Dr James Swarbrick - Researcher Profile

Biography

Position

Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

CHEMISTRY

Institution: durham university

Year awarded: 2005

CHEMISTRY

Institution: University of Newcastle Upon Tyne

Year awarded: 2005

Publications

Book Chapters

Swarbrick, J.D., Iliades, W., Simpson, J.S., Macreadie, I.G., 2009, Folate biosynthesis- Reappraisal of Old and Novel Targets in the Search for New Antimicrobials, in New Developments in Medicinal Chemistry, eds Marta P. Ortega, Irene C. Gil, Nova Science Publishers, Inc, New York, pp. 1-40.

Journal Articles

Chhabra, S., Dolezal, O., Collins, B.M., Newman, J., Simpson, J.S., Macreadie, I.G., Fernley, R., Peat, T., Swarbrick, J.D., 2012, Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor, PLoS ONE [P], vol 7, issue 1, Public Library of Science, USA, pp. 1-16.

Swarbrick, J., Ung, P., Chhabra, S., Graham, B., 2011, An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy, Angewandte Chemie - International Edition [P], vol 50, issue 19, WILEY-BLACKWELL, USA, pp. 4403-4406.

Graham, B., Loh, C., Swarbrick, J., Ung, P., Shin, J., Yagi, H., Jia, X., Chhabra, S., Barlow, N., Pintacuda, G., Huber, T., Otting, G., 2011, DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra, Bioconjugate Chemistry [P], vol 22, issue 10, American Chemical Society, United States, pp. 2118-2125.

Swarbrick, J., Ung, P., Su, X., Maleckis, A., Chhabra, S., Huber, T., Otting, G., Graham, B., 2011, Engineering of a bis-chelator motif into a protein alpha-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy, Chemical Communications [P], vol 47, ROYAL SOC CHEMISTRY, England, pp. 7368-7370.

Swarbrick, J., Shaw, D., Chhabra, S., Ghai, R., Valkov, E., Norwood, S., Seaman, M., Collins, B., 2011, VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins, PLoS ONE [P], vol 6, issue 5, PUBLIC LIBRARY SCIENCE, USA, pp. 1-15.

Chhabra, S., Newman, J., Peat, T.S., Fernley, R.T., Caine, J., Simpson, J.S., Swarbrick, J.D., 2010, Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 66, issue 5, Wiley-Blackwell Publishing, Inc., United States, pp. 575-578.

Swarbrick, J., Ashton, T., 2010, NMR studies of dextromethorphan in both isotropic and anisotropic states, Chirality [E], vol 22, issue 1, John Wiley & Sons, Inc., United States, pp. 42-49.

Branson, K.M., Mertens, H.D., Swarbrick, J.D., Fletcher, J.I., Kedzierski, L., Gayler, K.R., Gooley, P.R., Smith, B.J., 2009, Discovery of inhibitors of lupin diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase by virtual screening, Biochemistry [P], vol 48, issue 32, American Chemical Society, USA, pp. 7614-7620.

Swarbrick, J.D., Cubeddu, L., Ball, G.E., Curmi, P.M., Gooley, A.A., Williams, K.L., Mabbutt, B., 2009, NMR assignment of prespore specific antigen-a cell surface adhesion glycoprotein from Dictyostelium discoideum, Biomolecular NMR Assignments [P], vol 3, issue 1, Springer Netherlands, The Netherlands, pp. 1-3.

Swarbrick, J.D., Iliades, W., Simpson, J.S., Macreadie, I., 2008, Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials, The Open Enzyme Inhibition Journal [E], vol 1, issue 0, Bentham Open, Netherlands, pp. 12-33.

Mertens, H.D., Callaghan, J.M., Swarbrick, J.D., McConville, M.J., Gooley, P., 2007, A high-resolution solution structure of a trypanosomatid FYVE domain, Protein Science, vol 16, issue 11, Cold Spring Harbor Laboratory Press, New York USA, pp. 2552-2559.

Gibbs, G.M., Scanlon, M.J., Swarbrick, J.D., Curtis, S., Gallant, E., Dulhunty, A.F., O'Bryan, M.K., 2006, The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling, Journal of Biological Chemistry, vol 281, issue 7, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 4156-4163.

Swarbrick, J.D., Buyya, S., Gunawardana, D., Gayler, K.R., McLennan, A.G., Gooley, P., 2005, Structure and substrate-binding mechanism, of human Ap4A hydrolase, Journal of Biological Chemistry, vol 280, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 8471-8481.

Swarbrick, J.D., Bashtannyk, T., Dixon, M., Pau, R., Davidson, B.E., Gooley, P., 2002, Letter to the Editor: Backbone resonance assignment of the 2H, 13C, 15N labelled 32kDa central domain of Escherichia coli TyrR, Journal of Biomolecular NMR, vol 22, issue 4, Springer Verlag Dordrecht, Netherlands, pp. 381-382.

Fletcher, J.I., Swarbrick, J.D., Maksel, D.M., Gayler, K.R., Gooley, P., 2002, The structure of Ap(4)A hydrolase complexed with ATP-MgFx reveals the basis of substrate binding, Structure, vol 10, Cell Press, USA, pp. 205-213.

Swarbrick, J.D., Bashtannyk, T., Maksel, D., Zhang, X.R., Blackburn, G.M., Gayler, K.R., Gooley, P., 2000, The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L, Journal of Molecular Biology, vol 302, issue 5, Academic Press, UK, pp. 1165-1177.

Teaching Commitment

• NMR spectroscopy second year (unit coordinator)
• NMR spectroscopy third year
• NMR spectroscopy honours. Protein NMR and advanced small molecule NMR.
• Molecular spectroscopy - Analytical methods second year.

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action,
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Lanthanide tags for luminescent cellular imaging and paramegnetic structural NMR.

Supervisors:

Graham, B (Main), Swarbrick, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Nanoparticle-based agents for cancer imaging and therapy.

Supervisors:

Swarbrick, J (Main), Graham, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

New inhibitors towards Community Acquired Methicillin-resistant S.aureus treatments.

Supervisors:

Swarbrick, J (Main), Baell, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Novel anti-cancer agents for stabilising g-quadruplex DNA.

Supervisors:

Graham, B (Main), Chalmers, D (Associate), Swarbrick, J (Associate).

Completed Supervision

Student:

Chhabra, S.

Program of Study:

Structure and inhibitors of S. aureus HPPK - a folate pathway enzyme. (PHD) 2012.

Supervisors:

Simpson, J (Main), Swarbrick, J (Associate).