Dr Karen White - Researcher Profile

Biography

Position

External Project Coordinator
Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences

Qualifications

PHARMACY

Institution: University of Otago

Year awarded: 2005

BACHELOR OF PHARMACY

Institution: univ of otago new zealand

Year awarded: 1996

BACHLELOR OF SCIENCE

Institution: canterbury univ new zealand

Year awarded: 1994

Publications

Journal Articles

Younis, Y., Douelle, F., Feng, T., Cabrera, D.G., Le Manach, C., Nchinda, A.T., Duffy, S., White, K.L., Shackleford, D., Morizzi, J., Mannila, J.M., Katneni, K., Bhamidipati, R., Zabiulla, M.K., Joseph, J.T., Bashyam, S., Waterson, D., Witty, M.J., Hardick, D., Wittlin, S., Avery, V.M., Charman, S.A., Chibale, K., 2012, 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential, Journal of Medicinal Chemistry [P], vol 55, issue 7, American Chemical Society, Washington DC USA, pp. 3479-3487.

Keenan, M., Abbott, M.J., Alexander, P.W., Armstrong, T., Best, W.M., Berven, B., Botero, A., Chaplin, J.H., Charman, S.A., Chatelain, E., von Geldern, T.W., Kerfoot, M., Khong, A., Nguyen, T.T., McManus, J.D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R.C.A., Wang, S.Z., White, K.L., 2012, Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of chagas disease, Journal of Medicinal Chemistry [P], vol 55, issue 9, American Chemical Society, Washington DC USA, pp. 4189-4204.

Davis, R.A., Buchanan, M.S., Duffy, S., Avery, V.M., Charman, S.A., Charman, W.N., White, K.L., Shackleford, D., Edstein, M.D., Andrews, K., Camp, D.G., Quinn, R.J., 2012, Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp., Journal of Medicinal Chemistry [P], vol 55, issue 12, American Chemical Society, Washington DC USA, pp. 5851-5858.

Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D., 2012, Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target, Proceedings of the National Academy of Sciences of the United States of America [E], vol 109, issue 42, National Academy of Sciences, Washington DC USA, pp. 16823-16828.

Buckner, F.S., Bahia, M.T., Suryadevara, P.K., White, K.L., Shackleford, D., Chennamaneni, N.K., Hulverson, M.A., Laydbak, J.U., Chatelain, E., Scandale, I., Verlinde, C.L.M., Charman, S.A., Lepesheva, G.I., Gelb, M.H., 2012, Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib, Antimicrobial Agents And Chemotherapy [P], vol 56, issue 9, American Society for Microbiology, Washington DC, USA, pp. 4914-4921.

Cabrera, D.G., Douelle, F., Younis, Y., Feng, T., Le Manach, C., Nchinda, A.T., Street, L.J., Scheurer, C., Kamber, J., White, K.L., Montagnat, O.D., Ryan, E., Katneni, K., Zabiulla, M.K., Joseph, J.T., Bashyam, S., Waterson, D., Witty, M.J., Charman, S.A., Wittlin, S., Chibale, K., 2012, Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines, Journal of Medicinal Chemistry [P], vol 55, issue 24, American Chemical Society, Washington DC, USA, pp. 11022-11030.

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S., Chibale, K., 2011, Antimalarial Pyrido[1,2-a]benzimidazoles, Journal of Medicinal Chemistry [P], vol 54, ACS Publications, USA, pp. 4581-4589.

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q., Charman, S., 2011, Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice, Malaria Journal [P], vol 10, issue 150, BioMed Central, United Kingdom, pp. e1-e11.

Gujjar, R., El Mazouni, F., White, K., White, J., Creason, S., Shackleford, D., Deng, X., Charman, W., Bathurst, I., Burrows, J., Floyd, D., Matthews, D., Buckner, F., Charman, S., Phillips, M., Rathod, P., 2011, Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice, Journal of Medicinal Chemistry [P], vol 54, American Chemical Society, USA, pp. 3935-3949.

Cabera, D., Douelle, F., Feng, T., Nchinda, A., Younis, Y., White, K., Wu, Q., Ryan, E., Burrows, J., Waterson, D., Witty, M., Wittlin, S., Charman, S., Chibale, K., 2011, Novel orally active antimalarial thiazoles, Journal of Medicinal Chemistry [P], vol 54, American Chemical Society, USA, pp. 7713-7719.

Coteron, J., Marco, M., Esquivias, J., Deng, X., White, K., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D., Angulo-Barturen, I., Ferrer, S., Jimenez-Diaz, M., Gamo, F., Goldsmith, E., Charman, W., Bathurst, I., Floyd, D., Matthews, D., Burrows, J., Rathod, P., Charman, S., Phillips, M., 2011, Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential, Journal of Medicinal Chemistry [P], vol 54, issue 15, American Chemical Society, USA, pp. 5540-5561.

Charman, S., Arbe-Barnes, S., Bathurst, I., Brun, R., Campbell, M., Charman, W., Chiu, F., Chollet, J., Craft, C., Creek, D., Dong, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D., Sriraghavan, K., Stingelin, L., Tang, Y., Urwyler, H., Wang, X., White, K., Wittlin, S., Zhou, L., Vennerstrom, J., 2011, Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 11, National Academy of Sciences, Washington D.C., USA, pp. 4400-4405.

Gujjar, R., Marwaha, A., El Mazouni, F., White, J., White, K.L., Creason, S., Shackleford, D., Baldwin, J., Charman, W.N., Buckner, F.S., Charman, S.A., Rathod, P., Phillips, M., 2009, Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice, Journal of Medicinal Chemistry [P], vol 52, issue 7, American Chemical Society, USA, pp. 1864-1872.

White, K.L., Nguyen, G., Charman, W.N., Edwards, G.A., Faassen, W.A.(., Porter, C.J., 2009, Lymphatic transport of methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU, Journal Of Pharmacology And Experimental Therapeu..., vol 331, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 700-709.

White, K.L., Rades, T., Kearns, P., Toth, I., Hook, S., 2006, Immunogenicity of liposomes containing lipid core peptides and the adjuvant Quil A, Pharmaceutical Research [P], vol 23, issue 7, Springer New York LLC, USA, pp. 1473-1481.

White, K.L., Rades, T., Furneaux, R.H., Tyler, P.C., Hook, S., 2006, Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells, Journal of Pharmacy and Pharmacology [P], vol 58, issue 6, John Wiley & Sons Ltd., United Kingdom, pp. 729-737.

Demana, P.H., Fehske, C., White, K.L., Rades, T., Hook, S., 2004, Effect of incorporation of the adjuvant Quil A on structure and immune stimulatory capacity of liposomes, Immunology And Cell Biology [P], vol 82, issue 5, Nature Publishing Group, United Kingdom, Australia, pp. 547-554.

White, K.L., Kearns, P., Toth, I., Hook, S., 2004, Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides, Immunology And Cell Biology [P], vol 82, issue 5, Nature Publishing Group, United Kingdom, Australia, pp. 517-522.

Activities

Affiliations with institutes

Centre for Drug Candidate Optimisation
Monash Institute of Pharmaceutical Sciences