Dr Kellie Tuck - Researcher Profile

Biography

Kellie works in the School of Chemistry at Monash University as a Senior Lecturer

 

 

Kellie’s research areas of interest are:

 

• Research into the area of chemical biology, an exciting area at the interface between chemistry and biology. This area is interdisciplinary and involves collaborations with the Department of Biochemistry and Department of Microbiology.

 

 We are interested in

• Understanding how enzymes function and the rational design of inhibitors
• Synthesis of bioactive compounds; natural products and peptide mimetics
• Alternate assay methods for ATP-utilising enzymes
• Research into green, benign transformations

Keywords

Chemical biology

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2007

PHD - SCIENCE

Institution: University of Adelaide

Year awarded: 1999

Publications

Journal Articles

Langendorf, C.G., Tuck, K.L., Key, T., Fenalti, G., Pike, R.N., Rosado, C.J., Wong, A.S., Buckle, A.M., Law, R.H.P., Whisstock, J., 2013, Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates, Bioscience Reports [P], vol 33, issue 1, Portland Press Ltd, UK, pp. 137-149.

Pathberiya, L.G., Barlow, N., Nguyen, T.B.T., Graham, B., Tuck, K.L., 2012, Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate, Tetrahedron [P], vol 68, issue 46, Pergamon, Oxford UK, pp. 9435-9439.

Tranberg, C., Yang, A., Vetter, I., McArthur, J.R., Baell, J.B., Lewis, R.J., Tuck, K.L., Duggan, P., 2012, Omega-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca v2.2 ion channels, Marine Drugs [P], vol 10, issue 10, MDPI AG, Basel, Switzerland, pp. 2349-2368.

Andrews, P.C., Fraser, B.H., Gee, W.J., Giera, D., Junk, P.C., Massi, M., Tuck, K.L., 2010, A study of the formation and application of new chiral water soluble lanthanoid benzoates using real-time infrared spectroscopy, Polyhedron [P], vol 29, issue 7, PERGAMON-ELSEVIER SCIENCE LTD, Oxford England, pp. 1764-1770.

Lee, A., Grace, M., Meyer, A., Tuck, K., 2010, Fluorescent Zn2+ chemosensors, functional in aqueous solution under environmentally relevant conditions, Tetrahedron Letters [P], vol 51, issue 8, Pergamon Elsevier Science Ltd, Oxford England, pp. 1161-1165.

Langendorf, C., Key, T., Fenalti, G., Kan, W., Buckle, A.M., Caradoc-Davies, T.T., Tuck, K.L., Law, R.H.P., Whisstock, J., 2010, The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions, PLoS ONE [P], vol 5, issue 2, Pubic Library of Science, USA, pp. 1-12.

Blair, M., Forsyth, C.M., Tuck, K.L., 2010, Towards the synthesis of prevezol C: total enantioselective synthesis of (-)-2-epi-prevezol C, Tetrahedron Letters [P], vol 51, issue 37, Pergamon, United Kingdom, pp. 4808-4811.

Blair, M., Tuck, K.L., 2009, A new diastereoselective entry to the (1S,4R)- and (1S,4S)-isomers of 4-isopropyl-1-methyl-2-cyclohexen-1-ol, aggregation pheromones of the ambrosia beetle Platypus quercivorus, Tetrahedron-Asymmetry [P], vol 20, Elsevier, UK, pp. 2149-2153.

Andrews, P.C., Junk, P.C., Kemppinen, K.P., Konstas, K., Tuck, K.L., 2009, Application of lanthanoid catalysts for the synthesis of Michler's hydride, Letters in Organic Chemistry [P], vol 6, issue 3, Bentham Science Publishers Ltd, Netherlands, pp. 229-233.

Duggan, P.J., Lewis, R.J., Lok, Y.P., Lumsden, N.G., Tuck, K.L., Yang, A., 2009, Low molecular weight non-peptide mimics of omega-conotoxin GVIA, Bioorganic & Medicinal Chemistry Letters [P], vol 19, Elsevier, Netherlands, pp. 2763-2765.

Ali, A.S., Meyer, A.G., Tuck, K.L., 2009, O-Aryloxime ethers from the copper(II)-mediated cross-coupling of oximes and phenylboronic acids, Synlett [P], Georg Thiem Verlag, Germany, pp. 0955-0959.

Andersson, A., Baell, J.B., Duggan, P., Graham, J.E., Lewis, R.J., Lumsden, N.G., Tranberg, C., Tuck, K.L., Yang, A., 2009, Omega-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine, Bioorganic & Medicinal Chemistry [P], vol 17, Elsevier, UK, pp. 6659-6670.

Porter, J.L., Tobias, N.J., Hong, H., Tuck, K.L., Jenkin, G.A., Stinear, T.P., 2009, Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum, Microbiology-Sgm [P], vol 155, Society for General Microbiology, UK, pp. 1923-1933.

Perchyonok, V.T., Ryan, S.J., Langford, S.J., Hearn, M.T.W., Tuck, K.L., 2008, Facile and selective deallylations of esters under 'aqueous' free-radical conditions, Synlett, Georg Thieme Verlag, Germany, pp. 1233-1235.

Ciulli, A., Scott, D., Ando, M., Reyes, F., Saldanha, S.A., Tuck, K.L., Chirgadze, D.Y., Blundell, T.L., Abell, C., 2008, Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate., ChemBioChem, vol 9, Wiley-VCH Verlag, Germany, pp. 2606-2611.

Perchyonok, V.T., Tuck, K.L., Langford, S.J., Hearn, M.T.W., 2008, On the scope of radical reactions in aqueous media utilizing quaternary ammonium salts of phosphinic acids as chiral and achiral hydrogen donors, Tetrahedron Letters, vol 49, issue 32, Elsevier, UK, pp. 4777-4779.

Perchyonok, V.T., Lykakis, I.N., Tuck, K.L., 2008, Recent advances in C-H bond formation in aqueous media: A mechanistic perspective, Green Chemistry, vol 10, Royal Society of Chemistry, UK, pp. 153-163.

Duggan, P., Faber, J.M., Graham, J.E., Lewis, R.J., Lumsden, N.G., Tuck, K.L., 2008, Synthesis and Cav2.2 binding data for non-peptide mimetics of omega-conotoxin GVIA based on a 5-amino-anthranilamide core, Australian Journal of Chemistry, vol 61, issue 1, CSIRO, Australia, pp. 11-15.

Blair, M., Andrews, P.C., Fraser, B.H., Forsyth, C.M., Junk, P.C., Massi, M., Tuck, K.L., 2007, Facile methods for the separation of the cis- and trans-diastereomers of limonene 1,2-oxide and convenient routes to diequatorial and diaxial 1,2-diols, Synthesis, issue 4, Georg Theieme Verlag, Germany, pp. 1523-1527.

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K.L., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M.C.J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J., 2007, GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop, Nature Structural & Molecular Biology, vol 14, issue 4, Nature Publishing Group, New York NY USA, pp. 280-286.

Ciulli, A., Lobley, C.M.C., Tuck, K.L., Smith, A.G., Blundell, T.L., Abell, C., 2007, pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study, Acta Crystallogaphica Section D, vol 63, Blackwell Munksgaard, Denmark, pp. 171-178.

Tuck, K.L., Saldanha, S.A., Birch, L.M., Smith, A.G., Abell, C., 2006, The design and synthesis of inhibitors of pantothenate synthetase, Journal of Organic Biomolecular Chemistry, vol 4, Royal Society of Chemistry, UK, pp. 3598-3610.

Andrews, P.C., Blair, M., Fraser, B.H., Junk, P.C., Massi, M., Tuck, K.L., 2006, Water soluble lanthanoid benzoate complexes for the kinetic separation of cis/trans-limonene oxide, Tetrahedron-Asymmetry, vol 17, issue 19, Elsevier, Netherlands, pp. 2833-2838.

Tuck, K.L., 2005, Chemical biology: tools for advancing drug design, Chemistry in Australia, vol 72, Royal Australian Chemical Institute, Australia, pp. 7-9.

Shiozawa, H., Zerella, R., Bardsley, B.G., Tuck, K.L., Williams, D.H., 2003, Noncovalent bond lengths and their cooperative shortening: Dimers of vancomycin group antibiotics in crystals and in solution, Helvetica Chimica Acta, vol 86, issue 5, Wilet-V C H Verlag GMBH, Germany, pp. 1359-1370.

Tan, H.W., Tuck, K.L., Stupans, I., Hayball, P.J., 2003, Simultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detection, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [P], vol 785, Elsevier Science, Netherland, pp. 187-191.

Lobley, C.M.C., Schmitzberger, F., Kilkenny, M., Whitney, H., Offenhof, H.H., Chakauya, E., Webb, M., Birch, L.M., Tuck, K.L., Abell, C., Smith, A.G., Blundell, T.L., 2003, Structural insights into the evolution of the pantothenate-biosynthesis pathway, Biochemical Society Transactions, vol 31, issue 3, Portland Press Ltd, UK, pp. 563-571.

Tuck, K.L., Hayball, P.J., 2002, The beneficial effects and the fate of the major phenolic compounds in olive oil, The Journal of Nutritional Biochemistry, vol 13, issue 11, Elsevier, USA, pp. 636-644.

Tuck, K.L., Freeman, M.P., Hayball, P.J., Stretch, G.L., Stupans, I., 2001, The In Vivo Fate of Hydroxytyrosol and Tyrosol, Antioxidant Polyphenolic Constituents of Olive Oil, following Intravenous and Oral Dosing of Labelled Compounds to Rats, Journal of Nutrition, vol 131, American Society for Nutrition, USA, pp. 1993-1996.

Other

Hearn, M., Langford, S., Tuck, K., Harris, S., Boysen, R., Perchyonok, V., Danylec, B., Schwarz, L., Chowdhury, J., 2010, Moleculary Imprinted Polymers, Melbourne, Victoria, Australia.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Absolute molecular configuration strategies based on multidimensional separation with spectroscopy.

Supervisors:

Marriott, P (Main), Tuck, K (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

BCL-XL Antagonists Based on Alpha-helix Mimicry for Cancer Therapy.

Supervisors:

Tuck, K (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Design and synthesis of small organic molecules as blockers of neuronal calcium ion channels relevant to neuropathic pain.

Supervisors:

Tuck, K (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Natural Product Synthesis.

Supervisors:

Tuck, K (Main), Robinson, A (Associate).

Program of Study:

(MASTER'S BY RESEARCH).

Thesis Title:

Synthesis of O-Aryloxime Ethers via the Copper-Mediated Cross- coupling of arylboronic acidswith ary.

Supervisors:

Tuck, K (Main).

Completed Supervision

Student:

Ali, A.

Program of Study:

Organic synthesis. 2008.

Supervisors:

Tuck, K (Main).

Student:

Blair, M.

Program of Study:

The asymmetric synthesis of 2-epi-Prevezol C and the diastereoisomers of quercivorol. (PHD) 2009.

Supervisors:

Tuck, K (Main).

Student:

Graham, J.

Program of Study:

Synthesis of w-Conotoxin GVIA inspired small molecules in the search for relief of neuropathic pain. (PHD) 2009.

Supervisors:

Tuck, K (Main).