Dr Luigi Aurelio - Researcher Profile

Biography

Position

Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

PHD

Institution: La Trobe University

Year awarded: 2005

BACHELOR OF SCIENCE (HONS)

Institution: La Trobe University

Year awarded: 1999

Publications

Journal Articles

Valant, C., Aurelio, L., Devine, S.M., Ashton, T.D., White, J.M., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2012, Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A1 receptor, Journal of Medicinal Chemistry [P], vol 55, issue 5, American Chemical Society, USA, pp. 2367-2375.

Scammells, P., Flynn, B., Aurelio, L., 2011, New methodology for the N-alkylation of 2-amino-3-acylthiophenes, Organic & Biomolecular Chemistry [P], vol 9, issue 13, ROYAL SOC CHEMISTRY, England, pp. 4886-4902.

Aurelio, L., Christopoulos, A., Flynn, B., Scammells, P., Sexton, P., Valant, C., 2011, The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A(1) adenosine receptor, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 12, Pergamon-Elsevier Science Ltd, UK, pp. 3704-3707.

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P., Christopoulos, A., 2010, Delineating the mode of action of adenosine A1 receptor allosteric modulators, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, United States, pp. 444-455.

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A., Scammells, P., 2010, Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, United States, pp. 6550-6559.

Aurelio, L., Valant, C., Figler, H., Flynn, B.L., Linden, J., Sexton, P., Christopoulos, A., Scammells, P.J., 2009, 3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists, Bioorganic & Medicinal Chemistry [P], vol 17, issue 20, Pergamon, UK, pp. 7353-7361.

Aurelio, L., Valant, C., Flynn, B.L., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2009, Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes, Journal of Medicinal Chemistry [P], vol 52, issue 14, American Chemical Society, USA, pp. 4543-4547.

Aurelio, L., Flynn, B.L., Scammells, P.J., 2009, Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles, Australian Journal of Chemistry [E], vol 62, issue 5, C S I R O Publishing, Australia, pp. 402-406.

Aurelio, L., Figler, H., Flynn, B.L., Linden, J., Scammells, P.J., 2008, 5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers, Bioorganic and Medicinal Chemistry, vol 16, issue 3, Pergamon, UK, pp. 1319-1327.

Other

Scammells, P.J., Aurelio, L., Christopoulos, A., Sexton, P., Valant, C., Flynn, B.L., Linden, J., 2009, A1 adenosine receptor allosteric enhancers, USA, AU.

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences