Prof Matthew Wilce - Researcher Profile

Qualifications

PHD IN BIOCHEMISTRY/BIOPROCESSING & TECHNOLOGY

Institution: Monash University

Year awarded: 1991

BACHELOR OF SCIENCE (HONS) - BIOCHEMISTRY MAJOR

Institution: James Cook University North Queensland

Year awarded: 1986

Publications

Book Chapters

Wilce, J.A., Vivian, J.P., Wilce, M.C., 2012, Oligonucleotide binding proteins: the occurrence of dimer and multimer formation, in Advances, eds JM Matthews, Springer Science+Business Media, USA, pp. 91-104.

Journal Articles

Beckham, S.A., Brouwer, J.M., Roth, A., Wang, D., Sadler, A.J., John, M., Jahn-Hofmann, K., Williams, B.R.G., Wilce, J.A., Wilce, M.C.J., 2013, Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly, Nucleic Acids Research [P], vol 41, issue 5, Oxford University Press, UK, pp. 3436-3445.

Andrews, D., Xie, M., Hughes, V.A., Wilce, M.C.J., Roujeinikova, A., 2013, Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studies, Journal Of The Royal Society Interface [P], vol 10, issue 79, The Royal Society Publishing, UK, pp. 1-10.

Ambaye, N.D., Gunzburg, M.J., Lim, R.C.C., Price, J.T., Wilce, M.C.J., Wilce, J.A., 2013, The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents, Chemmedchem [P], vol 8, issue 2, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 280-288.

Battad, J., Traore, D.A., Byres, E., Rossjohn, J., Devenish, R.J., Olsen, S., Wilce, M.C., Prescott, M., 2012, A Green Fluorescent Protein Containing a QFG Tri-Peptide Chromophore: Optical Properties and X-Ray Crystal Structure, PLoS ONE [P], vol 7, issue 10, Public Library of Science, USA, pp. e47331.1-e47331.14.

Gopalan, R.D., Del Borgo, M.P., Bergman, Y.E., Unabia, S., Mulder, R.J., Wilce, M.C., Wilce, J.A., Aguilar, M.[., Perlmutter, P., 2012, Conformational stability studies of a stapled hexa-beta(3)-peptide library, Organic & Biomolecular Chemistry [P], vol 10, issue 9, R S C Publications, UK, pp. 1802-1806.

Yoga, Y.M.K., Traore, D.A., Sidiqi, M., Szeto, C., Pendini, N.R., Barker, A., Leedman, P., Wilce, J.A., Wilce, M.C., 2012, Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides, Nucleic Acids Research [P], vol 40, issue 11, Oxford University Press, UK, pp. 5101-5114.

Gunzburg, M.J., Ambaye, N.D., Del Borgo, M.P., Pero, S.C., Krag, D.N., Wilce, M.C., Wilce, J.A., 2012, Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity, Journal Of Molecular Recognition [P], vol 25, issue 1, John Wiley & Sons Ltd, UK, pp. 57-67.

Martin, L.L., Lu, J., Nafady, A., Le, T.H., Siriwardana, A.I., Qu, X., Traore, D.A.K., Wilce, M.C.J., Bond, A.M., 2012, Novel semiconducting biomaterials derived from a proline ester and tetracyanoquinodimethane identified by handpicked selection of individual crystals, Australian Journal of Chemistry [E], vol 65, issue 7, CSIRO Publishing, Collingwood Vic Australia, pp. 935-941.

Soares da Costa, T.P., Tieu, W., Yap, M.Y., Pendini, N.R., Polyak, S.W., Pedersen, D., Morona, R., Turnidge, J.D., Wallace, J.C., Wilce, M.C., Booker, G.W., Abell, A.D., 2012, Selective inhibition of biotin protein ligase from Staphylococcus aureus, Journal Of Biological Chemistry [P], vol 287, issue 21, American Society for Biochemistry & Molecular Biology Inc., USA, pp. 17823-17832.

Barker, A., Epis, M.R., Porter, C.J., Hopkins, B.R., Wilce, M.C., Wilce, J.A., Giles, K.M., Leedman, P.J., 2012, Sequence requirements for RNA binding by HuR and AUF1, Journal of Biochemistry [P], vol 151, issue 4, Oxford University Press, UK, pp. 423-437.

Li, Q., Lu, J., Boas, J.F., Traore, D.A.K., Wilce, M.C.J., Huang, F., Martin, L.L., Ueda, T., Bond, A.M., 2012, Spontaneous redox synthesis of the charge transfer material TTF4[SVMo11O40], Inorganic Chemistry [P], vol 51, issue 23, American Chemical Society, Washington DC USA, pp. 12929-12937.

Peddie, V., Butcher, R.J., Robinson, W.T., Wilce, M.C., Traore, D.A.K., Abell, A.D., 2012, Synthesis and conformation of fluorinated beta-peptidic compounds, Chemistry-A European Journal [P], vol 18, issue 21, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 6655-6662.

Lu, J., Le, T.H., Traore, D.A.K., Wilce, M.C.J., Bond, A.M., Martin, L.L., 2012, Synthetic precursors for TCNQF(4)(2-) compounds: synthesis, characterization, and electrochemical studies of (Pr4N)(2)TCNQF(4) and Li(2)TCNQF(4), Journal Of Organic Chemistry [P], vol 77, issue 23, American Chemical Society, Washington DC USA, pp. 10568-10574.

Kim, H.S., Wilce, M.C.J., Yoga, Y., Pendini, N.R., Gunzburg, M.J., Cowieson, N., Wilson, G.M., Williams, B., Gorospe, M., Wilce, J.A., 2011, Different modes of interaction by TIAR and HuR with target RNA and DNA, Nucleic Acids Research [P], vol 39, issue 3, Oxford University Press, UK, pp. 1117-1130.

Reinstein, O., Neves, M., Saad, M., Boodram, S., Lombardo, S., Beckham, S., Brouwer, J., Audette, G., Groves, P., Wilce, M., Johnson, P., 2011, Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism, Biochemistry [P], vol 50, issue 43, American Chemical Society, USA, pp. 9368-9376.

Don Paul, C., Traore, D., Byres, E., Rossjohn, J., Devenish, R., Kiss, C., Bradbury, A., Wilce, M., Prescott, M., 2011, Expression, purification, crystallization and preliminary X-ray analysis of eCGP123, an extremely stable monomeric green fluorescent protein with reversible photoswitching properties, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue 10, Wiley-Blackwell Publishing, Inc., USA, pp. 1266-1268.

Hussey, G., Chaudhury, A., Dawson, A., Lindner, D., Knudsen, C., Wilce, M., Merrick, W., Howe, P., 2011, Identification of an mRNP complex regulating tumorigenesis at the translational elongation step, Molecular Cell [P], vol 41, issue 4, Cell Press, USA, pp. 419-431.

Yoga, Y.M.K., Traore, D.A., Wilce, J.A., Wilce, M.C., 2011, Mutation and crystallization of the first KH domain of human polycytosine-binding protein 1 (PCBP1) in complex with DNA, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue Pt 10, Wiley-Blackwell Publishing, Inc., USA, pp. 1257-1261.

Ambaye, N., Pero, S., Gunzburg, M., Yap, M., Clayton, D., Del Borgo, M., Perlmutter, P., Aguilar, M., Shukla, G., Peletskaya, E., Cookson, M., Krag, D., Wilce, M., Wilce, J., 2011, Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression, Journal of Molecular Biology [P], vol 412, issue 3, Academic Press, UK, pp. 397-411.

Ambaye, N.D., Lim, R.C.C., Clayton, D.J., Gunzburg, M.J., Price, J.T., Pero, S.C., Krag, D.N., Wilce, M.C.J., Aguilar, M.I., Perlmutter, P., Wilce, J.A., 2011, Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain, Journal Of Peptide Science [P], vol 96, issue 2, John Wiley & Sons, Inc., USA, pp. 181-188.

Ambaye, N.D., Gunzburg, M.J., Lim, R.C., Price, J.T., Wilce, M.C., Wilce, J.A., 2010, Benzopyrazine derivatives: a novel class of Growth Factor receptor bound protein 7 antagonists, Bioorganic & Medicinal Chemistry [P], vol 19, Pergamon, UK, pp. 693-701.

Vivian, J., Riedmaier, P., Ge, H., Le Nours, J., Sansom, F.M., Wilce, M.C.J., Byres, E., Dias, M., Schmidberger, J., Cowan, P.J., d'Apice, A.J., Hartland, E.L., Rossjohn, J., Beddoe, T.C., 2010, Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases, Structure [P], vol 18, issue 2, Cell Press, USA, pp. 228-238.

Scoble, J.A., McAlister, A.D., Fulton, Z.J., Troy, S.T., Byres, E., Vivian, J., Brammananth, R., Wilce, M.C.J., Le Nours, J., Zaker-Tabrizi, L., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2010, Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase, Journal of Molecular Biology [P], vol 398, issue 1, Academic Press, UK, pp. 26-39.

Klaver, D.W., Wilce, M.C.J., Gasperini, R., Freeman, C., Juliano, J.P., Parish, C.R., Foa, L., Aguilar, M.I., Small, D.H., 2010, Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease, Journal Of Neurochemistry [P], vol 112, issue 6, Wiley-Blackwell Publishing Ltd, UK, USA, pp. 1552-1561.

Klaver, D., Wilce, M.C.J., Cui, H., Hung, A.C., Gasperini, R., Foa, L., Small, D.H., 2010, Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions, Biological Chemistry [P], vol 391, issue 8, Walter de Gruyter GmbH & Co KG, Germany, pp. 849-859.

Yap, M.Y., Wilce, M.C.J., Clayton, D.J., Perlmutter, P., Aguilar, M.I., Wilce, J.A., 2010, Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide, Acta Crystallographica Section F: Structural Biology..., vol 66, issue Pt 12, Wiley-Blackwell Publishing, Inc., USA, UK, pp. 1640-1643.

Crellin, P., Vivian, J., Scoble, J.A., Chow, F.M., West, N.P., Brammananth, R., Proellocks, N.I., Shahine, A.E., Le Nours, J., Wilce, M.C., Britton, W.J., Coppel, R.L., Rossjohn, J., Beddoe, T.C., 2010, Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, Journal Of Biological Chemistry [P], vol 285, issue 39, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 30050-30060.

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, The structural basis for autonomous dimerization of the pre-T-cell antigen receptor, Nature [P], vol 467, issue 7317, Nature Publishing Group, UK, pp. 844-848.

Walton, K.L., Makanji, Y., Chen, J., Wilce, M.C.J., Chan, K.L., Robertson, D.M., Harrison, C.A., 2010, Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex, Journal Of Biological Chemistry [P], vol 285, issue 22, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 17029-17037.

Gunzburg, M.J., Ambaye, N.D., Hertzog, J.T., Del Borgo, M.P., Pero, S.C., Krag, D.N., Wilce, M.C., Aguilar, M.I., Perlmutter, P., Wilce, J.A., 2010, Use of SPR to study the interaction of G7-18NATE peptide with the Grb7-SH2 domain, International Journal Of Peptide Research And Therapeutics [P], vol 16, issue 3, Springer Netherlands, The Netherlands, pp. 177-184.

Barry, E.F., Felquer, F.A., Powell, J.A., Biggs, L., Stomski, F.C., Urbani, A., Ramshaw, H.S., Hoffmann, P., Wilce, M.C.J., Grimbaldeston, M.A., Lopez, A.F., Guthridge, M.A., 2009, 14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival, Journal of Biological Chemistry, vol 284, issue 18, American Society for Biochemistry and Molecular Biology, Inc, USA, pp. 12080-12090.

Walton, K., Makanji, Y., Wilce, M.C.J., Chan, K.L., Robertson, D.M., Harrison, C.A., 2009, A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands, Journal Of Biological Chemistry [P], vol 284, issue 14, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 9311-9320.

Beddoe, T.C., Chen, Z., Clements, C.S., Ely, L.K., Bushell, S.R., Vivian, J.P., Kjer-Nielsen, L., Pang, S.S., Dunstone, M.A., Liu, Y.C., Macdonald, W.A., Perugini, M.A., Wilce, M.C.J., Burrows, S.R., Purcell, A.W., Tiganis, T., Bottomley, S.P., McCluskey, J., Rossjohn, J., 2009, Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 777-788.

Vivian, J., Beddoe, T.C., McAlister, A.D., Wilce, M.C.J., Zaker-Tabrizi, L., Troy, S.T., Byres, E., Hoke, D.E., Cullen, P.A., Lo, M., Murray, G.L., Adler, B., Rossjohn, J., 2009, Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp., Journal of Molecular Biology, vol 387, issue 5, Academic Press, UK, pp. 1229-1238.

Archbold, J.K., Macdonald, W.A., Gras, S., Ely, L.K., Miles, J.J., Bell, M.J., Brennan, R.M., Beddoe, T.C., Wilce, M.C.J., Clements, C.S., Purcell, A.W., McCluskey, J., Burrows, S.R., Rossjohn, J., 2009, Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition, The Journal of Experimental Medicine, vol 206, issue 1, Rockefeller University Press, USA, pp. 209-219.

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S.R., Beddoe, T.C., Wilce, M.C.J., Byres, E., Boyle, T.P., Doak, B.C., Simpson, J.S., Graham, B., Heras, B., Kahler, C.M., Rossjohn, J., Scanlon, M., 2009, Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis, Journal of Molecular Biology [P], vol 394, issue 5, Academic Press, UK, pp. 931-943.

Macdonald, W.A., Chen, Z., Gras, S., Archbold, J.K., Tynan, F.E., Clements, C.S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P.M., Wilce, M.C.J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A.W., Kappler, J., Burrows, S.R., Rossjohn, J., McCluskey, J., 2009, T cell allorecognition via molecular mimicry, Immunity [P], vol 31, issue 6, Cell Press, USA, pp. 897-908.

Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M.C.J., Wallace, J.C., Polyak, S.W., 2008, Biotin protein ligase from Candida albicans: Expression, purification and development of a novel assay, Archives of Biochemistry and Biophysics, vol 479, issue 2, Academic Press, USA, pp. 163-169.

Hopkins, E.J., Clements, C.S., Lin, J., Sullivan, L.C., Johnson, D., Huyton, T., Heroux, A., Hoare, H.L., Beddoe, T.C., Reid, H.H., Wilce, M.C., Brooks, A., Rossjohn, J., 2008, CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence, The Journal of Experimental Medicine, vol 205, issue 3, Rockefeller University Press, United States, pp. 725-735.

Fulton, Z.J., McAlister, A.D., Wilce, M.C., Brammananth, R., Zaker-Tabrizi, L., Perugini, M.A., Bottomley, S.P., Coppel, R.L., Crellin, P., Rossjohn, J., Beddoe, T.C., 2008, Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species, Journal of Biological Chemistry, vol 283, issue 41, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 27881-27890.

Byres, E., Paton, A.W., Paton, J.C., Lofling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., Beddoe, T.C., 2008, Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin, Nature, vol 456, issue 7222, Nature Publishing Group, United Kingdom, pp. 648-652.

Pendini, N.R., Bailey, L.M., Booker, G.W., Wilce, M.C.J., Wallace, J.C., Polyak, S.W., 2008, Microbial biotin protein ligases aid in understanding holocarboxylase synthetase deficiency, Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, vol 1784, issue 7-8, Elsevier BV, Netherlands, pp. 973-982.

Schmidberger, J.W., Wilce, J.A., Weightman, A.J., Wilce, M.C.J., 2008, Purification, crystallization and preliminary crystallographic analysis of DehI, a group I alpha-haloacid dehalogenase from Pseudomonas putida strain PP3, Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, vol 64, issue 7, Wiley-Blackwell Munksgaard, Denmark, USA, pp. 596-598.

Pendini, N.R., Polyak, S.W., Booker, G.W., Wallace, J.C., Wilce, M.C.J., 2008, Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 64, issue Pt 6, Wiley-Blackwell Publishing Inc., USA, pp. 520-523.

Vivian, J., Scoullar, J., Robertson, A.L., Bottomley, S.P., Horne, H.J., Chin, K.Y., Wielens, J., Thompson, P., Velkov, T., Piek, S., Byres, E., Beddoe, T.C., Wilce, M.C., Kahler, C.M., Rossjohn, J., Scanlon, M., 2008, Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis, The Journal of Biological Chemistry, vol 283, issue 47, American Society for Biochemistry and Molecular Biology Inc., United States, pp. 32452-32461.

Makanji, Y., Walton, K., Wilce, M.C.J., Chan, K.L., Robertson, D.M., Harrison, C.A., 2008, Suppression of inhibin A biological activity by alterations in the binding site for betaglycan, Journal of Biological Chemistry, vol 283, issue 24, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 16743-16751.

Schmidberger, J.W., Wilce, J.A., Weightman, A.J., Whisstock, J., Wilce, M.C.J., 2008, The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism, Journal of Molecular Biology, vol 378, issue 1, Academic Press, UK, pp. 284-294.

Tynan, F.E., Reid, H.H., Kjer-Nielsen, L., Miles, J.J., Wilce, M.C.J., Kostenko, L., Borg, N., Williamson, N.A., Beddoe, T.C., Purcell, A.W., Burrows, S.R., McCluskey, J., Rossjohn, J., 2007, A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule, Nature Immunology, vol 8, issue 3, Nature Publishing Group, New York NY USA, pp. 268-276.

Vivian, J.P., Porter, C.J., Wilce, J.A., Wilce, M.C.J., 2007, An asymmetric structure of the bacillus subtilis replication terminator protein in complex with DNA, Journal of Molecular Biology, vol 370, issue 3, Academic Press Ltd Elsevier Science Ltd, London England UK, pp. 481-491.

Borg, N., Wun, K.S., Kjer-Nielsen, L., Wilce, M.C.J., Pellicci, D.G., Koh, R., Besra, G.S., Bharadwaj, M., Godfrey, D.I., McCluskey, J., Rossjohn, J., 2007, CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor, Nature, vol 448, issue 7149, Nature Publishing Group, London England UK, pp. 44-49.

Schmidberger, J.W., Wilce, J.A., Tsang, J.S., Wilce, M.C.J., 2007, Crystal Structures of the Substrate Free-enzyme, and Reaction Intermediate of the HAD Superfamily Member, Haloacid Dehalogenase DehIVa from Burkholderia cepacia MBA4, Journal of Molecular Biology, vol 368, issue 3, Academic Press Elsevier Science Ltd, London England UK, pp. 706-717.

Kim, H., Kuwano, Y., Zhan, M., Pullmann Jr, R., Mazan-Mamczarz, K., Li, H., Kedersha, N., Anderson, P., Wilce, M.C.J., Gorospe, M., Wilce, J.A., 2007, Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR, Molecular and Cellular Biology, vol 27, issue 19, American Society of Microbiology, Washington DC USA, pp. 6806-6817.

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K.L., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M.C.J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J., 2007, GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop, Nature Structural & Molecular Biology, vol 14, issue 4, Nature Publishing Group, New York NY USA, pp. 280-286.

Porter, C.J., Matthews, J.M., Mackay, J.P., Pursglove, S.E., Schmidberger, J., Leedman, P., Pero, S.C., Krag, D., Wilce, M.C.J., Wilce, J.A., 2007, Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation, BMC Structural Biology, vol 7, issue 58, Biomed Central Ltd, London England UK, pp. 1-15.

Porter, C.J., Schuch, R., Pelzek, A.J., Buckle, A.M., McGowan, S., Wilce, M.C.J., Rossjohn, J., Russell, R., Nelson, D., Fischetti, V.A., Whisstock, J.C., 2007, The 1.6 angstrom crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis, Journal of Molecular Biology, vol 366, issue 2, Academic Press Ltd, Elsevier Science Ltd, London UK, pp. 540-550.

Sullivan, L.C., Clements, C.S., Beddoe, T.C., Johnson, D., Hoare, H.L., Lin, J., Huyton, T., Hopkins, E.J., Reid, H.H., Wilce, M.C.J., Kabat, J., Borrego, F., Coligan, J.E., Rossjohn, J., Brooks, A., 2007, The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition, Immunity, vol 27, issue 6, Cell Press, Cambridge MA USA, pp. 900-911.

Huyton, T., Rossjohn, J., Wilce, M.C.J., 2007, Toll-like receptors: structural pieces of a curve-shaped puzzle, Immunology and Cell Biology, vol 85, issue 6, Nature Publishing Group, New York NY USA, pp. 406-410.

Paton, A.W., Beddoe, T.C., Thorpe, C.M., Whisstock, J., Wilce, M.C.J., Rossjohn, J., Talbot, U.M., Paton, J.C., 2006, AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP, Nature, vol 443, issue 7111, Nature Publishing Group, London UK, pp. 548-552.

Vivian, J.P., Porter, C.J., Wilce, J.A., Wilce, M.C.J., 2006, Crystallization and preliminary X-ray diffraction analysis of the Bacillus subtilis replication termination protein in complex with the 37-base-pair TerI-binding site, Acta Crystallographica Section F - Structural Biology and Crystallization Communications, vol 62, issue 11, Blackwell Publishing, UK, pp. 1104-1107.

Marland, Z., Beddoe, T.C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J.C., Wilce, M.C.J., Coppel, R.L., Crellin, P.K., Rossjohn, J., 2006, Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 983-997.

Hatchell, E.C., Colley, S.M., Beveridge, D.J., Epis, M.R., Stuart, L.M., Giles, K.M., Redfern, A.D., Miles, L.E., Barker, A., MacDonald, L.M., Arthur, P.G., Liu, J.C., Golding, J.L., McCulloch, R., Metcalf, C.B., Wilce, J.A., Wilce, M.C., Lanz, R.B., O'Malley, B.W., Leedman, P.J., 2006, SLIRP, a small SRA binding protein, is a nuclear receptor corepressor, Molecular Cell [P], vol 22, issue 5, Cell Press, USA, pp. 657-668.

Wilmann, P.G., Turcic, K., Battad, J.M., Wilce, M.C.J., Devenish, R.J., Prescott, M., Rossjohn, J., 2006, The 1.7 angstrom crystal structure of Dronpa: A photoswitchable green fluorescent protein, Journal of Molecular Biology, vol 364, issue 2, Academic Press Ltd Elsevier Science Ltd, London England, pp. 213-224.

Wilmann, P.G., Battad, J., Petersen, J., Wilce, M.C.J., Dove, S., Devenish, R.J., Prescott, M., Rossjohn, J., 2006, The 2.1 angstrom crystal structure of copGFP, a representative member of the copepod clade within the green fluorescent protein superfamily, Journal of Molecular Biology, vol 359, issue 4, Academic Press Ltd Elsevier Science Ltd, London UK, pp. 890-900.

Sidiqi, M., Wilce, J.A., Porter, C.J., Barker, A., Leedman, P.J., Wilce, M.C., 2005, Formation of an alphacP1-KH3 complex with UC-rich RNA, European Biophysics Journal, vol 34, issue 5, Springer, New York USA, pp. 423-429.

Porter, C.J., Wilce, M.C., Mackay, J.P., Leedman, P.J., Wilce, J.A., 2005, Grb7-SH2 domain dimerisation is affected by a single point mutation, European Biophysics Journal, vol 34, issue 5, Springer, New York USA, pp. 454-460.

Hastings, A.F., Otting, G., Folmer, R.H., Duggin, I.G., Wake, R.G., Wilce, M.C.J., Wilce, J.A., 2005, Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy, Biochemical and Biophysical Research Communications, vol 335, issue 2, Academic Press, San Diego USA, pp. 361-366.

Sidiqi, M., Wilce, J.A., Vivian, J.P., Porter, C.J., Barker, A., Leedman, P.J., Wilce, M.C.J., 2005, Structure and RNA binding of the third KH domain of poly(C)-binding protein 1, Nucleic Acids Research, vol 33, issue 4, Oxford University Press, Oxford England, pp. 1213-1221.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide, Nature Immunology, vol 6, issue 11, Nature Publishing Group, New York USA, pp. 1114-1122.

Streltsov, V.A., Prokop, Z., Damborsky, J., Nagata, Y., Oakley, A.J., Wilce, M.C.J., 2003, Haloalkane dehalogenase LinB from sphingomonas paucimobilis UT26: x-ray crystallographic studies of dehalogenation of brominated substrates, Biochemistry, vol 42, issue 34, American Chemical Society, Washington USA, pp. 10104-10112.

Yeap, B.B., Voon, D.C., Vivian, J.P., McCulloch, R.K., Thomson, A.M., Giles, K.M., Czyzyk-Krzeska, M.F., Furneaux, H., Wilce, M.C.J., Wilce, J.A., Leedman, P., 2002, Novel Binding of HuR and Poly(C)-binding Protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA, Journal of Biological Chemistry, vol 277, issue 30, American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 27183-27192.

Tsunoda, S.P., Rodgers, A.J., Aggeler, R., Wilce, M.C.J., Yoshida, M., Capaldi, R.A., 2001, Large conformational changes of the subunit in the bacterial F1F0 ATP synthase provide a ratchet action to regulate this rotary motor enzyme, Proceedings of the National Academy of Sciences of the United States of America, vol 98, issue 12, National Academy of Sciences, Washington USA, pp. 6560-6564.

Wilce, J.A., Vivian, J.P., Hastings, A.F., Otting, G., Folmer, R.H., Duggin, I.G., Wake, R.G., Wilce, M.C.J., 2001, Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest, Nature Structural & Molecular Biology, vol 8, issue 3, Nature Publishing Group, New York USA, pp. 206-210.

Rodgers, A.J., Wilce, M.C.J., 2000, Structure of the gamma-epsilon complex of ATP synthase, Nature Structural & Molecular Biology, vol 7, issue 11, Nature Publishing Group, New York USA, pp. 1051-1054.

Rossjohn, J., Feil, S.C., Wilce, M., Sexton, J.L., Spithill, T.W., Parker, M.W., 1997, Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S - transferase, Journal of Molecular Biology, vol 273, Academic Press, Cambridge UK, pp. 857-872.

Conference Proceedings

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 571.

Rossjohn, J., Feil, S.C., Wilce, M., Sexton, J.L., Spithill, T.W., Parker, M.W., 1998, Crystallization, structural determination and analysis of a novel parasite vaccine candidate - Fasciola hepatica glutathion e S - transferase, Proceedings, 23rd Annual Lorne Conference on Protein Structure and Function, Lorne 8-12 February 1998, Lorne Protein Workshop Inc, Melbourne Vic Australia, p. C-66.

Other

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, Crucial link in immune development and regulation unearthed, Quality control mechanism that must take place for our immune system, Monash University, Clayton, Vic, Australia.

Grants

Title:

Functional biology of large serine recombinases from mobile antibiotic resistance elements.

Investigators:

Wilce, M, Rood, J, Lyras, D

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Molecular basis for RIG-I like receptor activation of the innate immune pathway.

Investigators:

Wilce, M, Wilce, J

Funding:

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

NHMRC Research Fellowship.

Investigators:

Wilce, M

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

(2012 - 2016). National Health & Medical Research Council (NHMRC).

(2013 - 2017). National Health & Medical Research Council (NHMRC).

Title:

Protein recognition of small RNAs in innate immunity.

Investigators:

Williams, B, Wilce, M, Wilce, J

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Protein-RNA recognition in innate immunity.

Investigators:

Williams, B, Wilce, M, Wilce, J

Funding:

(2008 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Protein-mRNA interactions and their role in post-transcriptional regulation.

Investigators:

Wilce, M, Wilce, J, Gorospe, M, Williams, B

Funding:

(2008 - 2012). Australian Research Council (ARC).

(2008 - 2012). Monash University.

Title:

Regulation of conformational changes associated with ligand binding of nucleic-acid binding proteins.

Investigators:

Wilce, M

Funding:

(2010 - 2014). Australian Synchrotron.

Title:

Specificity and architecture of protein-mRNA interactions regulating gene expression.

Investigators:

Wilce, M, Wilce, J, Gorospe, M

Funding:

(2011 - 2015). Australian Research Council (ARC).

(2011 - 2015). Monash University.

Title:

Structural Studies on Medically-Interesting Proteins.

Investigators:

Wilce, M

Funding:

(2007 - 2012). Australian Nuclear Science & Technology Organisation (ANSTO).

Title:

Structural Studies on Medicinally important Proteins.

Investigators:

Wilce, M

Funding:

(2006 - 2010). Australian Nuclear Science & Technology Organisation (ANSTO).

Title:

Structural studies of Medicinally important Proteins.

Investigators:

Wilce, M

Funding:

(2006 - 2010). Australian Synchrotron Research Program.

Title:

Towards the development of a new class of antibacterial drugs.

Investigators:

Martinac, B, Riley, T, Wilce, M, McKinley, A

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

Title:

Inhibitors of biotin protein ligase: a new class of antibiotic targetting Staphylcoccus aureus.

Investigators:

Wilce, M, Abell, A, Turnidge, J

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Innovative Synchrotron Science - Access Program to the Australian National Beamline Facility and Cutting-Edge Beamlines at International Synchrotrons.

Investigators:

Spiccia, L, Lay, P, Waite, T, Gerson, A, Harris, H, Collins, R, Dillon, C, Brugger, J, Garrett, R, Wilce, M, De Marco, R, Tardio, J, Zhang, L, Aguilar, M, Hambley, T, Harmer-Bassell, S, Burton, E, Bush, R, Johnston, S, Trevitt, A, Kepert, C, Chantler, C, Shimomura, O, Bond, C, Gray, E, Noller, B, Gentle, I, Sullivan, L, Creagh, D, Low, I

Funding:

(2011 - 2015). Australian Research Council (ARC).

(2011 - 2015). Monash University.

Title:

Understanding the mechanisms that govern hormone action in human cancer.

Investigators:

Leedman, P, Wilce, M, O'Malley, B

Funding:

(2006 - 2010). National Health & Medical Research Council (NHMRC).

Title:

A Biomolecular Small Angle X-ray Scattering Facility.

Investigators:

Wilce, M, Beddoe, T, Bottomley, S, Hertzog, P, Rossjohn, J, Whisstock, J, Williams, B, Cowieson, N, Hearn, M, Rood, J

Funding:

(2010 - 2014). Australian Research Council (ARC).

(2010 - 2014). Monash University.

Title:

A HIGH THROUGHPUT PROTEIN CRYSTALLIZATION & IMAGING FACILITY.

Investigators:

Rossjohn, J, Wilce, M, Whisstock, J, Bottomley, S, Smith, A, McCluskey, J, Purcell, A, Brooks, A

Funding:

(2007 - 2011). Australian Research Council (ARC).

(2007 - 2011). Monash University.

(2007 - 2011). Rino Grollo.

(2007 - 2011). The University of Melbourne.

Title:

Australian High Performance Computational Structural Biology Facility.

Investigators:

Buckle, A, Whisstock, J, Wilce, M, Smith, A, Bottomley, S, Abramson, D, Webb, G, Garcia De La Banda, M, Appelbe, W, Coppel, R

Funding:

(2008 - 2012). Australian Research Council (ARC).

(2008 - 2012). Monash University.

(2008 - 2012). Victorian Partnership For Advanced Computing (VPAC).

Title:

Enhanced NMR Research, Characterisation and Analysis Facility.

Investigators:

Langford, S, Brownlee, R, Boskovic, C, Spiccia, L, Hughes, A, Junk, P, Jones, C, Separovic, F, Aguilar, M, Wilce, M, Andrews, P, Batten, S, Robinson, A, Tuck, K, Wilce, J, Abbott, B, Bhosale, S, Hearn, M

Funding:

(2008 - 2012). Australian Research Council (ARC).

(2008 - 2012). La Trobe University.

(2008 - 2012). Monash University.

(2008 - 2012). The University of Melbourne.

(2008 - 2012). Victoria University (VU).

Title:

Molecular Machines: regulation of the catalysis and rotation of the enzyme ATP Synthase.

Investigators:

Wilce, M

Funding:

(2005 - 2009). Australian Research Council (ARC).

Title:

Structure and dynamics of a multiprotein-mRNA complex in the regulation of gene expression.

Investigators:

Wilce, M

Funding:

(2005 - 2009). Australian Research Council (ARC).

Postgraduate Research Supervisions

Completed Supervision

Student:

Ambaye, N.

Program of Study:

Discovery and optimization of Grb7 antagonists as potential antitumour therapeutics. (PHD) 2010.

Supervisors:

Wilce, J (Main), Wilce, M (Associate).

Student:

Kim, H.

Program of Study:

Biophyiscal and structural investigation into the RNA-binding properties of TIAR. (PHD) 2010.

Supervisors:

Wilce, J (Joint-Co), Wilce, M (Joint).

Student:

Yoga, Y.

Program of Study:

. 2008.

Supervisors:

Wilce, J (Joint-Co), Wilce, M (Joint).