Prof Bryan Williams - Researcher Profile

Biography

Professor Williams has a distinguished research career spanning over 30 years in the areas of innate immunity and cancer biology. He has published over 300 peer-reviewed journal articles and reviews. He is internationally recognised for his work in innate immunity, and for his studies on protein kinase R, an important innate immune signalling molecule. He has also gained prominence in the field of RNA interference.

Professor Bryan Williams is currently Director of the Monash Institute of Medical Research, where he also leads the Centre for Cancer Research. In addition, he holds an appointment as a Professor in the Faculty of Medicine, Nursing and Health Sciences at Monash University. He received his PhD in 1976 from the Department of Microbiology at the University of Otago, Dunedin, New Zealand. Following postdoctoral training at the National Institute for Medical Research at Mill Hill, London, he held faculty positions at the University of Toronto and the Hospital for Sick Children, Toronto, Canada, and was Chairman of the Department of Cancer Biology at the Lerner Research Institute of the Cleveland Clinic Foundation in Cleveland, Ohio, USA. He was also an Associate Director of the Case Comprehensive Cancer Centre in Cleveland. He is currently an Adjunct Professor at the Department of Immunology in the Lerner Research Institute, Cleveland Clinic Foundation.

 

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Related Links:

• Monash Institute of Medical Research website

Qualifications

PHD MICROBIOLOGY

Institution: University of Otago

Year awarded: 1976

B.SC HONOURS MICROBIOLOGY

Institution: University of Otago

Year awarded: 1973

Publications

Books

Borden, E., Williams, B. (eds), 2011, J Interferon Cytokine Res, Mary Ann Liebert, Inc. Publishers, United States.

Book Chapters

Gantier, M.P.M., Williams, B.R.G., 2010, Monitoring innate immune recruitment by siRNAs in mammalian cells, in RNA Interference: From Biology to Clinical Applications, eds Wei-Ping Min and Thomas Ichim, Humana Press, USA, pp. 21-33.

De Veer, M.J., Williams, B.R.G., 2003, ISG database - interferon-stimulated gene database, in Analysing Gene Expression: A Handbook of Methods: Possibilities and Pitfalls, eds Stefan Lorkowski and Paul Cullen, Wiley-VCH, Germany, pp. 836-837.

Journal Articles

Beckham, S.A., Brouwer, J.M., Roth, A., Wang, D., Sadler, A.J., John, M., Jahn-Hofmann, K., Williams, B.R.G., Wilce, J.A., Wilce, M.C.J., 2013, Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly, Nucleic Acids Research [P], vol 41, issue 5, Oxford University Press, UK, pp. 3436-3445.

Gantier, M.P.M., Stunden, H.J., McCoy, C., Behlke, M.A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., 2012, A miR-19 regulon that controls NF-{kappa}B signaling, Nucleic Acids Research [P], vol 40, issue 16, Oxford University Press, United Kingdom, pp. 8048-8058.

Suliman, B., Xu, D., Williams, B., 2012, HDACi: molecular mechanisms and therapeutic implications in the innate immune system, Immunology And Cell Biology [P], vol 90, issue 1, Nature Publishing Group, United Kingdom, pp. 23-32.

Sarvestani, S., Williams, B.R.G., Gantier, M.P.M., 2012, Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing, Journal of Interferon and Cytokine Research [P], vol 32, issue 8, Mary Ann Liebert, Inc. Publishers, United States, pp. 350-361.

Irving, A., Wang, D., Vasilevski, O., Latchoumanin, O., Kozer, N., Clayton, A., Szczepny, A., Morimoto, H., Xu, D., Williams, B., Sadler, A., 2012, Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense, Immunity [P], vol 36, issue 5, Cell Press, United States, pp. 795-806.

Sales, P.C., Williams, B.R.G., Silva, A.M., 2012, Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon, Journal of Interferon and Cytokine Research [P], vol 32, issue 10, Mary Ann Liebert, Inc. Publishers, United States, pp. 495-504.

Suliman, B.A., Xu, D., Williams, B.R.G., 2012, The promyelocytic leukemia zinc finger protein: two decades of molecular oncology, Frontiers in Oncology [E], vol 2, issue 74, Frontiers Research Foundation, Switzerland, pp. 1-12.

Khairuddin, N., Gantier, M., Blake, S., Wu, S., Behlke, M., Williams, B., McMillan, N., 2012, siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo, Immunology And Cell Biology [P], vol 90, issue 2, Nature Publishing Group, United Kingdom, pp. 187-196.

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F., Williams, B., 2011, Analysis of microRNA turnover in mammalian cells following Dicer1 ablation, Nucleic Acids Research [P], vol 39, issue 13, Oxford University Press, United Kingdom, pp. 5692-5703.

Kim, H.S., Wilce, M.C.J., Yoga, Y., Pendini, N.R., Gunzburg, M.J., Cowieson, N., Wilson, G.M., Williams, B., Gorospe, M., Wilce, J.A., 2011, Different modes of interaction by TIAR and HuR with target RNA and DNA, Nucleic Acids Research [P], vol 39, issue 3, Oxford University Press, UK, pp. 1117-1130.

Sadler, A., Williams, B., 2011, Dynamiting Viruses with MxA, Immunity [P], vol 35, issue 4, Cell Press, United States, pp. 491-493.

Borden, E., Williams, B., 2011, Interferon-stimulated genes and their protein products: What and how?, Journal of Interferon and Cytokine Research [P], vol 31, issue 1, Mary Ann Liebert, Inc. Publishers, United States, pp. 1-4.

Gantier, M., Williams, B., 2011, Making sense of viral RNA sensing, Molecular Therapy [P], vol 19, issue 9, Nature Publishing Group, United Kingdom, pp. 1578-1581.

Williams, B.R.G., 2010, Differentiating the interferon pathway, Cell Cycle [P], vol 9, issue 17, Landes Bioscience, Austin TX USA, p. 3400.

Gantier, M.P.M., Irving, A.T., Liaskos, M., Xu, D., Evans, V., Cameron, P.U., Bourne, J.A., Ferrero, R.L., John, M., Behlke, M.A., Williams, B.R.G., 2010, Genetic modulation of TLR8 response following bacterial phagocytosis, Human Mutation [P], vol 31, issue 9, John Wiley & Sons, Inc., USA, pp. 1069-1079.

Gantier, M.P.M., Tong, S., Behlke, M.A., Irving, A.T., Lappas, M., Nilsson, U.W., Latz, E., McMillan, N.A.J., Williams, B.R.G., 2010, Rational design of immunostimulatory siRNAs, Molecular Therapy [P], vol 18, issue 4, Nature Publishing Group, USA, pp. 785-795.

Nakayama, Y., Plisch, E.H., Sullivan, J., Thomas, C., Czuprynski, C.J., Williams, B.R.G., Suresh, M., 2010, Role of PKR and Type I IFNs in viral control during primary and secondary infection, Plos Pathogens [P], vol 6, issue 6 (e1000966), Public Library of Science, USA, pp. 1-19.

Crosbie, J., Anderson, R., Rothkamm, K., Restall, C., Cann, L.M., Ruwanpura, S.M., Meachem, S.J., Yagi, N., Svalbe, I.D., Lewis, R., Williams, B.R.G., Rogers, P.A.W., 2010, Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues, International Journal of Radiation Oncology Biology Physics [P], vol 77, issue 3, Elsevier Inc., USA, pp. 886-894.

Chattopadhyay, S., Marques, J.T., Yamashita, M., Peters, K.L., Smith, K., Desai, A., Williams, B.R.G., Sen, G.C., 2010, Viral apoptosis is induced by IRF-3-mediated activation of Bax, Embo Journal [P], vol 29, issue 10, Nature Publishing Group, USA, pp. 1762-1773.

Jones, K.L., Roche, M., Gantier, M.P.M., Begum, N.A., Honjo, T., Caradonna, S., Williams, B.R., Mak, J., 2010, X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells, Journal Of Biological Chemistry [P], vol 285, issue 24, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 18603-18614.

Thompson, M.R., Xu, D., Williams, B.R.G., 2009, ATF3 transcription factor and its emerging roles in immunity and cancer, Journal of Molecular Medicine [P], vol 87, issue 11, Springer, Germany, pp. 1053-1060.

Sadler, A.J., Latchoumanin, O.A.L., Hawkes, D.J., Mak, J., Williams, B.R.G., 2009, An antiviral response directed by PKR phosphorylation of the RNA helicase A, Plos Pathogens [P], vol 5, issue 2 (e1000311), Public Library of Science, USA, pp. 1-11.

Lane, B.R., Li, J., Zhou, M., Babineau, D., Faber, P., Novick, A.C., Williams, B.R.G., 2009, Differential expression in clear cell renal cell carcinoma identified by gene expression profiling, Journal Of Urology [P], vol 181, issue 2, Elsevier Inc., USA, pp. 849-860.

Irving, A.T., Williams, B.R.G., 2009, Latest advances in innate antiviral defence, F1000 BIOLOGY REPORTS [E], vol 1, issue 22, Biology Reports Ltd, London UK, pp. 1-4.

Lynch, H., Ray, C.A., Oie, K.L., Pollara, J.J., Petty, I.T.D., Sadler, A.J., Williams, B.R.G., Pickup, D.J., 2009, Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication, Virology [P], vol 391, issue 2, Academic Press, USA, pp. 177-186.

Xu, D., Holko, M., Sadler, A.J., Scott, B.M., Higashiyama, S., Berkofsky-Fessler, W., McConnell, M.J., Pandolfi, P.P., Licht, J.D., Williams, B.R.G., 2009, Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 802-816.

London, N.J.S., Kessler, P.M., Williams, B.R.G., Pauer, G.J., Hagstrom, S.A., Traboulsi, E.I., 2009, Sequence alterations in RX in patients with microphthalmia, anophthalmia, and coloboma, Molecular Vision [P], vol 15, Molecular Vision, USA, pp. 162-167.

Gantier, M.P.M., Williams, B.R.G., 2009, siRNA delivery not Toll-free, Nature Biotechnology [P], vol 27, issue 10, Nature Publishing Group, USA, pp. 911-912.

Zamanian-Daryoush, M., Marques, J.T., Gantier, M.P.M., Behlke, M.A., John, M., Rayman, P., Finke, J., Williams, B.R.G., 2008, Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells, Journal of Interferon & Cytokine Research, vol 28, issue 4, Mary Ann Liebert, Inc. Publishers, USA, pp. 221-233.

Sadler, A.J., Williams, B.R.G., 2008, Interferon-inducible antiviral effectors, Nature Reviews, Immunology, vol 8, issue 7, Nature Publishing Group, UK, pp. 559-568.

Chakrabarti, A., Sadler, A.J., Kar, N., Young, H.A., Silverman, R.H., Williams, B.R.G., 2008, Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA, Journal of Biological Chemistry, vol 283, issue 37, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 25132-25139.

Gupta, A., Kessler, P.M., Rawwas, J., Williams, B.R.G., 2008, Regulation of CRABP-II expression by MycN in Wilms tumor, Experimental Cell Research, vol 314, issue 20, Academic Press (Elsevier), USA, pp. 3663-3668.

Gantier, M.P.M., Tong, S., Behlke, M.A., Xu, D., Phipps, S., Foster, P.S., Williams, B.R.G., 2008, TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages, Journal of Immunology, vol 180, issue 4, American Association of Immunologists, USA, pp. 2117-2124.

Marques, J.T., Anwar, J., Eskildsen-Larsen, S., Rebouillat, D., Paludan, S.R., Sen, G.C., Williams, B.R.G., Hartmann, R., 2008, The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain, Journal of General Virology, vol 89, issue 11, Society for General Microbiology, UK, pp. 2767-2772.

Marques, J.T., White, C.L., Peters, G.A., Williams, B.R.G., Sen, G.C., 2008, The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli, Journal of Interferon & Cytokine Research, vol 28, issue 8, Mary Ann Liebert, Inc. Publishers, USA, pp. 469-475.

Carpentier, P.A., Williams, B.R.G., Miller, S.D., 2007, Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli, Glia, vol 55, issue 3, Wiley-Liss, Hoboken USA, pp. 239-252.

White, C.L., Whitmore, M.M., Williams, B.R.G., 2007, Enlarged spleens without enlarged lymph nodes in tlr3 -/-pkr -/- mice, Journal of Interferon and Cytokine Research, vol 27, issue 1, Mary Ann Liebert Inc, Rochelle NY USA, pp. 6-12.

Gantier, M.P.M., Sadler, A.J., Williams, B.R.G., 2007, Fine-tuning of the innate immune response by microRNAs, Immunology and Cell Biology, vol 85, issue 6, Nature Publishing Group, New York, NY, USA, pp. 458-462.

Masci, P., Olencki, T., Wood, L., Rybicki, L., Jacobs, B., Williams, B.R.G., Faber, P., Bukowski, R., Tong, K., Borden, E.C., 2007, Gene modulatory effects, pharmacokinetics, and clinical tolerance of interferon-alpha1b: A second member of the interferon-alpha family, Clinical Pharmacology & Therapeutics, vol 81, issue 3, Nature Publishing Group, USA, pp. 354-361.

Alirezaei, M., Watry, D.D., Flynn, C.F., Kiosses, W.B., Masliah, E., Williams, B.R.G., Kaul, M., Lipton, S.A., Fox, H.S., 2007, Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons, Journal of Neuroscience, vol 27, issue 41, Society for Neuroscience, USA, pp. 11047-11055.

Hultcrantz, M., Huhn, M.H., Wolf, M., Olsson, A., Jacobson, S., Williams, B.R.G., Korsgren, O., Flodstrom-Tullberg, M., 2007, Interferons induce an antiviral state in human pancreatic islet cells, Virology, vol 367, issue 1, Academic Press Inc Elsevier Science, USA, pp. 92-101.

Sengupta, S., Kim, K.S., Berk, M.P., Oates, R.K., Escobar, P., Belinson, J., Li, W., Lindner, D., Williams, B.R.G., Xu, Y., 2007, Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion, Oncogene, vol 26, issue 20, Nature Publishing Group, London England, pp. 2894-2901.

Whitmore, M.M., Iparraguirre, A., Kubelka, L., Weninger, W., Hai, T., Williams, B.R.G., 2007, Negative regulation of TLR-signaling pathways by activating transcription factor-3, Journal of Immunology, vol 179, issue 6, American Association of Immunologists, USA, pp. 3622-3630.

Rani, M.R.S., Shrock, J., Appachi, S., Rudick, R.A., Williams, B.R.G., Ransohoff, R.M., 2007, Novel interferon-beta-induced gene expression in peripheral blood cells, Journal of Leukocyte Biology, vol 82, issue 5, Federation of American Societies for Experimental Biology, USA, pp. 1353-1360.

Austin, B.A., Halford, W.P., Williams, B.R.G., Carr, D.J., 2007, Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea, Journal of Immunology, vol 178, issue 8, American Association of Immunologists, USA, pp. 5166-5172.

Singh, A.D., Sisley, K., Xu, Y., Li, J., Faber, P.W., Plummer, S.J., Mudhar, H.S., Rennie, I.G., Kessler, P.M., Casey, G., Williams, B.R.G., 2007, Reduced expression of autotaxin predicts survival in uveal melanoma, British Journal of Ophthalmology, vol 91, issue 10, B M J Publishing Group, London, UK, pp. 1385-1392.

Silva, A.M., Wang, D., Komar, A.A., Castilho, B.A., Williams, B.R.G., 2007, Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner, The Journal of Biological Chemistry, vol 282, issue 14, American Society for Biochemistry and Molecular Biology Inc, USA, pp. 10164-10171.

Sadler, A.J., Williams, B.R.G., 2007, Structure and function of the protein kinase R, Current Topics in Microbiology and Immunology, vol 316, Springer-Verlag Berlin, Berlin, Germany, pp. 253-292.

Gantier, M.P.M., Williams, B.R.G., 2007, The response of mammalian cells to double-stranded RNA, Cytokine and Growth Factor Reviews, vol 18, issue 5-6, Elsevier, Oxford UK, pp. 363-371.

Terenzi, F., White, C.L., Pal, S., Williams, B.R.G., Sen, G.C., 2007, Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice, Journal of Virology, vol 81, issue 16, American Society for Microbiology, USA, pp. 8656-8665.

Hensley, S.E., Cun, A.S., Giles-Davis, W., Li, Y., Xiang, Z., Lasaro, M.O., Williams, B.R.G., Silverman, R.H., Ertl, H.C., 2007, Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector, Molecular Therapy, vol 15, issue 2, Nature Publishing Group, USA, pp. 393-403.

Kelly, K.M., Zhuang, H., Nacionales, D.C., Scumpia, P.O., Lyons, R., Akaogi, J., Lee, P., Williams, B.R.G., Yamamoto, M., Akira, S., Satoh, M., Reeves, W.H., 2006, "Endogenous adjuvant" activity of the RNA components of lupus auto antigens Sm/RNP and Ro 60, Arthritis and Rheumatism, vol 54, issue 5, Wiley-Liss, Hoboken NJ USA, pp. 1557-1567.

Marques, J.T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M.A., Williams, B.R.G., 2006, A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells, Nature Biotechnology, vol 24, issue 5, Nature Publishing Group, New York USA, pp. 559-565.

Boiko, A.D., Porteous, S., Razorenova, O.V., Krivokrysenko, V.I., Williams, B.R.G., Gudkov, A.V., 2006, A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation, Genes & Development, vol 20, issue 2, Cold Spring Harbor Laboratory Press, Woodbury NY USA, pp. 236-252.

Bakheet, T., Williams, B.R.G., Khabar, K.S.A., 2006, ARED 3.0: the large and diverse AU-rich transcriptome., Nucleic Acids Research, vol 34, issue Database Issue, Oxford University Press, Oxford UK, pp. D111-D114.

Gupta, A., Williams, B.R.G., Hanash, S.M., Rawwas, J., 2006, Cellular retinoic acid-binding protein II is a direct transcriptional target of MycN in neuroblastoma, Cancer Research, vol 66, issue 16, American Association for Cancer Research, Philadelphia PA USA, pp. 8100-8108.

Xu, W., Zheng, S., Goggans, T., Kiser, P., Quinones-Mateu, M.E., Janocha, A.J., Comhair, S.A., Slee, R., Williams, B.R.G., Erzurum, S.C., 2006, Cystic fibrosis and normal human airway epithelial cell response to influenza A viral infection, Journal of Interferon and Cytokine Research, vol 26, issue 9, Mary Ann Liebert Inc., New Rochelle NY USA, pp. 609-627.

Gabel, F., Wang, D., Madern, D., Sadler, A.J., Dayie, K., Daryoush, M.Z., Schwahn, D., Zaccai, G., Lee, X., Williams, B.R.G., 2006, Dynamic flexibility of double-stranded RNA activated PKR in solution, Journal of Molecular Biology, vol 359, issue 3, Academic Press Ltd Elsevier Science Ltd, London England, pp. 610-623.

Sutton, D., Kim, S., Shuai, X., Leskov, K., Marques, J.T., Williams, B.R.G., Boothman, D.A., Gao, J., 2006, Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro., International Journal of Nanomedicine, vol 1, issue 2, Dove Medical Press Ltd, Auckland New Zealand, pp. 155-162.

Holko, M., Williams, B.R.G., 2006, Functional annotation of IFN-alpha-stimulated gene expression profiles from sensitive and resistant renal cell carcinoma cell lines, Journal of Interferon & Cytokine Research, vol 26, issue 8, Mary Ann Liebert Inc., New Rochelle USA, pp. 534-547.

Nguyen, Q.N., Chavli, R.V., Marques, J.T., Conrad, P.G., Wang, D., He, W., Belisle, B.E., Zhang, A., Pastor, L.M., Witney, F.R., Morris, M., Heitz, F., Divita, G., Williams, B.R.G., McMaster, G.K., 2006, Light controllable siRNAs regulate gene suppression and phenotypes in cells, Biochimica et Biophysica Acta - Biomembranes, vol 1758, issue 3, Elsevier Science, Amsterdam Netherlands, pp. 394-403.

Austin, B.A., Halford, W.P., Silverman, R.H., Williams, B.R.G., Carr, D.J., 2006, OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures, Journal of Interferon and Cytokine Research, vol 26, issue 4, Mary Ann Liebert Inc., New Rochelle NY USA, pp. 220-225.

Samuel, M.A., Whitby, K., Keller, B.C., Marri, A., Barchet, W., Williams, B.R.G., Silverman, R.H., Gale Jr, M., Diamond, M.S., 2006, PKR and RNase L contribute to protection against lethal West Nile virus infection by controlling early viral spread in the periphery and replication in neurons, Journal of Virology, vol 80, issue 14, American Society for Microbiology, Washington DC USA, pp. 7009-7019.

Chang, K., Cai, Z., Zhang, C., Sen, G.C., Williams, B.R.G., Luo, G., 2006, Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities, Journal of Virology, vol 80, issue 15, The American Society for Microbiology, Washington USA, pp. 7364-7374.

Green, J., Khabar, K.S.A., Koo, B.A., Williams, B.R.G., Polyak, S.J., 2006, Stability of CXCL-8 and related AU-rich mRNAs in the context of hepatitis C virus replication in vitro, Journal of Infectious Diseases, vol 193, issue 6, University of Chicago Press, Chicago IL USA, pp. 802-811.

Carr, D.J., Wuest, T., Tomanek, L., Silverman, R.H., Williams, B.R.G., 2006, The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection, Immunology, vol 118, issue 4, Blackwell Publishing, Oxford UK, pp. 520-526.

Li, W., Kessler, P.M., Yeger, H., Alami, J., Reeve, A.E., Heathcott, R., Skeen, J., Williams, B.R.G., 2005, A gene expression signature for release of primary wilms tumors, Cancer Research, vol 65, issue 7, American Association for Cancer Research, Philadelphia PA USA, pp. 2592-2601.

Malathi, K., Paranjape, J.M., Bulanova, E., Shim, M., Guenther-Johnson, J.M., Faber, P.W., Eling, T.E., Williams, B.R.G., Silverman, R.H., 2005, A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L, Proceedings of the National Academy of Sciences of the United States of America, vol 102, issue 41, National Academy of Sciences, Washington DC USA, pp. 14533-14538.

Khabar, K.S.A., Bakheet, T., Williams, B.R.G., 2005, AU-rich transient response transcripts in the human genome: expressed sequence tag clustering and gene discovery approach, Genomics, vol 85, issue 2, Elsevier Science, San Diego CA USA, pp. 165-175.

Marques, J.T., Williams, B.R.G., 2005, Activation of the mammalian immune system by siRNAs, Nature Biotechnology, vol 23, issue 11, Nature Publishing Group, New York NY USA, pp. 1399-1405.

Elco, C.P., Guenther, J., Williams, B.R.G., Sen, G.C., 2005, Analysis of genes induced by sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3, Journal of Virology, vol 79, issue 7, American Society for Microbiology, Washington DC USA, pp. 3920-3929.

De Veer, M.J., Sledz, C.A., Williams, B.R.G., 2005, Detection of foreign RNA: implications for RNAi, Immunology and Cell Biology, vol 83, issue 3, Nature Publishing Group, New York USA, pp. 224-228.

Al-Khatib, K., Williams, B.R.G., Silverman, R.H., Halford, W.P., Carr, D.J., 2005, Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection, Experimental Eye Research, vol 80, issue 2, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 167-173.

Williams, B.R.G., 2005, Dicing with siRNA, Nature Biotechnology, vol 23, issue 2, Nature Publishing Group, New York NY USA, pp. 181-182.

Zhou, Y., Chase, B.I., Whitmore, M.M., Williams, B.R.G., Zhou, A., 2005, Double-stranded RNA-dependent protein kinase (PKR) is downregulated by phorbol ester, FEBS Journal, vol 272, Blackwell Publishing, Oxford UK, pp. 1568-1576.

Marques, J.T., Rebouillat, D., Ramana, C.V., Murakami, J., Hill, J.E., Gudkov, A.V., Silverman, R.H., Stark, G.R., Williams, B.R.G., 2005, Down-regulation of p53 by double-stranded RNA modulates the antiviral response, Journal of Virology, vol 79, issue 17, American Society for Microbiology, Washington DC USA, pp. 11105-11114.

Akyerli, C.B., Beksac, M., Holko, M., Frevel, M.A., Dalva, K., Ozbek, U., Soydan, E., Ozcan, M., Ozet, G., Ilhan, O., Gurman, G., Akan, H., Williams, B.R.G., Ozcelik, T., 2005, Expression of IFITM1 in chronic myeloid leukemia patients, Leukemia Research, vol 29, issue 3, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 283-286.

Smith, J.A., Schmechel, S.C., Williams, B.R.G., Silverman, R.H., Schiff, L.A., 2005, Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation, Journal of Virology, vol 79, issue 4, American Society for Microbiology, Washington DC USA, pp. 2240-2250.

Sledz, C.A., Williams, B.R.G., 2005, RNA interference in biology and disease, Blood, vol 106, issue 3, American Society of Hematology, USA, pp. 787-794.

Carr, D.J., Tomanek, L., Silverman, R.H., Campbell, I.L., Williams, B.R.G., 2005, RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2, Journal of Virology, vol 79, issue 14, American Society for Microbiology, Washington DC USA, pp. 9341-9345.

Flodstrom-Tullberg, M., Hultcrantz, M., Stotland, A., Maday, A., Tsai, D., Fine, C., Williams, B.R.G., Silverman, R.H., Sarvetnick, N., 2005, RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during Coxsackievirus infection, The Journal of Immunology, vol 174, issue 3, American Association of Immunologists, Bethesda MD USA, pp. 1171-1177.

Williams, B.R.G., 2005, Targeting specific cell types with silencing RNA, New England Journal of Medicine, vol 353, issue 13, Massachusetts Medical Society, Waltham MA USA, pp. 1410-1411.

Li, W., Kessler, P.M., Williams, B.R.G., 2005, Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia, Oncogene, vol 24, issue 3, Nature Publishing Group, London UK, pp. 457-468.

Graham, K., Li, W., Williams, B.R.G., Fraizer, G., 2005, Vascular endothelial growth factor (VEGF) is suppressed in WT1-transfected LNCaP cells, Gene Expression, vol 13, issue 1, Cognizant Communication Corp., Elmsford NY USA, pp. 1-14.

Xu, Z., Wang, D., Lee, X., Williams, B.R.G., 2004, Biochemical analyses of multiple fractions of PKR purified from Escherichia coli, Journal of Interferon and Cytokine Research, vol 24, issue 9, Mary Ann Liebert Inc., Larchmont NY USA, pp. 522-535.

Al-Khatib, K., Williams, B.R.G., Silverman, R.H., Halford, W.P., Carr, D.J., 2004, Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta, Journal of Immunology, vol 172, issue 9, American Association of Immunologists, Bethesda MD USA, pp. 5638-5647.

Khabar, K.S.A., al-Haj, L., al-Zoghaibi, F., Marie, M., Dhalla, M., Polyak, S.K., Williams, B.R.G., 2004, Expressed gene clusters associated with cellular sensitivity and resistance towards anti-viral and anti-proliferative actions of interferon, Journal of Molecular Biology, vol 342, issue 3, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 833-846.

Chang, H., Paulson, M., Holko, M., Rice, C.M., Williams, B.R.G., Marie, I., Levy, D.E., 2004, Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity, Proceedings of the National Academy of Sciences of the United States of America, vol 101, issue 26, National Academy of Sciences, Washington DC USA, pp. 9578-9583.

Jackson, M.W., Agarwal, M.K., Agarwal, M.L., Agarwal, A., Stanhope-Baker, P., Williams, B.R.G., Stark, G.R., 2004, Limited role of N-terminal phosphoserine residues in the activation of transcription by p53, Oncogene, vol 23, issue 25, Nature Publishing Group, London UK, pp. 4477-4487.

Gorchakov, R., Frolova, E., Williams, B.R.G., Rice, C.M., Frolov, I., 2004, PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection, Journal of Virology, vol 78, issue 16, American Society for Microbiology, Washington DC USA, pp. 8455-8467.

Raghavan, A., Dhalla, M., Bakheet, T., Ogilvie, R.L., Vlasova, I.A., Khabar, K.S.A., Williams, B.R.G., Bohjanen, P., 2004, Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation, Genomics, vol 84, issue 6, Academic Press Inc. Elsevier Science, San Diego CA USA, pp. 1002-1013.

Dong, B., Zhou, Q., Zhao, J., Zhou, A., Harty, R.N., Bose, S., Banerjee, A., Slee, R., Guenther, J., Williams, B.R.G., Wiedmer, T., Sims, P.J., Silverman, R.H., 2004, Phospholipid scramblase 1 potentiates the antiviral activity of interferon, Journal of Virology, vol 78, issue 17, American Society for Microbiology, Washington DC USA, pp. 8983-8993.

Silva, A.M., Whitmore, M.M., Xu, Z., Jiang, Z., Li, X., Williams, B.R.G., 2004, Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation, Journal of Biological Chemistry, vol 279, issue 36, American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 37670-37676.

Sledz, C.A., Williams, B.R.G., 2004, RNA interference and double-stranded-RNA-activated pathways, Biochemical Society Transactions, vol 32, issue 6, Portland Press Ltd., UK, pp. 952-956.

Whitmore, M.M., DeVeer, M.J., Edling, A., Oates, R.K., Simons, B., Lindner, D., Williams, B.R.G., 2004, Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity, Cancer Research, vol 64, issue 16, American Association for Cancer Research, Philadelphia PA USA, pp. 5850-5860.

Stanhope-Baker, P., Kessler, P.M., Li, W., Agarwal, M.L., Williams, B.R.G., 2004, The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53, Journal of Biological Chemistry, vol 279, issue 32, The American Society for Biochemistry Molecular Biology Inc., Bethesda MD USA, pp. 33575-33585.

Williams, B.R.G., Sen, G.C., 2003, A viral on/off switch for interferon, Science, vol 300, issue 5622, American Association for the Advancement of Science, Wasington DC USA, pp. 1100-1101.

Bakheet, T., Williams, B.R.G., Khabar, K.S.A., 2003, ARED 2.0: an update of AU-rich element mRNA database, Nucleic Acids Research, vol 31, issue 1, Oxford University Press, Oxford UK, pp. 421-423.

Sledz, C.A., Holko, M., De Veer, M.J., Silverman, R.H., Williams, B.R.G., 2003, Activation of the interferon system by short-interfering RNAs, Nature Cell Biology, vol 5, issue 9, Nature Publishing Group, London England, pp. 834-839.

Sawicki, D.L., Silverman, R.H., Williams, B.R.G., Sawicki, S.G., 2003, Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R, Journal of Virology, vol 77, issue 3, American Society for Microbiology, Washington DC USA, pp. 1801-1811.

Leitner, W.W., Hwang, L.N., De Veer, M.J., Zhou, A., Silverman, R.H., Williams, B.R.G., Dubensky, T.W., Ying, H., Restifo, N.P., 2003, Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways, Nature Medicine, vol 9, issue 1, Nature America Inc., New York USA, pp. 33-39.

Chawla-Sarkar, M., Lindner, D.J., Liu, Y., Williams, B.R.G., Sen, G.C., Silverman, R.H., Borden, E.C., 2003, Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis, Apoptosis, vol 8, issue 3, Kluwer Academic Publishers, The Netherlands, pp. 237-249.

Yin, Z., Haynie, J., Williams, B.R.G., Yang, Y., 2003, C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding protein that inhibits protein kinase R, Journal of Biological Chemistry, vol 278, issue 25, American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 22838-22845.

Alami, J., Williams, B.R.G., Yeger, H., 2003, Derivation and characterization of a Wilms' tumour cell line, WiT 49, International Journal of Cancer, vol 107, issue 3, Wiley-Liss, New York NY USA, pp. 365-374.

Alami, J., Williams, B.R.G., Yeger, H., 2003, Differential expression of E-cadherin and catenin in primary and metastatic Wilms's tumours, Journal of Clinical Pathology: Molecular Pathology, vol 56, issue 4, British Medical Journal Publishing Group, London UK, pp. 218-225.

Tebo, J., Der, S., Frevel, M.A., Khabar, K.S.A., Williams, B.R.G., Hamilton, T.A., 2003, Heterogeneity in control of mRNA stability by AU-rich elements, Journal of Biological Chemistry, vol 278, issue 14, American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 12085-12093.

Espert, L., Degols, G., Gongora, C., Blondel, D., Williams, B.R.G., Silverman, R.H., Mechti, N., 2003, ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses, Journal of Biological Chemistry, vol 278, issue 18, American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 16151-16158.

Zheng, S., De, B.P., Choudhary, S., Comhair, S.A., Goggans, T., Slee, R., Williams, B.R.G., Pilewski, J., Haque, S.J., Erzurum, S.C., 2003, Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis, Immunity, vol 18, issue 5, Cell Press, Cambridge MA USA, pp. 619-630.

Leaman, D.W., Chawla-Sarkar, M., Jacobs, B., Vyas, K., Sun, Y., Ozdemir, A., Yi, T., Williams, B.R.G., Borden, E.C., 2003, Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-b compared with IFN-a2, Journal of Interferon and Cytokine Research, vol 23, issue 12, Mary Ann Liebert Inc., Larchmont NY USA, pp. 745-756.

Jiang, Z., Zamanian-Daryoush, M., Nie, H., Silva, A.M., Williams, B.R.G., Li, X., 2003, Poly(dI.dC)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR, Journal of Biological Chemistry, vol 278, issue 19, The American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 16713-16719.

Sledz, C.A., Williams, B.R.G., 2003, RNA interference and interferon, Discovery Medicine, vol 3, issue 18, Solariz, Inc., USA, pp. 30-31.

Khabar, K.S.A., Siddiqui, Y.M., al-Zoghaibi, F., al-Haj, L., Dhalla, M., Zhou, A., Dong, B., Whitmore, M.M., Paranjape, J.M., Al-Ahdal, M.N., Al-Mohanna, F., Williams, B.R.G., Silverman, R.H., 2003, RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR, Journal of Biological Chemistry, vol 278, issue 22, American Society for Biochemistry and Molecular Biology Inc., Bethesda MD USA, pp. 20124-20132.

Toshchakov, V., Jones, B.W., Lentschat, A., Silva, A.M., Perera, P., Thomas, K., Cody, M., Zhang, S., Williams, B.R.G., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N., 2003, TLR2 and TLR4 agonists stimulate unique repertoires of host resistance genes in murine macrophages: interferon-b-dependent signaling in TLR4-mediated responses, Journal of Endotoxin Research, vol 9, issue 3, Maney Publishing, Leeds UK, pp. 169-175.

Al-Khatib, K., Williams, B.R.G., Silverman, R.H., Halford, W.P., Carr, D.J., 2003, The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-b-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture, Virology, vol 313, issue 1, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 126-135.

Navarro, A., Frevel, M.A., Gamero, A.M., Williams, B.R.G., Feldman, G., Larner, A.C., 2003, Thrombomodulin RNA is destabilized through its 3'-untranslated element in cells exposed to IFN-g, Journal of Interferon and Cytokine Research, vol 23, issue 12, Mary Ann Liebert Inc., Larchmont NY USA, pp. 723-728.

Lopez, C.B., Garcia-Sastre, A., Williams, B.R.G., Moran, T.M., 2003, Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses, Journal of Infectious Diseases, vol 187, issue 7, University of Chicago Press, Chicago IL USA, pp. 1126-1136.

Feinberg, A.P., Williams, B.R.G., 2003, Wilms' tumor as a model for cancer biology, Methods in Molecular Biology, vol 222, Humana Press, Inc., USA, pp. 239-248.

Frevel, M.A., Bakheet, T., Silva, A.M., Hissong, J.G., Khabar, K.S.A., Williams, B.R.G., 2003, p38 mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts, Molecular and Cellular Biology, vol 23, issue 2, American Society for Microbiology, Washington DC USA, pp. 425-436.

Al-Khatib, K., Williams, B.R.G., Silverman, R.H., Halford, W.P., Carr, D.J., 2002, Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-b, Journal of Interferon and Cytokine Research, vol 22, issue 8, Mary Ann Liebert Inc., Larchmont NY USA, pp. 861-871.

Xiang, Y., Condit, R.C., Vijaysri, S., Jacobs, B., Williams, B.R.G., Silverman, R.H., 2002, Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus, Journal of Virology, vol 76, issue 10, American Society for Microbiology, Washington DC USA, pp. 5251-5259.

Harle, P., Cull, V., Agbaga, M., Silverman, R.H., Williams, B.R.G., James, C.M., Carr, D.J., 2002, Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication, Journal of Virology, vol 76, issue 13, American Society for Microbiology, Washington DC USA, pp. 6558-6567.

Alami, J., Williams, B.R.G., Yeger, H., 2002, Expression and localization of HGF and met in Wilms' tumours, Journal of Pathology, vol 196, issue 1, John Wiley and Sons Ltd, Chichester UK, pp. 76-84.

Wang, X., Basler, C.F., Williams, B.R.G., Silverman, R.H., Palese, P., Garcia-Sastre, A., 2002, Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains, Journal of Virology, vol 76, issue 24, American Society for Microbiology, Washington DC USA, pp. 12951-12962.

Guidotti, L.G., Morris, A., Mendez, H., Koch, R., Silverman, R.H., Williams, B.R.G., Chisari, F.V., 2002, Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice, Journal of Virology, vol 76, issue 6, American Society for Microbiology, Washington DC USA, pp. 2617-2621.

Toshchakov, V., Jones, B.W., Perera, P., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R.G., Major, J., Hamilton, T.A., Fenton, M.J., Vogel, S.N., 2002, TLR4, but not TLR2, mediates IFN-b-induced STAT1a/b-dependent gene expression in macrophages, Nature Immunology, vol 3, issue 4, Nature America Inc., New York NY USA, pp. 392-398.

Williams, B.R.G., 2002, Type I interferons (IFN) are essential mediators of innate and specific immunity against viruses, Viral Immunology, vol 15, issue 1, Mary Ann Liebert Inc., Larchmont NY USA, pp. 1-2.

Bakheet, T., Frevel, M.A., Williams, B.R.G., Greer, W., Khabar, K.S.A., 2001, ARED: Human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins, Nucleic Acids Research, vol 29, issue 1, Oxford University Press, Oxford England, pp. 246-254.

De Veer, M.J., Holko, M., Frevel, M.A., Walker, E., Der, S., Paranjape, J.M., Silverman, R.H., Williams, B.R.G., 2001, Functional classification of interferon-stimulated genes identified using microarrays, Journal of Leukocyte Biology, vol 69, Federation of American Societies for Experimental Biology, Bethesda MD USA, pp. 912-920.

De Veer, M.J., Holko, M., Frevel, M.A., Walker, E., Der, S., Paranjape, J.M., Silverman, R.H., Williams, B.R.G., 2001, Functional classification of interferon-stimulated genes identified using microarrays, Journal of Leukocyte Biology, vol 69, Federation of American Societies for Experimental Biology, Bethesda USA, pp. 912-920.

Deb, A., Zamanian-Daryoush, M., Xu, Z., Kadereit, S., Williams, B.R.G., 2001, Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3, The EMBO Journal, vol 20, issue 10, Nature Publishing Group, New York USA, pp. 2487-2496.

Deb, A., Haque, S.J., Mogensen, T.H., Silverman, R.H., Williams, B.R.G., 2001, RNA-dependent protein kinase PKR is required for activation of NFkappaB by IFN-gamma in a STAT1-independent pathway, Journal of Immunology, vol 166, The American Association of Immunologists, Bethesda MD USA, pp. 6170-6180.

Daryoush, M.Z., Mogensen, T.H., DiDonato, J.A., Williams, B.R., 2000, NF-k-B Activation by double-stranded-RNA-Activated protein kinase (PKR) is mediated through NF-kB-inducing kinase and IkB kinase, Molecular and Cellular Biology, vol 20, issue 4, American Society for Microbiology, USA, pp. 1278-1290.

Williams, B.R.G., Xu, Z., 2000, The B56& regulatory subunit of protein phosphatase 2A is a target for regulation by the double-stranded RNA-dependent protein kinase PKR, Molecular and Cell Biology, vol 20, American Society for Microbiology, USA, pp. 5285-5299.

Other

Williams, B.R.G., 2009, A protein supports interferons' protective function, A lay summary of a published journal article for Immunology in the News, a free quarterly newsletter published by the Dana Foundation, Dana Press, USA.

Williams, B.R.G., Sadler, A.J., 2006, PKR, UCSD-Nature Molecule Pages: a comprehensive signalling database., Nature Publishing Group, http://www.signaling-gateway.org/molecule/query?afcsid=A000792&mpv=1.

Grants

Title:

Covaris E-series/Agilent bioanalyzer 2100.

Investigators:

Williams, B, Hertzog, P, Watkins, D, Risbridger, G, Jenkins, B, Wallace, E, Mackay-Fisson, F, Mackay, C

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

DEXA body composition and bone density analysis suite.

Investigators:

Clarke, I, Mitchell, C, Cowley, M, Tiganis, T, Oldfield, B, Rosa, M, Walker, D, Lackmann, M, Watt, M, Armitage, J, Denton, K, Evans, R, Kett, M, Brown, R, Tilbrook, A, Andrews, Z, Smith, J, Spencer, S, Strauss, B, Simpson, E, Williams, B

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Development of a signature for early response to influenza strains that determine/correlate with severity of infection, vacine response and changes in virulence.

Investigators:

Hertzog, P, Visvanathan, K, Mansell, A, Sasaduesz, J, Williams, B

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

(2009 - 2014). National Health & Medical Research Council (NHMRC).

Title:

Establish the Australian Cancer Research Foundation (ACRF) Centre for Cancer Genomic Medicine.

Investigators:

Williams, B, Hertzog, P, Watkins, D, Jenkins, B, Williams, E, Risbridger, G

Funding:

(2012 - 2016). Australian Cancer Research Foundation.

Title:

Functional analysis of relapse predictive genes in Wilms tumour.

Investigators:

Williams, B

Funding:

(2008 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Gelsolin as a novel antiviral target.

Investigators:

Sadler, A, Williams, B

Funding:

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

Genetic research by Gene Expression analysis (Equipment grant).

Investigators:

Hertzog, P, Williams, B, Vasic, V

Funding:

(2011 - 2015). Rebecca L. Cooper Medical Research Foundation Ltd.

Title:

IFNs and cytokines: Signalling and action.

Investigators:

Williams, B

Funding:

(2006 - 2010). National Institutes of Health (NIH), USA.

Title:

Monash Institute of Medical Research Men's Health Program.

Investigators:

Williams, B

Funding:

(2009 - 2014). John T Reid Victorian Charitable Trust.

Title:

NHMRC Standard Equipment Grant 2007.

Investigators:

Hertzog, P, Adler, B, Rossjohn, J, Williams, B, Boyd, R, Berndt, M

Funding:

(2008 - 2012). National Health & Medical Research Council (NHMRC).

Title:

Protein recognition of small RNAs in innate immunity.

Investigators:

Williams, B, Wilce, M, Wilce, J

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Protein-RNA recognition in innate immunity.

Investigators:

Williams, B, Wilce, M, Wilce, J

Funding:

(2008 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Protein-mRNA interactions and their role in post-transcriptional regulation.

Investigators:

Wilce, M, Wilce, J, Gorospe, M, Williams, B

Funding:

(2008 - 2012). Australian Research Council (ARC).

(2008 - 2012). Monash University.

Title:

Regulation of innate immunity and tumour progression by activating transcription factor 3.

Investigators:

Williams, B, Xu, D

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Role of PLZF in regulating the Interferon response.

Investigators:

Williams, B

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Role of the IFN-induced Helicase IFIH1 in Type 1 Diabetes.

Investigators:

Williams, B

Funding:

(2008 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Structural and functional analysis of the protein kinase R.

Investigators:

Williams, B

Funding:

(2011 - 2015). Australian Research Council (ARC).

(2011 - 2015). Monash University.

Title:

The biological effects of synchrotron microbeam radiation therapy on normal and tumour tissues.

Investigators:

Rogers, P, Lewis, R, Svalbe, I, Williams, B, Blakey, D

Funding:

(2007 - 2011). Cancer Council Victoria.

(2008 - 2013). Cancer Council Victoria.

(2009 - 2013). Cancer Council Victoria.

Title:

The role of PLZF in regulating the antiviral activity of interferons.

Investigators:

Williams, B, Xu, D

Funding:

(2010 - 2013). National Health & Medical Research Council (NHMRC).

Title:

A novel lipid sensitive kinase and its role in obesity-induced inflammation and insulin resistance.

Investigators:

Williams, B, Febbraio, M, Lancaster, G, Sadler, A

Funding:

(2010 - 2015). National Health & Medical Research Council (NHMRC).

Title:

A Biomolecular Small Angle X-ray Scattering Facility.

Investigators:

Wilce, M, Beddoe, T, Bottomley, S, Hertzog, P, Rossjohn, J, Whisstock, J, Williams, B, Cowieson, N, Hearn, M, Rood, J

Funding:

(2010 - 2014). Australian Research Council (ARC).

(2010 - 2014). Monash University.

Title:

High Content Cell Signaling Discovery and Screening Facility.

Investigators:

Hertzog, P, Williams, B, Rossjohn, J, Adler, B, Trounson, A, Sexton, P, Berndt, M

Funding:

(2008 - 2012). Australian Research Council (ARC).

(2008 - 2012). Monash University.

(2008 - 2012). Victorian Infectious Diseases Reference Laboratory.

Title:

Interferon regulated dsRNA activated kinase, PKR.

Investigators:

Williams, B

Funding:

(2006 - 2009). National Institutes of Health (NIH), USA.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Characterizing the role of promyelocytic leukaemia zinc finger (PLZF) in modulating the innate immune response.

Supervisors:

Williams, B (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Exploring the cellular and molecular basis of the development of castrate resistant prostate cancer.

Supervisors:

Williams, B (Main), Xu, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of role for PKR in obesity related diseases.

Supervisors:

Sadler, A (Joint), Williams, B (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of role for PKR in obesity related diseases .

Supervisors:

Sadler, A (Main), Tipping, P (Associate), Williams, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of the role of IFIH-1 and the effect of rotavirus in Type 1 Diabetes.

Supervisors:

Sadler, A (Joint), Williams, B (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Sensing of foreign RNAs by toll-like receptor (TLR) 7/8 and therapeutic applications.

Supervisors:

Williams, B (Main), Gantier, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The Role of Laminin 5 in Head and Neck Squamous Cell Cancer.

Supervisors:

Williams, B (Main), Smith, J (Associate).

Completed Supervision

Student:

Chung, T.

Program of Study:

CD30 receptor: regulation of expression and its role in cultured human embryonic stem cells. (PHD) 2008.

Supervisors:

Williams, B (Joint-Co), Wolvetang, E (Joint).