wiley & Sons Ltd, United Kingdom, pp. 255-264.

Greenhill, C., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P.J., Mansell, A.S., Jenkins, B.J., 2010, IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3, Journal Of Immunology [P], vol 186, issue 2, American Association of Immunologists, United States, pp. 1199-1208.

Mejias-Luque, R., Linden, S., Garrido, M., Tye, Y., Najdovska, M., Jenkins, B.J., Iglesias, M., Ernst, M., de Bolos, C., 2010, Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors, Oncogene [P], vol 29, issue 12, Nature Publishing Group, United Kingdom, pp. 1753-1762.

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P.J., Topley, N., Williams, A.S., Hunter, C., Jenkins, B.J., Wang, E., Jones, S.A., 2010, Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation, Faseb Journal [P], vol 25, issue 1, Federation of American Societies for Experimental Biology, United States, pp. 409-419.

Nowell, M., Williams, A.S., Carty, S., Scheller, J., Hayes, A., Jones, G., Richards, P., Slinn, S., Ernst, M., Jenkins, B.J., Topley, N., Rose-John, S., Jones, S.A., 2009, Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis, Journal Of Immunology [P], vol 182, issue 1, American Association of Immunologists, United States, pp. 613-622.

Fielding, C.A., McLoughlin, R.M., McLeod, L., Colmont, C., Najdovska, M., Grail, D., Ernst, M., Jones, S.A., Topley, N., Jenkins, B.J., 2008, IL-6 regulates neutrophil trafficking during acute inflammation via STAT3, Journal Of Immunology [P], vol 181, issue 3, American Association of Immunologists, United States, pp. 2189-2195.

Ernst, M.R., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, Y.M.H., Matthews, V.B., Armes, J.E., Bhathal, P.S., Hughes, N.R., Marcusson, E.G., Karras, J.G., Na, S., Sedgwick, J., Hertzog, P.J., Jenkins, B.J., 2008, STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice, Journal of Clinical Investigation, vol 118, issue 5, American Society for Clinical Investigation, USA, pp. 1727-1738.

Jenkins, B.J., Roberts, A.W., Greenhill, C., Najdovska, M., Lundgren-May, T., Robb, L.M., Grail, D., Ernst, M.R., 2007, Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis, Blood, vol 109, issue 6, American Society of Hematology, Washington USA, pp. 2380-2388.

Brender, C., Tannahill, G.M., Jenkins, B.J., Fletcher, J., Columbus, R., Saris, C.J., Ernst, M.R., Nicola, N.A., Hilton, D.J., Alexander, W.S., Starr, R.J., 2007, Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27, Blood, vol 110, issue 7, American Society of Hematology, USA, pp. 2528-2536.

Judd, L., Bredin, K., Kalantzis, A., Jenkins, B., Ernst, M., Giraud, A., 2006, STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis, Gastroenterology [P], vol 131, issue 4, WB Saunders Co., United States, pp. 1073-1085.

Howlett, M., Judd, L., Jenkins, B., La Gruta, N., Grail, D., Ernst, M., Giraud, A., 2005, Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130, Gastroenterology [P], vol 129, issue 3, WB Saunders Co., United States, pp. 1005-1018.

Jenkins, B.J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R.M., Jones, S.A., Topley, N., Baumann, H., Judd, L.M., Giraud, A.S., Boussioutas, A., Zhu, H., Ernst, M.R., 2005, Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling, Nature Medicine, vol 11, Nature Publishing Group, New York USA, pp. 845-852.

McLoughlin, R.M., Jenkins, B.J., Grail, D., Williams, A.S., Fielding, C.A., Parker, C.R., Ernst, M.R., Topley, N., Jones, S.A., 2005, IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation, Proceedings of the National Academy of Sciences, vol 102, issue 27, The National Academy of Science, USA, pp. 9589-9594.

Sims, N., Jenkins, B., Nakamura, A., Quinn, J., Li, R., Gillespie, M., Ernst, M., Robb, L., Martin, T., 2005, Interleukin-11 receptor signaling is required for normal bone remodeling, Journal of Bone and Mineral Research [P], vol 20, issue 7, Wiley-Blackwell Publishing Inc, United States, pp. 1093-1102.

Jenkins, B.J., Roberts, A.W., Najdovska, M., Grail, D., Ernst, M.R., 2005, The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis, Blood, vol 105, issue 9, The American Society of Hematology, USA, pp. 3512-3520.

Ernst, M., Jenkins, B., 2004, Acquiring signalling specificity from the cytokine receptor gp130, Trends in Genetics [P], vol 20, issue 1, Elsevier Ltd., United Kingdom, pp. 23-32.

Judd, L., Alderman, B., Howlett, M., Shulkes, A., Dow, C., Moverley, J., Grail, D., Jenkins, B., Ernst, M., Giraud, A., 2004, Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130, Gastroenterology [P], vol 126, issue 1, WB Saunders Co., United States, pp. 196-207.

Sims, N.A., Jenkins, B.J., Quinn, J.M., Nakamura, A., Glatt, M., Gillespie, M.T., Ernst, M.R., Martin, J.T., 2004, Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways, The Journal of Clnical Investigations, vol 113, pp. 379-389.

Jenkins, B.J., Grail, D., Inglese, M., Quilici, C., Bozinovksi, S., Wong, P., Ernst, M.R., 2004, Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression, Molecular and Cellular biology, vol 24, issue 4, American Society for microbiology, USA, pp. 1453-1463.

Tebbutt, N.C., Giraud, A.S., Inglese, M., Jenkins, B.J., Waring, P., Clay, F.J., Malki, S., Grail, D., Hollande, F., Heath, J.K., Ernst, M.R., 2002, Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice, Nature Medicine [P], vol 8, issue 10, Nature Publishing Group, United States, pp. 1089-1097.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Deregulated IL-6 signalling as a key molecular bridge linking the pathogenesis of emphysema and L/C.

Supervisors:

Jenkins, B (Main), Ruwanpura, S (Associate), Watkins, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Deregulated gp130 signalling contributes to lung tumourigensis and the development of cancer-related cachexia.

Supervisors:

Jenkins, B (Main), Bardin, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

STAT3 and the AIM2 Inflammasome in Gastric Cancer.

Supervisors:

Jenkins, B (Main), Sievert, W (Associate).

Completed Supervision

Student:

Greenhill, C.

Program of Study:

IL-6 trans-signalling modulates TLR4-dependent inflammatory responses via STAT1 and STAT3. (PHD) 2011.

Supervisors:

Jenkins, B (Main).

Student:

Tye, Y.

Program of Study:

Elucidating the role of TLR2 in STAT3-mediated gastric tumourigenesis. (PHD) 2012.

Supervisors:

Jenkins, B (Main).