Miss Lisa Kaminskas - Researcher Profile

Biography

Position

NHMRC Australian Biomedical Training Fellow

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Qualifications

PHD

Institution: adelaide university

Year awarded: 2004

Publications

Book Chapters

Kaminskas, L., Boyd, B., 2011, Nanosized drug delivery vectors and the reticuloendothelial system, in Intracellular Delivery: Fundamentals and Applications, eds Ales Prokop, Springer Science+Business Media, USA, pp. 155-178.

Journal Articles

Kaminskas, L., McLeod, V., Kelly, B., Sberna, G., Boyd, B., Williamson, M., Owen, D., Porter, C., 2012, A comparison of changes to doxorubicin pharmacokinetics, antitumour activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems, Nanomedicine-Nanotechnology Biology And Medicine [P], vol 8, issue 1, Elsevier, Netherlands, pp. 103-111.

Kaminskas, L.M., McLeod, V.M., Porter, C.J., Boyd, B.J., 2012, Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation, Molecular Pharmaceutics [P], vol 9, issue 3, American Chemical Society, USA, pp. 355-373.

Burcham, P.C., Raso, A., Kaminskas, L.M., 2012, Chaperone heat shock protein 90 mobilization and hydralazine cytoprotection against acrolein-induced carbonyl stress, Molecular Pharmacology [P], vol 82, issue 5, The American Society for Pharmacology and Experimental Therapeutics, Bethesda, Maryland USA, pp. 876-886.

Kaminskas, L.M., McLeod, V.M., Kelly, B.D., Cullinane, C.M., Sberna, G., Williamson, M., Boyd, B.J., Owen, D.J., Porter, C.J., 2012, Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumour models, Molecular Pharmaceutics [P], vol 9, American Chemical Society, United States, pp. 422-432.

Kaminskas, L., McLeod, V., Sberna, G., Boyd, B., Owen, D., Porter, C., 2011, Capping methotrexate alpha-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers, Molecular Pharmaceutics [E], vol 8, American Chemical Society, USA, pp. 338-349.

Kaminskas, L., Kelly, B., McLeod, V., Sberna, G., Owen, D., Boyd, B., Porter, C., 2011, Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker, Journal of Controlled Release [P], vol 152, Elsevier Science Publishers, The Netherlands, pp. 241-248.

Kaminskas, L., Boyd, B., Porter, C., 2011, Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties, Nanomedicine [P], vol 6, issue 6, Future Medicine, UK, pp. 1063-1084.

Kaminskas, L., McLeod, V., Porter, C., Boyd, B., 2011, Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance, Journal of Pharmaceutical Sciences [P], vol 11, John Wiley & Sons Inc, USA, pp. 5069-5077.

Sou, T., Orlando, L., McIntosh, M., Kaminskas, L., Morton, D., 2011, Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach, International Journal of Pharmaceutics [P], vol 421, issue 2, Elsevier/North-Holland Biomedical Press., Netherlands, pp. 220-229.

Sou, T., Meeusen, E., De Veer, M., Morton, D., Kaminskas, L., McIntosh, M., 2011, New developments in dry powder pulmonary vaccine delivery, Trends in Biotechnology [P], vol 29, issue 4, Elsevier Ltd., Trends Journals, United Kingdom, pp. 191-198.

Kaminskas, L., Porter, C., 2011, Targeting the lymphatics using denritic polymers (dendrimers), Advanced Drug Delivery Reviews [P], vol 63, Elsevier Science, Netherlands, pp. 890-900.

Kaminskas, L.M., Kota, J., McLeod, V.M., Kelly, B.D., Karellas, P., Porter, C.J., 2009, PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats, Journal of Controlled Release [P], vol 140, issue 2, Elsevier B.V., The Netherlands, pp. 108-116.

Kaminskas, L.M., Wu, Z., Barlow, N., Krippner, G.Y., Porter, C.J.H., 2009, Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers, Journal of Pharmaceutical Sciences [P], vol 98, issue 10, John Wiley & Sons, Inc, USA, pp. 3871-3875.

Kaminskas, L.M., Kelly, B.D., McLeod, V.M., Boyd, B.J., Krippner, G.Y., Williams, E., Porter, C.J., 2009, Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers, Molecular Pharmaceutics [P], vol 6, issue 4, American Chemical Society, USA, pp. 1190-1204.

Kaminskas, L.M., Boyd, B.J., Karellas, P., Krippner, G.Y., Lessene, R., Kelly, B., Porter, C.J., 2008, The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimers, Molecular Pharmaceutics, vol 5, issue 3, Amercian Chemical Society, USA, pp. 449-463.

Kaminskas, L.M., Boyd, B.J., Karellas, P., Henderson, S., Giannis, M., Krippner, G.Y., Porter, C.J., 2007, Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition, Molecular Pharmaceutics, vol 4, issue 6, American Chemical Society, US, pp. 949-961.

Boyd, B.J., Kaminskas, L.M., Karellas, P., Krippner, G.Y., Lessene, R., Porter, C.J.H., 2006, Cationic poly-L-lysine dendrimers: Pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats, Molecular Pharmaceutics, vol 3, issue 5, American Chemical Society, USA, pp. 614-627.

Conference Proceedings

Sou, T., Nassta, G., Kaminskas, L., McIntosh, M., Prankerd, R., Orlando, L., Morton, D., 2011, Particle engineering of a mannitol-based powder formulation for delivery of biomolecules to the lung, Drug Delivery to the Lungs 22, 07-09/12/2011, The Aerosol Society, England, pp. 52-55.

Other

Krippner, G.Y., Lichti, G., Razzino, P., Kelly, B.D., Pallich, S., Henderson, S.A., Scheppokat, A.M., Williams, C.C., Porter, C.J., Boyd, B.J., Kaminskas, L.M., Rendle, P.M., Greatrex, B.W., 2007, Macromolecular compounds having controlled stoichiometry, Australia, Europe.

Boyd, B.J., Kaminskas, L.M., Porter, C.J., Karellas, P., Krippner, G.Y., Kelly, B.D., Wu, Z., Razzino, P., Pallich, S., 2007, Modified Macromolecule, Australia, Europe.

Activities

Affiliations with institutes

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Improving chemotherapeutic efficancy against lymphatic metastases via the selective lymphatic delivery of chemotherapeutic nanomedicines.

Supervisors:

Porter, C (Main), Kaminskas, L (Associate), Mcintosh, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Subcutaneous pharmacokinetics of therapeutic antibodies: uptake pathways and approaches to improving absorption.

Supervisors:

Kaminskas, L (Joint), Mcintosh, M (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The development of influenza dry powder antigen formulation for pulmonary vaccine delivery..

Supervisors:

Mcintosh, M (Main), Morton, D (Associate), Kaminskas, L (Associate).