Dr Yu-Ping Yuan - Researcher Profile

Biography

Yu-Ping works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

BACHELOR OF MEDICINE

Institution: China

Year awarded: 2006

PHD MEDICINE

Institution: AMREP

Year awarded: 2006

Publications

Journal Articles

Nesbitt, W.S., Harper, I.S., Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2012, A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow, Methods in molecular biology (Clifton, N.J.) [P], vol 788, Humana Press, USA, pp. 73-89.

Straub, A., Krajewski, S., Hohmann, J., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y., Nandurkar, H., Jackson, S., Hickey, M., Peter, K., 2011, Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 31, issue 7, Lippincott Williams & Wilkins, USA, pp. 1607-1616.

Schoenwaelder, S.M., Yuan, Y., Josefsson, E.C., White, M.J., Yao, Y., Mason, K.D., O'Reilly, L.A., Henley, K.J., Ono, A., Hsiao, S.T., Willcox, A.E.H., Roberts, A.W., Huang, D.C.S., Salem, H.H., Kile, B., Jackson, S., 2009, Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function, Blood [P], vol 114, issue 3, American Society of Hematology, USA, pp. 663-666.

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y., Schwarz, M., Hagemeyer, C.E., Eisenhardt, S.U., Ahrens, I., Bode, C., Jackson, S., Peter, K., 2007, A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 27, issue 3, Lippincott Williams & Wilkins, Philadelphia USA, pp. 9-15.

Jackson, S., Cranmer, S.L., Mangin, P., Yuan, Y., 2007, Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb, Blood, vol 109, issue 2, American Society of Hematology, USA, pp. 846-847.

Jackson, S., Mangin, P., Yuan, Y., 2006, "Pulling strings": Shear, platelets, and microparticles, Blood [E], vol 107, issue 9, American Society of Hematology, United States, pp. 3418-3419.

Mangin, P., Yap, C.L.S., Nonne, C., Sturgeon, S.A., Goncalves, I., Yuan, Y., Schoenwaelder, S.M., Wright, C.E., Lanza, F., Jackson, S., 2006, Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency, Blood, vol 107, issue 11, American Society of Hematology, Washington USA, pp. 4346-4353.

Goncalves, I., Nesbitt, W.S., Yuan, Y., Jackson, S.P., 2005, Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets, The Journal of Biological Chemistry, vol 280, issue 15, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 15430-15437.

Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V.B., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H., 2005, PI 3-kinase p110beta: A new target for antithrombotic therapy, Nature Medicine, vol 11, issue 5, Nature Publishing Group, New York USA, pp. 507-514.

Maxwell, M.J., Yuan, Y., Anderson, K.E., Hibbs, M.L., Salem, H.H., Jackson, S.P., 2004, SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets, The Journal of Biological Chemistry, vol 279, issue 31, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 32196-32204.

Goncalves, I., Hughan, S.C., Schoenwaelder, S.M., Yap, C.L.S., Yuan, Y., Jackson, S.P., 2003, Integrin IIb3-dependent calcium signals regulate platelet-fribrinogen interactions under flow, The Journal of Biological Chemistry, vol 278, issue 37, The American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 34812-34822.

Mangin, P., Yuan, Y., Goncalves, I., Eckly, A., Freund, M., Cazenave, J., Gachet, C., Jackson, S.P., Lanza, F., 2003, Signaling role for phospholipase Cg 2 in platelet glycoprotein Iba calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcRg chain and FcgRIIA, The Journal of Biological Chemistry, vol 278, issue 35, The American Society of Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 32880-32891.

Lourbakos, A., Yuan, Y., Jenkins, A.L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J., Pike, R.N., 2001, Activation of protease-activated receptors by gingipains from porphyromonas gingivalis leads to platelet aggregation: a new trait in micobial pathogenicity, Blood, vol 97, issue 12, American Society of Hematology, Washington DC USA, pp. 3790-3797.

Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2000, Calpain regulation of integrin alphaIIbbeta3 signaling in human platelets, Platelets, vol 11, Taylor & Francis Ltd, London UK, pp. 189-198.

Mistry, N., Cranmer, S.L., Yuan, Y., Mangin, P., Dopeide, S.M., Harper, I., Giuliano, S., Dunstan, D.E., Lanza, F., Salem, H.H.H., Jackson, S.P., 2000, Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction, Blood, vol 96 issue 10, The American Society of Hematology, Washington DC USA, pp. 3480-3489.

Jackson, S., Mistry, N., Yuan, Y., 2000, Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton., Trends in Cardiovascular Medicine [P], vol 10, ELSEVIER SCIENCE LONDON, England, pp. 192-197.

Yap, C.L., Hughan, S.C., Cranmer, S.L., Nesbitt, W.S., Rooney, M.M., Giuliano, S., Kulkarni, S., Dopeide, S.M., Yuan, Y., Salem, H.H.H., Jackson, S.P., 2000, Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3, The Journal of Biological Chemistry, vol 275 issue 52, Amer Soc for Biochemistry and Molecular Biology, Bethesda UK, pp. 41377-41388.

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S.L., Yap, C.L., Nesbitt, W.S., Harper, I., Mistry, N., Dopheide, S.M., Hughan, S.C., Williamson, D., De La Salle, C., Salem, H.H., Lanza, F., Jackson, S.P., 1999, The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells, Journal of Biological Chemistry, vol 274 issue 51, American Society for Molecular Biology Inc., Rockville Pike Bethesda MD USA, pp. 36241-36251.

Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., Jackson, S.P., 1997, Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytosskeletal Attachment of Integrin aPb b3(Platelet Glyoprotein IIb/IIIa and the Cellular Retraction of Fibrin Clots, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 1694-1702.

Yuan, Y., Dopeide, S.M., Ivanidis, C., Salem, H.H., Jackson, S.P., 1997, Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 21847-21854.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

PI3 Kinase Inhibitors as adjunct thrombolytic therapies.

Supervisors:

Jackson, S (Main), Schoenwaelder, S (Associate), Yuan, Y (Associate).

Completed Supervision

Student:

Goncalves, I.

Program of Study:

INVESTIGATION OF THE MECHANISM BY WHICH SHEAR FORCES STIMULATE PLATELET ACTIVATION. (PHD) 2005.

Supervisors:

Jackson, S (Joint-Co), Yuan, Y (Joint).