Dr Justin Hamilton - Researcher Profile

Dr Justin Hamilton

Address

Australian Centre for Blood Diseases
6th Floor, Burnet Tower, The Alfred Hospital

Contact Details

Tel: +61 3 990 30125

Email: Justin.Hamilton@monash.edu


Biography

Justin works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Dr Justin Hamilton is a Heart Foundation Career Development Fellow in the Thrombosis Research Unit of the Australian Centre for Blood Diseases (Melbourne, Australia).  His group studies the role of platelets, platelet thrombin receptors, and their signaling effectors, in haemostasis, thrombosis, and inflammatory conditions.  Justin received his PhD from the Department of Pharmacology at The University of Melbourne, where he was awarded the Chancellor’s Prize in Medicine for the best PhD thesis of 2001.  He then performed post-doctoral studies as a NHMRC CJ Martin Fellow in Prof. Shaun Coughlin’s laboratory at the University of California, San Francisco.  His work has been published in numerous journals, including Nature, PNAS, Blood, and Circulation Research, and is funded by the Heart Foundation and the NHMRC.

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Keywords

Cardiovascular Diseases, Platelets, Protease-activated receptors, Thrombosis

Qualifications

PHD(MEDICINE)
Institution: The University of Melbourne
Year awarded: 2001
BSC(HONS)
Institution: The University of Melbourne
Year awarded: 1997

Publications

Journal Articles

Al-Tamimi, M., Tan, C., Qiao, J.L., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J.F., Davis, A., Jing, J., Mu, F., Hamilton, J.R., Jackson, S., Ludwig, A., Berndt, M.C., Ward, C., Kritharides, L., Andrews, R.K., Gardiner, E.E., 2012, Pathologic shear triggers shedding of vascular receptors: A novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels, Blood [P], vol 119, issue 18, American Society of Hematology, United States, pp. 4311-4320.

Lee, H., Hamilton, J.R., 2012, Physiology, pharmacology, and therapeutic potential of protease-activated receptors in vascular disease, Pharmacology and Therapeutics [P], vol 134, issue 2, Elsevier Inc., United States, pp. 246-259.

Lee, H., Sturgeon, S.A., Mountford, J.K., Jackson, S., Hamilton, J.R., 2012, Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice, British Journal of Pharmacology [P], vol 166, issue 7, John Wiley & Sons Ltd, United Kingdom, pp. 2188-2197.

Lee, H., Sturgeon, S., Jackson, S., Hamilton, J., 2012, The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions, Thrombosis and Haemostasis [P], vol 107, issue 2, Schattauer GmbH, Germany, pp. 328-337.

Takiguchi, M., James, C., Josefsson, E.C., Carmichael, C.L., Premsrirut, P.K., Lowe, s.w., Hamilton, J.R., Huang, D.C., Kile, B., Dickins, R.A., 2010, Transgenic, inducible RNAi in megakaryocytes and platelets in mice, Journal of Thrombosis and Haemostasis [E], vol 8, issue 1538-7933, Wiley-Blackwell Publishing Ltd., UK, pp. 2751-2756.

Hamilton, J.R., Cornelissen, I., Mountford, J.K., Coughlin, S.R., 2009, Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice, Atherosclerosis [P], vol 205, issue 2, Elsevier Ireland Ltd, Ireland, pp. 427-432.

Hamilton, J.R., 2009, Protease-activated receptors as targets for antiplatelet therapy, Blood Reviews [P], vol 23, issue 2, Churchill Livingstone, UK, pp. 61-65.

Busso, N., Chobaz-Peclat, V., Hamilton, J.R., Spee, P., Wagtmann, N., So, A., 2008, Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation, Arthritis Research & Therapy [P], vol 10, issue 2, BioMed Central Ltd, UK, pp. 1-8.

Ono, A., Westein, E., Hsiao, S.T., Nesbitt, W.S., Hamilton, J.R., Schoenwaelder, S.M., Jackson, S., 2008, Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth, Blood, vol 112, issue 1, American Society of Hematology, United States, pp. 90-99.

Hamilton, J.R., Kaplan, Z., Jackson, S., Opat, S., 2007, Antiplatelet therapy: present status and future prospects, Expert Opinion on Drug Discovery, vol 2, issue 8, Informa Healthcare, UK, pp. 1035-1040.

Busso, N., Frasnelli, M., Feifel, R., Cenni, B., Steinhoff, M., Hamilton, J.R., So, A., 2007, Evaluation of protease-activated receptor 2 in murine models of arthritis, Arthritis and Rheumatism, vol 56, John Wiley & Sons, Inc, USA, pp. 101-107.

Vandendries, E.R., Hamilton, J.R., Coughlin, S.R., Furie, B., Furie, B.C., 2007, Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis, Proceedings of the National Academy of Sciences, vol 104, issue 1, National Academy of Sciences, USA, pp. 288-292.

Su, X., Camerer, E., Hamilton, J.R., Coughlin, S.R., Matthay, M.A., 2005, Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms, The Journal of Immunology, vol 175, American Association of Immunologists, USA, pp. 2598-2605.

Camerer, E., Duong, D.N., Hamilton, J.R., Coughlin, S.R., 2004, Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency, Blood, vol 103, issue 1, American Society of Hematology, USA, pp. 152-154.

Hamilton, J.R., Cornelissen, I., Coughlin, S.R., 2004, Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets, Journal of Thrombosis and Haemostasis, vol 2, Blackwell Publishing Inc., USA, pp. 1-7.

Kataoka, H., Hamilton, J.R., McKemy, D.D., Camerer, E., Zheng, Y., Cheng, A., Griffin, C., Coughlin, S.R., 2003, Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells, Blood, vol 102, issue 9, American Society of Hematology, USA, pp. 3224-3231.

Hamilton, J.R., Moffatt, J.D., Tatoulis, J., Cocks, T.M., 2002, Enzymatic activation of endothelial protease-activated receptors is dependent on artery diameter in human and porcine isolated coronary arteries., British Journal of Pharmacology, vol 136, Nature Publishing Group, UK, pp. 492-501.

Hamilton, J.R., Weiss, E.J., Lease, K.E., Coughlin, S.R., 2002, Protection against thrombosis in mice lacking PAR3, Blood, vol 100, pp. 3240*-3244.

Weiss, E.J., Hamilton, J.R., Lease, K.E., Coughlin, S.R., 2002, Protection against thrombosis in mice lacking PAR3., Blood, vol 100, issue 9, American Society of Hematology, USA, pp. 3240-3244.

Hamilton, J.R., Frauman, A.G., Cocks, T.M., 2001, Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists, Circ.Res, vol 89, pp. 92*-98.

Hamilton, J.R., Frauman, A.G., Cocks, T.M., 2001, Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists., Circulation Research, vol 89, Lippincott Williams & Wilkins, USA, pp. 92-98.

Hamilton, J.R., Moffatt, J.D., Frauman, A.G., Cocks, T.M., 2001, Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries, Journal of Cardiovascular Pharmacology, vol 38, Lippincott Williams & Wilkins, USA, pp. 108-119.

Other

Coughlin, S.R., Camerer, E., Hamilton, J.R., 2005, Protease-activated receptors in hemostasis, thrombosis, and vascular biology, Hemostasis and thrombosis: basic principles and clinical practice (the pre-eiminent reference on coagulation disorders), Lippincott Williams & Wilkins, Philadelphia, PA, USA.

Grants

Title:
Defining the function of the thrombin receptor, PAR4, on human platelets.
Investigators:
Hamilton, J
Funding:
(2013 - 2017). National Health & Medical Research Council (NHMRC).
Title:
Defining the roles of platelet protease-activated receptors in thrombosis.
Investigators:
Hamilton, J
Funding:
(2008 - 2012). Heart Foundation.
Title:
Defining the roles of protease-activeated receptors in thrombosis.
Investigators:
Hamilton, J, Salem, H
Funding:
(2008 - 2011). National Health & Medical Research Council (NHMRC).
Title:
Investigation of the role of Class II PI 3-kinase in platelet function.
Investigators:
Jackson, S, Hamilton, J
Funding:
(2011 - 2015). National Health & Medical Research Council (NHMRC).
Title:
Nikon AIR Confocal Microscope.
Investigators:
Jackson, S, Medcalf, R, Mackay-Fisson, F, Plebanski, M, Andrews, R, Jane, S, Curtis, D, Morganti-Kossmann, M, Peter, K, Chin-Dusting, J, Mak, J, Pereira, C, Hamilton, J, Cody, S
Funding:
(2011 - 2015). National Health & Medical Research Council (NHMRC).
Title:
Roles of endothelial cell protease-activated receptors during inflammation.
Investigators:
Hamilton, J
Funding:
(2005 - 2009). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:
Mountford, J.
Program of Study:
Defining the role of Class II Phosphoinositide 3-Kinases in platelet function. (PHD) 2012.
Supervisors:
Hamilton, J (Joint-Co), Jackson, S (Joint).