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Assoc Prof Benjamin Boyd - Researcher Profile

Address

Faculty of Pharmacy and Pharmaceutical Sciences
381 Royal Parade, Parkville

Contact Details

Tel: +61 3 990 39112

Fax: +61 3 9903 9560

Email: Ben.Boyd@monash.edu

Web: http://www.pharm.monash.edu.au/research/mips/drugdelivery.html

Profile
Summary
Keywords
Qualifications
Publications
Teaching
Commitment
Activities
Supervisions

Biography

Position

Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Group coordinator – Drug Delivery Sciences group
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Nature at its finest

Read the rest of the profile

Macular degeneration is the world's leading cause of blindness, affecting 30 per cent of people over 70. Current treatments work only temporarily and must be delivered directly to the eye – to maintain their visions patients must endure monthly injections into the eyeball.

However, Professor Boyd's team are developing a novel from of drug delivery that could prevent sufferers from becoming, as he terms it, "pin-cushions".

Using naturally occurring lipids (molecules such as fats that bond together to form cell membranes) and agricultural surfactants (compounds commonly used in washing detergents to emulsify fats and oils) Professor Boyd can create new materials that contain and then deliver drugs where and when they are needed.

The process, detailed in a recent submission to the Journal of the American Chemical Society, allows for the creation of light-sensitive materials that will release a dose of drug only when "switched on" by the use of an external laser.

This process would mean patients undergo a single procedure to implant the material, and report to their ophthalmologist only as symptoms appear for a simple laser activated dose of sight-restoring drug.

The secret to Professor Boyd's delivery system lies in allowing self-assembling materials to bond together as they would in nature.

"These are purely self-assembled structures; they do the work themselves - it’s nature at its finest," Professor Boyd says.

"Once we understand the self-assembly process in materials we can begin to get them to do what we want, when we want them to do it. The drug delivery becomes the easy part. It’s getting the materials to do what we want them to do under the right conditions that's the trick."

Professor Boyd's team are also working on a targeted delivery system using the same materials.

Broken down into smaller particles, these drug-carrying materials would be introduced to the body and travel dormant through the blood stream, until they are ‘switched on’ by a laser beamed onto the specific site where they are needed.

While both the targeted and on-demand technologies are still in development, Professor Boyd has two further applications of the technology that are close to fruition.

His research group has received ARC Linkage funding to produce structured materials to create cheaper, more effective agricultural herbicides and pesticides that use less water in delivery. The engineered materials more vigorously cling to target crops, reducing losses caused by rain and resulting in orders of magnitude less chemicals and water used in the field.

Another ARC Linkage grant in conjunction with a biosensor company is being used to develop a hand-held meter capable of accurately and rapidly diagnosing conditions such as a heart attack in the doctor’s surgery . The biosensor would remove the ambiguity of diagnosing heart attacks - often confused with indigestion - and replace lengthy delays associated with current laboratory testing of blood samples.

Professor Boyd is confident both applications will become the core technology in the field within five years.

Keywords

Colloidal aspects of lipid-based formulation design and assessment, Dendrimers as colloidal drug delivery systems, Drug delivery, disposition and dynamics, Lipid based liquid crystalline drug delivery systems.

Qualifications

GRAD. DIP.DRUG EVALUATION & PHARMACEUTICAL SCIENCE: Institution: University of Melbourne; Year awarded: 2004

PHD CHEMISTRY: Institution: University of Melbourne; Year awarded: 1999

Publications

Book Chapters

Boyd, B., Nguyen, T., Mullertz, A., 2011, Lipids in oral controlled release drug delivery, in Controlled Release in Oral Drug Delivery, eds Clive G. Wilson, Patrick J. Crowley, Springer Science+Business Media, USA, pp. 299-327.

Kaminskas, L., Boyd, B., 2011, Nanosized drug delivery vectors and the reticuloendothelial system, in Intracellular Delivery: Fundamentals and Applications, eds Ales Prokop, Springer Science+Business Media, USA, pp. 155-178.

Boyd, B.J., 2005, Controlled Release from Cubic Liquid-Crystalline Particles (Cubosomes), in Bicontinuous Liquid Crystals, eds Matthew L. Lynch, Patrick T. Spicer, Taylor & Francis, Boca Raton Florida USA, pp. 285-304.

Drummond, C.J., Fong, C., Krodkiewksa, I., Boyd, B.J., Baker, I.J., 2003, Sugar fatty acid esters, in Novel surfactants: preparation, applications and biodegradability, eds Krister Holmberg, Marcell Dekker Inc, New York, pp. 95-128.

Journal Articles

Kaminskas, L., McLeod, V., Kelly, B., Sberna, G., Boyd, B., Williamson, M., Owen, D., Porter, C., 2012, A comparison of changes to doxorubicin pharmacokinetics, antitumour activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems, Nanomedicine-Nanotechnology Biology And Medicine [P], vol 8, issue 1, Elsevier, Netherlands, pp. 103-111.

Mulet, X., Boyd, B.J., Drummond, C.J., 2012, Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions, Journal of Colloid and Interface Science [P], vol online, issue online, Academic Press, United States, pp. e1-e20.

Fong, W.K., Malic, N., Evans, R.A., Hawley, A., Boyd, B.J., Hanley, T.L., 2012, Alkylation of spiropyran moiety provides reversible photo-control over nanostructured soft materials, Biointerphases [P], vol 7, issue 3, SpringerOpen, Heidelberg Germany, pp. e1-e5.

Kaminskas, L.M., McLeod, V.M., Porter, C.J., Boyd, B.J., 2012, Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation, Molecular Pharmaceutics [P], vol 9, issue 3, American Chemical Society, USA, pp. 355-373.

White, P.J., Hickey, P.L., Tu, L.S., Headey, S.J., Scanlon, M., Boyd, B.J., Pouton, C.W., 2012, Colloidal characteristics and formulation of pure protein particulate vaccines, Journal of Pharmacy and Pharmacology [P], vol 64, issue 10, John Wiley & Sons Ltd, United Kingdom, pp. 1386-1393.

Fong, W.K., Hanley, T.L., Thierry, B., Kirby, N., Waddington, L., Boyd, B.J., 2012, Controlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiation, Langmuir [P], vol 28, issue 40, American Chemical Society, Washington DC USA, pp. 14450-14460.

Kaminskas, L.M., McLeod, V.M., Kelly, B.D., Cullinane, C.M., Sberna, G., Williamson, M., Boyd, B.J., Owen, D.J., Porter, C.J., 2012, Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumour models, Molecular Pharmaceutics [P], vol 9, American Chemical Society, United States, pp. 422-432.

Wallace, S.J., Li, J., Nation, R.L., Boyd, B.J., 2012, Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology, Drug Delivery and Translational Research [E], vol 2, Springer, Germany, pp. 284-292.

Lau, S., Graham, B., Cao, N., Boyd, B.J., Pouton, C.W., White, P.J., 2012, Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation, Molecular Pharmaceutics [P], vol 9, issue 1, American Chemical Society, USA, pp. 71-80.

Chong, J., Mulet, X., Waddington, L., Boyd, B.J., Drummond, C.J., 2012, High-throughput discovery of novel steric stabilizers for cubic lyotropic liquid crystal nanoparticle dispersions, Langmuir [P], vol 28, American Chemical Society, USA, pp. 9223-9232.

Tan, A., Martin, A.L., Nguyen, T., Boyd, B.J., Prestidge, C.A., 2012, Hybrid nanomaterials that mimic the food effect: controlling enzymatic digestion for enhanced oral drug absorption, Angewandte Chemie [P], vol 51, issue 22, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 5475-5479.

Wallace, S.J., Li, J., Nation, R.L., Prankerd, R.J., Boyd, B.J., 2012, Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, John Wiley & Sons, USA, pp. 3347-3359.

Muir, B.W., Acharya, D.P., Kennedy, D., Mulet, X., Evans, R.A., Periera, S.M., Wark, K., Boyd, B.J., Nguyen, T., Hinton, T.M., Waddington, L., Kirby, N., Wright, D.K., Wang, H., Egan, G.F., Moffat, B.A., 2012, Metal-free and MRI visible theranostic lyotropic liquid crystal nitroxide-based nanoparticles, Biomaterials [P], vol 33, issue 19, Elsevier, Netherlands, pp. 2723-2733.

Boetker, J., Rades, T., Rantanen, J., Hawley, A., Boyd, B.J., 2012, Structural elucidation of rapid solution-mediated phase transitions in pharmaceutical solids using in situ synchrotron SAXS/WAXS, Molecular Pharmaceutics [P], vol 9, issue 9, American Chemical Society, Washington DC USA, pp. 2787-2791.

Boyd, B.J., 2012, Towards an understanding of nanostructures formed during digestion, and their impact on drug delivery and absorption, American Pharmaceutical Review [P], vol 15, issue 1, Russell Publishing LLC, Indianapolis Indiana USA, pp. 1-7.

Tilley, A.J., Dong, Y.D.C., Chong, J., Hanley, T.L., Kirby, N., Drummond, C.J., Boyd, B.J., 2012, Transfer of lipid between triglyceride dispersions and lyotropic liquid crystal nanostructured particles using time-resolved SAXS, Soft Matter [P], vol 8, issue 20, RSC Publications, Cambridge UK, pp. 5696-5708.

Dong, Y.D.C., Larson, I.C., Barnes, T., Prestidge, C.A., Allen, S., Chen, X., Roberts, C.J., Boyd, B.J., 2012, Understanding the interfacial properties of nanostructured liquid crystalline materials for surface-specific delivery applications, Langmuir [P], vol 28, issue 37, American Chemical Society, Washington DC, USA, pp. 13485-13495.

Dong, Y., Larson, I., Barnes, T., Prestidge, C., Boyd, B., 2011, Adsorption of nonlamellar nanostructured liquid-crystalline particles to biorelevant surfaces for improved delivery of bioactive compounds., ACS Applied Materials & Interfaces [P], vol 3, issue 5, American Chemical Society, USA, pp. 1771-1780.

Dong, C., Boyd, B., 2011, Applications of X-ray scattering in pharmaceutical science, International Journal of Pharmaceutics [P], vol 417, issue 1-2, Elsevier/North-Holland Biomedical Press, The Netherlands, pp. 101-111.

Kaminskas, L., McLeod, V., Sberna, G., Boyd, B., Owen, D., Porter, C., 2011, Capping methotrexate alpha-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers, Molecular Pharmaceutics [E], vol 8, American Chemical Society, USA, pp. 338-349.

Kaminskas, L., Kelly, B., McLeod, V., Sberna, G., Owen, D., Boyd, B., Porter, C., 2011, Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker, Journal of Controlled Release [P], vol 152, Elsevier Science Publishers, The Netherlands, pp. 241-248.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds, Journal of Nucleic Acids [E], vol 2011, issue 154609, SAGE-Hindawi Access to Research, England, pp. 1-5.

Kaminskas, L., Boyd, B., Porter, C., 2011, Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties, Nanomedicine [P], vol 6, issue 6, Future Medicine, UK, pp. 1063-1084.

Kaminskas, L., McLeod, V., Porter, C., Boyd, B., 2011, Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance, Journal of Pharmaceutical Sciences [P], vol 11, John Wiley & Sons Inc, USA, pp. 5069-5077.

Phan, S., Fong, W., Kirby, N., Hanley, T., Boyd, B., 2011, Evaluating the link between self-assembled mesophase structure and drug release, International Journal of Pharmaceutics [P], vol 421, issue 1, Elsevier/North-Holland Biomedical Press, The Netherlands, pp. 176-182.

Nguyen, T., Hanley, T., Porter, C., Boyd, B., 2011, Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poorly water soluble drug after oral administration, Journal of Controlled Release [P], vol 153, Elsevier, Netherlands, pp. 180-186.

Rizwan, S., Assmus, D., Boehnke, A., Hanley, T., Boyd, B., Rades, T., Hook, S., 2011, Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines, European Journal of Pharmaceutics and Biopharmaceutics [P], vol 79, issue 1, Wissenschaftliche Verlagsgesellschaft - Elsevier Science, Netherlands, pp. 15-22.

Warren, D., Anby, M., Hawley, A., Boyd, B., 2011, Real time evolution of liquid crystalline nanostructure during the digestion of formulation lipids using synchrotron small-angle X-ray scattering, Langmuir [P], vol 27, American Chemical Society, USA, pp. 9528-9534.

Zhai, J., Waddington, L., Wooster, T.J., Aguilar, M., Boyd, B.J., 2011, Revisiting beta-casein as a stabilizer for lipid liquid crystalline nanostructured particles, Langmuir [P], vol 27, issue 24, American Chemical Society, USA, pp. 14757-14766.

Chong, J., Mulet, X., Waddington, L., Boyd, B., Drummond, C., 2011, Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers, Soft Matter [P], vol 7, issue 10, The Royal Society of Chemistry, UK, pp. 4768-4777.

Tilley, A., Dong, C., Amenitsch, H., Rappolt, M., Boyd, B., 2011, Transfer of lipid and phase reorganisation in self-assembled liquid crystal nanostructured particles based on phytantriol, Physical Chemistry Chemical Physics [P], vol 13, Royal Society of Chemistry, England, pp. 3026-3032.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of SiRNA across the vascular endothelium, Journal Of Gene Medicine [P], vol 13, issue 7-8, WILEY-BLACKWELL, USA, p. 438.

Rizwan, S., Boyd, B., Rades, T., Hook, S., 2010, Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins, Expert Opinion on Drug Delivery [P], vol 7, issue 10, Informa Healthcare, United Kingdom, pp. 1133-1144.

Dong, C.Y., Tilley, A.J., Larson, I.C., Lawrence, J., Amenitsch, H., Rappolt, M., Hanley, T.L., Boyd, B.J., 2010, Nonequilibrium effects in self-assembled mesophase materials: unexpected supercooling effects for cubosomes and hexosomes, Langmuir [P], vol 26, issue 11, American Chemical Society, USA, pp. 9000-9010.

Nguyen, T., Hanley, T., Porter, C., Larson, I., Boyd, B., 2010, Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant media, Journal of Pharmacy and Pharmacology [P], vol 62, John Wiley & Sons Ltd., United Kingdom, pp. 844-855.

Nguyen, T., Hanley, T., Porter, C., Larson, I., Boyd, B., 2010, Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water-soluble drugs II. In-vivo evaluation, Journal of Pharmacy and Pharmacology [P], vol 62, issue 7, John Wiley & Sons Ltd., United Kingdom, pp. 856-865.

Fong, W.K., Hanley, T.L., Thierry, B., Kirby, N., Boyd, B.J., 2010, Plasmonic nanorods provide reversible control over nanostructure of self-assembled drug delivery materials, Langmuir [P], vol 26, issue 9, American Chemical Society, USA, pp. 6136-6139.

Wallace, S.J., Li, J., Nation, R.L., Prankerd, R.J., Velkov, T., Boyd, B.J., 2010, Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization, Journal of Physical Chemistry B [P], vol 114, American Chemical Society, USA, pp. 4836-4840.

Tan, A., Simovic, S., Davey, A., Rades, T., Boyd, B.J., Prestidge, C.A., 2010, Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems, Molecular Pharmaceutics [P], vol 7, issue 2, American Chemical Society, USA, pp. 522-532.

Pascual-Izzara, C., Dong, A., Pas, S.J., Boyd, B.J., Drummond, C.J., Hill, A., 2009, Advanced algorithms for PALS analysis of self-assembled amphiphiles, Materials Science Forum [P], vol 607, issue 0, Thompson Scientific, Switzerland, pp. 257-259.

Pascual-Izzara, C., Dong, A., Pas, S.J., Hill, A., Boyd, B.J., Drummond, C.J., 2009, Advanced fitting algorithms for analysing positron annihilation lifetime spectra, Nuclear Instruments & Methods In Physics Research..., vol 603, issue 3, Elsevier BV, The Netherlands, pp. 456-466.

Tilley, A.J., Morton, D.A.V., Hanley, T., Boyd, B.J., 2009, Liquid crystalline coated drug particles as a potential route to long acting intravitreal steroids, Current Drug Delivery [P], vol 6, issue 4, Bentham Science Publishers Ltd, Netherlands, pp. 322-331.

Rizwan, S.B., Hanley, T., Boyd, B.J., Rades, T., Hook, S., 2009, Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics, Journal of Pharmaceutical Sciences [P], vol 98, issue 11, John Wiley & Sons, Inc., USA, pp. 4191-4204.

Lee, K.W., Nguyen, T., Hanley, T., Boyd, B.J., 2009, Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs, International Journal of Pharmaceutics [P], vol 365, issue 1-2, Elsevier BV, Netherlands, pp. 190-199.

Boyd, B.J., Dong, Y., Rades, T., 2009, Nonlamellar liquid crystalline nanostructured particles: advances in materials and structure determination, Journal Of Liposome Research [P], vol 19, issue 1, Informa Healthcare, US, pp. 12-28.

White, P.J., Anastasopoulos, F., Pouton, C.W., Boyd, B.J., 2009, Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides., Expert Reviews in Molecular Medicine [P], vol 11, issue e10, Cambridge University Press, UK, pp. 1-19.

Kaminskas, L.M., Kelly, B.D., McLeod, V.M., Boyd, B.J., Krippner, G.Y., Williams, E., Porter, C.J., 2009, Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers, Molecular Pharmaceutics [P], vol 6, issue 4, American Chemical Society, USA, pp. 1190-1204.

Dong, A., Pascual-Izzara, C., Pas, S.J., Hill, A., Boyd, B.J., Drummond, C.J., 2009, Positron annihilation lifetime spectroscopy (PALS) as a characterization technique for nanostructured self-assembled amphiphile systems, Journal of Physical Chemistry B [P], vol 113, issue 1, American Chemical Society, USA, pp. 84-91.

Fong, W.K., Hanley, T.L., Boyd, B.J., 2009, Stimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivo, Journal of Controlled Release [P], vol 135, issue 3, Elsevier BV, The Netherlands, pp. 218-226.

White, P.J., Anastasopoulos, F., Church, J.E., Kuo, C.(., Boyd, B.J., Hickey, P.L., Sze Tu, L., Burns, P., Lew, A.M., Heath, W.R., Davey, G.M., Pouton, C.W., 2008, Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants, Vaccine, vol 26, issue 52, Elsevier Ltd, Netherlands, pp. 6824-6831.

Dong, Y., Dong, A., Larson, I.C., Rappolt, M., Amenitsch, H., Hanley, T.L., Boyd, B.J., 2008, Impurities in commercial phytantriol significantly alter its lyotropic liquid-crystalline phase behavior, Langmuir, vol 24, issue 13, American Chemical Society, USA, pp. 6998-7003.

Boyd, B.J., 2008, Past and future evolution in colloidal drug delivery systems, Expert Opinion in Drug Delivery, vol 5, issue 1, Informa UK, United Kingdom, pp. 69-85.

Kaminskas, L.M., Boyd, B.J., Karellas, P., Krippner, G.Y., Lessene, R., Kelly, B., Porter, C.J., 2008, The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of pegylated poly L-lysine dendrimers, Molecular Pharmaceutics, vol 5, issue 3, Amercian Chemical Society, USA, pp. 449-463.

Boyd, B.J., Khoo, S.M., Whittaker, D.V., Davey, G., Porter, C.J., 2007, A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats, International Journal of Pharmaceutics, vol 340, issue 1-2, Elsevier, Netherlands, pp. 52-60.

Rizwan, S.B., Dong, Y., Boyd, B.J., Rades, T., Hook, S., 2007, Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM), Micron, vol 38, Pergamon, UK, pp. 478-485.

Kaminskas, L.M., Boyd, B.J., Karellas, P., Henderson, S., Giannis, M., Krippner, G.Y., Porter, C.J., 2007, Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition, Molecular Pharmaceutics, vol 4, issue 6, American Chemical Society, US, pp. 949-961.

Boyd, B.J., Rizwan, S., Dong, Y., Hook, S.M., Rades, T., 2007, Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: hexosomes are not necessarily flat hexagonal prisms, Langmuir, vol 23, issue 25, American Chemical Society, USA, pp. 12461-12464.

Dong, Y., Larson, I.C., Hanley, T.L., Boyd, B.J., 2006, Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructure, Langmuir, vol 22, issue 23, American Chemical Society, USA, pp. 9512-9518.

Boyd, B.J., Kaminskas, L.M., Karellas, P., Krippner, G.Y., Lessene, R., Porter, C.J.H., 2006, Cationic poly-L-lysine dendrimers: Pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats, Molecular Pharmaceutics, vol 3, issue 5, American Chemical Society, USA, pp. 614-627.

Sek, L., Boyd, B.J., Charman, W.N., Porter, C.J.H., 2006, Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone, Journal of Pharmacy and Pharmacology, vol 58, issue 6, Pharmaceutical Press, UK, pp. 809-820.

Boyd, B.J., Whittaker, D.V., Khoo, S., Davey, G., 2006, Hexosomes formed from glycerate surfactants-Formulation as a colloidal carrier for irinotecan, International Journal of Pharmaceutics, vol 318, issue 1-2, Elsevier BV, Netherlands, pp. 154-162.

Boyd, B.J., Whittaker, D.V., Khoo, S., Davey, G., 2006, Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems, International Journal of Pharmaceutics, vol 309, issue 1-2, Elsevier BV, Netherlands, pp. 218-226.

Ma, J., Boyd, B.J., Drummond, C.J., 2006, Positional isomers of linear sodium dodecyl benzene sulfonate: solubility, self-assembly, and air/water interfacial activity, Langmuir, vol 22, issue 21, American Chemical Society, USA, pp. 8646-8654.

Boyd, B.J., 2005, Colloidal Drug Delivery, Drug Delivery Report Autumn/Winter 2005, vol 15, PharmaVentures, UK, pp. 63-70.

Kossena, G.A., Charman, W.N., Boyd, B.J., Porter, C.J.H., 2005, Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug, Journal of Pharmaceutical Sciences, vol 94, issue 3, John Wiley & Sons, Inc., USA, pp. 481-492.

Fong, C., Krodkiewska, I., Wells, D., Boyd, B.J., Booth, J., Bhargava, S., McDowall, A., Hartley, P.G., 2005, Submicron dispersions of hexosomes based on novel glycerate surfactants, Australian Journal of Chemistry, vol 58, issue 9, CSIRO Publishing, Australia, pp. 683-687.

Kossena, G.A., Charman, W.N., Boyd, B.J., Porter, C.J.H., 2004, A novel cubic phase of medium chain lipid origin for the delivery of poorly water soluble drugs, Journal of Controlled Release, vol 99, issue 2, Elsevier, The Netherlands, pp. 217-229.

Kaukonen, A., Boyd, B.J., Porter, C.J.H., Charman, W.N., 2004, Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations, Pharmaceutical Research, vol 21, issue 2, Kluwer Academic/Plenum Publishers, Dordrecht The Netherlands, pp. 245-253.

Kaukonen, A., Boyd, B.J., Charman, W.N., Porter, C.J.H., 2004, Drug solubilization behaviour during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids, Pharmaceutical Research, vol 21, issue 2, Kluwer Academic/Plenum Publishers, Dordrecht The Netherlands, pp. 254-260.

Kossena, G.A., Charman, W.N., Boyd, B.J., Dunstan, D.E., Porter, C.J.H., 2004, Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach, Journal of Pharmaceutical Sciences, vol 93, issue 2, Wiley-Liss, Inc., Hoboken USA, pp. 332-348.

Porter, C.J.H., Kaukonen, A., Boyd, B.J., Edwards, G.A., Charman, W.N., 2004, Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation, Pharmaceutical Research, vol 21, issue 8, Kluwer Academic/Plenum Publishers, Dordrecht The Netherlands, pp. 1405-1412.

Porter, C.J.H., Kaukonen, A., Taillardat-Bertschinger, A., Boyd, B.J., O'Connor, J.M., Edwards, G.A., Charman, W.N., 2004, Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine, Journal of Pharmaceutical Sciences, vol 93, issue 5, John-Liss, Inc., Hoboken USA, pp. 1110-1121.

Boyd, B.J., 2003, Characterisation of drug release from cubosomes using the pressure ultrafiltration method, International Journal of Pharmaceutics, vol 260, issue 2, Elsevier Science BV, pp. 239-247.

Kossena, G.A., Boyd, B.J., Porter, C.J.H., Charman, W.N., 2003, Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs, Journal of Pharmaceutical Sciences, vol 92, issue 3, John Wiley & Sons, Inc., USA, pp. 634-648.

Boyd, B.J., Porter, C.J.H., Charman, W.N., 2003, Using the polymer partitioning method to probe the thermodynamic activity of poorly water-soluble drugs solubilized in model lipid digestion products, Journal of Pharmaceutical Sciences, vol 92, issue 6, John Wiley & Sons, Inc., USA, pp. 1262-1271.

Boyd, B.J., Krodkiewska, I., Drummond, C., Grieser, F., 2002, Chiral glucose-derived surfactants: the effect of stereochemistry on thermotropic and lyotropic phase behaviour, Langmuir, vol 18, American Chemical Society, USA, pp. 597-601.

Boyd, B.J., Drummond, C., Krodkiewska, I., Weerawardena, i., Furlong, D., Grieser, F., 2001, Alkyl chain positional isomers of dodecyl beta-D-glucoside: Thermotropic and lyotropic phase behavior and detergency, Langmuir, vol 17, issue 20, American Chemical Society, USA, pp. 6100-6107.

Boyd, B.J., Drummond, C., Krodkiewska, I., Grieser, F., 2000, How chain length, headgroup polymerization, and anomeric configuration govern the thermotropic and lyotropic liquid crystalline phase behavior and the air-water interfacial adsorption of glucose-based surfactants, Langmuir, vol 16, issue 19, American Chemical Society, USA, pp. 7359-7367.

Conference Proceedings

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of sirna across the vascular endothelium, The Journal of Gene Medicine, 04-06 Mat 2011, John Wiley & Sons, England, p. e1.

Boyd, B., 2010, Assessing stabilizers for non-lamellar liquid crystalline particles, International Conference on Nanoscience and Nanotechnology (ICONN), Sydney, 2010, Australian Research Council Nanotechnology network, Australia, pp. 1-2.

Boyd, B., 2010, Plasmonic switching of liquid crystalline nanostructure for external control over drug delivery, ICONN 2010, Australian Research Council Nanotechnology Network, Australia, pp. 1-2.

Boyd, B., 2010, Surface and interfacial properties of nanostructured liquid crystalline systems, International Conference on Nanoscience and Nanotechnology (ICONN), Sydney, 2010, Australian Research Council Nanotechnology Network, Australia, pp. 1-2.

Lee, K.W., Porter, C.J., Boyd, B.J., 2009, Gastric procesing is a critical determinant of the ability of lipid-based formulations to enhance the oral bioavailability of a model poorly water-soluble drug, 36th Annual Meeting & Exposition of the Controlled Release Society, 18/07-22/07/2009, Controlled Release Society, USA, p. on cd.

Boyd, B.J., Nguyen, T., Hanley, T., Porter, C.J., 2009, Non-digestible lipid-based liquid crystalline formulations, even in dispersed submicron form, provide dramatically sustained plasma concentrations for poorly water soluble drugs., 36th Annual Meeting & Exposition of the Controlled Release Society, 18/07-22/07/2009, Controlled Release Society, USA, p. on cd.

Boyd, B.J., Fong, W.K., Hanley, T., 2009, Responsive lipid-based mesophase materials - opportunity for a new class of on demand drug delivery system, 36th Annual Meeting & Exposition of the Controlled Release Society, 18/07-22/07/2009, Controlled Release Society, USA, p. on cd.

Dong, A., Pascual-Izzara, C., Dong, Y., Pas, S.J., Hill, A.J., Boyd, B.J., Drummond, C.J., 2008, Positron annihilation lifetime spectroscopy (PALS) and small angle x-ray scattering (SAXS) of self-assembled amphiphiles, Proceedings of SPIE 2007: Microelectronics, MEMS, and Nanotechnology, 4 December 2007 to 7 December 2007, SPIE The International Society of Optical Engineering, Australia, pp. 1-6.

Boyd, B.J., 2006, Oral Drug Delivery 2020?, Proceedings of the Annual Conference of the Australasian Pharmaceutical Science Association, 03 December 2006 to 05 December 2006, Australia.

Lee, K.W.Y., Boyd, B.J., 2006, Tailoring nanostructured liquid crystalline materials to control the oral absorption of hydrophilic compounds, Proceedings of the 33rd Annual Meeting and Exposition of the Controlled Release Society, 22 July 2006 to 26 July 2006, Controlled Release Society, St Paul USA, p. 649.

Other

Goodchild, J., Goodchild, C., Boyd, B., 2011, Anaesthetic Formulation, Switzerland.

Boyd, B., Warren, D., Hawley, A., Dong, C., 2010, Real-time structural evolution during digestion of lipid-based delivery systems for poorly water-soluble drugs, Personalized medicines and products for the next generation, Curran Associates, USA.

Boyd, B.J., Davey, G.A., Drummond, C.J., Fong, C., Hartley, P.G., Krodkiewska, I., Murphy, A.J., Tait, R.J., Warr, G.G., Wells, D., Whittaker, D.V., Ye, Y.R., 2009, Urea-, glycerate- and, hydroxyamide-headed hydrocarbon chain lyotropic phases forming surfactants, Australia.

Dong, C.Y., Boyd, B.J., Larson, I.C., 2007, Agrochemical composition comprising liquid crystal particles, United States of America.

Krippner, G.Y., Lichti, G., Razzino, P., Kelly, B.D., Pallich, S., Henderson, S.A., Scheppokat, A.M., Williams, C.C., Porter, C.J., Boyd, B.J., Kaminskas, L.M., Rendle, P.M., Greatrex, B.W., 2007, Macromolecular compounds having controlled stoichiometry, Australia, Europe.

Boyd, B.J., Kaminskas, L.M., Porter, C.J., Karellas, P., Krippner, G.Y., Kelly, B.D., Wu, Z., Razzino, P., Pallich, S., 2007, Modified Macromolecule, Australia, Europe.

Khoo, S.M., Boyd, B.J., Whittaker, D.V., Davey, G.A., Drummond, C.J., Murphy, A.J., Tait, R.J., 2005, Compositions and Methods for Delivery of Biologically Active Agents, Australia, USA, Europe, Asia.

Boyd, B.J., Davey, G.A., Drummond, C.J., Fong, C., Hartley, P., Krodkiewska, I., Murphy, A.J., Tait, R.J., Warr, G.G., Wells, D., Whittaker, D.V., Ye, Y.R., 2004, Urea-, glycerate- and, hydroxyamide-headed hydrocarbon chain lyotropic phases forming surfactants, Worldwide.

Teaching Commitment

Bachelor of Pharmaceutical Sciences

First year physical chemistry
Second year product development (including industry placements)
Third year - Advanced Formulation and Nanotechnology

Activities

Affiliations with institutes

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Visiting professorships, fellowships, or other appointments

Honorary Lecturer
University of Otago

Postgraduate Research Supervisions

Current Supervision

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Biofunctionalised liquid crystal nanoparcticles as targeted responsive drug delivery systems.
Supervisors:: Boyd, B (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Cyclodextrin nanoparticles for drug delivery.
Supervisors:: Majumder, M (Main), Boyd, B (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Developing a novel polymer recycling system.
Supervisors:: Saito, K (Main), Boyd, B (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Lipid self assembly structure and drug behaviour during real-time digestion of lipid based formulation..
Supervisors:: Boyd, B (Main).

Program of Study:: (MASTER'S BY RESEARCH).
Thesis Title:: Magnesium alloys as bioresorbable biomaterials.
Supervisors:: Birbilis, N (Main), Boyd, B (Associate), Nisbet, D (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Nanostructure at complex surfactant-polymer interfaces.
Supervisors:: Boyd, B (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Photoresponsive self-assembled nanomaterials for on-demand drug delivery.
Supervisors:: Boyd, B (Main).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Structural effects on the acid-base behaviour of drugs.
Supervisors:: Prankerd, R (Main), Boyd, B (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: TBA.
Supervisors:: Prankerd, R (Main), Boyd, B (Associate).

Program of Study:: (DOCTORATE BY RESEARCH).
Thesis Title:: Understanding Rapid Structural Transformations in Solid State Pharmaceutical Systems.
Supervisors:: Boyd, B (Main), Larson, I (Associate).

Completed Supervision

Student:: Dong, A.
Program of Study:: Application of positron annihilation lifetime spectroscopy (PALS) to the characterization of nanostructure in ordered self-assembled systems. (PHD) 2012.
Supervisors:: Boyd, B (Main).
Student:: Dong, Y.
Program of Study:: Investigation of nanostructured liquid crystal particles as novel agrochemical delivery agents. (PHD) 2009.
Supervisors:: Larson, I (Main), Boyd, B (Associate).
Student:: Kossena, G.
Program of Study:: Assessing the phase behaviour, solubilisation and bioavailability enhancement provided by the digestion products of commonly used formulation lipids. (PHD) 2005.
Supervisors:: Porter, C (Main), Charman, W (Associate), Boyd, B (Associate).
Student:: Nguyen, T.
Program of Study:: Investigation of novel liquid crystalline materials for the sustained oral delivery of poorly water soluble drugs. (PHD) 2008.
Supervisors:: Boyd, B (Main), Larson, I (Associate), Porter, C (Associate).
Student:: Wallace, S.
Program of Study:: Formulation approaches to pulmonary delivery of colistin combination antibiotic therapy. (PHD) 2011.
Supervisors:: Nation, R (Main), Boyd, B (Associate), Li, J (Associate).