Prof Shaun Jackson - Researcher Profile

Biography

Shaun works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

PHD

Institution: Monash University

Year awarded: 1995

MBBS (BACHELOR OF MEDICINE, BACHELOR OF SURGERY)

Institution: Monash University

Year awarded: 1989

BACHELOR OF MEDICAL SCIENCE

Institution: Monash University

Year awarded: 1989

Publications

Book Chapters

Jackson, S., Schoenwaelder, S., 2010, PI 3-Kinase p-110-beta regulation of platelet integrin alpha-II-beta-3, in Phosphoinositide 3-kinase in Health and Disease, eds Christian Rommel, Bart Vanhaesebroeck and Peter K Vogt, Springer, US, pp. 203-224.

Kulkarni, S., Nesbitt, W.S., Dopheide, S.M., Hughan, S.C., Harper, I.S., Jackson, S.P., 2004, Techniques to examine platelet adhesive interactions under flow, in Methods in Molecular Biology: Platelets and Megakaryocytes, eds Jonathan M Gibbins and Martyn P Mahaut-Smith, Humana Press, USA, pp. 165-186.

Journal Articles

Nesbitt, W.S., Harper, I.S., Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2012, A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow, Methods in molecular biology (Clifton, N.J.) [P], vol 788, Humana Press, USA, pp. 73-89.

Jackson, S., Schoenwaelder, S.M., 2012, Antithrombotic phosphoinositide 3-kinase ? inhibitors in humans: A 'shear' delight!, Journal Of Thrombosis And Haemostasis [P], vol 10, issue 10, Wiley-Blackwell Publishing Ltd, Chichester, West Sussex PO19 8SQ United Kingdom, pp. 2123-2126.

Schoenwaelder, S., Jackson, S., 2012, Bcl-xL–inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function, Blood [P], vol 119, issue 5, American Society of Hematology, United States, pp. 1320-1321.

White, M., Schoenwaelder, S., Josefsson, E., Jarman, K., Henley, K., James, C., Debrincat, M., Jackson, S., Huang, D., Kile, B., 2012, Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function, Blood [P], vol 119, issue 18, American Society of Hematology, United States, pp. 4283-4290.

Al-Tamimi, M., Tan, C., Qiao, J.L., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J.F., Davis, A., Jing, J., Mu, F., Hamilton, J.R., Jackson, S., Ludwig, A., Berndt, M.C., Ward, C., Kritharides, L., Andrews, R.K., Gardiner, E.E., 2012, Pathologic shear triggers shedding of vascular receptors: A novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels, Blood [P], vol 119, issue 18, American Society of Hematology, United States, pp. 4311-4320.

Lee, H., Sturgeon, S.A., Mountford, J.K., Jackson, S., Hamilton, J.R., 2012, Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice, British Journal of Pharmacology [P], vol 166, issue 7, John Wiley & Sons Ltd, United Kingdom, pp. 2188-2197.

Lee, H., Sturgeon, S., Jackson, S., Hamilton, J., 2012, The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions, Thrombosis and Haemostasis [P], vol 107, issue 2, Schattauer GmbH, Germany, pp. 328-337.

Guerreiro, A., Fattet, S., Kulesza, D., Atamer, A., Elsing, A., Shalaby, T., Jackson, S., Schoenwaelder, S., Grotzer, M., Delattre, O., Arcaro, A., 2011, A sensitized RNA interference screen identifies a novel role for the PI3K p110I-gamma isoform in medulloblastoma cell proliferation and chemoresistance, Molecular Cancer Research [P], vol 9, issue 7, American Association for Cancer Research, USA, pp. 925-935.

Jackson, S., 2011, Arterial thrombosis-insidious, unpredictable and deadly, Nature Medicine [P], vol 17, issue 11, Nature Publishing Group, USA, pp. 1423-1436.

Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., Andrews, R., Mason, K., Salem, H., Huang, D., Kile, B., Roberts, A., Jackson, S., 2011, Bcl-x L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets, Blood [P], vol 118, issue 6, American Society of Hematology, USA, pp. 1663-1674.

Heemskerk, J., Sakariassen, K., Zwaginga, J.J., Brass, L., Jackson, S.P., Farndale, R., 2011, Collagen surfaces to measure thrombus formation under flow: Possibilities for standardization, Journal Of Thrombosis And Haemostasis [P], vol 9, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 856-858.

Straub, A., Krajewski, S., Hohmann, J., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y., Nandurkar, H., Jackson, S., Hickey, M., Peter, K., 2011, Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 31, issue 7, Lippincott Williams & Wilkins, USA, pp. 1607-1616.

Cranmer, S., Ashworth, K., Yao, Y., Berndt, M.C., ruggeri, Z.M., Andrews, R., Jackson, S., 2011, High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIba-filamin interaction, Blood [P], vol 117, issue 9, American Society of Hematology, United States, pp. 2718-2727.

Liu, Y., Gao, X., Fang, L., Jennings, N., Su, Y., Xu, Q., Samson, A., Kiriazis, H., Wang, X., Shan, L., Sturgeon, S., Medcalf, R., Jackson, S., Dart, A., Du, X., 2011, Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction, Arteriosclerosis, Thrombosis, and Vascular Biology [E], vol 31, issue 4, Lippincott Williams & Wilkins, United States, pp. 834-841.

Wen, P., Osborne, S., Zanin, M., Low, P., Wang, H., Schoenwaelder, S., Jackson, S., Wedlich-Soldner, R., Vanhaesebroeck, B., Keating, D., Meunier, F., 2011, Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells, Nature Communications [E], vol 2, issue 1, Nature Publishing Group, UK, pp. 491-502.

Tovar-Lopez, F., Rosengarten, G., Khoshmanesh, K., Westein, E., Jackson, S., Nesbitt, W., Mitchell, A., 2011, Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice, Journal of Biomechanics [P], vol 44, issue 6, Elsevier BV, The Netherlands, pp. 1031-1039.

De Laurentiis, A., Pardo, O., Palamidessi, A., Jackson, S., Schoenwaelder, S., Reichmann, E., Scita, G., Arcaro, A., 2011, The catalytic class IA PI3K isoforms play divergent roles in breast cancer cell migration, Cellular Signalling [P], vol 23, issue 3, Elsevier Inc., USA, pp. 529-541.

Kaplan, Z., Jackson, S., 2011, The role of platelets in atherothrombosis, Hematology [P], vol 2011, issue 1, American Society of Hematology, USA, pp. 51-61.

Tovar-Lopez, F.J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A., Nesbitt, W., 2010, A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood, Lab On A Chip [P], vol 10, issue 3, Royal Society of Chemistry, United Kingdom, pp. 291-302.

Qiu, M., Jiang, L., Matthaei, K.I., Schoenwaelder, S.M., Kuffner, T., Mangin, P., Joseph, J.E., Low, J., Connor, D., Valenzuela, S., Curmi, P.M., Brown, L.J., Mahaut-Smith, M., Jackson, S., Breit, S.N., 2010, Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene, Genesis [P], vol 48, issue 2, John Wiley & Sons, Inc., USA, pp. 127-136.

Zeller, K.S., Idevall-Hagren, O., Stefansson, A., Velling, T., Jackson, S., Downward, J., Tengholm, A., Johansson, S., 2010, PI3-kinase p110alpha mediates beta1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading, Cellular Signalling [P], vol 22, issue 12, Elsevier Inc., United States, pp. 1838-1848.

Schoenwaelder, S.M., Ono, A., Nesbitt, W.S., Lim, J.M.C., Jarman, K.E., Jackson, S., 2010, Phosphoinositide 3-kinase p110beta regulates integrin alphaIIbbeta3 avidity and the cellular transmission of contractile forces, Journal Of Biological Chemistry [P], vol 285, issue 4, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 2886-2896.

Devi, S., Kuligowski, M.P., Kwan, R.Y.Q., Westein, E., Jackson, S., Kitching, A.R., Hickey, M.J., 2010, Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway., American Journal Of Pathology [P], vol 177, issue 3, American Society for Investigative Pathology, United States, pp. 1131-1142.

Jackson, S., Schoenwaelder, S., 2010, Procoagulant platelets: are they necrotic?, Blood [P], vol 116, issue 12, American Society of Hematology, United States, pp. 2011-2018.

Jackson, S., Kaplan, Z., 2010, SR-BI and fatty platelets, Blood [P], vol 116, issue 11, American Society of Hematology, United States, pp. 1827-1828.

Nesbitt, W.S., Westein, E., Tovar-Lopez, F.J., Tolouei, E., Mitchell, A., Jia, F., Carberry, J.J., Fouras, A., Jackson, S., 2009, A shear gradient-dependent platelet aggregation mechanism drives thrombus formation, Nature Medicine [P], vol 15, issue 6, Nature Publishing Group, USA, pp. 665-673.

Jackson, S., Nesbitt, W.S., Westein, E., 2009, Dynamics of platelet thrombus formation, Journal Of Thrombosis And Haemostasis [P], vol 7, issue S1, Wiley-Blackwell Publishing Ltd, UK, pp. 17-20.

Woollard, K.J., Sturgeon, S.A., Chin-Dusting, J.P., Salem, H.H., Jackson, S., 2009, Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular Injury, Journal Of Biological Chemistry [P], vol 284, issue 19, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 13110-13118.

Arthur, J.F., Jackson, S., 2009, Is thrombin the problem or (dis)solution?, Blood [P], vol 113, issue 24, American Society of Hematology, USA, pp. 6046-6047.

Wei, A., Schoenwaelder, S.M., Andrews, R.K., Jackson, S., 2009, New insights into the haemostatic function of platelets, British Journal Of Haematology [P], vol 147, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 415-430.

Gilio, K., Munnix, I.C.A., Mangin, P., Cosemans, J.M.E., Feijge, M.A.H., van der Meijden, P.E.J., Olieslagers, S., Chrzanowska-Wodnicka, M., Lillian, R., Schoenwaelder, S.M., Koyasu, S., Sage, S.O., Jackson, S., Heemskerk, J.W.M., 2009, Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 33750-33762.

Calkin, A., Drew, B.G., Ono, A., Duffy, S.J., Gordon, M., Schoenwaelder, S.M., Sviridov, D., Cooper, M.E., Kingwell, B.A., Jackson, S., 2009, Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux, Circulation [P], vol 120, issue 21, Lippincott Williams & Wilkins, USA, pp. 2095-2104.

Kim, S., Mangin, P., Dangelmaier, C., Lillian, R., Jackson, S., Daniel, J., Kunapuli, S.P., 2009, Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 33763-33772.

Marques, M., Kumar, A., Poveda, A.M., Zuluaga, S., Hernandez, C., Jackson, S., Pasero, P., Carrera, A.C., 2009, Specific function of phosphoinositide 3-kinase beta in the control of DNA replication, Proceedings Of The National Academy Of Sciences O..., vol 106, issue 18, National Academy of Sciences, USA, pp. 7525-7530.

Schoenwaelder, S.M., Yuan, Y., Josefsson, E.C., White, M.J., Yao, Y., Mason, K.D., O'Reilly, L.A., Henley, K.J., Ono, A., Hsiao, S.T., Willcox, A.E.H., Roberts, A.W., Huang, D.C.S., Salem, H.H., Kile, B., Jackson, S., 2009, Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function, Blood [P], vol 114, issue 3, American Society of Hematology, USA, pp. 663-666.

Mu, F., Andrews, R.K., Arthur, J.F., Munday, A.D., Cranmer, S.L., Jackson, S., Stomski, F.C., Lopez, A.F., Berndt, M.C., 2008, A functional 14-3-3{zeta}-independent association of PI3-kinase with glycoprotein Ib{alpha}, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex, Blood, vol 111, issue 9, American Society of Hematology, United States, pp. 4580-4587.

Wei, A., Jackson, S., 2008, Boosting platelet production, Nature Medicine, vol 14, issue 9, Nature Publishing Group, United States, pp. 917-918.

Frazzetto, M., Suphioglu, C., Zhu, J., Schmidt-Kittler, O., Jennings, I., Cranmer, S.L., Jackson, S., Kinzler, K., Vogelstein, B., Thompson, P., 2008, Dissecting isoform selectivity of P13K inhibitors: The role of non-conserved residues in the catalytic pocket, Biochemical Journal, vol 414, issue 3, Portland Press Ltd., UK, pp. 383-390.

van der Meijden, P.E.J., Schoenwaelder, S.M., Feijge, M.A.H., Cosemans, J.M.E., Munnix, I.C.A., Wetzker, R., Heller, R., Jackson, S., Heemskerk, J.W.M., 2008, Dual P2Y12 receptor signaling in thrombin-stimulated platelets - involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity, The FEBS Journal, vol 275, issue 2, Wiley-Blackwell Publishing Ltd., UK, pp. 371-385.

Ono, A., Westein, E., Hsiao, S.T., Nesbitt, W.S., Hamilton, J.R., Schoenwaelder, S.M., Jackson, S., 2008, Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth, Blood, vol 112, issue 1, American Society of Hematology, United States, pp. 90-99.

Woollard, K., Suhartoyo, A., Harris, E.E., Eisenhardt, S.U., Jackson, S., Peter, K., Dart, A.M., Hickey, M.J., Chin-Dusting, J.P., 2008, Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation, Circulation Research, vol 103, issue 10, Lippincott Williams & Wilkins, United States, pp. 1128-1138.

Guerreiro, A.S., Fattet, S., Fischer, B., Shalaby, T., Jackson, S.P., Schoenwaelder, S.M., Grotzer, M.A., Delattre, O., Arcaro, A., 2008, Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration, Clinical Cancer Research, vol 14, issue 21, American Association for Cancer Research (A AC R), United States, pp. 6761-6769.

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y., Schwarz, M., Hagemeyer, C.E., Eisenhardt, S.U., Ahrens, I., Bode, C., Jackson, S., Peter, K., 2007, A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 27, issue 3, Lippincott Williams & Wilkins, Philadelphia USA, pp. 9-15.

Hamilton, J.R., Kaplan, Z., Jackson, S., Opat, S., 2007, Antiplatelet therapy: present status and future prospects, Expert Opinion on Drug Discovery, vol 2, issue 8, Informa Healthcare, UK, pp. 1035-1040.

Jackson, S., Cranmer, S.L., Mangin, P., Yuan, Y., 2007, Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb, Blood, vol 109, issue 2, American Society of Hematology, USA, pp. 846-847.

Kulkarni, S., Woollard, K.J., Thomas, S., Oxley, D., Jackson, S.P., 2007, Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading, Blood, vol 110, issue 6, American Society of Hematology, USA, pp. 1879-1886.

Chaussade, C., Rewcastle, G.W., Kendall, J.D., Denny, W.A., Cho, K., Gronning, L.M., Chong, M., Anagnostou, S.H., Jackson, S., Daniele, N., Shepherd, P.R., 2007, Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling, Biochemical Journal, vol 404, issue 3, Portland Press Ltd, UK, pp. 449-458.

Maxwell, M.J., Westein, E., Nesbitt, W.S., Giuliano, S., Dopheide, S.M., Jackson, S., 2007, Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation, Blood, vol 109, issue 2, American Society of Hematology, USA, pp. 566-576.

Schoenwaelder, S.M., Ono, A., Sturgeon, S.A., Chan, S.M., Mangin, P., Maxwell, M.J., Turnbull, S., Mulchandani, M., Anderson, K.E., Kauffenstein, G., Rewcastle, G.W., Kendall, J., Gachet, C., Salem, H.H., Jackson, S., 2007, Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin aIIb?3 adhesive function in platelets, The Journal of Biological Chemistry, vol 282, issue 39, The American Society for Biochemistry and Molecular Biology Inc, USA, pp. 28648-28658.

Kim, S., Garcia, A., Jackson, S., Kunapuli, S.P., 2007, Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform, Blood, vol 110, issue 13, American Society of Hematology, USA, pp. 4206-4213.

Arcaro, A., Doepfner, K.T., Boller, D., Guerreiro, A.S., Shalaby, T., Jackson, S., Schoenwaelder, S.M., Delattre, O., Grotzer, M.A., Fischer, B., 2007, Novel role for insulin as an autocrine growth factor for malignant brain tumour cells, Biochemical Journal, vol 406, issue 1, Portland Press Ltd, UK, pp. 57-66.

Ferguson, G.J., Milne, L., Kulkarni, S., Sasaki, T., Walker, S., Andrews, S., Crabbe, T., Finan, P., Jones, G., Jackson, S., Camps, M., Rommel, C., Wymann, M.P., Hirsch, E., Hawkins, P.T., Stephens, L.R., 2007, PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis, Nature Cell Biology, vol 9, issue 1, Nature Publishing Group, London England, pp. 86-91.

Kendall, J., Rewcastle, G.W., Frederick, R., Mawson, C., Denny, W.A., Marshall, E.S., Baguley, B.C., Chaussade, C., Jackson, S., Shepherd, P.R., 2007, Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors, Biorganic and Medicinal Chemistry, vol 15, issue 24, Pergamon-Elsevier Science Ltd, UK, pp. 7677-7687.

Jackson, S., Calkin, A., 2007, The clot thickens - Oxidized lipids and thrombosis, Nature Medicine, vol 13, issue 9, Nature Publishing Group, United States, pp. 1015-1016.

Jackson, S., Calkin, A., 2007, The clot thickens - oxidized lipids and thrombosis, Nature Medicine, vol 13, issue 9, Nature Publishing Group, USA, pp. 1015-1016.

Jackson, S., 2007, The growing complexity of platelet aggregation, Blood, vol 109, issue 12, American Society of Hematology, USA, pp. 5087-5095.

Jackson, S., Mangin, P., Yuan, Y., 2006, "Pulling strings": Shear, platelets, and microparticles, Blood [E], vol 107, issue 9, American Society of Hematology, United States, pp. 3418-3419.

McCormack, M.P., Hall, M.A., Schoenwaelder, S.M., Zhao, Q., Ellis, S., Prentice, J.A., Clarke, A.J., Slater, N.J., Salmon, J.M., Jackson, S.P., Jane, S.M., Curtis, D.J., 2006, A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis, Blood, vol 108, issue 7, American Society of Hematology, Washington DC USA, pp. 2248-2256.

Cosemans, J.M.E., Munnix, I.C.A., Wetzker, R., Heller, R., Jackson, S.P., Heemskerk, J.W.M., 2006, Continuous signaling via PI3K isoforms betta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization, Blood, vol 108, issue 9, American Society of Hematology, USA, pp. 3045-3052.

Nesbitt, W.S., Jackson, S., 2006, Imaging signaling processes in platelets, Blood Cells, Molecules, and Diseases, vol 36, issue 2, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 139-144.

Shen, Y., Cranmer, S.L., Aprico, A., Whisstock, J., Jackson, S., Berndt, M.C., Andrews, R.K., 2006, Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor, The Journal of Biological Chemistry, vol 281, issue 36, American Society for Biochemistry and Molecular Biology, Inc, Bethesda USA, pp. 26419-26423.

Woollard, K., Kling, D., Kulkarni, S., Dart, A.M., Jackson, S., Chin-Dusting, J., 2006, Raised plasma soluble P-selectin in peripheral arterial occlusive disease enhances leukocyte adhesion, Circulation Research, vol 98, issue 1, Lippincott Williams & Wilkins, Baltimore USA, pp. 149-156.

Woollard, K., Kling, D., Kulkarni, S., Dart, A.M., Jackson, S., Chin-Dusting, J., 2006, Raised soluble P-selectin in peripheral arterial occlusive disease enhances leukocyte-platelet adhesion independent of circulating microparticle levels, European Heart Journal, vol 27, Oxford Univ Press, Oxford England, p. 754.

Maxwell, M.J., Dopheide, S.M., Turner, S.J., Jackson, S., 2006, Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 26, issue 3, Lippincott Williams and Wilkins, Philadelphia USA, pp. 663-669.

Nesbitt, W.S., Mangin, P., Salem, H.H., Jackson, S., 2006, The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis., Journal of Molecular Medicine, vol 84, issue 12, Springer-Verlag, Germany, pp. 989-995.

Mangin, P., Yap, C.L.S., Nonne, C., Sturgeon, S.A., Goncalves, I., Yuan, Y., Schoenwaelder, S.M., Wright, C.E., Lanza, F., Jackson, S., 2006, Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency, Blood, vol 107, issue 11, American Society of Hematology, Washington USA, pp. 4346-4353.

Jackson, S., Schoenwaelder, S.M., 2006, Type I phosphoinositide 3-kinases: potential antithrombotic targets?, Cellular and Molecular Life Sciences, vol 63, issue 10, Birkhauser Verlag AG, Basel Switzerland, pp. 1085-1090.

Jackson, S., 2006, We-W40:4 Platelet ADP receptors and phosphoinositide 3-kinases are essential in preventing thromboembolism on collagen and fibrous atherosclerotic lesions, Atherosclerosis Supplements, vol 7, issue 3, Elsevier Ireland Ltd, Ireland, p. 325.

Cranmer, S.L., Pikovski, I., Mangin, P.H., Thompson, P.E., Domagala, T., Frazzetto, M., Salem, H.H., Jackson, S.P., 2005, Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha, Biochemical Journal, vol 387, issue 3, Portland Press Ltd, London UK, pp. 849-858.

Goncalves, I., Nesbitt, W.S., Yuan, Y., Jackson, S.P., 2005, Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets, The Journal of Biological Chemistry, vol 280, issue 15, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 15430-15437.

Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V.B., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H., 2005, PI 3-kinase p110beta: A new target for antithrombotic therapy, Nature Medicine, vol 11, issue 5, Nature Publishing Group, New York USA, pp. 507-514.

Condliffe, A.M., Davidson, K., Anderson, K.E., Ellson, C.D., Crabbe, T., Okkenhaug, K., Vanhaesebroeck, B.M., Turner, M., Webb, L., Wymann, M.P., Hirsch, E., Ruckle, T., Camps, M., Rommel, C., Jackson, S.P., Chilvers, E.R., Stephens, L.R., Hawkins, P.T., 2005, Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils, Blood, vol 106, issue 4, The American Society of Hematology, Washington USA, pp. 1432-1440.

Mangin, P.H., David, T., Lavaud, V., Cranmer, S.L., Pikovski, I., Jackson, S.P., Berndt, M.C., Cazenave, J., Gachet, C., Lanza, F., 2004, Identification of a novel 14-3-3, binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha, Blood, vol 104, issue 2, American Society of Hematology, Washington USA, pp. 420-427.

Jackson, S., Yap, C.L.S., Anderson, K.E., 2004, Phosphoinositide 3-kinases and the regulation of platelet function, Biochemical Society Transactions, vol 32, issue 2, Portland Press, UK, pp. 387-392.

Kulkarni, S., Jackson, S.P., 2004, Platelet factor XIII and calpain negatively regulate integrin IIb3 adhesive function and thrombus growth, The Journal of Biological Chemistry, vol 279, issue 29, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 30697-30706.

Maxwell, M.J., Yuan, Y., Anderson, K.E., Hibbs, M.L., Salem, H.H., Jackson, S.P., 2004, SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets, The Journal of Biological Chemistry, vol 279, issue 31, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 32196-32204.

Jackson, S.P., Schoenwaelder, S.M., 2003, Antiplatelet Therapy: In search of the 'Magic Bullet', Nature Reviews Drug Discovery, vol 2, issue 10, Nature Publishing Group, London UK, pp. 1-15.

Giuliano, S., Nesbitt, W.S., Rooney, M.M., Jackson, S.P., 2003, Bidirectional integrin signalling regulating platelet adhesion under flow: contribution of protein kinase C, Biochemical Journal, vol 372, Portland Press, London UK, pp. 163-172.

Anderson, K.E., Jackson, S.P., 2003, Class I phosphoinositide 3-kinases, The International Journal of Biochemistry & Cell Biology, vol 35, issue 7, Pergamon-Elsevier Science Ltd, UK, pp. 1028-1033.

Cranmer, S.L., Jackson, S.P., 2003, GPIb, filamin, and platelet activation: a view from within, Blood, vol 102, issue 6, American Society of Hematology, USA, p. 1937.

Goncalves, I., Hughan, S.C., Schoenwaelder, S.M., Yap, C.L.S., Yuan, Y., Jackson, S.P., 2003, Integrin IIb3-dependent calcium signals regulate platelet-fribrinogen interactions under flow, The Journal of Biological Chemistry, vol 278, issue 37, The American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 34812-34822.

Nesbitt, W.S., Giuliano, S., Kulkarni, S., Dopheide, S.M., Harper, I.S., Jackson, S.P., 2003, Intercellular calcium communication regulates platelet aggregation and thrombus growth, The Journal of Cell Biology, vol 160, issue 7, The Rockefeller University Press, New York USA, pp. 1151-1161.

Perrault, C., Mangin, P., Santer, M., Baas, M., Moog, S., Cranmer, S.L., Pikovski, I., Williamson, D., Jackson, S.P., 2003, Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex, Blood, vol 101, issue 9, American Society of Hematology, Washington USA, pp. 3477-3484.

Jackson, S.P., Nesbitt, W.S., Kulkarni, S., 2003, Signaling events underlying thrombus formation, Journal of Thrombosis and Haemostasis, vol 1, issue 7, Schattauer GMBH-Verlag Medizin Naturwissenschaften, Stuttgart Germany, pp. 1602-1612.

Mangin, P., Yuan, Y., Goncalves, I., Eckly, A., Freund, M., Cazenave, J., Gachet, C., Jackson, S.P., Lanza, F., 2003, Signaling role for phospholipase Cg 2 in platelet glycoprotein Iba calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcRg chain and FcgRIIA, The Journal of Biological Chemistry, vol 278, issue 35, The American Society of Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 32880-32891.

Nesbitt, W.S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S.M., Yap, C.L., Harper, I.S., Salem, H., Jackson, S.P., 2002, Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow, The Journal of Biological Chemistry, vol 277, issue 4, The Amer Society for Biochemistry and Molecular Biology Inc, USA, pp. 2965-2972.

Yap, C.L., Anderson, K.E., Hughan, S.C., Dopheide, S.M., Salem, H., Jackson, S.P., 2002, Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3, BLOOD, vol 99, issue 1, The American Society of Hematology, USA, pp. 151-158.

Williamson, D., Pikovski, I., Cranmer, S.L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H., Jackson, S.P., 2002, Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear, The Journal of Biological Chemistry, vol 277, issue 3, The Amer Society for Biochemistry and Molecular Biolog Inc, Bethesda MD USA, pp. 2151-2159.

Schoenwaelder, S.M., Hughan, S.C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P.E., Salem, H., Jackson, S.P., 2002, RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear, Journal of Biological Chemistry, vol 277, issue 17, Amer Soc for Biochemistry and Molecular Biology, Inc, Bethesda MD USA, pp. 14738-14746.

Dopheide, S.M., Maxwell, M.J., Jackson, S.P., 2002, Shear-dependent tether formation during platelet translocation on von Willebrand factor, Blood, vol 99, issue 1, The American Society of Hematology, Washington DC USA, pp. 159-167.

Dopheide, S.M., Yap, C.L.S., Jackson, S., 2001, Dynamic aspects of platelet adhesion under flow, Clinical And Experimental Pharmacology And Physiology [P], vol 28, WILEY-BLACKWELL PUBLISHING, INC, AUSTRALIA, pp. 355-363.

Tait, S., Cranmer, S.L., Jackson, S.P., Dawes, I., Chong, B., 2001, Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations, Blood, vol 98, issue 6, American Society of Hematology, Washington DC USA, pp. 1812-1818.

Jones, K., Hughan, S.C., Dopheide, S.M., Farndale, R., Jackson, S.P., Jackson, D., 2001, Platelet andothelial cell adhesion molecule-1 is a negative regulator of platelet-collagen interactions, Blood, vol 98, issue 5, American Society of Hematology, Washigton DC USA, pp. 1456-1463.

Kulkarni, S., Dopeide, S.M., Yap, C.L., Ravanat, C., Freund, M., Mangin, P., Heel, K.A., Street, A., Harper, I., Lanza, F., Jackson, S.P., 2000, A revised model of platelet aggregation, The Journal of Clinical Investigation, vol 105 issue 6, American Society Clinical Investigation Inc, Ann Arbor USA, pp. 783-791.

Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2000, Calpain regulation of integrin alphaIIbbeta3 signaling in human platelets, Platelets, vol 11, Taylor & Francis Ltd, London UK, pp. 189-198.

Mistry, N., Cranmer, S.L., Yuan, Y., Mangin, P., Dopeide, S.M., Harper, I., Giuliano, S., Dunstan, D.E., Lanza, F., Salem, H.H.H., Jackson, S.P., 2000, Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction, Blood, vol 96 issue 10, The American Society of Hematology, Washington DC USA, pp. 3480-3489.

Jackson, S., Mistry, N., Yuan, Y., 2000, Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton., Trends in Cardiovascular Medicine [P], vol 10, ELSEVIER SCIENCE LONDON, England, pp. 192-197.

Ulsemer, P., Lanza, F., Baas, M., Schwartz, A., Ravanat, C., Briquel, M., Cranmer, S.L., Jackson, S.P., 2000, Role of the leucine-rich domain of platelet GPIbalpha in correct post-translational processing - The Nancy I Bernard-Soulier mutation expressed on CHO cells, Thrombosis and Haemostasis, vol 84, FK Schattauer Verlag GMBH, Stuttgart Germany, pp. 104-111.

Yap, C.L., Hughan, S.C., Cranmer, S.L., Nesbitt, W.S., Rooney, M.M., Giuliano, S., Kulkarni, S., Dopeide, S.M., Yuan, Y., Salem, H.H.H., Jackson, S.P., 2000, Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3, The Journal of Biological Chemistry, vol 275 issue 52, Amer Soc for Biochemistry and Molecular Biology, Bethesda UK, pp. 41377-41388.

Cranmer, S.L., Ulsemer, P., Cooke, B.M., Salem, H.H., De La Salle, C., Lanza, F., Jackson, S.P., 1999, Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear, The Journal of Biological Chemistry, vol 274 issue 10, Amer Soc for Biochemistry & Molecular Biology Inc, Bethesda USA, pp. 6097-6106.

Williamson, D., Giuliano, S., Jackson, S.P., 1999, Platelet adhesion receptors: novel targets for anti-thrombotic therapy, Australian and New Zealand Journal of Medicine, vol 29, ADIS Press Australasia Pty Ltd, Balgowlah Australia, pp. 452-461.

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S.L., Yap, C.L., Nesbitt, W.S., Harper, I., Mistry, N., Dopheide, S.M., Hughan, S.C., Williamson, D., De La Salle, C., Salem, H.H., Lanza, F., Jackson, S.P., 1999, The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells, Journal of Biological Chemistry, vol 274 issue 51, American Society for Molecular Biology Inc., Rockville Pike Bethesda MD USA, pp. 36241-36251.

Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., Jackson, S.P., 1997, Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytosskeletal Attachment of Integrin aPb b3(Platelet Glyoprotein IIb/IIIa and the Cellular Retraction of Fibrin Clots, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 1694-1702.

Yuan, Y., Dopeide, S.M., Ivanidis, C., Salem, H.H., Jackson, S.P., 1997, Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 21847-21854.

Schoenwaelder, S.M., Kulkarni, S., Salem, H.H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T.C., Jackson, S.P., 1997, Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 24876-24884.

Conference Proceedings

Berry, J.D., Thompson, M.C., Carberry, J.J., Jackson, S., 2008, Forces on an adhering cell, ICTAM 2008 Cd-ROM Proceedings, 25 - 29 August 2008, University of Adelaide, Adelaide, Australia, pp. 11690 (article)-11691.

Other

Abbott, B., Anderson, K., Goncalves, I., Jackson, S., Vijaya, K., Warwick, N., Hishani, P., Robertson, A.D., Saylik, D., Schoenwaelder, S.M., Thompson, P., 2009, Inhibition of phosphoinositide 3-kinase-beta (AU), Australia.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B.M., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2007, Inhibition of phosphoinositide 3-kinase beta, New Zealand.

Robertson, A.D., Jackson, S., Kenche, V., Yap, C.L.S., Prabaharan, H., Thompson, P., 2006, Therapeutic Morpholino-substituted compounds, Australia.

Woollard, K., Nesbitt, W.S., Harper, I.S., Sturgeon, S.A., Jackson, S., 2006, Visualizing thrombus formation in vivo: current limitations and future prospects, International Review of Thrombosis, Reviews Medical Company Ltd, Osaka Japan.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2004, Inhibition of phosphoinositide 3-kinase beta.

Robertson, A.D., Jackson, S., Kenche, V., Yaip, C., Hishani, P., Thompson, P., 2004, Therapeutic Morpholino-substituted compounds, New Zealand.

Dopeide, S.M., Cooke, B.M., Jackson, S.P., 1999, Method for measuring cellular adhesion, International.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Determining the role of GPIb binding to thrombin specifically pertaining to its effect on fibrin generation and impact on leukocyte - platelet interaction.

Supervisors:

Jackson, S (Main), Salem, H (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

PI3 Kinase Inhibitors as adjunct thrombolytic therapies.

Supervisors:

Jackson, S (Main), Schoenwaelder, S (Associate), Yuan, Y (Associate).

Completed Supervision

Student:

Berry, J.

Program of Study:

Cell modelling with applications to cell-wall interactions. (PHD) 2010.

Supervisors:

Carberry, J (Joint), Thompson, M (Joint-Co), Jackson, S (Associate).

Student:

Ghasemzadeh, M.

Program of Study:

Investigation of signalling cross-talk between platelets and neutrophils. (PHD) 2009.

Supervisors:

Jackson, S (Main), Salem, H (Associate).

Student:

Giuliano, S.

Program of Study:

CALCIUM SIGNALLING REGULATING PLATLET ADHESION AND THROMBUS GROWTH. (PHD) 2003.

Supervisors:

Jackson, S (Main).

Student:

Goncalves, I.

Program of Study:

INVESTIGATION OF THE MECHANISM BY WHICH SHEAR FORCES STIMULATE PLATELET ACTIVATION. (PHD) 2005.

Supervisors:

Jackson, S (Joint-Co), Yuan, Y (Joint).

Student:

Hughan, S.

Program of Study:

INVESTIGATION OF INTERGRIN AIIbB3 ACTIVATION DURING PLATELET ADHESION. (PHD) 2003.

Supervisors:

Jackson, S (Main).

Student:

Kulkarni, S.

Program of Study:

Investigation of Mechanisms Regulating Platelet Aggregation Under Flow. (PHD) 2002.

Supervisors:

Salem, H (Main), Jackson, S (Associate).

Student:

Maxwell, M.

Program of Study:

INVESTIGATION OF MECHANISMS REGULATING PLATELET ADHESION DYNAMICS UNDER FLOW. (PHD) 2005.

Supervisors:

Jackson, S (Main), Salem, H (Associate).

Student:

Mistry, N.

Program of Study:

INVESTIGATION OF THE ROLE OF THE PLATELET CYTOSKELETON IN REGULATING THE INTERACTION BETWEEN GLYCOPROTEIN IB/V/IX AND VON WILLEBRAND FACTOR. (PHD) 2003.

Supervisors:

Salem, H (Main), Jackson, S (Associate).

Student:

Mountford, J.

Program of Study:

Defining the role of Class II Phosphoinositide 3-Kinases in platelet function. (PHD) 2012.

Supervisors:

Hamilton, J (Joint-Co), Jackson, S (Joint).

Student:

Ono, A.

Program of Study:

Investigation of novel mechanisms regulating platelet contractile function. (PHD) 2009.

Supervisors:

Jackson, S (Main), Schoenwaelder, S (Associate).

Student:

Pikovski, I.

Program of Study:

Structure-Function Relationship of Platlet Receptor Glycoprotein Ib/V/IX.. (Masters) 2003.

Supervisors:

Jackson, S (Main), Cranmer, S (Associate).

Student:

Tolouei, E.

Program of Study:

Investigation of shear dependent platelet aggregation. (PHD) 2012.

Supervisors:

Carberry, J (Main), Fouras, A (Associate), Jackson, S (Associate).

Student:

Westein, E.

Program of Study:

Identification of a rheology dependent platelet aggregation mechanism. (PHD) 2009.

Supervisors:

Jackson, S (Main).

Student:

Yap, C.

Program of Study:

INVESTIGATION OF SHEER DEPENDENT SIGNALLING BETWEEN PLATELET GLYCOPROTEIN Ib/V/IX AND INTEGRIN IIb/IIla. (PHD) 2002.

Supervisors:

Salem, H (Main), Jackson, S (Associate).