Dr James Pearson - Researcher Profile

Biography

James works in the Office of the Snr DVC & DVC (Research) at Monash University as a Senior Research Fellow.

Keywords

angiography; contrast agent; imaging; microvessels; synchrotron radiation, contraction myosin crossbridge heart sarcomere, diabetes, heart failure

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Adelaide

Year awarded: 1995

BACHELOR OF SCIENCE (HONOURS)

Institution: University of Adelaide

Year awarded: 1989

Publications

Books

Bicudo, J.E.P., Buttemer, W.A., Chappell, M.A., Pearson, J.T., Bech, C., 2010, Ecological and Environmental Physiology of Birds, Oxford University Press, UK.

Journal Articles

Zohdi, V., Wood, B.R., Pearson, J.T., Bambery, K.R., Black, M.J., 2013, Evidence of altered biochemical composition in the hearts of adult intrauterine growth-restricted rats, European Journal Of Nutrition [P], vol 52, issue 2, Springer Heidelberg, Germany, pp. 749-758.

Jenkins, M.J., Edgley, A.J., Sonobe, T., Umetani, K., Schwenke, D., Fujiii, Y., Brown, R.D., Kelly, D.J., Shirai, M., Pearson, J.T., 2012, Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 32, issue 2, Lippincott Williams & Wilkins, USA, pp. 370-377.

Zohdi, V., Black, M., Pearson, J., 2011, Elevated vascular resistance and afterload reduce the cardiac output response to dobutamine in early growth-restricted rats in adulthood, British Journal Of Nutrition [P], vol 106, issue 9, Cambridge University Press, UK, pp. 1374-1382.

Schwenke, D., Gray, E., Pearson, J., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., Kangawa, K., Umetani, K., Shirai, M., 2011, Exogenous ghrelin improves blood flow distribution in pulmonary hypertension-assessed using synchrotron radiation microangiography, Pflugers Archiv-European Journal Of Physiology [P], vol 462, issue 3, Springer, USA, pp. 397-406.

Sonobe, T., Schwenke, D., Pearson, J., Yoshimoto, M., Fujiii, Y., Umetani, K., Shirai, M., 2011, Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography, Journal Of Applied Physiology [P], vol 111, issue 1, American Physiological Society, USA, pp. 75-80.

Schwenke, D.O., Pearson, J.T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., Umetani, K., Shirai, M., 2011, Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension, Journal Of Applied Physiology [P], vol 110, issue 4, American Physiological Society, USA, pp. 901-908.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Cragg, P.A., Shirai, M., 2010, Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats, Acta Physiologica [P], vol 200, issue 3, Wiley-Blackwell Publishing Ltd, USA, pp. 279-287.

Eppel, G.A., Lo Jacono, D., Shirai, M., Umetani, K., Evans, R.G., Pearson, J.T., 2009, Contrast angiography of the rat renal microcirculation in vivo using synchrotron radiation, American Journal of Physiology - Renal Physiology [P], vol 296, issue 5, American Physiological Society, USA, pp. F1023-F1031.

Pearson, J.T., Lewis, R., 2009, Introduction: Frontiers in research reviews: synchrotron radiation for dynamic imaging of living systems. Introduction, Clinical and Experimental Pharmacology and Physiology, vol 36, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 84-87.

Shirai, M., Schwenke, D.O., Eppel, G.A., Evans, R.G., Edgley, A.J., Tsuchimochi, H., Umetani, K., Pearson, J.T., 2009, Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo, Clinical and Experimental Pharmacology and Physiology, vol 36, Wiley-Blackwell Publishing Asia, Australia, pp. 107-116.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Umetani, K., Shirai, M., 2008, Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography, Journal of Applied Physiology, vol 104, Americal Physiological Society, USA, pp. 88-96.

Pearson, J.T., Shirai, M., Tsuchimochi, H., Schwenke, D.O., Ishida, T., Kangawa, K., Suga, H., Yagi, N., 2007, Effects of Sustained Length-Dependent Activation on In Situ Cross-Bridge Dynamics in Rat Hearts, Biophysical Journal, vol 93, issue 12, Biophysical Society, Bethesda MD USA, pp. 4319-4329.

Schwenke, D.O., Pearson, J.T., Umetani, K., Kangawa, K., Shirai, M., 2007, Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography, Journal of Applied Physiology, vol 102, issue 2, American Physiological Society, Bethesda USA, pp. 787-793.

Schwenke, D.O., Pearson, J.T., Tsuchimochi, H., Kangawa, K., Shirai, M., 2007, Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide, Clinical and Experimental Pharmacology & Physiology, vol 34, issue 1-2, Blackwell Publishing, Oxford England UK, pp. 88-94.

Pearson, J.T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenke, D.O., Shimouchi, A., Kangawa, K., Tanabe, T., 2007, alpha2-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice, Pflugers Archive - European Journal of Physiology, vol 454, issue 1, Springer, Germany, pp. 29-39.

Kogata, N., Arai, Y., Pearson, J.T., Hashimoto, K., Hidaka, K., Koyama, T., Somekawa, S., Nakaoka, Y., Ogawa, M., Adams, R.H., Okada, M., Mochizuki, N., 2006, Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization, Circulation Research, vol 98, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 897-904.

Schwenke, D.O., Pearson, J.T., Kangawa, K., Shirai, M., 2006, Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?, Acta Physiologica, vol 186, issue 4, Blackwell Publishing, UK, pp. 309-318.

Schwenke, D.O., Pearson, J.T., Mori, H., Shirai, M., 2006, Does central nitric oxide elicit pulmonary hypertension in conscious rats?, Respiratory Physiology & Neurobiology, vol 153, issue 3, Elsevier Science B V, Netherlands, pp. 250-260.

Schwenke, D.O., Pearson, J.T., Mori, H., Shirai, M., 2006, Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice, Journal of Pharmacological and Toxicological Methods, vol 53, Elsevier Inc., USA, pp. 277-283.

Runciman, S., Seymour, R.S., Baudinette, R.V., Pearson, J.T., 2005, An allometric study of lung morphology during development in the Australian pelican, Pelicanus conspicillatus, from embryo to adult, Journal of Anatomy, vol 207, issue 4, Blackwell Publishing Ltd, UK, pp. 365-380.

Schwenke, D.O., Pearson, J.T., Tsuchimochi, H., Mori, H., Shirai, M., 2005, Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat, Clinical and Experimental Pharmacology and Physiology, vol 32, issue 11, Blackwell Publishing, Oxford England, pp. 952-959.

Seymour, R.S., Runciman, S., Baudinette, R.V., Pearson, J.T., 2004, Developmental allometry of pulmonary structure and function in the altricial Australian pelican Pelecanus conspicillatus, The Journal of Experimental Biology, vol 207, issue 15, The Company of Biologists Ltd, Cambridge England, pp. 2663-2669.

Pearson, J.T., Shirai, M., Ito, H., Tokunaga, N., Tsuchimochi, H., Nishiura, N., Schwenke, D.O., Ishibashi-Ueda, H., Akiyama, R., Mori, H., Kangawa, K., Suga, H., Yagi, N., 2004, In situ measurements of crossbridge dynamics and lattice spacing in rat hearts by x-ray diffraction: sensitivity to regional ischemia, Circulation, vol 109, Lippincott Williams & Wilkins, Philadelphia USA, pp. 2976-2979.

Hanada, R., Teranishi, H., Pearson, J.T., Kurokawa, M., Hosoda, H., Fukushima, N., Fukue, Y., Serino, R., 2004, Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway, Nature Medicine, vol 10, issue 10, Nature Publishing Group, New York USA, pp. 1067-1073.

Shirai, M., Pearson, J.T., Shimouchi, A., Nagaya, N., Tsuchimochi, H., Ninomiya, I., Mori, H., 2003, Changes in functional and histological distributions of nitric oxide synthase caused by chronic hypoxia in rat small pulmonary arteries, British Journal of Pharmacology, vol 139, issue 5, Nature Publishing Group, London UK, pp. 899-910.

Pearson, J.T., Seymour, R.S., Baudinette, R.V., Runciman, S., 2002, Respiration and energetics of embryonic development in a large altricial bird, the Australian pelican (Pelecanus conspicillatus), Journal of Experimental Biology, vol 205, issue 18, The Company of Biologists Ltd, Cambridge UK, pp. 2925-2933.

Tazawa, H., Pearson, J.T., Komoro, T., Ar, A., 2001, Allometric relationships between embryonic heart rate and fresh egg mass in birds, The Journal of Experimental Biology, vol 204, issue 1, The Company of Biologists Ltd, Cambridge England, pp. 165-174.

Moriya, K., Pearson, J.T., Burggren, W.W., Ar, A., Tazawa, H., 2000, Continuous measurements of instantaneous heart rate and its fluctuations before and after hatching in chickens, The Journal of Experimental Biology, vol 203, The Company of Biologists Ltd, Cambridge UK, pp. 895-903.

Conference Proceedings

Umetani, K., Pearson, J.T., Schwenke, D., Shirai, M., 2011, Development of synchrotron radiation x-ray intravital microscopy for in vivo imaging of rat heart vascular function, 33rd Annual International Conference of the IEEE EMBS, 30/8/2011 - 3/9/2011, Institute of Electrical and Electronics Engineers, USA, pp. 7791-7794.

Goldhammer, M.A., Tonhardt, H., Akiyama, R., Pearson, J.T., Tazawa, H., Nichelmann, M., Hochel, J., 2004, Prenatal development of rhythmic blood pressure and heart rate fluctuations in check (Gallus gallus var. domesticus) embryos - A chance to compensate environmental stress, Avian and Poultry Biology Reviews, 9-11 October 2003, Science & Technology Letters, St Albans, England, UK, p. 188.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(MASTER'S BY RESEARCH).

Thesis Title:

Applications of synchrotron radiation microangiography to heart failure therapies.

Supervisors:

Pearson, J (Main), Evans, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms regulating the increase in pulmonary blood flow at birth.

Supervisors:

Hooper, S (Main), Pearson, J (Associate), Polglase, G (Associate).

Completed Supervision

Student:

Chen, Y.

Program of Study:

TBD. 2011.

Supervisors:

Joshi, M (Joint), Pearson, J (Joint-Co).

Student:

Lai, J.

Program of Study:

. 2006.

Supervisors:

Pearson, J (Main), Edgley, A (Joint-Co).