Dr Kumar Visvanathan - Researcher Profile

Biography

Kumar works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of NSW

Year awarded: 2000

Publications

Journal Articles

Giles, M., Visvanathan, K., Lewin, S.R., Sasadeusz, J., 2012, Chronic hepatitis B infection and pregnancy, Obstetrical and Gynecological Survey [P], vol 67, issue 1, Lippincott Williams & Wilkins, Ltd., United States, pp. 37-44.

Crane, M., Visvanathan, K., Lewin, S.R., 2012, HIV Infection and TLR signalling in the liver, Gastroenterology Research and Practice [P], vol 2012, Hindawi Publishing Corporation, United States, p. e473925.

Mulley, W., Visvanathan, K., Hurt, A.C., Brown, F.G., Polkinghorne, K.R., Mastorakos, T., Lewicki, M.C., Stuart, R.L., Tan, S., Chean, R., Kerr, P., Kanellis, J., 2012, Mycophenolate and lower graft function reduce the seroresponse of kidney transplant recipients to pandemic H1N1 vaccination, Kidney International [P], vol 82, issue 2, Nature Publishing Group, United Kingdom, pp. 212-219.

Ratnam, D., Sievert, W., Visvanathan, K., 2012, Natural killer cells display impaired responses to toll like receptor 9 that support viral persistence in chronic hepatitis B, Cellular Immunology [P], vol 279, issue 1, Academic Press, United States, pp. 109-115.

Testro, A.G., Visvanathan, K., Skinner, N., Markovska, V., Crowley, P., Angus, P.W., Gow, P.J., 2011, Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4, Journal Of Gastroenterology And Hepatology [P], vol 26, issue 1, Cambridge University Press, UK, pp. 155-163.

Giles, M., Visvanathan, K., Sasadeusz, J., 2011, Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding, Antiviral Therapy [P], vol 16, issue 5, International Medical Press, UK, pp. 621-628.

Berzsenyi, M., Roberts, S., Preiss, S., Woollard, D., Beard, M., Skinner, N., Bowden, D., Visvanathan, K., 2011, Hepatic TLR2 & TLR4 expression correlates with hepatic inflammation and TNF-a in HCV & HCV/HIV infection, Journal Of Viral Hepatitis [P], vol 18, issue 12, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 852-860.

Lang, T., Lo, C., Skinner, N., Locarnini, S., Visvanathan, K., Mansell, A., 2011, The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway, Journal Of Hepatology [P], vol 55, issue 4, Elsevier BV, Netherlands, pp. 762-769.

Testro, A.G., Gow, P.J., Angus, P.W., Wongseelashote, S., Skinner, N.A., Markovska, V., Visvanathan, K., 2010, Effects of antibiotics on expression and function of Toll-like receptors 2 and 4 on mononuclear cells in patients with advanced cirrhosis, Journal Of Hepatology [P], vol 52, issue 2, Elsevier BV, Netherlands, pp. 199-205.

Summers, S.A., van der Veen, B.S., O'Sullivan, K., Gan, P., Ooi, J., Heeringa, P., Satchell, S.C., Mathieson, P.W., Saleem, M.A., Visvanathan, K., Holdsworth, S.R., Kitching, A.R., 2010, Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis, Kidney International [P], vol 78, issue 12, Nature Publishing Group, United Kingdom, pp. 1263-1274.

Thompson, A., Nguyen, T., Iser, D., Ayres, A., Jackson, K., Littlejohn, M., Slavin, J., Bowden, S., Gane, E., Abbott, W., Lau, G., Lewin, S., Visvanathan, K., Desmond, P., Locarnini, S., 2010, Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers, Hepatology [P], vol 51, issue 6, John Wiley & Sons, Inc, United States of America, pp. 1933-1944.

Summers, S.A., Steinmetz, O., Ooi, J., Gan, P., O'Sullivan, K., Visvanathan, K., Akira, S., Kitching, A.R., Holdsworth, S.R., 2010, Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis, American Journal Of Pathology [P], vol 177, issue 5, American Society for Investigative Pathology, United States, pp. 2234-2244.

Howell, J.A., Visvanathan, K., 2009, A novel role for human leukocyte antigen-DP in chronic hepatitis B infection: A genomewide association study, Hepatology [P], vol 50, issue 2, John Wiley & Sons, Inc., United States, pp. 647-649.

Woolley, I.J., Brown, C.M.S., Hutchinson, P.E., Turkou, V., Visvanathan, K., Wood, E.M., 2009, Duffy antigen expression on reticulocytes does not alter following blood loss in an autologous donation model, Vox Sanguinis [E], vol 97, issue 3, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 268-272.

Horne, K., Li, X., Jacobson, L.P., Palella, F., Jamieson, B.D., Margolick, J.B., Martinson, J., Turkozu, V., Visvanathan, K., Woolley, I.J., 2009, Duffy antigen polymorphisms do not alter progression of HIV in African Americans in the MACS cohort, Cell Host and Microbe [P], vol 5, issue 5, Cell Press, United States, pp. 415-417.

Crane, M., Oliver, B., Matthews, G., Avihingsanon, A., Ubolyam, S., Markovska, V., Chang, J.J., Dore, G., Price, P., Visvanathan, K., French, M., Ruxrungtham, K., Lewin, S.R., 2009, Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy, Journal Of Infectious Diseases [P], vol 199, issue 7, University of Chicago Press, United States, pp. 974-981.

Thompson, A.J., Colledge, D., Rodgers, S., Wilson, R., Revill, P., Desmond, P., Mansell, A.S., Visvanathan, K., Locarnini, S., 2009, Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro, Antiviral Therapy [P], vol 14, issue 6, International Medical Press, United Kingdom, pp. 797-808.

Testro, A.G., Visvanathan, K., 2009, Toll-like receptors and their role in gastrointestinal disease, Journal of Gastroenterology and Hepatology [E], vol 24, Wiley-Blackwell Publishing Asia, Australia, pp. 943-954.

Preiss, S., Thompson, A., Chen, X., Rogers, S., Markovska, V., Desmond, P.V., Visvanathan, K., Li, K., Locarnini, S., Revill, P., 2008, Characterization of the innate immune signalling pathways in hepatocyte cell lines, Journal of Viral Hepatitis, vol 15, issue 12, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 888-900.

Pathirana, R.D., O'Brien-Simpson, N.M., Visvanathan, K., Hamilton, J.A., Reynolds, E.C., 2008, The role of the RgpA-Kgp proteinase-adhesin complexes in the adherence of Porphyromonas gingivalis to fibroblasts, Microbiology, vol 154, issue 10, Society for General Microbiology, United Kingdom, pp. 2904-2911.

Chapman, S.J.R., Woolley, I.J., Visvanathan, K., Korman, T., 2007, Acute pancreatitis caused by tipranavir/ritonavir-induced hypertriglyceridaemia., AIDS, vol 21, issue 4, Lippincott Williams & Wilkins, United States, pp. 532-533.

Pathirana, R.D., O'Brein-Simpson, N.M., Visvanathan, K., Hamilton, J.A., Reynolds, E.C., 2007, Flow cytometric analysis of adherence of Porphyromonas gingivalis to oral epithelial cells, Infection and Immunity, vol 75, issue 5, American Society for Microbiology, United States, pp. 2484-2492.

Visvanathan, K., Skinner, N.A., Thompson, A.J.V., Riordan, S.M., Sozzi, V., Edwards, R., Rodgers, S., Kurtovic, J., Chang, J., Lewin, S.R., Desmond, P., Locarnini, S., 2007, Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein, Hepatology, vol 45, issue 1, John Wiley & Sons, Inc., USA, pp. 102-110.

Thompson, A.J.V., Locarnini, S., Visvanathan, K., 2007, The natural history and the staging of chronic hepatitis B: time for reevaluation of the virus-host relationship based on molecular virology and immunopathogenesis considerations?, Gastroenterology, vol 133, issue 3, W.B. Saunders Co., United States, pp. 1031-1035.

Chang, J.J., Thompson, A.J.V., Visvanathan, K., Kent, S.J., Cameron, P.U., Wightman, F., Desmond, P.V., Locarnini, S., Lewin, S.R., 2007, The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection, Hepatology, vol 46, issue 5, John Wiley & Sons Inc, USA, pp. 1332-1340.

Harrington, Z., Visvanathan, K., Skinner, N.A., Curtis, N., Currie, B.J., Carapetis, J.R., 2006, B-cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settings, Medical Journal of Australia, vol 184, issue 10, Australasian Medical Publishing Company Ltd, Sydney NSW Australia, pp. 507-510.

Chen, L.F., Woolley, I.J., Visvanathan, K., Korman, T., 2006, Hypovolemic shock and metabolic acidosis in a refugee secondary to O1 serotype Vibrio cholerae enteritis, Communicable Diseases Intelligence, vol 30, issue 2, Department of Health and Ageing, National Centre for Disease Control, Australia, pp. 233-235.

Visvanathan, K., Lewin, S.R., 2006, Immunopathogenesis: Role of innate and adaptive immune-responses, Seminars in Liver Disease, vol 26, issue 2, Thieme Medical Publishers Inc., New York USA, pp. 104-115.

Riordan, S.M., Skinner, N.A., Kurtovic, J., Locarnini, S., Visvanathan, K., 2006, Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B, Clinical and Vaccine Immunology, vol 13, issue 8, American Society for Microbiology, USA, pp. 972-974.

Sundararajan, V., Korman, T., Macisaac, C., Presneill, J.J., Cade, J.F., Visvanathan, K., 2006, The microbiology and outcome of sepsis in Victoria, Australia, Epidemiology and Infection, vol 134, issue 2, Cambridge University Press, New York USA, pp. 307-314.

Riordan, S.M., Skinner, N.A., Kurtovic, J., Locarnini, S., McIver, C.J., Williams, R., Visvanathan, K., 2006, Toll-like receptor expression in chronic hepatitis C: correlation with pro-inflammatory cytokine levels and liver injury, Inflammation Research, vol 55, issue 7, Birkhaeuser Verlag AG, Switzerland, pp. 279-285.

Sundararajan, V., Maclsaac, C.M., Presneill, J.J., Cade, J.F., Visvanathan, K., 2005, Epidemiology of sepsis in Victoria, Australia, Critical Care Medicine, vol 33, issue 1, Lippincott Williams & Wilkins, United States, pp. 71-80.

Skinner, N.A., Macisaac, C., Hamilton, J.A., Visvanathan, K., 2005, Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14 dimCD16+ monocytes in response to sepsis-related antigens, Clinical and Experimental Immunology, vol 141, issue 2, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 270-278.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A study of the relationship between vitamin D status and the severity and outcomes of chronic non-cholestatic liver disease..

Supervisors:

Roberts, S (Main), Sievert, W (Associate), Visvanathan, K (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Innate immune markers in mycobacterial disease. Tool-like receptors and their function in mycobacterial inferctions - a longitudinal translatioanl study examining infected patients.

Supervisors:

Visvanathan, K (Main), Jenkin, G (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of hepatic natural killer (NK) cells during hepatitis B virus (HBV) flares and hepatitis B.

Supervisors:

Sievert, W (Joint-co), Visvanathan, K (Joint).