Dr Onisha Patel - Researcher Profile

Biography

Onisha works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: RMIT

Year awarded: 2004

Publications

Journal Articles

Sanderson, J.P., Brennan, P.J., Mansour, S., Matulis, G., Patel, O.G., Lissin, N., Godfrey, D.I., Kawahara, K., Rossjohn, J., Brenner, M.B., Gadola, S.D., 2013, CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells, European Journal Of Immunology [P], vol 43, issue 3, Wiley - V C H Verlag GmbH & Co, KGaA, Germany, pp. 815-825.

Wun, K.S., Ross, F., Patel, O.G., Besra, G.S., Porcelli, S.A., Richardson, S.K., Keshipeddy, S., Howell, A.R., Godfrey, D.I., Rossjohn, J., 2012, Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex, Journal Of Biological Chemistry [P], vol 287, issue 46, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 39139-39148.

Kjer-Nielsen, L., Patel, O.G., Corbett, A.J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N.A., Purcell, A.W., Dudek, N.L., McConville, M.J., O'Hair, R.A., Khairallah, G.N., Godfrey, D.I., Fairlie, D.P., Rossjohn, J., McCluskey, J., 2012, MR1 presents microbial vitamin B metabolites to MAIT cells, Nature [P], vol 491, issue 7426, Nature Publishing Group, UK, pp. 717-723.

Rossjohn, J., Pellicci, D.G., Patel, O.G., Gapin, L., Godfrey, D.I., 2012, Recognition of CD1d-restricted antigens by natural killer T cells, Nature Reviews Immunology [P], vol 12, issue 12, Nature Publishing Group, UK, pp. 845-857.

Patel, O.G., Pellicci, D.G., Gras, S., Sandoval Romero, M.L., Uldrich, A.P., Mallevaey, T., Clarke, A.J., Le Nours, J., Theodossis, A., Cardell, S.L., Gapin, L., Godfrey, D.I., Rossjohn, J., 2012, Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor, Nature Immunology [P], vol 13, issue 9, Nature Publishing Group, USA, pp. 857-863.

Reantragoon, R., Kjer-Nielsen, L., Patel, O.G., Chen, Z., Illing, P.T., Bhati, M., Kostenko, L., Bharadwaj, M., Meehan, B., Hansen, T.H., Godfrey, D.I., Rossjohn, J., McCluskey, J., 2012, Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor, Journal of Experimental Medicine [P], vol 209, issue 4, Rockefeller University Press, USA, pp. 761-774.

Mallevaey, T., Clarke, A.J., Scott-Browne, J.P., Young, M.H., Roisman, L.C., Pellicci, D.G., Patel, O., Vivian, J.P., Matsuda, J.L., McCluskey, J., Godfrey, D.I., Marrack, P., Rossjohn, J., Gapin, L., 2011, A molecular basis for NKT cell recognition of CD1d-self-antigen, Immunity [P], vol 34, issue 3, Cell Press, USA, pp. 315-326.

Wun, K., Cameron, G., Patel, O., Pang, S.S., Pellicci, D.G., Sullivan, L.C., Keshipeddy, S., Young, M.H., Uldrich, A.P., Thakur, M.S., Richardson, S.K., Howell, A.R., Illarionov, P.A., Brooks, A.G., Besra, G.S., McCluskey, J., Gapin, L., Porcelli, S.A., Godfrey, D.I., Rossjohn, J., 2011, A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells, Immunity [P], vol 34, issue 3, Cell Press, USA, pp. 327-339.

Uldrich, A., Patel, O., Cameron, G., Pellicci, D., Day, E., Sullivan, L., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J., Cao, B., Brooks, A., Williams, S., Illarionov, P., Besra, G., Turner, S., Porcelli, S., McCluskey, J., Smyth, M., Rossjohn, J., Godfrey, D., 2011, A semi-invariant V{alpha}10{+} T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties, Nature Immunology [P], vol 12, issue 7, Nature Publishing Group, USA, pp. 616-623.

Patel, O., Cameron, G., Pellicci, D., Liu, Z., Byun, H., Beddoe, T., McCluskey, J., Franck, R., Castano, A., Harrak, Y., Llebaria, A., Bittman, R., Porcelli, S., Godfrey, D., Rossjohn, J., 2011, NKT TCR recognition of CD1d-a-C-galactosylceramide, Journal Of Immunology [P], vol 187, issue 9, The American Association of Immunologists, Inc., USA, pp. 4705-4713.

Pellicci, D., Clarke, A., Patel, O., Mallevaey, T., Beddoe, T., Le Nours, J., Uldrich, A., McCluskey, J., Besra, G., Porcelli, S., Gapin, L., Godfrey, D., Rossjohn, J., 2011, Recognition of beta-linked self glycolipids mediated by natural killer T cell antigen receptors, Nature Immunology [P], vol 12, issue 9, Nature Publishing Group, USA, pp. 827-833.

Patel, O.G., Pellicci, D.G., Uldrich, A.P., Sullivan, L.C., Bhati, M., McKnight, M.A., Richardson, S.K., Howell, A.R., Mallevaey, T., Zhang, J., Bedel, R., Besra, G., Brooks, A.G., Kjer-Nielsen, L., McCluskey, J., Porcelli, S.A., Gapin, L., Rossjohn, J., Godfrey, D.I., 2011, Vbeta2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 47, National Academy of Sciences, USA, pp. 19007-19012.

Godfrey, D.I., Pellicci, D.G., Patel, O., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., 2010, Antigen recognition by CD1d-restricted NKT T cell receptors, Seminars In Immunology [P], vol 22, issue 2, Academic Press, UK, pp. 61-67.

Florence, W.C., Xia, C., Gordy, L.E., Chen, W., Zhang, Y., Scott-Browne, J., Kinjo, Y., Yu, K.O., Keshipeddy, S., Pellicci, D.G., Patel, O., Kjer-Nielsen, L., McCluskey, J., Godfrey, D.I., Rossjohn, J., Richardson, S.K., Porcelli, S.A., Howell, A.R., Hayakawa, K., Gapin, L., Zajonc, D.M., Wang, P.G., Joyce, S., 2009, Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands, Embo Journal [P], vol 28, issue 22, Nature Publishing Group, UK, Germany, pp. 3579-3590.

Pellicci, D.G., Patel, O., Kjer-Nielsen, L., Pang, S.S., Sullivan, L.C., Kyparissoudis, K., Brooks, A.G., Reid, H.H., Gras, S., Lucet, I.S., Koh, R., Smyth, M.J., Mallevaey, T., Matsuda, J.L., Gapin, L., McCluskey, J., Godfrey, D.I., Rossjohn, J., 2009, Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the Vbeta8.2 and Vbeta7 Semi-invariant NKT T Cell Receptors, Immunity [P], vol 31, issue 1, Cell Press, USA, pp. 47-59.

Williams, N.K., Bamert, R.S., Patel, O., Wang, C., Walden, P.M., Wilks, A.F., Fantino, E., Rossjohn, J., Lucet, I.S., 2009, Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains, Journal of Molecular Biology, vol 387, issue 1, Academic Press, USA, pp. 219-232.

Mallevaey, T., Scott-Browne, J.P., Matsuda, J.L., Young, M.H., Pellicci, D.G., Patel, O., Thakur, M., Kjer-Nielsen, L., Richardson, S.K., Cerundolo, V., Howell, A.R., McCluskey, J., Godfrey, D.I., Rossjohn, J., Marrack, P., Gapin, L., 2009, T cell receptor CDR2beta and CDR3beta loops collaborate functionally to shape the iNKT cell repertoire, Immunity [P], vol 31, issue 1, Cell Press, USA, pp. 60-71.

Walter, M., Lucet, I., Patel, O., Broughton, S.E., Bamert, R.S., Williams, N.K., Fantino, E., Wilks, A.F., Rossjohn, J., 2007, The 2.7 Angstrom crystal structure of the autoinhibited human c-Fms kinase domain, Journal of Molecular Biology, vol 367, issue 3, Academic Press Ltd Elsevier Science Ltd, London England UK, pp. 839-847.

Lucet, I.S., Fantino, E., Styles, M., Bamert, R.S., Patel, O.G., Broughton, S.E., Walter, M., Burns, C.J., Treutlein, H., Wilks, A.F., Rossjohn, J., 2006, The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor, Blood, vol 107, issue 20 September 2005, American Society of Hematology, Washington DC USA, pp. 176-183.

Patel, O., Karnik, K., Macreadie, I.G., 2004, Over-production of dihydrofolate reductase leads to sulfa-dihydropteroate resistance in yeast, FEMS Microbiology Letters, vol 236, issue 2, Blackwell Publishing, Oxford England, pp. 301-305.

Patel, O.G., Mberu, E.K., Nzila, A.M., Macreadie, I.G., 2004, Sulfa drugs strike more than once, Trends in Parasitology, vol 20, issue 1, Elsevier Science Ltd, Oxford England, pp. 1-3.

Patel, O., Satchell, J., Baell, J.B., Fernley, R., Coloe, P., Macreadie, I., 2003, Inhibition studies of sulfonamide-containing folate analogs in yeast, Microbial Drug Resistance, vol 9, issue 2, Mary Ann Liebert Inc., New Rochelle USA, pp. 139-145.

Patel, O., Fernley, R., Macreadie, I., 2003, Saccharomyces cerevisiae expression vectors with thrombin-cleavable N- and C-terminal 6x(His) tags, Biotechnology Letters, vol 25, issue 4, Springer, Dordrecht The Netherlands, pp. 331-334.

Patel, O., Castelli, L.A., Fernley, R., Coloe, P., Macreadie, I., 2002, Production of a functional dihydrofolate synthase with a cleavable poly-His tag in Saccharomyces cerevisiae, Biotechnology Letters, vol 24, issue 8, Springer New York LLC, US, pp. 657-662.

Bayly, A.M., Berglez, J.M., Patel, O., Castelli, L.A., Hankins, E.G., Coloe, P., Sibley, C.H., Macreadie, I., 2001, Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae, FEMS Microbiology Letters, vol 204, issue 2, Blackwell Publishing, Oxford, England, pp. 387-390.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Natural killer T cell recognition of lipid-based antigens.

Supervisors:

Rossjohn, J (Main), Patel, O (Associate).