Dr Barbara Kemp - Researcher Profile

Biography

Dr Barbara Kemp-Harper is a vascular pharmacologist whose research focuses on improving blood vessel function in hypertension, high cholesterol and diabetes. She is a Senior Lecturer in the Department of Pharmacology, Monash University and a group leader within the Vascular Biology and Immunopharmacology Group. Barbara leads the Vascular Signalling Group and currently holds a NHMRC Project Grant.

Barbara has a long standing interest in the mechanisms underlying blood vessel dysfunction in cardiovascular disease. She is particularly interested in nitric oxide, a biologically active gas, which is produced in blood vessels to help maintain adequate blood flow and blood pressure. In disease states, nitric oxide signalling is compromised and Barbara's work seeks to identify new therapeutic strategies to overcome nitric oxide dysfunction. She has become internationally recognised for her work on nitroxyl, a novel sibling of nitric oxide, which has many advantages over nitric oxide. Barbara's work has identified a potential for nitroxyl-like drugs to be used in the treatment of angina, high blood pressure and high cholesterol.

Qualifications

PHD

Institution: Monash University

Year awarded: 1995

BSC (HONS)

Institution: Monash University

Year awarded: 1991

Publications

Book Chapters

Kemp, B.K., Schmidt, H., 2009, cGMP in the vasculature, in cGMP: Generators, Effectors and Therapeutic Implications, eds HHHW Schmidt,F Hofmann,J-P Stasch, Springer, Heidelberg Berlin, pp. 447-467.

Journal Articles

Lin, E., Irvine, J.C., Cao, A.H., Alexander, A.E., Love, J.E., Patel, R., McMullen, J.R., Kaye, D.M., Kemp-Harper, B.K., Ritchie, R.H., 2012, Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation, PLoS ONE [P], vol 7, issue 4 (Art. No.: e34892), Public Library of Science, USA, pp. 1-11.

Irvine, J.C., Ganthavee, V., Love, J.E., Alexander, A.E., Horowitz, J.D., Stasch, J., Kemp-Harper, B.K., Ritchie, R.H., 2012, The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy, PLoS ONE [P], vol 7, issue 11 (Art. No.: e44481), Public Library of Science, USA, pp. 1-11.

Irvine, J.C., Kemp-Harper, B.K., Widdop, R.E., 2011, Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: Comparison with GTN and DEA/NO, Antioxidants and Redox Signaling [P], vol 14, issue 9, Mary Ann Liebert, Inc. Publishers, USA, pp. 1615-1624.

Chrissobolis, S., Miller, A.A., Drummond, G.R., Kemp-Harper, B.K., Sobey, C.G., 2011, Oxidative stress and endothelial dysfunction in cerebrovascular disease, Frontiers in Bioscience [P], vol 16, Frontiers in Bioscience, USA, pp. 1733-1745.

Bullen, M., Miller, A., Dharmarajah, J., Drummond, G., Sobey, C., Kemp, B., 2011, Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia, American Journal Of Physiology-Heart And Circulatory Physiology [P], vol 301, issue 4, American Physiological Society, USA, pp. H1405-H1414.

Yuill, K.H., Yarova, P., Kemp-Harper, B.K., Garland, C.J., Dora, K., 2010, A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries, Antioxidants and Redox Signaling [P], vol 14, Mary Ann Liebert, Inc. Publishers, USA, pp. 1625-1635.

Bullen, M.L., Miller, A.A., Andrews, K., Irvine, J.C., Ritchie, R.H., Sobey, C.G., Kemp-Harper, B.K., 2010, Nitroxyl (HNO) as a vasoprotective signaling molecule, Antioxidants and Redox Signaling [P], vol 14, Mary Ann Liebert, Inc. Publishers, USA, pp. 1675-1686.

Andrews, K.L., Irvine, J.C., Tare, M., Apostolopoulos, J., Favaloro, J.L., Triggle, C.R., Kemp-Harper, B.K., 2009, A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries, British Journal of Pharmacology, vol 157, issue 4, John Wiley & Sons Ltd, UK, pp. 540-550.

Ritchie, R.H., Irvine, J.C., Rosenkranz, A.C., Patel, R., Wendt, I.R., Horowitz, J.D., Kemp, B.K., 2009, Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO. and beyond, Pharmacology and Therapeutics [P], vol 124, issue 3, Elsevier Inc., USA, pp. 279-300.

Favaloro, J.L., Kemp-Harper, B.K., 2009, Redox variants of NO (NO. and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms, American Journal of Physiology: Heart and Circulatory Physiology, vol 296, issue 5, American Physiological Society, USA, pp. H1274-H1280.

Kemp-Harper, B.K., Feil, R., 2008, Meeting report: cGMP matters, Science Signaling, vol 1, issue 9, American Association for the Advancement of Science, United States, pp. 1-6.

Irvine, J.C., Ritchie, R.H., Favaloro, J.L., Andrews, K.L., Widdop, R.E., Kemp-Harper, B.K., 2008, Nitroxyl (HNO): the Cinderella of the nitric oxide story, Trends in Pharmacological Sciences, vol 29, issue 12, Elsevier Ltd, UK, pp. 601-608.

Kirsch, M., Kemp-Harper, B.K., Weissmann, N., Grimminger, F., Schmidt, H., 2008, Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling, FASEB Journal, vol 22, Federation of American Societies for Experimental Biology, Bethesda MD USA, pp. 30-40.

Villar, I.C., Panayiotou, C.M., Sheraz, A., Madhani, M., Scotland, R.S., Nobles, M., Kemp, B.K., Ahluwalia, A., Hobbs, A.J., 2007, Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor, Cardiovascular Research, vol 74, issue 3, Elsevier Science BV, Amsterdam Netherlands, pp. 515-525.

Fitzgerald, S.M., Kemp, B.K., Parkington, H.C., Head, G.A., Evans, R.G., 2007, Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol 293, issue 2, American Physiological Society, Bethesda MD USA, pp. R707-R713.

Selemidis, S., Dusting, G.J., Peshavariya, H.M., Kemp, B.K., Drummond, G.R., 2007, Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells, Cardiovascular Research, vol 75, issue 2, Elsevier Science BV, Amsterdam Netherlands, pp. 349-358.

Irvine, J.C., Favaloro, J.L., Widdop, R.E., Kemp, B.K., 2007, Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortae, Hypertension, vol 49, issue 4, Lipponcott Williams & Wilkins, Philadelphia PA USA, pp. 885-892.

Favaloro, J.L., Kemp-Harper, B.K., 2007, The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature, Cardiovascular Research, vol 73, issue 3, Elsevier, Amsterdam The Netherlands, pp. 587-596.

Stasch, J., Schmidt, P.M., Nedvetsky, P.I., Nedvetskaya, T.Y., Kumar H.S., A., Meurer, S., Deile, M., Taye, A., Knorr, A., Lapp, H., Muller, H., Turgay, Y., Rothkegel, C., Tersteegen, A., Kemp-Harper, B.K., Muller-Esterl, W., Schmidt, H.H., 2006, Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels, Journal of Clinical Investigation, vol 116, issue 9, American Society for Clinical Investigation Inc, Ann Arbor MI USA, pp. 2552-2561.

Feil, R., Kemp-Harper, B.K., 2006, cGMP signalling: from bench to bedside, EMBO Reports, vol 7, issue 2, Nature Publishing Group, London England, pp. 149-153.

Fitzgerald, S.M., Kemp-Harper, B.K., Tare, M., Parkington, H.C., 2005, Role of endothelium-derived hyperpolarizing factor in endothelial dysfunction during diabetes, Clinical and Experimental Pharmacology and Physiology, vol 32, issue 5-6, Blackwell Publishing Asia, Carlton Vic Australia, pp. 482-487.

Irvine, J.C., Favaloro, J.L., Kemp-Harper, B.K., 2003, NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries, Hypertension, vol 41, issue 6, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1301-1307.

Mathur, A., Hong, Y., Kemp, B.K., Barrientos, A.A., Erusalimsky, J.D., 2000, Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes, Cardiovascular Research, vol 46, Elsevier, Amsterdam Netherlands, pp. 126-138.

Bell, K.L., Kemp, B.K., McPherson, G.A., Hodgson, W.C., 1999, The smooth muscle relaxant effects of venom from the inland taipan (Oxyuranus microlepidotus), Toxicon, vol 37, Pergamon-Elsevier, Oxford England, pp. 229-231.

Kemp, B.K., Smolich, J.J., Cocks, T.M., 1997, Evidence for specific regional patterns of responses to different vasoconstrictors and vasodilators in sheep isolated pulmonary arteries and veins, British Journal of Pharmacology, vol 121, Stockton Press, Hampshire UK, pp. 441-450.

Conference Proceedings

Smolich, J.J., Kemp, B.K., Chen, H., 1998, Adenosine infusion causes transient pulmonary vasoconstriction but sustained systemic vasodilation in conscious sheep, Australian & New Zealand Journal of Medicne, HOBART, TAS. 10-13 AUG 1997, ADIS INTERNATIONAL PTY LTD, FRENCHS FOREST NSW, p. 125.

Davis, E.A., Kemp, B.K., Jarrott, B., 1998, Characterisation of the action of C-type natriuretic peptide on rat isolated intralobar renal arteries and aortae, Xth International Vascular Biology Meeting, Cairns, QLD, August 1998, Vascular Biology Meeting, Cairns Qld Australia, p. 53 P80.

McPherson, G.A., Kemp, B.K., 1998, Inter species difference in thromboxane A2 receptors are deliniated by glibenclamide, Pharmacology and Toxicology, Munchen, Germany, Aug.1998, Munksgaard, Copenhagen, p. 105 A56.

Kemp, B.K., Davis, E.A., Jarrott, B., 1998, Mechanisms of action of C-type natriueretic peptide in rat intralobar renal arteries, Naunyn-Schmiedeberg's Archives of Pharmacology, Munchen, Germany, July 1998, Springer, Berlin, p. R243.

Bell, K.L., Kemp, B.K., McPherson, G.A., Hodgson, W.C., 1998, Studies examining the smooth muscle relaxant effects of venom from the inland taipan (Oxyuranus Microlepidotus) in rat isolated atria, Toxicon, Cuernevaca, Mexico, Pergamon, Exeter UK, pp. 1308-1309.

Davis, E.A., Kemp, B.K., Jarrott, B., 1997, Functional charcertisation of the action of C-type natriuretic peptide on rat isolated intralobar renal arteries, Proceedings of the Australasian Society of Clinical and Experimental Pharmacology and Toxicology, 30 November - 3 December, 1997, ASCEPT, Sydney NSW Australia, p. 49.

Kemp, B.K., Davis, E.A., Jarrott, B., 1997, Mechanisms of action of C-type natriuretic peptide in intralobar renal arteries, High Blood Pressure Research Council of Australia, December 11-13, 1997, High Blood Pressure Research Council of Australia, Melbourne Vic Australia, p. 77.

Kemp, B.K., McPherson, G.A., 1997, Nitric oxide and ATP-sensitive K+ channels modulate the contractility of guinea-pig isolated coronary arteries, Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 30 November - 3 December, 1997, ASCEPT, Sydney NSW Australia, p. 23.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Nitroxyl (HNO) as a vasoprotective signalling molecule in cardiovascular disease..

Supervisors:

Kemp, B (Joint-co), Miller, A (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

THE INFLAMMASOME AS A MEDIATOR OF VASCULAR INFLAMMATION IN HYPERTENSION.

Supervisors:

Drummond, G (Main), Kemp, B (Associate).

Program of Study:

(POSTGRADUATE QUALIFYING OR PRELIMINARY).

Thesis Title:

signal transduction pathways associated with prevention of fibrosis.

Supervisors:

Kemp, B (Joint), Samuel, C (Joint-co).

Completed Supervision

Student:

Al-Magableh, M.

Program of Study:

The role of hydrogen sulfide in the cardiovascular system. (PHD) 2011.

Supervisors:

Favaloro, J (Main), Kemp, B (Associate).

Student:

Irvine, J.

Program of Study:

The regulation of cardiovascular function by nitroxyl (HNO). (PHD) 2007.

Supervisors:

Widdop, R (Main), Kemp, B (Associate).

Student:

Ravi, R.

Program of Study:

Targeting the NO/sGC/cGMP signaling pathway in health and disease. (PHD) 2011.

Supervisors:

Kemp, B (Joint-Co), Sobey, C (Joint).