Dr Duangporn Jamsai - Researcher Profile

Biography

Duangporn Jamsai is a Research Fellow at the Department Anatomy & Developmental Biology, Monash University, where she has established her own group within the research team of Prof. Moira O’Bryan. Her research focuses on the genetics of male germ cell development and uses mouse models/clinical samples to reveal critical pathways in male fertility.

Duangporn completed her Ph.D. in the field of thalassemia in December 2003 at Mahidol University (Thailand). She was awarded a highly competitive Royal Golden Jubilee Ph.D. scholarship from the Thailand Research Fund, which allowed her to conduct some parts of her Ph.D. research at the Murdoch Childrens Research Institute (MCRI, Melbourne) from 1999-2001. During this period, she was also awarded the Thalassemia Society of Victoria research grant. After two and a half years of productive research at the MCRI, she returned to Mahidol University to complete her Ph.D.

In January 2004, she migrated permanently to Australia and joined the “Male Germ Cell Biology & Male Infertility” group at the Monash Institute of Reproduction & Development under the supervision of Prof. Moira O’Bryan. Conceptually, this is a radical shift in research discipline and research environment. Despite this, her outstanding achievement as an early career scientist was recognised by the award of an NHMRC Peter Doherty Postdoctoral Fellowship (2006-2010), which has been particularly productive. These include the development of unique research tools e.g. mouse models and a male infertility repository. These resources have given Duangporn a significant internationally competitive edge in the area of male fertility. 

Qualifications

MOLECULAR GENETICS AND GENETIC ENGINEERING

Institution: Mahidol University

Year awarded: 2003

MEDICAL TECHNOLOGY

Institution: Chulalongkorn University

Year awarded: 1998

Publications

Book Chapters

Jamsai, D., O'Bryan, M.K., 2010, Mouse models as tools in fertility research and male-based contraceptive development, in Fertility Control (Handbook of Experimental Pharmacology), eds Ursula-F Habenicht and R John Aitken, Springer, USA, pp. 179-194.

Orford, M.R., Jamsai, D., McLenachan, S., Ioannou, P.A., 2004, Modification of human bacterial articifial chromosome clones for functional studies and therapeutic applications, in Methods in Molecular Biology 'Mammalian Artificial Chromosomes', eds V Sgaramella & S Eridani, Humana Press Inc, USA, pp. 243-266.

Journal Articles

Jamsai, D., O'Connor, A., Deboer, K.D., Clark, B., Smith, S.J., Browne, C.M., Bensley, J.G.A., Merriman, J.A., Yuen, W.S., Koopman, P.A., Jones, K.T., O'Bryan, M.K., 2013, Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse, PLoS ONE [P], vol 8, issue 2, Public Library of Science, USA, pp. 1-7.

O'Donnell, L., Rhodes, D., Smith, S.J., Merriner, D.J., Clark, B.J., Borg, C.L., Whittle, B., O'Connor, A.E., Smith, L.B., McNally, F.J., de Kretser, D.M., Goodnow, C.C., Ormandy, C.J., Jamsai, D., O'Bryan, M.K., 2012, An essential role for katanin p80 and microtubule severing in male gamete production, Plos Genetics [P], vol 8, issue 5 (Art. ID: e1002698), Public Library of Science, USA, pp. 1-12.

O'Bryan, M.K., Grealy, A., Stahl, P.J., Schlegel, P.N., McLachlan, R.L., Jamsai, D., 2012, Genetic variants in the ETV5 gene in fertile and infertile men with nonobstructive azoospermia associated with Sertoli cell-only syndrome, Fertility and Sterility [P], vol 98, issue 4 (Art. ID: e1-3), Elsevier Inc., USA, pp. 827-835.e3.

Lo, C.Y.J., Jamsai, D., O'Connor, A.E., Borg, C.L., Clark, B., Whisstock, J.C., Field, M.C., Adams, V., Ishikawa, T., Aitken, R.J., Whittle, B., Goodnow, C.C., Ormandy, C.J., O'Bryan, M.K., 2012, RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly, PLoS Genetics [E], vol 8, issue 10 (Art. No.: e1002969), Public Library of Science, USA, pp. 1-11.

Gibbs, G., Orta, G., Reddy, T., Koppers, A., Martinez-Lopez, P., de la Vega-Beltran, J., Lo, J., Veldhuis, N., Jamsai, D., Mcintyre, P., Darszon, A., O'Bryan, M., 2011, Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 17, National Academy of Sciences, USA, pp. 7034-7039.

Jamsai, D., Sarraj, M., Merriner, D.J., Drummond, A.E., Jones, K.T., McLachlan, R., O'Bryan, M.K., 2011, GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population, International Journal Of Andrology [P], vol 34, issue 6 (Part 1), Wiley-Blackwell Publishing Ltd, UK, pp. 624-632.

Jamsai, D., Rijal, S., Bianco, D.M., O'Connor, A., Merriner, D.J., Smith, S.J., Gibbs, G.M., O'Bryan, M.K., 2010, A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse, Biology Of The Cell [P], vol 102, issue 2, Portland Press Ltd, UK & Germany, pp. 93-106.

Jamsai, D., O'Bryan, M.K., 2010, Genome-wide ENU mutagenesis for the discovery of novel male fertility regulators, Systems Biology in Reproductive Medicine [P], vol 56, issue 3, Informa Healthcare, UK, pp. 246-259.

Gibbs, G., Lo, C.Y.J., Nixon, B., Jamsai, D., O'Connor, A., Rijal, S., Sanchez-Partida, L.G., Hearn, M.T.W., Bianco, D.M., O'Bryan, M.K., 2010, Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding, Endocrinology [P], vol 151, issue 5, The Endocrine Society, USA, pp. 2331-2342.

Jamsai, D., O'Bryan, M.K., 2010, Mouse models in male fertility research, Asian Journal of Andrology [P], vol 13, Nature Publishing Group, USA, China, pp. 139-151.

Jamsai, D., Bianco, D.M., Smith, S.J., Merriner, D.J., Ly-Huynh, J.D., Herlihy, A., Niranjan, B., Gibbs, G.M., O'Bryan, M.K., 2008, Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail, Reproduction, vol 135, issue 6, Bio Scientifica Ltd, England, pp. 751-759.

Jamsai, D., Reilly, A., Smith, S.J., Gibbs, G.M., Baker, H.W.G., McLachlan, R.I., de Kretser, D.M., O'Bryan, M.K., 2008, Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian Men, Human Reproduction, vol 23, issue 9, Oxford University Press, UK, pp. 2151-2159.

Gibbs, G.M., Bianco, D.M., Jamsai, D., Herlihy, A., Ristevski, S., Aitken, R.J., de Kretser, D.M., O'Bryan, M.K., 2007, Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm, Biology of Reproduction, vol 77, issue 1, Soc Study Reproduction, Madison USA, pp. 108-114.

Jamsai, D., Zaibak, F., Vadolas, J., Voullaire, L., Fowler, K.J., Gazeas, S., Peters, H., Fucharoen, S., Williamson, R., Ioannou, P.A., 2006, A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia, Genomics [P], vol 88, issue 3, Academic Press, USA, pp. 309-315.

Vadolas, J., Nefedov, M., Wardan, H., Mansooriderakshan, S., Voullaire, L., Jamsai, D., Williamson, R., Ioannou, P.A., 2006, Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation, Journal Of Biological Chemistry [P], vol 281, issue 11, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 7399-7405.

Changsri, K., Akkarapathumwong, V., Jamsai, D., Winichagoon, P., Fucharoen, S., 2006, Molecular mechanism of high hemoglobin F production in Southeast Asian-type hereditary persistence of fetal hemoglobin, International Journal of Hematology [P], vol 83, issue 3, Springer Japan KK, Japan, pp. 229-237.

Jamsai, D., Zaibak, F., Khongnium, W., Vadolas, J., Voullaire, L., Fowler, K.J., Gazeas, S., Fucharoen, S., Williamson, R., Ioannou, P.A., 2005, A humanized mouse model for a common beta0-thalassemia mutation, Genomics [P], vol 85, issue 4, Academic Press, USA, pp. 453-461.

Vadolas, J., Wardan, H., Bosmans, M., Zaibak, F., Jamsai, D., Voullaire, L., Williamson, R., Ioannou, P.A., 2005, Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment, Biochimica et Biophysica Acta - Gene Regulatory M..., vol 1728, issue 3, Elsevier BV, The Netherlands, pp. 150-162.

Jamsai, D., Nefedov, M., Narayanan, K., Orford, M.R., Fucharoen, S., Williamson, R., Ioannou, P.A., 2003, Insertion of common mutations into the human beta-globin locus using GET Recombination and an EcoRI endonuclease counterselection cassette, Journal of Biotechnology [P], vol 101, issue 1, Elsevier BV, The Netherlands, pp. 1-9.

Jamsai, D., Orford, M.R., Fucharoen, S., Williamson, R., Ioannou, P.A., 2003, Insertion of modifications in the beta-globin locus using GET recombination with single-stranded oligonucleotides and denatured PCR fragments, Applied Biochemistry and Biotechnology - Part B Mol..., vol 23, issue 1, Humana Press, Inc., USA, pp. 29-36.

Jamsai, D., Orford, M.R., Nefedov, M., Fucharoen, S., Williamson, R., Ioannou, P.A., 2003, Targeted modification of a human beta-globin locus BAC clone using GET Recombination and an I-Scei counterselection cassette, Genomics [P], vol 82, issue 1, Academic Press, USA, pp. 68-77.

Conference Proceedings

O'Bryan, M.K., Borg, C.L., Jamsai, D., 2009, Mouse models as a tool to discover key regulators of male fertility, 9th International Congress of Andrology, 7-10 March 2009, MediMond International Proceedings, Italy, p. 57.

Grants

Title:

American Society of Andrology (ASA) 33rd Annual Conference, April 2008 Albuquerque, New Mexico.

Investigators:

Jamsai, D

Funding:

(2008 - 2011). CASS Foundation Limited.

Title:

GGN as a regulator of DNA double strand break repair and genome integrity.

Investigators:

O'Bryan, M, Jamsai, D, Ormandy, C, Handel, M

Funding:

(2011 - 2015). Australian Research Council (ARC).

Title:

Ian Potter Travel Grant Application - February 2007 (Jamsai).

Investigators:

Jamsai, D

Funding:

(2007 - 2011). Ian Potter Foundation.

Title:

Mouse models for human male infertility: ID 384297.

Investigators:

Jamsai, D

Funding:

(2006 - 2009). National Health & Medical Research Council (NHMRC).

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Refrigerated benchtop centrifuge.

Investigators:

Jamsai, D

Funding:

(2006 - 2010). Collier Charitable Fund.

(2006 - 2010). Monash University.

Title:

The mechanism of spermatid differentiation - a link to tumour suppression.

Investigators:

Jamsai, D

Funding:

(2010 - 2013). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:

Swain, L.

Program of Study:

THE DEVELOPMENT OF A MOUSE gDNA AND SPERM REPOSITORY FOR THE RAPID GENERATION OF GENETICALLY MODIFIED MOUSE LINES. (Masters) 2007.

Supervisors:

O''Bryan, M (Main), Jamsai, D (Associate).