Dr James Chan - Researcher Profile

Biography

James works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DIPLOMA OF EDUCATION

Institution: University of Melbourne

Year awarded: 2003

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 1998

SCIENCE (HONS)

Institution: UNIVERSITY OF MELBOURNE

Year awarded: 1994

Publications

Journal Articles

Liu, Y., Vaghjiani, V., Tee, J., To, K., Cui, P., Oh, D., Manuelpillai, U., Toh, B., Chan, M., 2012, Amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis, PLoS ONE [P], vol 7, issue 4 (e35758), Public Library of Science, United States, pp. 1-9.

Manuelpillai, U.C., Lourensz, D., Vaghjiani, V., Tchongue, J., Lacey, D., Tee, J.Y., Murthi, P., Chan, M.K.J., Hodge, A., Sievert, W., 2012, Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis, PLoS ONE [P], vol 7, issue 6 (Art. No: e38631), Public Library of Science, United States, pp. 1-11.

Oh, D.Y., Cui, P., Hosseini, H., Mosse, J.A., Toh, B., Chan, M.K.J., 2012, Potently immunosuppressive 5-fluorouracil-resistant mesenchymal stromal cells completely remit an experimental autoimmune disease, Journal Of Immunology [P], vol 188, issue 5, American Association of Immunologists, United States, pp. 2207-2217.

Pratama, G., Vaghjiani, V., Tee, J., Liu, Y., Chan, M., Tan, C., Murthi, P., Gargett, C., Manuelpillai, U., 2011, Changes in culture expanded human amniotic epithelial cells: Implications for potential therapeutic applications, PLoS ONE [P], vol 6, issue 11 (Art. No: e26136), Public Library of Science, United States, pp. 1-12.

Alderuccio, F., Nasa, Z., Chung, J., Ko, H., Chan, M., Toh, B., 2011, Hematopoietic stem cell gene therapy as a treatment for autoimmune diseases, Molecular Pharmaceutics [P], vol 8, issue 5, American Chemical Society, USA, pp. 1488-1494.

Hosseini, H., Oh, D., Chan, S.T., Chen, X., Nasa, Z., Yagita, H., Alderuccio, F., Toh, B., Chan, J.M., 2011, Non-myeloablative transplantation of bone marrow expressing self-antigen establishes peripheral tolerance and completely prevents autoimmunity in mice, Gene Therapy [P], vol E, issue 0, Nature Publishing Group, USA, pp. 1-10.

Chan, J.M., Alderuccio, F., Toh, B., 2011, Transplantation of genetically modified haematopoietic stem cells to induce antigen-specific tolerance as a cure for autoimmune diseases, Current Stem Cell Research and Therapy [P], vol 6, issue 1, Bentham Science Publishers Ltd, Netherlands, pp. 44-49.

Chen, X., Chan, S.T., Hosseini, H., Layton, D.S., Boyd, R.L., Alderuccio, F.P., Toh, B., Chan, M.K.J., 2011, Transplantation of retrovirally transduced bone marrow prevents autoimmune disease in aged mice by peripheral tolerance mechanisms, Autoimmunity [P], vol 44, issue 5, Informa Healthcare, UK, pp. 384-393.

Alderuccio, F., Chan, M., Ko, H., Chung, J., Nasa, Z., Toh, B., 2010, A molecular Trojan horse: Hijacking the bone marrow to treat autoimmune diseases, Discovery medicine [P], vol 9, issue 49, Solariz, Inc, United States, pp. 512-518.

Ko, H.-., Chung, J.-., Nasa, Z., Chan, J., Siatskas, C., Toh, B.-., Alderuccio, F., 2010, Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease, Autoimmunity [P], vol 44, issue 3, Informa Healthcare, United Kingdom, pp. 177-187.

Ko, H., Kinkel, S., Hubert, F., Nasa, Z., Chan, M., Siatskas, C., Hirubalan, P., Toh, B., Scott, H., Alderuccio, F., 2010, Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis, European Journal Of Immunology [P], vol 40, issue 12, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 3499-3509.

Alderuccio, F.P., Chan, M.K.J., Scott, D., Toh, B., 2009, Gene therapy and bone marrow stem-cell transfer to treat autoimmune disease, Trends in Molecular Medicine [P], vol 15, issue 8, Elsevier Ltd, United Kingdom, pp. 344-351.

Chan, J., Ban, E., Chun, K.H., Wang, S., McQualter, J.L., Bernard, C.C.A., Toh, B., Alderuccio, F.P., 2008, Methylprednisolone induces reversible clinical and pathological remission and loss of lymphocyte reactivity to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis, Autoimmunity, vol 41, issue 5, Informa Healthcare, United Kingdom, pp. 405-413.

Chan, J., Ban, E., Chun, K.H., Wang, S., Backstrom, B.T., Bernard, C.C.A., Toh, B., Alderuccio, F.P., 2008, Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease., Journal of Immunology, vol 181, issue 11, American Association of Immunologists, United States, pp. 7571-7580.

Alderuccio, F.P., Chan, J., Toh, B., 2008, Tweaking the immune system: Gene therapy-assisted autologous haematopoietic stem cell transplantation as a treatment for autoimmune disease, Autoimmunity, vol 41, issue 8, Taylor & Francis Ltd, United Kingdom, pp. 679-685.

Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., Alderuccio, F.P., 2006, Gene therapy strategies towards immune tolerance to treat the autoimmune diseases, Current Gene Therapy, vol 6, issue 1, Bentham Science Publishers, Netherlands, pp. 45-58.

Alderuccio, F.P., Siatskas, C., Chan, M.K.J., Field, J., Murphy, K., Nasa, Z., Toh, B., 2006, Haematopoietic stem cell gene therapy to treat autoimmune disease., Current Stem Cell Research and Therapy, vol 1, Bentham Science Publishers, Netherlands, pp. 279-287.

Chan, M.K.J., Siatskas, C., Field, J., Toh, B., Alderuccio, F.P., 2006, Mechanisms and applications of stem cell gene therapy in autoimmunity, Drug Discovery Today: Disease Mechanisms, vol 3, issue 2, Elsevier Ltd, England, pp. 219-223.

Chan, M.K.J., Clements, W., Field, J., Nasa, Z., Lock, P., Yap, F., Toh, B., Alderuccio, F.P., 2006, Transplantation of bone marrow genetically engineered to express proinsulin II protects againts autoimmune insulitis in NOD mice, The Journal of Gene Medicine, vol 8, issue 11, John Wiley & Sons, Inc., UK, pp. 1281-1290.

McCartney-Francis, N., Chan, M.K.J., Wahl, S.M., 2003, Inflammatory joint disease: clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destruction, Methods in Molecular Biology, vol 225, issue Suppl., Humana Press, United States, pp. 147-159.

Wahl, S.M., McCartney-Francis, N., Chan, M.K.J., Dionne, R., Ta, L., Orenstein, J.M., 2003, Nitric oxide in experimental joint inflammation: benefit or detriment?, Cells Tissues Organs, vol 174, issue 1-2, S Karger AG, Basel Switzerland, pp. 26-33.

Chan, M.K.J., Villarreal, G., Jin, W.W., Stepan, T., Burnstein, H., Wahl, S.M., 2002, Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product, Molecular Therapy, vol 6, issue 6, Academic Press, United States, pp. 727-736.

Conference Proceedings

Nasa, Z., Chung, J., Joglekar, A., Chan, M., Toh, B., Alderuccio, F., 2011, Low toxic non-myeloablative regimen as preconditioning for induction of immune tolerance using gene therapy, 7th Biennial Meeting of the Australasian-Gene-Therapy-Society, mAY 2011, Wiley-Blackwell, USA, p. 442.

Oh, D.Y., Cui, P., Mosse, J.A., Toh, B., Chan, M.K.J., 2009, Highly purified mouse mesenchymal stem cells exhibit equal potential in non-hematopoietic differentiation and enhanced immunosuppressive ability, International Society for Stem Cell Research: ISSCR 7th Annual Meeting; The world's premier stem cell research event; Friday Poster Session Abstracts, 8 July 2009 to 11 July 2009, ISSCR, Deerfield Illinois USA, p. 252.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Immune-modulation of different mesenchymal and placental stem cells on a mouse model of multiple sclerosis..

Supervisors:

Ban-Hock, T (Joint-co), Chan, J (Joint).

Completed Supervision

Student:

Hosseini, H.

Program of Study:

. 2010.

Supervisors:

Ban-Hock, T (Main), Chan, J (Joint).

Student:

Ko, H.

Program of Study:

Combining gene therapy and haematopoietic stem cell transplantation to induce immune tolerance in an experimental model of multiple sclerosis. (PHD) 2010.

Supervisors:

Alderuccio, F (Main), Chan, J (Associate), Toh, B (Associate).

Student:

Oh, D.

Program of Study:

The isolation, characterization and application of a population of highly immunosuppressive bone marrow-derived mesenchymal stromal cells in autoimmune disease. (PHD) 2012.

Supervisors:

Mosse, J (Main), Chan, J (Associate), Toh, B (Associate).