Dr Jamie Simpson - Researcher Profile

Biography

Position

Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

PHD

Institution: The University of Queensland

Year awarded: 2000

SCIENCE (HONOURS)

Institution: The University of Queensland

Year awarded: 1995

Publications

Book Chapters

Swarbrick, J.D., Iliades, W., Simpson, J.S., Macreadie, I.G., 2009, Folate biosynthesis- Reappraisal of Old and Novel Targets in the Search for New Antimicrobials, in New Developments in Medicinal Chemistry, eds Marta P. Ortega, Irene C. Gil, Nova Science Publishers, Inc, New York, pp. 1-40.

Journal Articles

Chhabra, S., Dolezal, O., Collins, B.M., Newman, J., Simpson, J.S., Macreadie, I.G., Fernley, R., Peat, T., Swarbrick, J.D., 2012, Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor, PLoS ONE [P], vol 7, issue 1, Public Library of Science, USA, pp. 1-16.

Vinh, N., Simpson, J.S., Scammells, P.J., Chalmers, D.K., 2012, Virtual screening using a conformationally flexible target protein: models for ligand binding to p38 alpha MAPK, Journal Of Computer-Aided Molecular Design [P], vol 26, issue 4, Springer, Netherlands, pp. 409-423.

Chua, T., Simpson, J., Ventura, S., 2011, Ethanol extracts of saw palmetto contain the indirectly acting sympathomimetic: tyramine, Prostate [P], vol 71, issue 1, John Wiley & Sons, Inc., United States, pp. 71-80.

Doak, B., Scanlon, M., Simpson, J., 2011, Synthesis of unsymmetrical 1,1 '-disubstituted Bis(1,2,3-triazole)s using monosilylbutadiynes, Organic Letters [P], vol 13, issue 3, AMER CHEMICAL SOC, USA, pp. 537-539.

Chhabra, S., Newman, J., Peat, T.S., Fernley, R.T., Caine, J., Simpson, J.S., Swarbrick, J.D., 2010, Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 66, issue 5, Wiley-Blackwell Publishing, Inc., United States, pp. 575-578.

Brandi, A., Simpson, J., Ventura, S., 2010, Isoflavones isolated from red clover (Trifolium pratense) inhibit smooth muscle contraction of the isolated rat prostate gland, Phytomedicine : international journal of phytotherapy and phytopharmacology [P], vol 17, issue 11, Urban und Fischer Verlag, Germany, pp. 895-901.

Velkov, T., Hughes, M.L.R., Horne, H.J., Simpson, J.S., Porter, C.J., Scanlon, M., 2009, Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein, Molecular And Cellular Biochemistry [P], vol 326, issue 1-2, Springer New York LLC, USA, pp. 87-95.

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S.R., Beddoe, T.C., Wilce, M.C.J., Byres, E., Boyle, T.P., Doak, B.C., Simpson, J.S., Graham, B., Heras, B., Kahler, C.M., Rossjohn, J., Scanlon, M., 2009, Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis, Journal of Molecular Biology [P], vol 394, issue 5, Academic Press, UK, pp. 931-943.

Paxman, J.J., Borg, N., Horne, H.J., Thompson, P., Chin, K.Y., Sharma, P., Simpson, J.S., Wielens, J., Piek, S., Kahler, C.M., Sakellaris, H., Pearce, M.C., Bottomley, S.P., Rossjohn, J., Scanlon, M., 2009, The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes, Journal Of Biological Chemistry [P], vol 284, issue 26, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 17835-17845.

Headey, S.J., Vom, A., Simpson, J.S., Scanlon, M., 2008, Backbone assignments of the 34kDa ketopantoate reductase from E. coli, Biomolecular NMR Assignments [P], vol 2, issue 1, Springer Netherlands, Netherlands, pp. 93-96.

Swarbrick, J.D., Iliades, W., Simpson, J.S., Macreadie, I., 2008, Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials, The Open Enzyme Inhibition Journal [E], vol 1, issue 0, Bentham Open, Netherlands, pp. 12-33.

Simpson, J.S., Dumanski, P., O'Connell, J.L., Simpson, G., Easton, C.J., 2006, Aromatic chlorination of omega-phenylalkylamines and omega-phenylalkylamides in carbon tetrachloride and alpha,alpha,alpha-trifluorotoluene, Organic and Biomolecular Chemistry, vol 4, issue 14, The Royal Society of Chemistry, England, pp. 2716-2723.

Philbrook, A., Blake, C.J., Dunlop, N.F., Easton, C.J., Keniry, M.A., Simpson, J.S., 2005, Demonstration of co-polymerization in melamine-urea-formaldehyde reactions using 15N NMR correlation spectroscopy, Polymer, vol 46, issue 7, Elsevier Ltd., Uk, pp. 2153-2156.

Ciavatta, M.L., Gavagnin, M., Manzo, E., Puliti, R., Mattia, C.A., Mazzarella, L., Cimino, G., Simpson, J.S., Garson, M.J., 2005, Structural and stereochemical revision of isocyanide and isothiocyanate amphilectenes from the Caribbean marine sponge Cribochalina sp., Tetrahedron, vol 61, issue 33, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 8049-8053.

Simpson, J.S., Brust, A., Garson, M.J., 2004, Biosynthetic Pathways to Dichloroimines: Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponge Stylotella aurantium, Organic and Biomolecular Chemistry, vol 2, Royal Society of Chemistry, London, UK, pp. 949-956.

Simpson, J.S., Garson, M.J., 2004, Biosynthetic Pathways to Isocyanides and Isothiocyanates; Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponges Amphimedon terpenensis and Axinyssa n.sp, Organic and Biomolecular Chemistry, vol 2, Royal Society of Chemistry, London, UK, pp. 939-948.

Barr, L., Dumanski, P.G., Easton, C.J., Harper, J.B., Lee, K., Lincoln, S.F., Meyer, A.G., Simpson, J.S., 2004, Cyclodextrin Molecular Reactors, Journal of Inclusion Phenomena and Macrocyclic Chemistry, vol 50, issue 1-2, Springer Netherlands, Netherlands, pp. 19-24.

Barratt, B.J., Easton, C.J., Henry, D.J., Li, I.H.W., Radom, L., Simpson, J.S., 2004, Inhibition of Peptidylglycine a-Amidating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals, Journal of the American Chemistry Society, vol 126, issue 41, American Chemical Society, USA, pp. 13306-13311.

Garson, M.J., Simpson, J.S., 2004, Marine Isocyanides and Related Natural Products - Structure, Biosynthesis and Ecology, Natural Product Reports, vol 21, Royal Society of Chemistry, London, UK, pp. 164-179.

Easton, C.J., Edwards, A.J., McNabb, S.B., Merrett, M.C., O'Connell, J.L., Simpson, G.W., Simpson, J.S., Willis, A.C., 2003, Allylic halogenation of unsaturated amino acids, Organic & Biomolecular Chemistry, vol 1, issue 1, Royal Society of Chemistry, UK, pp. 2492-2498.

Dumanski, P., Easton, C.J., Lincoln, S.F., Simpson, J.S., 2003, Effect of Cyclodextrins on Electrophilic Aromatic Bromination in Aqueous Solution, Australian Journal of Chemistry, vol 56, issue 11, CSIRO, Australia, pp. 1107-1111.

Barr, L.B., Easton, C.J., Lee, K., Lincoln, S.F., Simpson, J.S., 2002, Metallocyclodextrin Catalysts for Hydrolysis of Phosphate Triesters, Tetrahedron Letters, vol 43, Elsevier, Amsterdam Netherlands, pp. 7797-7800.

Simpson, J.S., Garson, M.J., 2001, Advanced precursors in marine biosynthetic study. Part 2: The biosynthesis of isocyanides and isothiocyanates in the tropical marine sponge Axinyssa n.sp, Tetrahedron Letters, vol 42, issue 25, Pergamon, UK, pp. 4267-4269.

Simpson, J.S., Garson, M.J., Blunt, J.W., Munro, M.H.G., Hooper, J.N.A., 2000, Mycalamides C and D, Cytotoxic Compounds from the Marine Sponge Stylinos n. species, The Journal of Natural Products, vol 63, American Chemical Society/ American Society of Pharmacognosy, USA, pp. 704-706.

Conference Proceedings

Chua, T., Simpson, J.S., Ventura, S., 2006, Fractionation of saw palmetto extracts and bioassay of fractions in isolated rat prostate gland, Proceedings of the Australian Health and Medical Research Congress 2006, 26.11.06-1.12.06, Australian Health and Medical Research Congress, Melbourne Vic Australia, p. 407.

Other

Simpson, J.S., Barratt, B.J., Easton, C.J., 2004, Enzyme Inhibitors, Australia Europe Asia USA.

Teaching Commitment

• PSC1022 - Bioorganic and Medicinal Chemistry II
• PAC1142 - Bioorganic and Medicinal Chemistry II
• PSC3121 - Synthetic Medicinal Chemistry (Unit coordinator)
• PSC3122 - Chemical Technologies for the Pharmaceutical Sciences (Unit coordinator)

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Chemical and pharmacological investigation of the effects of phytotherapeutics on the contractility of the prostate gland.

Supervisors:

Simpson, J (Joint), Ventura, S (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Inhibitors of integrin-collagen binding as potential anti-cancer agents..

Supervisors:

Scanlon, M (Joint-co), Simpson, J (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular insights into the interaction between plasmodium apical membrane antigen 1 and an invasion-inhibitory peptide.

Supervisors:

Scanlon, M (Joint-co), Simpson, J (Joint).

Completed Supervision

Student:

Chhabra, S.

Program of Study:

Structure and inhibitors of S. aureus HPPK - a folate pathway enzyme. (PHD) 2012.

Supervisors:

Simpson, J (Main), Swarbrick, J (Associate).

Student:

Chua, T.

Program of Study:

Effects of saw palmetto extracts on prostate gland function in the rat. (PHD) 2012.

Supervisors:

Ventura, S (Main), Simpson, J (Associate).

Student:

Doak, B.

Program of Study:

Fragment based discovery of DsbA inhibitors. (PHD) 2012.

Supervisors:

Scanlon, M (Joint-Co), Simpson, J (Joint).

Student:

Kerr, D.

Program of Study:

Practical Nazarov chemistry for organic synthesis: concise synthesis of roseophilin and auxiliary mediated asymmetric Nazarov reaction. (PHD) 2009.

Supervisors:

Simpson, J (Main), Scammells, P (Associate).

Student:

Masters, K.

Program of Study:

Studies in the synthesis of frondosins B to E. (PHD) 2008.

Supervisors:

Simpson, J (Main).

Student:

Opie, C.

Program of Study:

The synthesis of triazole peptidomimetics. (PHD) 2012.

Supervisors:

Simpson, J (Main).

Student:

Sharma, P.

Program of Study:

Inhibition of oxidative protein folding in gram-negative bacteria: fragment-based design of DsbA inhibitors. (PHD) 2011.

Supervisors:

Scanlon, M (Main), Simpson, J (Associate), Manallack, D (Associate).

Student:

Vom, A.

Program of Study:

A fragment-based approach to the identification of novel ketopantoate reductase inhibitors. (PHD) 2012.

Supervisors:

Simpson, J (Main), Capuano, B (Associate), Yuriev, E (Associate).