Dr Caroline Speed - Researcher Profile

Biography

Caroline works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Lecturer.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1996

SCIENCE (HONS)

Institution: Monash University

Year awarded: 1992

Publications

Journal Articles

Kovacic, A., Speed, C.J., Simpson, E.R., Clyne, C., 2004, Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes, Molecular Endocrinology [P], vol 18, issue 1, The Endocrine Society, USA, pp. 252-259.

Clyne, C., Kovacic, A., Speed, C.J., Zhou, J., Pezzi, V., Simpson, E.R., 2004, Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue, Molecular and Cellular Endocrinology [P], vol 215, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 39-44.

Simpson, E.R., Clyne, C., Rubin, G., Boon, W., Robertson, K.M., Britt, K.L., Speed, C.J., Jones, M., 2002, Aromatase--a brief overview, Annual Review Of Physiology [P], vol 64, Annual Reviews, USA, pp. 93-127.

Rubin, G.L., Duong, J.H., Clyne, C., Speed, C.J., Murata, Y., Gong, C., Simpson, E.R., 2002, Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose, Endocrinology [P], vol 143, issue 8, The Endocrine Society, USA, pp. 2863-2871.

Clyne, C., Speed, C.J., Zhou, J., Simpson, E.R., 2002, Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes, Journal Of Biological Chemistry [P], vol 277, issue 23, American Society for Biochemistry and Molecular Biology Inc, USA, pp. 20591-20597.

Simpson, E.R., Clyne, C., Speed, C.J., Rubin, G., Bulun, S., 2001, Tissue-specific estrogen biosynthesis and metabolism, Annals of the New York Academy of Sciences [P], vol 949, Wiley-Blackwell Publishing Inc, USA, pp. 58-67.

Kong, A.M., Speed, C.J., O'Malley, C., Layton, M.J., Meehan, T., Loveland, K.L., Cheema, S.S., Ooms, L.M., Mitchell, C.A., 2000, Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network, Journal of Biological Chemistry, vol 275, American Soc for Biochem & Molecular Biology, Inc, Bethesda USA, pp. 24052-24064.

Speed, C.J., Mitchell, C.A., 2000, Sustained elevation in inositol 1,4,5-trisphosphate results in inhibition of phosphatidylinositol transfer protein activity and chronic depletion of the agonist-sensitive phosphoinositide pool, Journal of Cell Biology, vol 113, Company of Biologists Ltd, Cambridge UK, pp. 2631-2638.

Speed, C.J., Neylon, C.B., Little, P.J., Mitchell, C.A., 1999, Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses followig endothelin-1 stimulation, Journal of Cell Science, vol 112, The Company of Biologists Ltd, Cambridge UK, pp. 669-679.

Mitchell, C.A., Speed, C.J., Bird, P.I., O'Malley, C., Matzaris, M., Badger, A., 1998, Distinct membrane and cystosolic forms of inositol polyphosphate 5-phosphatase II. Efficient localization requires two discrete domains, Journal of Biological Chemistry, vol 273, American Soc. for Biiochem. and Mol. Biol., USA, pp. 8256-8267.

Campbell, J.K., Gurung, R., Romero, S., Speed, C.J., Andrews, R.K., Berndt, M.C., Miitchell, C.A., 1997, Activation of the 43 kDa Inositol Polyphospate 5 - Phosphatase by 14 - 3 - 3z, Biochemistry, vol 36, ACS Publications, Duke University Medical Centre, pp. 15363-15370.