Prof William Sievert - Researcher Profile

Biography

William works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

FELLOW

Institution: Royal Australasian College of Physicians

Year awarded: 1990

GASTROENTEROLOGY

Institution: American Board of Internal Medicine

Year awarded: 1986

INTERNAL MEDICINE

Institution: American Board of Internal Medicine

Year awarded: 1983

MEDICINE

Institution: Texas Tech University School of Medicine

Year awarded: 1980

Publications

Book Chapters

Sievert, W., 2009, Antiviral therapy for chronic hepatitis C, in Hepatitis C: An Expanding Perspective, eds Gregory Dore, MeredithTemple-Smith and Andrew Lloyd, IP communications, Australia, pp. 192-210.

Journal Articles

Gellad, Z.F., Muir, A.J., McHutchison, J.G., Sievert, W., Sharara, A.I., Brown, K.A., Flisiak, R., Jacobson, I.M., Kershenobich, D., Manns, M.P., Schulman, K., Reed, S.D., 2012, Cost-effectiveness of truncated therapy for hepatitis C based on rapid virologic response, Value In Health [P], vol 15, issue 6, Elsevier Inc., United States, pp. 876-886.

Crawford, D., Dore, G., Sievert, W., Cheng, W., Weltman, M.D., McCaughan, G., Rawlinson, W., Marks, P., Yoshihara, M., Rizkalla, B., Roberts, S.K., 2012, Early on-treatment viral load and baseline METAVIR score: improved prediction of sustained virological response in HCV genotype 1 patients, Antiviral Therapy [P], vol 17, issue 5, International Medical Press, United Kingdom, pp. 849-854.

Ratnam, D., Dev, A.T., Nguyen, T., Sundararajan, V., Harley, H., Cheng, W., Lee, A., Rusli, F., Chen, R., Bell, S., Pianko, S., Sievert, W., 2012, Efficacy and tolerability of pegylated interferon-alpha-2a in chronic hepatitis B: a multicenter clinical experience, Journal Of Gastroenterology And Hepatology [P], vol 27, issue 9, Wiley-Blackwell Publishing Asia, Australia, pp. 1447-1453.

Lok, A.S., Trinh, H., Carosi, G., Akarca, U.S., Gadano, A., Habersetzer, F., Sievert, W., Wong, D., Lovegren, M., Cohen, D., Llamoso, C., 2012, Efficacy of entecavir with or without tenofovir disoproxil fumarate for nucleos(t)ide-naive patients with chronic hepatitis B, Gastroenterology [P], vol 143, issue 3 (Art. ID: e1), W.B. Saunders Co., United States, pp. 619-628.

Manuelpillai, U.C., Lourensz, D., Vaghjiani, V., Tchongue, J., Lacey, D., Tee, J.Y., Murthi, P., Chan, M.K.J., Hodge, A., Sievert, W., 2012, Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis, PLoS ONE [P], vol 7, issue 6 (Art. No: e38631), Public Library of Science, United States, pp. 1-11.

Manns, M.P., Akarca, U.S., Chang, T., Sievert, W., Yoon, S., Tsai, N., Min, A., Pangerl, A., Beebe, S., Yu, M., Wongcharatrawee, S., 2012, Long-term safety and tolerability of entecavir in patients with chronic hepatitis B in the rollover study ETV-901, Expert Opinion on Drug Safety [P], vol 11, issue 3, Informa Healthcare, United Kingdom, pp. 361-368.

Ratnam, D., Sievert, W., Visvanathan, K., 2012, Natural killer cells display impaired responses to toll like receptor 9 that support viral persistence in chronic hepatitis B, Cellular Immunology [P], vol 279, issue 1, Academic Press, United States, pp. 109-115.

Knight, V., Tchongue, J., Dowling, D., Tipping, P., Sievert, W., 2012, Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells, Hepatology [P], vol 55, issue 3, John Wiley & Sons, Inc., United States, pp. 879-887.

Tye, Y.M.H., Kennedy, C.L., Najdovska, M., McLeod, L., McCormack, W., Hughes, N.R., Dev, A.T., Sievert, W., Ooi, C., Ishikawa, T., Oshima, H., Bhathal, P.S., Parker, A.E., Oshima, M., Tan, P., Jenkins, B.J., 2012, STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation, Cancer Cell [P], vol 22, issue 4, Cell Press, United States, pp. 466-478.

Sievert, W., Altraif, I., Razavi, H., Abdo, A., Ahmed, E., AlOmair, A., Amarapurkar, D., Chen, C., Dou, X., Khayat, H., elShazly, M., Esmat, G., Guan, R., Han, K., Koike, K., Largen, A., McCaughan, G., Mogawer, S., Monis, A., Nawaz, A., Piratvisuth, T., Sanai, F., Sharara, A., Sibbel, S., Sood, A., Suh, D., Wallace, C., Young, K., Negro, F., 2011, A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt, Liver International [P], vol 31, issue Supp 2, Wiley-Blackwell Publishing, Inc., United States, pp. 61-80.

Leung, C., Tsoi, E., Burns, G., Sievert, W., 2011, An argument for the universal prophylaxis of hepatitis B infection in patients receiving rituximab: A 7-year institutional experience of hepatitis screening, Oncologist [P], vol 16, issue 5, AlphaMed Press, Inc., USA, pp. 579-584.

Baleriola, C., Rawlinson, W., Dore, G., Chaverot, S., Stelzer-Braid, S., Yoshihara, M., Crawford, D., Sievert, W., McCaughan, G., Weltman, M., Cheng, W., Rizkalla, B., Dubois, D., Thommes, J., Roberts, S., 2011, Effect of low-level HCV viraemia at week 24 on HCV treatment response in genotype 1 patients, Antiviral Therapy [P], vol 16, issue 2, International Medical Press, United Kingdom, pp. 173-180.

Holmes, J., Sievert, W., Thompson, A., 2011, IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection, Biomarkers In Medicine [P], vol 5, issue 4, Future Medicine Ltd., United Kingdom, pp. 461-478.

Patterson, S., George, J., Strasser, S., Lee, A., Sievert, W., Nicoll, A., Desmond, P., Roberts, S., Locarnini, S., Bowden, S., Angus, P., 2011, Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B, Gut [P], vol 60, issue 2, B M J Group, United Kingdom, pp. 247-254.

Kennedy, C., Najdovska, M., Jones, G., McLeod, L., Hughes, N., Allison, C., Ooi, C., Tan, P., Ferrero, R., Jones, S., Dev, A., Sievert, W., Bhathal, P., Jenkins, B., 2011, The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17, Journal Of Pathology [P], vol 225, issue 2, John Wiley & Sons Ltd, United Kingdom, pp. 255-264.

Sievert, W., Dore, G., McCaughan, G., Yoshihara, M., Crawford, D., Cheng, W., Weltman, M., Rawlinson, W., Rizkalla, B., DePamphilis, J., Roberts, S., 2011, Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in hepatitis C virus genotype 1, Hepatology [P], vol 53, issue 4, John Wiley & Sons, Inc., United States, pp. 1109-1117.

Swan, M., Moore, G., Sievert, W., Devonshire, D., 2010, Efficacy and safety of single-session argon plasma coagulation in the management of chronic radiation proctitis, Gastrointestinal Endoscopy [P], vol 72, issue 1, Mosby Inc, United States of America, pp. 150-154.

Wu, I., Lai, C., Han, S., Han, K., Gordon, S., Chao, Y., Tan, C., Sievert, W., Tanwandee, T., Xu, D., Neo, B., Chang, T., 2010, Efficacy of entecavir in chronic hepatitis B patients with mildly elevated alanine aminotransferase and biopsy-proven histological damage, Hepatology [P], vol 51, issue 4, John Wiley & Sons, Inc, United States, pp. 1185-1189.

Cheng, W., Roberts, S., McCaughan, G., Sievert, W., Weltman, M., Crawford, D., Rawlinson, W., Marks, P., Thommes, J., Rizkalla, Yoshihara, M., Dore, G., 2010, Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing, Journal Of Hepatology [P], vol 53, issue 4, Elsevier BV, Netherlands, Denmark, pp. 616-623.

Manuelpillai, U., Tchongue, J., Dowling, D., Vaghjiani, V., Samuel, C., Liu, A., Williams, E., Sievert, W., 2010, Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl 4-treated mice, Cell Transplantation [P], vol 19, issue 9, Cognizant Communication Corp., United States, pp. 1157-1168.

Lubel, J.S., Herath, C.B., Tchongue, J., Grace, J., Jia, Z., Spencer, K., Casley, D., Crowley, P., Sievert, W., Burrell, L., Angus, P., 2009, Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat, Clinical Science [P], vol 117, issue 11, Portland Press Ltd., United Kingdom, pp. 375-386.

Lubel, J.S., Herath, C.B., Tchongue, J., Grace, J., Jia, Z., Crowley, P., Casley, D., Sievert, W., Burrell, L., Angus, P., 2009, Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat, Clinical Science [P], vol 117, issue 11, Portland Press Ltd., United Kingdom, pp. 375-386.

Roberts, S.K., Weltman, M., Crawford, D., McCaughan, G., Sievert, W., Cheng, W., Rawlinson, W., Desmond, P., Marks, P., Yoshihara, M., Rizkalla B., DePamphilis, J., Dore, G., 2009, Impact of high-dose peginterferon alfa-2a on virological response rates in patients with hepatitis C genotype 1: A randomized controlled trial, Hepatology [P], vol 50, issue 4, John Wiley & Sons, Inc., USA, pp. 1045-1055.

Knight, V.H., Sievert, W., 2009, When less may not be best - the challenge of individualising antiviral therapy for chronic hepatitis C infection, Journal Of Gastroenterology And Hepatology [P], vol 24, issue 3, Wiley-Blackwell Publishing Asia, Australia, pp. 330-332.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A study of the relationship between vitamin D status and the severity and outcomes of chronic non-cholestatic liver disease..

Supervisors:

Roberts, S (Main), Sievert, W (Associate), Visvanathan, K (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms of fibrosis resolution in human amniotic epithelial cell therapy for liver fibrosis .

Supervisors:

Manuelpillai, U (Joint), Sievert, W (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

STAT3 and the AIM2 Inflammasome in Gastric Cancer.

Supervisors:

Jenkins, B (Main), Sievert, W (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of hepatic natural killer (NK) cells during hepatitis B virus (HBV) flares and hepatitis B.

Supervisors:

Sievert, W (Joint-co), Visvanathan, K (Joint).

Completed Supervision

Student:

Dev, A.

Program of Study:

FACTORS EFFECTING THE EPIDEMIOLOGY AND TREATMENT OF HEPATITIS C IN SOUTHEAST ASIANS. (PHD) 2003.

Supervisors:

Sievert, W (Main), Holdsworth, S (Associate).

Student:

Patella, S.

Program of Study:

ACTIVIN A AND FOLLISTATIN IN LIVER FIBROSIS AND CIRRHOSIS. (PHD) 2002.

Supervisors:

Sievert, W (Main), Phillips, D (Associate).

Student:

Pianko, S.

Program of Study:

HEPATITIS C INDUCED LIVER INJURY AND FACTORS INFLUENCING RESPONSE TO INTERFERON BASED THERAPY. (PHD) 2002.

Supervisors:

Holdsworth, S (Main), Sievert, W (Associate).