Dr Christopher Siatskas - Researcher Profile

Biography

Christopher works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1998

BACHELOR OF SCIENCE (HONOURS)

Institution: Monash University

Year awarded: 1990

Publications

Book Chapters

Siatskas, C., Yoshimitsu, M., Medin, J., 2004, Transduction and post-translational events in gene therapy trageting hematopoietic stem cells: Focus on Fabry disease, in Focus on Stem Cell Research, eds Erik V Greer, Nova Biomedical Books, USA, pp. 191-227.

Boyd, R.L., Siatskas, C., 1997, Improvement of chicken disease resistance by haemopoietic cytokines, in Perspectives in Avian Endocrinology, Society for Endocrinology, Bristol UK, pp. 463-474.

Journal Articles

Payne, N.J., Sun, G., Herszfeld, D., Tat-Goh, P.A., Verma, P.J., Parkington, H.C., Coleman, H.A., Tonta, M.A., Siatskas, C., Bernard, C.C.A., 2012, Comparative study on the therapeutic potential of neurally differentiated stem cells in a mouse model of multiple sclerosis, PLoS ONE [P], vol 7, issue 4 (Art. No.: e35093), Public Library of Science, USA, pp. 1-14.

Payne, N.L., Dantanarayana, A., Sun, G., Moussa, L., Caine, S., McDonald, C., Herszfeld, D., Bernard, C.C., Siatskas, C., 2012, Early intervention with gene-modified mesenchymal stem cells overexpressing interleukin-4 enhances anti-inflammatory responses and functional recovery in experimental autoimmune demyelination, Cell Adhesion and Migration [P], vol 6, issue 3, Landes Bioscience, USA, pp. 179-189.

Petratos, S., Ozturk, E., Azari, M.F., Kenny, R., Lee, J.Y., Magee, K.A., Harvey, A.R., McDonald, C., Taghian, K., Moussa, L., Aui, P., Siatskas, C., Litwak, S.A., Fehlings, M.G., Strittmatter, S.M., Bernard, C.C., 2012, Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation, Brain [P], vol 135, issue Pt 6, Oxford University Press, UK, pp. 1794-1818.

Siatskas, C., Seach, N.L., Sun, G., Emerson-Webber, A.C., Silvain, A., Toh, B., Alderuccio, F.P., Backstrom, B.T., Boyd, R.L., Bernard, C.C., 2012, Thymic gene transfer of myelin oligodendrocyte glycoprotein ameliorates the onset but not the progression of autoimmune demyelination, Molecular Therapy [P], vol 20, issue 7, Nature Publishing Group, UK, pp. 1349-1359.

McDonald, C., Siatskas, C., Bernard, C.C., 2011, The emergence of amnion epithelial stem cells for the treatment of Multiple Sclerosis, Inflammation and Regeneration [P], vol 31, issue 3, The Japanese Society of Inflammation and Regeneration, Japan, pp. 256-271.

Payne, N., Siatskas, C., Barnard, A.L., Bernard, C.C.A., 2011, The prospect of stem cells as multi-faceted purveyors of immune modulation, repair and regeneration in multiple sclerosis, Current Stem Cell Research and Therapy [P], vol 6, issue 1, Bentham Science Publishers Ltd, The Netherlands, pp. 50-62.

Siatskas, C., Payne, N.L., Short, M.A., Bernard, C.C., 2010, A consensus statement addressing mesenchymal stem cell transplantation for multiple sclerosis: It's time!, Stem Cell Reviews [P], vol 6, issue 4, Humana Press Inc, USA, pp. 500-506.

Ko, H.-., Chung, J.-., Nasa, Z., Chan, J., Siatskas, C., Toh, B.-., Alderuccio, F., 2010, Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease, Autoimmunity [P], vol 44, issue 3, Informa Healthcare, United Kingdom, pp. 177-187.

Ko, H., Kinkel, S., Hubert, F., Nasa, Z., Chan, M., Siatskas, C., Hirubalan, P., Toh, B., Scott, H., Alderuccio, F., 2010, Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis, European Journal Of Immunology [P], vol 40, issue 12, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 3499-3509.

Symes, J., Siatskas, C., Fowler, D., Medin, J., 2009, Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells, Cancer Gene Therapy [P], vol 16, issue 5, Nature Publishing Group, UK, pp. 439-452.

Siatskas, C., Bernard, C.C.A., 2009, Stem cell and gene therapeutic strategies for the treatment of multiple sclerosis, Current Molecular Medicine [P], vol 9, issue 8, Bentham Science Publishers Ltd., The Netherlands, pp. 992-1016.

Payne, N., Siatskas, C., Bernard, C.C.A., 2008, The promise of stem cell and regenerative therapies for multiple sclerosis, Journal of Autoimmunity, vol 31, issue 3, Academic Press, UK, pp. 288-294.

Yoshimitsu, M., Higuchi, K., Ramsubir, S., Nonaka, T., Rasaiah, V.I., Siatskas, C., Liang, S., Murray, G.J., Brady, R.O., Medin, J., 2007, Efficient correction of Fabry mice and patient cells mediated by lentiviral transduction of hematopoietic stem/progenitor cells, Gene Therapy [P], vol 14, issue 3, Nature Publishing Group, UK, pp. 256-265.

Siatskas, C., Bernard, C.C.A., 2007, Emerging approaches to treat multiple sclerosis, Australasian Science [P], vol 28, Control Publications Pty. Ltd, Australia, pp. 18-22.

Thomson, C.W., Mossoba, M.E., Siatskas, C., Chen, W., Sung, A., Medin, J., Zhang, L., 2007, Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells, Molecular Therapy [P], vol 15, issue 4, Nature Publishing Group, UK, pp. 818-824.

Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., Alderuccio, F.P., 2006, Gene therapy strategies towards immune tolerance to treat the autoimmune diseases, Current Gene Therapy, vol 6, issue 1, Bentham Science Publishers, Netherlands, pp. 45-58.

Alderuccio, F.P., Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., 2006, Haematopoietic stem cell gene therapy to treat autoimmune disease., Current Stem Cell Research and Therapy, vol 1, Bentham Science Publishers, Netherlands, pp. 279-287.

Chan, M.K.J., Siatskas, C., Field, J., Toh, B., Alderuccio, F.P., 2006, Mechanisms and applications of stem cell gene therapy in autoimmunity, Drug Discovery Today: Disease Mechanisms, vol 3, issue 2, Elsevier Ltd, England, pp. 219-223.

Ayach, B.B., Yoshimitsu, M., Dawood, F., Sun, M., Arab, S., Chen, M., Higuchi, K., Siatskas, C., Lee, P., Lim, H., Zhang, J., Cukerman, E., Stanford, W.L., Medin, J., Liu, P.P., 2006, Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 103, issue 7, National Academy of Sciences, USA, pp. 2304-2309.

Lund, N., Branch, D.R., Sakac, D., Lingwood, C.A., Siatskas, C., Robinson, C.J., Brady, R.O., Medin, J., 2005, Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus, AIDS [P], vol 19, issue 14, Lippincott Williams & Wilkins, USA, pp. 1543-1546.

Siatskas, C., Underwood, J., Ramezani, A., Hawley, R.G., Medin, J., 2005, Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms, Faseb Journal [P], vol 19, issue 12, Federation of American Socieites for Experimental Biology, USA, pp. 1752-1754.

Smith, S.L., Kiss, J.E., Siatskas, C., Medin, J., Moldwin, R.L., 2004, Enhanced effect of vascular endothelial growth factor, thrombopoietin peptide agonist, SCF, and Flt3-L on LTC-IC and reporter gene transduction from umbilical cord blood CD34+ cells, Transfusion [P], vol 44, issue 3, Wiley-Blackwell Publishing, Inc., USA, pp. 438-449.

Li, J., Shi, W., Chia, M., Sanchez-Sweatman, O., Siatskas, C., Huang, D., Busson, P., Klamut, H.J., Yeh, W., Richardson, C., O'Sullivan, B., Gullane, P., Neligan, P., Medin, J., Liu, F., 2003, Efficacy of targeted FasL in nasopharyngeal carcinoma, Molecular Therapy [P], vol 8, issue 6, Nature Publishing Group, UK, pp. 964-973.

Siatskas, C., Boyd, R.L., 2000, Regulation of chicken haemopoiesis by cytokines, Developmental & Comparative Immunology, vol 24, Pergamon-Elsevier Science Ltd, Oxford England, pp. 37-59.

Conference Proceedings

Siatskas, C., Boyd, R.L., 1997, Identification and characterisation of a novel stronal cell derived haemopoietic growth factor, Proceedings of the Australian Poultry Science Symposium, Sydney February 97, The Poultry Research Foundation, Sydney NSW Australia, pp. 22-31.