Dr Stavros Selemidis - Researcher Profile

Stavros Selemidis

Address

Department of Pharmacology
Faculty of Medicine, Nursing & Health Sciences, Clayton

Contact Details

Email: Stavros.Selemidis@monash.edu


Biography

Stavros works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Australian Research Council Future Fellow.

Dr Stavros Selemidis obtained his Ph.D. in 2001 in the Department of Pharmacology at the University of Melbourne, working with A/Prof Thomas Cocks in the area of endothelium and regulation of coronary artery tone.  In 2003 he was awarded an NHMRC Peter Doherty Research Fellowship to conduct postdoctoral studies at the Howard Florey Institute with Prof Gregory Dusting where he examined mechanisms of oxidative stress and cytoprotection in the vasculature. In 2005 he moved to the Department of Pharmacology, Monash University with A/Prof Chris Sobey and Dr Grant Drummond who head the Vascular Biology and Immunopharmacology Group.

Dr Selemidis is currently an Australian Research Council Future Fellow. He has served on a Training Fellowship Review Panel for the NHMRC, and is currently the responsible Investigator on Cancer Council of Victoria and National Heart Foundation grants.  He has had over 10 invitations to speak at both National and International conferences, and research institutions. Stavros’s research is focused on oxidative stress with a particular emphasis on the role of NADPH oxidases. Stavros has collaborations with Dr Ross Vlahos (University of Melbourne) and Dr John Stambas (Deakin and CSIRO) examining the potential of NADPH oxidase inhibition as a therapeutic target against influenza A virus induced lung injury. Also, Stavros is examining the role of NADPH oxidases in angiogenesis in cancer with Dr Elizabeth Williams (Monash Institute of Medical Research).

Qualifications

DOCTOR OF PHILOSOPHY
Institution: University of Melbourne
Year awarded: 2001
SCIENCE (PHARMACOLOGY) - THESIS
Institution: UNIVERSITY OF MELBOURNE
Year awarded: 1997
SCIENCE (HONS)
Institution: UNIVERSITY OF MELBOURNE
Year awarded: 1996

Publications

Journal Articles

Coso, S., Harrison, I., Harrison, C., Vinh, A., Sobey, C., Drummond, G., Williams, E., Selemidis, S., 2012, NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts, Antioxidants and Redox Signaling [P], vol 16, issue 11, Mary Ann Liebert Inc Publishers, United States, pp. 1229-1247.

Harrison, C.B., Selemidis, S., Guida, E., Sobey, C.G., King, P.T., Drummond, G.R., 2012, NOX2ß: a novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages, PLoS ONE [P], vol 7, issue 10 (Art. NO.: e48326), Public Library of Science, USA, pp. 1-14.

Vlahos, R., Stambas, J., Selemidis, S., 2012, Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy, Trends in Pharmacological Sciences [P], vol 33, issue 1, Elsevier Ltd * Trends Journals, UK, pp. 3-8.

Drummond, G.R., Selemidis, S., Griendling, K., Sobey, C.G., 2011, Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets, Nature Reviews Drug Discovery [P], vol 10, issue 6, Nature Publishing Group, UK, pp. 453-471.

Vlahos, R., Stambas, J., Bozinovski, S., Broughton, B.R., Drummond, G.R., Selemidis, S., 2011, Inhibition of nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation, Plos Pathogens [P], vol 7, issue 2, Public Library of Scince, USA, pp. 1-12.

Judkins, C.P., Diep, H., Broughton, B.R.S., Mast, A., Hooker, E.U., Miller, A.A., Selemidis, S., Dusting, G.J., Sobey, C.G., Drummond, G.R., 2010, Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE -/- mice, American Journal Of Physiology-Heart And Circulator..., vol 298, issue 1, American Physiological Society, USA, pp. H-24-H-32.

Harrison, C.B., Drummond, G.R., Sobey, C.G., Selemidis, S., 2010, Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice, Clinical And Experimental Pharmacology And Physio..., vol 37, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 429-434.

Brait, V.H., Jackman, K.A., Walduck, A., Selemidis, S., Diep, H., Mast, A., Guida, E., Broughton, B.R., Drummond, G.R., Sobey, C.G., 2010, Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide, Journal of Cerebral Blood Flow and Metabolism [P], vol 30, issue 7, Nature Publishing Group, USA, pp. 1306-1317.

Peshavariya, H.M., Dusting, G.J., Jiang, F., Halmos, L.R., Sobey, C.G., Drummond, G.R., Selemidis, S., 2009, NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival, Naunyn-Schmiedeberg's Archives of Pharmacology, vol 380, issue 2, Springer, Germany, pp. 193-204.

Westover, A.J., Harrison, C.B., Selemidis, S., 2009, Nox2-containing NADPH oxidase and xanthine oxidase are sources of superoxide in mouse trachea, Clinical and Experimental Pharmacology and Physiology, vol 36, Wiley-Blackwell Publishing Asia, Australia, pp. 331-333.

Peshavariya, H., Jiang, F., Taylor, C.J., Selemidis, S., Chang, C.W.T., Dusting, G.J., 2009, Translation-linked mRNA destabilization accompanying serum-induced Nox4 expression in human endothelial cells, Antioxidants and Redox Signaling [P], vol 11, issue 10, Mary Ann Liebert Inc Publishers, USA, pp. 2399-2408.

Drummond, G.R., Selemidis, S., Cocks, T.M., 2008, B2 kinin receptor activation is the predominant mechanism by which trypsin mediates endothelium-dependent relaxation in bovine coronary arteries, Naunyn-Schmiedeberg's Archives of Pharmacology, vol 378, issue 1, Springer, Germany, pp. 33-41.

Selemidis, S., Sobey, C.G., Wingler, K., Schmidt, H., Drummond, G.R., 2008, NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition, Pharmacology & Therapeutics, vol 120, issue 3, Elsevier Inc., United States, pp. 254-291.

Selemidis, S., 2008, Suppressing NADPH oxidase-dependent oxidative stress in the vasculature with nitric oxide donors, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 11, Wiley-Blackwell Publishing Asia, Australia, pp. 1395-1401.

Peshavariya, H.M., Dusting, G.J., Selemidis, S., 2007, Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase, Free Radical Research, vol 41, issue 6, Taylor & Francis Ltd, Abingdon England UK, pp. 699-712.

Selemidis, S., Dusting, G.J., Peshavariya, H.M., Kemp, B.K., Drummond, G.R., 2007, Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells, Cardiovascular Research, vol 75, issue 2, Elsevier Science BV, Amsterdam Netherlands, pp. 349-358.

Selemidis, S., Cocks, T.M., 2007, Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries, Naunyn-Schmiedeberg's Archives in Pharmacology, vol 375, issue 2, Springer, New York NY USA, pp. 85-94.

Opitz, N., Drummond, G.R., Selemidis, S., Meurer, S., Schmidt, H.H.H., 2007, The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms", Free Radical Biology & Medicine, vol 42, issue 2, Elsevier Science Inc, New York USA, pp. 175-179.

Selemidis, S., Cocks, T.M., 2002, Endothelium-dependent hyperpolarization as a remote anti-atherogenic mechanism, Trends in Pharmacological Sciences, vol 23, issue 5, Elsevier Science London, London, England, UK, pp. 213-220.

Drummond, G.R., Selemidis, S., Cocks, T.M., 2000, Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent relaxations to bradykinin in the bovine isolated coronary artery: no role for cytochrome P450 and K+, British Journal of Pharmacology, vol 129, issue 4, Nature Publishing Group, London England, pp. 811-819.

Selemidis, S., Cocks, T.M., 2000, Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms, British Journal of Pharmacology, vol 129, issue 7, Nature Publishing Group, UK, pp. 1315-1322.

Grants

Title:
Novel pharmacological targets for suppression of tumour angiogenesis.
Investigators:
Selemidis, S, Williams, E, Drummond, G
Funding:
(2010 - 2013). Cancer Council Victoria. $300,000.00
Title:
Physiological and therapeutic regulation of nadph oxidase in the vasculature by nitric oxide.
Investigators:
Selemidis, S, Sobey, C, Drummond, G
Funding:
(2009 - 2012). Heart Foundation. $129,000.00
Title:
Understanding the biology of reactive oxygen species (ROS).
Investigators:
Selemidis, S
Funding:
(2012 - 2016). Australian Research Council (ARC). $193,160.00
(2012 - 2016). Australian Research Council (ARC). $514,528.00
Title:
A National Biomedical Electron Paramagnetic Resonance and Molecular Imaging Centre.
Investigators:
Schmidt, H, Selemidis, S, Wingler, K, McGrath, B, Parkington, H, Morgan, M, Murray, K, Bond, A, Tuck, K, Spiccia, L, Langford, S, Thompson, M, Young, C, Best, S, Wedd, A, Separovic, F, Donnelly, P, Boskovic, C, Masters, C, Barnham, K, Hanson, G, Martinac, B, Gahan, L, Schenk, G, Riley, M
Funding:
(2007 - 2011). Australian Research Council (ARC). $500,000.00
(2007 - 2011). Monash University. $109,000.00
(2007 - 2011). Monash University. $143,000.00
(2007 - 2011). Monash University. $50,000.00
(2007 - 2011). Monash University. $65,000.00
(2007 - 2011). The University of Melbourne. $270,000.00
(2007 - 2011). University of Queensland. $150,000.00
Title:
Roles of NADPH oxidase and caveolae in oxidatives.
Investigators:
Selemidis, S
Funding:
(2003 - 2010). National Health & Medical Research Council (NHMRC). $94,750.00

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Understanding the biology of reactive oxygen species in health and disease.
Supervisors:
Selemidis, S (Main).

Completed Supervision

Student:
Harrison, C.
Program of Study:
Nox2 in the vascularture: novel mechanisms of regulation. (PHD) 2011.
Supervisors:
Selemidis, S (Main), Sobey, C (Associate).