Prof Phillip Bird - Researcher Profile

Biography

Phillip is a professor in the Department of Biochemistry and Molecular Biology at Monash University. The Department is part of the School of Biomedical Sciences within the Faculty of Medicine, Nursing & Health Sciences.

He is a molecular cell biologists interested in proteases (granzymes) and their regulators operating in the immune and neural systems. He uses biochemistry, structural biology, model cell systems and model organisms (mice, zebrafish) in his research.

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Keywords

Molecular Cell Biology; Protease Biology

Qualifications

PHD - MEDICINE, DENTISTRY & HEALTH SCIENCES

Institution: University of Melbourne

Year awarded: 1988

BACHELOR OF SCIENCE (DEGREE WITH HONOURS)

Institution: University of Melbourne

Year awarded: 1980

Publications

Book Chapters

Stewart, S.E., Mangan, M.S., Bird, P.I., Kaiserman, D., 2012, Detection of human and mouse granzyme B activity in cell extracts, in Methods in Molecular Biology - Leucocytes Methods and Protocols, eds JM Walker, Humana Press, USA, pp. 251-260.

Bird, C.H., Hitchen, C.R., Prescott, M., Harper, I.S., Bird, P.I., 2012, Immunodetection of granzyme B tissue distribution and cellular localisation, in Methods in Molecular Biology - Leucocytes Methods and Protocols, eds J.M. Walker, Humana Press, USA, pp. 237-250.

Kaiserman, D., Hitchen, C.R., Levina, V., Bottomley, S.P., Bird, P.I., 2011, Intracellular production of recombinant serpins in yeast, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Phillip I Bird, Academic Press, USA, pp. 1-12.

Song, J., Matthews, A., Reboul, C.F., Kaiserman, D., Pike, R.N., Bird, P.I., Whisstock, J.C., 2011, Predicting serpin/protease interactions, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Philip I Bird, Academic Press, USA, pp. 237-273.

Whisstock, J.C., Bird, P.I., 2011, Preface, in Methods in Enzymology - Biology of Serpins, eds JN Abelson & MI Simon, Academic Press Elsevier Inc, UK, p. 19.

Askew, D.J., Coughlin, P.B., Bird, P.I., 2007, Mouse Serpins and Transgenic Studies, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds Gary A Silverman and David A Lomas, World Scientific, Singapore, pp. 101-130.

Bird, P.I., 1998, Serpins and Regulation of Cell Death, in Apoptosis: Mechanisms and Role in Disease, Springer, Berlin, pp. 64-89.

Journal Articles

Teoh, S.S., Wang, H., Risbridger, G.P., Whisstock, J.C., Bird, P.I., 2012, A versatile monoclonal antibody specific to human SERPINB5, Hybridoma [E], vol 31, issue 5, Mary Ann Liebert Inc. Publishers, USA, pp. 333-339.

Sutton, V.R., Sedelies, K.A., Dewson, G., Christensen, M.E., Bird, P.I., Kluck, R.M., Trapani, J.A., Waterhouse, N.J., 2012, Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737, Cell Death & Disease [E], vol 3, issue 7 (Art. ID: e344), Nature Publishing Group, UK, pp. 1-9.

D'Angelo, M., Dunstone, M.A., Whisstock, J.C., Trapani, J., Bird, P.I., 2012, Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi, BMC Evolutionary Biology [P], vol 12, issue Art. ID: 59, BioMed Central Ltd, UK, pp. 1-12.

Rizzitelli, A., Meuter, S., Vega Ramos, J., Bird, C.H., Mintern, J.D., Mangan, M.M., Villadangos, J.A., Bird, P.I., 2012, Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell-mediated antigen cross-presentation, Immunology And Cell Biology [P], vol 90, issue 9, Nature Publishing Group, UK, pp. 841-851.

Stewart, S., D'Angelo, M., Bird, P., 2011, Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers, Biochimica et Biophysica Acta - Proteins and Proteomics [P], vol E, Elsevier Science BV, The Netherlands, pp. 1-9.

Plasman, K., Van Damme, P., Kaiserman, D., Impens, F., Demeyer, K., Helsens, K., Goethals, M., Bird, P.I., Vandekerckhove, J., Gevaert, K., 2011, Probing the efficiency of proteolytic events by positional proteomics, Molecular & Cellular Proteomics [P], vol 10, issue 2 (Art. No: M110.003301), Amercian Society for Biochemistry and Molecular Biology, Inc., USA, pp. 1-10.

Anthony, D.A., Andrews, D., Chow, M., Watt, S.V., House, C.M., Akira, S., Bird, P.I., Trapani, J.A., Smyth, M.J., 2010, A role for granzyme M in TLR4-driven inflammation and endotoxicosis, Journal Of Immunology [P], vol 185, issue 3, American Association of Immunologists, USA, pp. 1794-1803.

D'Angelo, M., Bird, P.I., Peters, C., Reinheckel, T., Trapani, J.A., Sutton, V.R., 2010, Cathepsin H is an additional convertase of pro-granzyme B, Journal Of Biological Chemistry [P], vol 285, issue 27, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 20514-20519.

Kaiserman, D., Bird, P.I., 2010, Control of granzymes by serpins, Cell Death and Differentiation [P], vol 17, Nature Publishing Group, UK, pp. 586-595.

Teoh, S., Whisstock, J., Bird, P.I., 2010, Maspin (SERPINB5) is an obligate intracellular serpin, Journal Of Biological Chemistry [P], vol 285, issue 14, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 10862-10869.

Silverman, G.A., Whisstock, J.C., Bottomley, S.P., Huntington, J.A., Kaiserman, D., Luke, C.J., Pak, S.C., Reichhart, J.-., Bird, P.I., 2010, Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems, Journal Of Biological Chemistry [P], vol 285, issue 32, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 24299-24305.

Whisstock, J.C., Silverman, G.A., Bird, P.I., Bottomley, S.P., Kaiserman, D., Luke, C.J., Pak, S.C., Reichhart, J.-., Huntington, J.A., 2010, Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions, Journal Of Biological Chemistry [P], vol 285, issue 32, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 24307-24312.

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P., Thompson, P., 2010, Synthesis of "difficult" fluorescence quenched substrates of granzyme C, International Journal of Peptide Research and Therapeutics [E], vol 16, Springer, New York New York USA, pp. 159-165.

Law, R.H.P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T.T., Baran, K., Dunstone, M.A., D'Angelo, M., Orlova, E.V., Coulibaly, F.J., Verschoor, S., Browne, K.A., Ciccone, A., Kuiper, M.J., Bird, P.I., Trapani, J.A., Saibil, H.R., Whisstock, J.C., 2010, The structural basis for membrane binding and pore formation by lymphocyte perforin, Nature [P], vol 468, issue 7322, Nature Publishing Group, UK, pp. 447-451.

Bird, C.H., Rizzitelli, A., Harper, I., Prescott, M., Bird, P.I., 2010, Use of granzyme B-based fluorescent protein reporters to monitor granzyme distribution and granule integrity in live cells, Biological Chemistry [P], vol 391, issue 8, Walter de Gruyter GmbH & Co. KG, Germany, pp. 999-1004.

Prakash, M.D., Bird, C.H., Bird, P.I., 2009, Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement, Immunology and Cell Biology, vol 87, Nature Publishing Group, United Kingdom, Australia, pp. 249-254.

Bird, P.I., Trapani, J.A., Villadangos, J.A., 2009, Endolysosomal proteases and their inhibitors in immunity, Nature Reviews Immunology [P], vol 9, issue 12, Nature Publishing Group, UK, pp. 871-882.

Levina, V., Dai, W., Knaupp, A.S., Kaiserman, D., Pearce, M.C., Cabrita, L.D., Bird, P.I., Bottomley, S.P., 2009, Expression, purification and characterization of recombinant Z alpha1-Antitrypsin-The most common cause of alpha1-Antitrypsin deficiency, Protein Expression And Purification [P], vol 68, issue 2, Academic Press, USA, pp. 226-232.

Cullen, S.P., Afonina, I.S., Donadini, R., Luthi, A.U., Medema, J.P., Bird, P.I., Martin, S.J., 2009, Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing, Journal of Biological Chemistry, vol 284, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 5137-5147.

Kaiserman, D., Buckle, A.M., Van Damme, P., Irving, J.A., Law, R.H.P., Matthews, A.Y., Bashtannyk-Puhalovich, T.A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J.C., Bird, P.I., 2009, Structure of granzyme C reveals an unusual mechanism of protease autoinhibition, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 14, National Academy of Sciences, USA, pp. 5587-5592.

Ng, N.M., Quinsey, N.S., Matthews, A.Y., Kaiserman, D., Wijeyewickrema, L.C., Bird, P.I., Thompson, P.E., Pike, R.N., 2009, The effects of exosite occupancy on the substrate specificity of thrombin, Archives Of Biochemistry And Biophysics [P], vol 489, issue 1-2, Academic Press, USA, pp. 48-54.

Trapani, J.A., Bird, P.I., 2008, A renaissance in understanding the multiple and diverse functions of granzymes?, Immunity, vol 29, issue 5, Cell Press, United States, pp. 665-667.

Buzza, M.S., Dyson, J.M., Choi, H., Gardiner, E.E., Andrews, R.K., Kaiserman, D., Mitchell, C.A., Berndt, M.C., Dong, J., Bird, P.I., 2008, Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor, Journal of Biological Chemsitry, vol 283, issue 33, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 22498-22504.

Sedelies, K.A., Ciccone, A., Clarke, C.J.P., Oliaro, J., Sutton, V.R., Scott, F.L., Silke, J., Susanto, O., Green, D.R., Johnstone, R.W., Bird, P.I., Trapani, J.A., Waterhouse, N.J., 2008, Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity, Cell Death and Differentiation, vol 15, issue 4, Nature Publishing Group, United Kingdom, pp. 708-717.

Kerr, F.K., Thomas, A.R., Wijeyewickrema, L.C., Whisstock, J., Boyd, S.E., Kaiserman, D., Matthews, A.Y., Bird, P.I., Thielens, N.M., Rossi, V., Pike, R.N., 2008, Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor, Molecular Immunology, vol 45, Pergamon-Elsevier Science Ltd, Oxford England UK, pp. 670-677.

Rosado, C.J., Kondos, S., Bull, T.E., Kuiper, M., Law, R.H.P., Buckle, A.M., Voskoboinik, I., Bird, P.I., Trapani, J.A., Whisstock, J., Dunstone, M.A., 2008, The MACPF/CDC family of pore-forming toxins, Cellular Microbiology, vol 10, issue 9, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 1765-1774.

Mangan, M., Kaiserman, D., Bird, P.I., 2008, The role of serpins in vertebrate immunity, Tissue Antigens, vol 72, issue 1, Wiley-Blackwell Munksgaard, Denmark, pp. 1-10.

Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J., 2007, A common fold mediates vertebrate defense and bacterial attack, Science, vol 317, issue 5844, American Association of Advancement in Science, Washington, DC, USA, pp. 1548-1551.

Scott, F.L., Sun, J., Whisstock, J., Kato, K., Bird, P.I., 2007, SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes, Journal of Biochemistry, vol 142, issue 4, Japanese Biochemical Society, Tokyo, Japan, pp. 435-442.

Law, R.H.P., Zhang, Q., McGowan, S., Buckle, A.M., Silverman, G.A., Wong, W., Rosado, C.J., Langendorf, C., Pike, R.N., Bird, P.I., Whisstock, J., 2006, An overview of the serpin superfamily, Genome Biology, vol 7, issue 5, Biomed Central Ltd, London UK, pp. 216-1-216-11.

Waterhouse, N.J., Sutton, V.R., Sedelies, K.A., Ciccone, A., Jenkins, M., Turner, S.J., Bird, P.I., Trapani, J.A., 2006, Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis, The Journal of Cell Biology, vol 173, issue 1, The Rockefeller University Press, New York USA, pp. 133-144.

Baran, K., Ciccone, A., Peters, C., Yagita, H., Bird, P.I., Villadangos, J.A., Trapani, J.A., 2006, Cytotoxic T lymphocytes from Cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells, The Journal of Biological Chemistry, vol 281, issue 41, American Society for Biochemistry and Molecular Biology Inc, Bethesda USA, pp. 30485-30491.

Popova, E.Y., Claxton, D.F., Lukasova, E., Bird, P.I., Grigoryev, S.A., 2006, Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood, Experimental Hematology, vol 34, issue 4, Elsevier Science Inc, New York USA, pp. 453-462.

Buzza, M.S., Bird, P.I., 2006, Extracellular granzymes: current perspectives, Biological Chemistry, vol 387, issue 7, Walter de Gruyter & Co, Berlin Germany, pp. 827-837.

Waterhouse, N.J., Sedelies, K.A., Sutton, V.R., Pinkoski, M.J., Thia, K.Y., Johnstone, R.W., Bird, P.I., Green, D.R., Trapani, J.A., 2006, Functional dissociation of deltapsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis, Cell Death and Differentiation, vol 13, issue 4, Nature Publishing Group, London England, pp. 607-618.

Estella, E., McKenzie, M.D., Catterall, T., Sutton, V.R., Bird, P.I., Trapani, J.A., Kay, T.W., Thomas, H.E., 2006, Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid, Diabetes, vol 55, issue 8, American Diabetes Association, Virginia USA, pp. 2212-2219.

Kaiserman, D., Whisstock, J.C., Bird, P.I., 2006, Mechanisms of serpin dysfunction in disease, Expert Reviews in Molecular Medicine, vol 8, issue 31, Cambridge University Press, New York USA, pp. 1-19.

Gillard, A., Scarff, K.L., Loveland, K.A.L., Ricardo, S.D., Bird, P.I., 2006, Modulation and redistribution of proteinase inhibitor 8 (Serpinb8) during kidney regeneration, American Journal of Nephrology, vol 26, issue 1, Karger, Basel Switzerland, pp. 34-42.

Classen, C.F., Bird, P.I., Debatin, K., 2006, Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection, Clinical and Experimental Immunology, vol 143, issue 3, Blackwell Publishing, Oxford England, pp. 534-542.

Buzza, M.S., Hosking, P., Bird, P.I., 2006, The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform Moles, Placenta, vol 27, issue 1, WB Saunders Co Ltd, London England, pp. 62-69.

Kaiserman, D., Bird, C.H., Sun, J., Matthews, A.Y., Ung, K.S., Whisstock, J.C., Thompson, P.E., Trapani, J.A., Bird, P.I., 2006, The major human and mouse granzymes are structurally and functionally divergent, The Journal of Cell Biology, vol 175, issue 4, Rockefeller University Press, USA, pp. 619-630.

Kaiserman, D., Bird, P.I., 2005, Analysis of vertebrate genomes suggests a new model for clade B serpin evolution, BMC Genomics, vol 6, issue 167, Biomed Central Ltd, London England, pp. 1-10.

Bird, C.H., Sun, J., Ung, K.S., Karambalis, D., Whisstock, J.C., Trapani, J.A., Bird, P.I., 2005, Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells, Molecular and Cellular Biology, vol 25, issue 17, American Society for Microbiology, Washington USA, pp. 7854-7867.

Bird, C.H., Buzza, M.S., Sun, J., Ung, K.S., Whisstock, J.C., Trapani, J.A., Bird, P.I., 2005, Contribution of cationic sites to granzyme B uptake into target cells, Tissue Antigens, vol 66, issue 5, Blackwell Publishing, Oxford England, pp. 362-363.

Kerr, F.K., O'Brien, G., Quinsey, N.S., Whisstock, J., Boyd, S.E., Garcia De La Banda, M.J., Kaiserman, D., Matthews, A.Y., Bird, P.I., Pike, R.N., 2005, Elucidation of the substrate specificity of the C1s protease of the classical complement pathway, Journal of Biological Chemistry, vol 280, issue 47, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 39510-39514.

Buzza, M.S., Zamurs, L., Sun, J., Bird, C.H., Smith, A.I., Trapani, J.A., Froelich, C.J., Nice, E.C., Bird, P.I., 2005, Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin, Journal of Biological Chemistry, vol 280, issue 25, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 23549-23558.

Bird, P.I., Buzza, M.S., Sun, J., 2005, Extracellular matrix remodelling by granzyme B, Tissue Antigens, vol 66, issue 5, Blackwell Publishing, Oxford England, p. 362.

Blink, E., Jiansheng, Z., Hu, W., Calanni, S.T., Trapani, J.A., Bird, P.I., Jans, D.A., 2005, Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: Modulation by the serpin inhibitor PI-9, Journal of Cellular Biochemistry, vol 95, issue 3, Wiley-Liss, Hoboken USA, pp. 598-610.

Whisstock, J., Bottomley, S.P., Bird, P.I., Pike, R.N., Coughlin, P.B., 2005, Serpins 2005 - fun between the beta-sheets : Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia), FEBS Journal, vol 272, issue 19, Blackwell Publishing, Oxford UK, pp. 4868-4873.

Law, R.H.P., Irving, J.A., Buckle, A.M., Ruzyla, K., Buzza, M.S., Bashtannyk-Puhalovich, T.A., Beddoe, T.C., Nguyen, K., Worrall, M.D., Bottomley, S.P., Bird, P.I., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix, Journal of Biological Chemistry, vol 280, issue 23, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 22356-22364.

Waterhouse, N.J., Sedelies, K.A., Browne, K.A., Wowk, M.E., Newbold, A., Sutton, V.R., Clarke, C.J.P., Oliaro, J., Lindemann, R.K., Bird, P.I., Johnstone, R.W., Trapani, J.A., 2004, A central role for Bid in granzyme B-induced apoptosis, The Journal of Biological Chemistry, vol 280, issue 6, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 4476-4482.

Kim, T.W., Hung, C., Boyd, D.A.K., He, L., Lin, C., Kaiserman, D., Bird, P.I., Wu, T.C., 2004, Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6, Cancer Research, vol 64, issue 1, American Association Cancer Research, Philadelphia USA, pp. 400-405.

Sun, J., Bird, C.H., Thia, K.Y., Matthews, A.Y., Trapani, J.A., Bird, P.I., 2004, Granzyme B encoded by the commonly occurring human RAH allele retains pro-aptotic activity, Journal of Biological Chemistry, vol 279, issue 17, American Society of Biochemistry and Molecular Biology Inc, Bethesda USA, pp. 16907-16911.

Silverman, G.A., Whisstock, J.C., Askew, D.J., Pak, S.C., Luke, C.J., Cataltepe, S., Irving, J.A., Bird, P.I., 2004, Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis, Cellular and Molecular Life Sciences, vol 61, issue 3, Birkhauser Verlag AG, Basel Switzerland, pp. 301-325.

Bird, P.I., Pak, S.C., Worrall, D.M., Bottomley, S.P., 2004, Production of recombinant serpins in Escherichia coli, Methods, vol 32, issue 2, Academic Press Inc. Elsevier Science, San Diego USA, pp. 169-176.

Pemberton, P.A., Bird, P.I., 2004, Production of serpins using yeast expression systems, Methods, vol 32, issue 2, Academic Press Inc Elsevier Science, San Diego USA, pp. 185-190.

Scarff, K.L., Ung, K.S., Nandurkar, H., Crack, P.J., Bird, C.H., Bird, P.I., 2004, Targeted distruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke, Molecular and Cellular Biology, vol 24, issue 9, American Society for Microbiology, Washington USA, pp. 4075-4082.

Benning, L.N., Whisstock, J.C., Sun, J., Bird, P.I., Bottomley, S.P., 2004, The human serpin proteinase inhibitor-9 self-associates at physiological temperatures, Protein Science, vol 13, issue 7, Cold Spring Harbor Laboratory Press, Woodbury USA, pp. 1859-1864.

Scarff, K.L., Ung, K.S., Sun, J., Bird, P.I., 2003, A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice, Genesis, vol 36, issue 3, Wiley-Liss, New York USA, pp. 149-157.

Ida, H., Nakashima, T., Kedersha, N.L., Yamasaki, S., Huang, M., Izumi, Y., Miyashita, T., Origuchi, T., Kawakami, A., Migita, K., Bird, P.I., Anderson, P.S., Eguchi, K., 2003, Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death, European Journal of Immunology, vol 33, issue 12, Wiley-V C H Verlag GMBH, Weinheim Germany, pp. 3284-3292.

Welss, T., Sun, J., Irving, J.A., Blum, R., Smith, A.I., Whisstock, J.C., Pike, R.N., Von Mikecz, A., Ruzicka, T., Bird, P.I., Abts, H., 2003, Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis, Biochemistry, vol 42, issue 24, American Chemical Society, Washington USA, pp. 7381-7389.

Hirst, C.E., Buzza, M.S., Bird, C.H., Warren, H.S., Cameron, P.U., Zhang, M., Ashton-Rickardt, P.G., Bird, P.I., 2003, The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency, The Journal of Immunology, vol 170, issue 2, American Association of Immunologists, Bethesda USA, pp. 805-815.

Benarafa, C., Cooley, J., Zeng, W., Bird, P.I., Remold-O'Donnell, E., 2002, Characterization of four murine homologs of the human ov-sepin monocyte neutrophil elastase inhibitor MNEI (SERPINB1), Journal of Biological Chemistry, vol 277, issue 44, American Society of Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 42028-42033.

Kaiserman, D., Knaggs, S., Scarff, K.L., Gillard, A., Mirza, G., Cadman, M., McKeone, R., Denny, P., Cooley, J., Benarafa, C., Remold-O'Donnell, E., Ragoussis, J., Bird, P.I., 2002, Comparison of human chromasome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repetoire in the mouse, Genomics, vol 79, issue 3, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 349-362.

Skoldberg, F., Ronnblom, L., Thornnemo, M., Lindahl, A., Bird, P.I., Rorsman, F., Kampe, O., Landgren, E., 2002, Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus, Biochemical and Biophysical Research Communications, vol 291, issue 4, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 951-958.

Pike, R.N., Bottomley, S., Irving, J., Bird, P.I., Whisstock, J.C., 2002, Serpins: finely balanced conformational traps, IUBMB Life, vol 54, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 1-7.

Sun, J., Whisstock, J.C., Harriott, P., Walker, B., Novak, A.J., Thompson, P., Smith, A., Bird, P.I., 2001, Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop, Journal of Biological Chemistry, vol 276, issue 18, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 15177-15184.

Bird, C., Blink, E., Hirst, C.E., Buzza, M.S., Steele, P.M., Sun, J., Jans, D.A., Bird, P.I., 2001, Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1, Molecular and Cellular Biology, vol 21, issue 16, American Society of Microbiology, Washington DC USA, pp. 5396-5407.

Hirst, C.E., Buzza, M.S., Sutton, V.R., Trapani, J.A., Loveland, K.L., Bird, P.I., 2001, Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction, Molecular Human Reproduction, vol 7, issue 12, Oxford University Press, Oxford England, pp. 1133-1142.

Abts, H., Welss, T., Scheuring, S., Scott, F.L., Irving, J., Michel, G., Bird, P.I., Ruzicka, T., 2001, Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis, DNA and Cell Biology, vol 20, issue 3, Mary Ann Leibert Inc Publishing, New York NY USA, pp. 123-131.

Kato, K., Kishi, T., Kamachi, T., Akisada, M., Oka, T., Midorikawa, R., Takio, K., Dohmae, N., Bird, P.I., Sun, J., Scott, F.L., Miyake, Y., Yamamoto, K., Machida, A., Tanaka, T., Matsumoto, K., Shibata, M., Shiosaka, S., 2001, Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain, The Journal of Biological Chemistry, vol 276, issue 18, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 14562-14571.

Buzza, M.S., Hirst, C.E., Bird, C., Hosking, P., McKendrick, J., Bird, P.I., 2001, The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses, Cellular Immunology, vol 210, issue 1, Academic Press Inc, San Diego California USA, pp. 21-29.

Silverman, G.A., Bird, P.I., Carrell, R.W., Church, F., Coughlin, P.B., Gettins, P., Irving, J., Lomas, D., Luke, C., Moyer, R., Pemberton, P., Remold-O'Donnell, E., Salvesen, G., Travis, J., Whisstock, J.C., 2001, The serpins are an expanding superfamily of structurally similar but functionally diverse proteins, Journal of Biological Chemistry, vol 276, issue 36, American Society for Biochemistry and Molecular Biology, Bethesda MD USA, pp. 33293-33296.

Yan, M., Sun, J., Bird, P.I., Liu, D., Grigg, M., Lim, Y., 2001, a1A -and a1B -adrenoceptors are the major subtypes in human saphenous vein, Life Sciences, vol 68, issue 10, Pergamon-Elsevier Science Ltd, Oxford England, pp. 1191-1198.

Sun, J., Bird, C., Buzza, M.S., McKee, K.E., Whisstock, J.C., Bird, P.I., 1999, Expression and purification of recombinant human granzyme B from "Pichia pastoris", Biochemical and Biophysical Research Communications, vol 261, Academic Press, www.idealibrary.com, pp. 251-255.

Sun, J., Bird, C.H., Buzza, M.S., McKee, K.E., Whisstock, J.C., Bird, P.I., 1999, Expression and purification of recombinant human granzyme B from Pichia pastoris, Biochemical and Biophysical Research Communications, vol 261, Academic Press Inc., San Diego CA USA, pp. 251-255.

Scott, F.L., Eyre, H.J., Lioumi, M., Ragoussis, J., Irving, J.A., Sutherland, G.A., Bird, P.I., 1999, Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the gene Clusters at 18q21-q23 and 6p25, Genomics, vol 62 issue 3, Academic Press Inc., San Diego CA USA, pp. 490-499.

Scott, F.L., Eyre, H.J., Lioumi, M., Ragoussis, J., Irving, J., Sutherland, G.A., Bird, P.I., 1999, Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new P18-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25, Genomics, vol 62, Academic Press, www.idealibrary.com, pp. 490-499.

Bird, P.I., 1999, Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins, Immunology and Cell Biology, vol 77, Blackwell Science Asia, Carlton Vic Australia, pp. 47-57.

Scott, F.L., Hirst, C., Sun, J., Bird, C., Bottomley, S.P., Bird, P.I., 1999, The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, Cathepsin G, Blood, vol 93 issue 6, American Society of Haematology, Washington DC USA, pp. 2089-2097.

Scott, F.L., Hirst, C., Sun, J., Bird, C., Bottomley, S.P., Bird, P.I., 1999, The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule proterase, Cathepsin G, Blood, vol 93, no 6, The American Society of Hematology, USA, pp. 2089-2097.

Bird, P.I., Sun, J., Stephens, R., Mirza, G., Ragoussis, J., Kanai, H., 1998, A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 19q21 ovalbumin serpin genes, Cytogenet Cell Genet, vol 82, Karger, Switzerland, pp. 273-277.

Mitchell, C.A., Speed, C.J., Bird, P.I., O'Malley, C., Matzaris, M., Badger, A., 1998, Distinct membrane and cystosolic forms of inositol polyphosphate 5-phosphatase II. Efficient localization requires two discrete domains, Journal of Biological Chemistry, vol 273, American Soc. for Biiochem. and Mol. Biol., USA, pp. 8256-8267.

Bird, P.I., Cerruti, L., Scott, F.L., Coughlin, P.B., Salem, H.H., Paddle-Ledinek, J.E., 1998, Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation, Experimental cell research, vol 245, Academic Press, USA, pp. 263-271.

Bird, P.I., Sun, J., Bird, C., Sutton, V.R., Hirst, C., Novak, A., Kumar, S., Trapani, J.A., 1998, Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzzyme B-mediated apoptosis without perturbing the fast cell death pathway, Mol and Cell Biology, vol 18,11, American Soc for Microbiology, USA, pp. 6387-6398.

Bird, P.I., Bird, C., Chu, M.D., Teasdale, M., 1998, Turnover of thrombomodulin at the cell surface occurs at a similar rate to receptors that are not actively internalized, Thromb. Haemost, vol 80, Schattauer Verlag, Stuttgart, pp. 119-127.

Sun, J., Ooms, L.M., Bird, C., Sutton, V.R., Trapani, J.A., Bird, P.I., 1997, A New Family of 10 Murine Ovalbumin Serpins Includes Two Homologs of Proteinase Inhibitor 8 and Two Homologs of the Granzyme B Inhibitor (Proteinase Inhibitor 9), Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 15434-15441.

Scott, F.L., Eyre, H.J., Ooms, L.M., Sun, J., Bird, P.I., Sutherland, G.R., 1997, Proteinases inhibitor 8 Map position 18q21.3, Chromosome Research, vol 5, Thomson Rapid Science Publisher, USA, p. 279.

Sun, J., Bottomley, S., Kumar, S., Bird, P.I., 1997, Recombinant caspase - 3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme, Biochemical and Biophysical Research Communications, vol 238, Academic Press, Orlando FL USA, pp. 920-924.

Sun, J., Bottomley, S.P., Kumar, S., Bird, P.I., 1997, Reconbinant Caspase-3 Expressed in "Pichia pastoris" is Fully Activiated and Kinetically Indistinguishable for the Native Enzyme, Biochemical and Biophysical Research Communications, vol 238, Academic Press, USA, pp. 920-924.

Conference Proceedings

Ng, N., Boyd, S.E., Bird, P.I., Thompson, P., Matthews, A.Y., Kaiserman, D., Pike, R.N., 2007, The effects of thrombomodulin on the substrate specificity of thrombin, 5th General Meeting of the International Proteolysis Society Book of Abstracts, 20 October 2007 to 24 October 2007, Novartis Pharma A, Basel Switzerland, p. 375.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Granzyme structure and function during vertebrate evolution.

Supervisors:

Bird, P (Main), Kaiserman, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Producing a Danio rerio (zebrafish) model of Z antitrypsin.

Supervisors:

Bottomley, S (Main), Bird, P (Associate), Verkade, H (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of MACPF proteins in zebrafish development..

Supervisors:

Bird, P (Main), Verkade, H (Associate), Whisstock, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of mammalian membrane attack complex/perforin (MACPF) proteins in Neurobiology and Neural development.

Supervisors:

Bird, P (Joint), Whisstock, J (Joint-co).

Completed Supervision

Student:

Benning, L.

Program of Study:

The intracellular serpins PI-6 and PI-9: an analysis of conformational change. (PHD) 2007.

Supervisors:

Bottomley, S (Main), Bird, P (Joint).

Student:

Buzza, M.

Program of Study:

EMERGING ROLES OF GRANZYME B AND ITS INHIBITOR PI-9 BEYOND THE IMMUNE SYSTEM. (PHD) 2004.

Supervisors:

Bird, P (Main).

Student:

Fodero-Tavoletti, M.

Program of Study:

Cloning and characterisation of human non-transmembrane protein tyrosine phosphatase 20 (hPTPN20). (PHD) 2006.

Supervisors:

Bird, P (Joint), Tiganis, T (Joint-Co).

Student:

Gillard, A.

Program of Study:

Distribution and functions of protease inhibitor 8 (SERPINB8). (PHD) 2010.

Supervisors:

Bird, P (Main).

Student:

Gillard, A.

Program of Study:

Structure and Function of Mouse P1-8. 2001.

Supervisors:

Bird, P (Main).

Student:

Hirst, C.

Program of Study:

TISSUE DISTRIBUTION AND REGULATION OF THE GRANZYME B INHIBITOR, PROTEINASE INHIBITOR 9. (PHD) 2002.

Supervisors:

Bird, P (Main).

Student:

Johnson, N.

Program of Study:

CHARACTERISATION OF RECOMBINANT GRANZYME M. 2005.

Supervisors:

Bird, P (Main).

Student:

Kaiserman, D.

Program of Study:

Cytotoxicity and its inhibition in the mouse and human immune systems. (PHD) 2006.

Supervisors:

Bird, P (Main).

Student:

Kong, A.

Program of Study:

CLONING AND CHARACTERISATION OF A NOVEL 72KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE.. (PHD) 2001.

Supervisors:

Mitchell, C (Main), Bird, P (Associate).

Student:

Romero Lopez, S.

Program of Study:

CHARACTERIZATION OF THE 43 kDa INOSITOL POLYPHOSPHATE 5-PHOSHATASE: CATALYTIC FUNCTION AND INTRACELLULAR LOCATION. (PHD) 2000.

Supervisors:

Mitchell, C (Main), Bird, P (Joint).

Student:

Scott, F.

Program of Study:

MOLECULAR CELL BIOLOGY. (PHD) 2000.

Supervisors:

Salem, H (Main), Bird, P (Associate).