Assoc Prof Philip Thompson - Researcher Profile

Biography

Position

Associate Dean (Research Training)
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Research & Supervision Interests

• Structure-based design and synthesis of kinase and phosphodiesterase inhibitors
• Peptides and Peptidomimetics

Keywords

Structure-based design and synthesis of kinase, phosphodiesterase inhibitors, Peptides and Peptidomimetics

Qualifications

BSc(Hons)

Institution: University of Melbourne

Year awarded: 2006

PhD

Institution: University of Melbourne

Year awarded: 1991

Publications

Book Chapters

Mercer, L.D., Nunan, J., Jones, N.M., Lawrence, A.J., Cheung, N.S., Mercer, J.F., Firth, S.D., Thompson, P.E., Jarrott, B., Finkelstein, D.I., Beart, P.M., 1999, Immunohistochemistry with antibodies to the Cholecystokinin-A receptor reveals a widespread distribution in rat and monkey central nervous system, in Peptidergic G protein-coupled receptors: from basic research to clinical applications, IOS Press, Amsterdam Netherlands, pp. 175-180.

Journal Articles

Liu, M., Mountford, S.J., Zhang, L., Lee, I.J., Herzog, H., Thompson, P., 2013, Synthesis of BVD15 peptide analogues as models for radioligands in tumour imaging, International Journal Of Peptide Research And Therapeutics [P], vol 19, Springer, New York USA, pp. 33-41.

Zheng, Z., Amran, S.I., Zhu, J., Schmidt-Kittler, O., Kinzler, K., Vogelstein, B., Shepherd, P.R., Thompson, P., Jennings, I., 2012, Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis, Biochemical Journal [P], vol 444, Portland Press Ltd., UK, pp. 529-535.

Nguyen, W., Howard, B.L., Jenkins, D., Wulff, H., Thompson, P., Manallack, D.T., 2012, Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate, Bioorganic & Medicinal Chemistry Letters [P], vol 22, issue 23, Pergamon, UK, pp. 7106-7109.

Azad, M.A.K., Huang, J.X., Cooper, M.A., Roberts, K.D., Thompson, P., Nation, R.L., Li, J., Velkov, T., 2012, Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein, Biochemical Pharmacology [P], vol 84, issue 3, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 278-291.

Pinson, J., Schmidt-Kittler, O., Frazzetto, M., Zheng, Z., Jennings, I., Kinzler, K., Vogelstein, B., Chalmers, D.K., Thompson, P., 2012, Synthesis and pharmacological evaluation of 4-iminothiazolidinones for inhibition of PI3 kinase, Australian Journal of Chemistry [E], vol 65, issue 10, CSIRO Publishing, Australia, pp. 1396-1404.

Kamaruddin, M., Ung, P., Hossain, M., Jarasrassamee, B., O'Malley, W., Thompson, P., Scanlon, D., Cheng, H., Graham, B., 2011, A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 1, Pergamon, United Kingdom, pp. 329-331.

Velkov, T., Thompson, P., El-Kabbani, O., Lindh, F., Stambas, J., Rockman, S., 2011, A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses, Acta Virologica [P], vol 55, issue 2, AEPRESS SRO, SLOVAKIA, pp. 131-137.

Howard, B., Thompson, P., Manallack, D., 2011, Active site similarity between human and plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design, Journal Of Computer-Aided Molecular Design [P], vol 25, issue 8, SPRINGER, NETHERLANDS, pp. 753-762.

Agostino, M.J., Sandrin, M.S., Thompson, P.E., Farrugia, W., Ramsland, P.A., Yuriev, E., 2011, Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications, Expert Opinion on Biological Therapy [P], vol 11, issue 2, Informa Healthcare, UK, pp. 211-224.

Agostino, M., Sandrin, M., Thompson, P., Farrugia, W., Ramsland, P., Yuriev, E., 2011, Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications, Expert Opinion on Biological Therapy [P], vol 11, issue 2, Informa UK Ltd, UK, pp. 211-224.

Cheng, A., Kotsimbos, T.C., Reynolds, A., Bowler, S., Brown, S., Hancox, R., Holmes, M., Irving, L., Jenkins, C., Thompson, P.E., Simpson, G., Waterer, G., Wood-Baker, R., Kelly, P.M., 2011, Clinical and epidemiological profile of patients with severe H1N1/09 pandemic influenza in Australia and New Zealand: An observational cohort study, British Medical Journal [P], vol E, issue 1 (Art. No: e000100), B M J Group, United Kingdom, pp. 1-7.

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R., Li, J., 2011, Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions, Analytical Biochemistry [P], vol 409, issue 2, Academic Press, United States, pp. 273-283.

Blackmore, T., Thompson, P., 2011, IMIDAZOLIDIN-4-ones: their syntheses and applications, Heterocycles [P], vol 83, issue 9, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 1953-1975.

Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P., Chai, S., 2011, Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers, British Journal of Pharmacology [P], vol 164, issue 1, John Wiley & Sons Ltd, UK, pp. 37-47.

Zheng, Z., Amran, S., Thompson, P., Jennings, I., 2011, Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110 alpha inhibition, Molecular Pharmacology [P], vol 80, issue 4, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, USA, pp. 657-664.

Agostino, M., Sandrin, M., Thompson, P., Ramsland, P., Yuriev, E., 2011, Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens, Biopolymers [P], vol 96, issue 2, John Wiley & Sons, Inc., United States, pp. 193-206.

Kwezi, L., Ruzvidzo, O., Wheeler, J., Grovender, K., Iacuone, S., Thompson, P., Gehring, C., Irving, H., 2011, The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants, Journal Of Biological Chemistry [P], vol 286, issue 25, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, Saudi Arabia, pp. 22580-22588.

Pinson, J., Schmidt-Kittler, O., Zhu, J., Jennings, I., Kinzler, K., Vogelstein, B., Chalmers, D., Thompson, P., 2011, Thiazolidinedione-based PI3K alpha inhibitors: an analysis of biochemical and virtual screening methods, Chemmedchem [P], vol 6, issue 3, WILEY-BLACKWELL, USA, pp. 514-522.

Nankervis, J., Feil, S., Hancock, N., Zheng, Z., Ng, H., Morton, C., Holien, J., Ho, P., Frazzetto, M., Jennings, I., Manallack, D., Martin, T., Thompson, P., Parker, M., 2011, Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 23, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 7089-7093.

Neale, D., Thompson, P., White, P., Chalmers, D., Yuriev, E., Manallack, D., 2010, Binding mode prediction of PDE4 inhibitors: a comparison of modelling methods, Australian Journal of Chemistry [E], vol 63, issue 3, C S I R O Publishing, Australia, pp. 396-404.

Agostino, M., Sandrin, M., Thompson, P., Yuriev, E., Ramsland, P., 2010, Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps, Glycobiology [P], vol 20, issue 6, Oxford University Press, United States, pp. 724-735.

Albiston, A., Pham, V., Ye, S., Ng, L., Lew, R., Thompson, P., Butler, J., Morton, C., Parker, M., Chai, S., 2010, Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase, Molecular Pharmacology [P], vol 78, issue 4, The American Society for Pharmacology and Experimental Therapeutics, Bethesda Maryland USA, pp. 600-607.

Velkov, T., Thompson, P., Nation, R.L., Li, J., 2010, Structure-Activity Relationships of Polymyxin Antibiotics, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, USA, pp. 1898-1916.

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P., Thompson, P., 2010, Synthesis of "difficult" fluorescence quenched substrates of granzyme C, International Journal of Peptide Research and Therapeutics [E], vol 16, Springer, New York New York USA, pp. 159-165.

Nguyen, W., Neale, D., Howard, B., Thompson, P., White, P., Wulff, H., Manallack, D., 2010, Use of Kv1.3 blockers for inflammatory skin conditions, Current Medicinal Chemistry [P], vol 17, issue 26, Bentham Science Publishers Ltd., Netherlands, pp. 2882-2896.

Agostino, M.J., Sandrin, M.S., Thompson, P., Yuriev, E., Ramsland, P.A., 2009, In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies, Molecular Immunology [P], vol 47, issue 2-3, Pergamon, UK, pp. 233-246.

Kaiserman, D., Buckle, A.M., Van Damme, P., Irving, J.A., Law, R.H.P., Matthews, A.Y., Bashtannyk-Puhalovich, T.A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J.C., Bird, P.I., 2009, Structure of granzyme C reveals an unusual mechanism of protease autoinhibition, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 14, National Academy of Sciences, USA, pp. 5587-5592.

Paxman, J.J., Borg, N., Horne, H.J., Thompson, P., Chin, K.Y., Sharma, P., Simpson, J.S., Wielens, J., Piek, S., Kahler, C.M., Sakellaris, H., Pearce, M.C., Bottomley, S.P., Rossjohn, J., Scanlon, M., 2009, The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes, Journal Of Biological Chemistry [P], vol 284, issue 26, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 17835-17845.

Hanna-Elias, A., Thompson, P., Manallack, D.T., Irving, H.R., Coupar, I.M., Berque-Bestel, I., Iskander, M.N., 2009, The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands, Protein and Peptide Letters [P], vol 16, issue 7, Bentham Science Publishers Ltd., Netherlands, pp. 805-809.

Ng, N.M., Quinsey, N.S., Matthews, A.Y., Kaiserman, D., Wijeyewickrema, L.C., Bird, P.I., Thompson, P.E., Pike, R.N., 2009, The effects of exosite occupancy on the substrate specificity of thrombin, Archives Of Biochemistry And Biophysics [P], vol 489, issue 1-2, Academic Press, USA, pp. 48-54.

Camerino, M.A., Chalmers, D.K., Thompson, P., 2008, Computer-assisted design of cyclic peptides and peptidomimetics, Chimica Oggi- Chemistry Today, vol 26, issue 5, Tekno Scienze, Italy, pp. 46-51.

Frazzetto, M., Suphioglu, C., Zhu, J., Schmidt-Kittler, O., Jennings, I., Cranmer, S.L., Jackson, S., Kinzler, K., Vogelstein, B., Thompson, P., 2008, Dissecting isoform selectivity of P13K inhibitors: The role of non-conserved residues in the catalytic pocket, Biochemical Journal, vol 414, issue 3, Portland Press Ltd., UK, pp. 383-390.

Camerino, M.A., Kong, D.C.M., Chalmers, D.K., Thompson, P., 2008, Solid phase synthesis and circular dichroism analysis of (i -> i + 4) cyclic lactam analogues of kisspeptin, International Journal of Peptide Research and Therapeutics, vol 14, issue 4, Springer, Netherlands, pp. 323-331.

Vivian, J., Scoullar, J., Robertson, A.L., Bottomley, S.P., Horne, H.J., Chin, K.Y., Wielens, J., Thompson, P., Velkov, T., Piek, S., Byres, E., Beddoe, T.C., Wilce, M.C., Kahler, C.M., Rossjohn, J., Scanlon, M., 2008, Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis, The Journal of Biological Chemistry, vol 283, issue 47, American Society for Biochemistry and Molecular Biology Inc., United States, pp. 32452-32461.

Thompson, P., Manganiello, V., Degerman, E., 2007, Re-discovering PDE3 inhibitors - New opportunities for a long neglected target, Current Topics in Medicinal Chemistry, vol 7, issue 4, Bentham Science Publishers Ltd, Netherlands, pp. 421-436.

Abbott, B., Thompson, P.E., 2006, Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity, Bioorganic & Medicinal Chemistry Letters, vol 16, issue 4, Pergamon, UK, pp. 969-973.

Kaiserman, D., Bird, C.H., Sun, J., Matthews, A.Y., Ung, K.S., Whisstock, J.C., Thompson, P.E., Trapani, J.A., Bird, P.I., 2006, The major human and mouse granzymes are structurally and functionally divergent, The Journal of Cell Biology, vol 175, issue 4, Rockefeller University Press, USA, pp. 619-630.

Abbott, B.M., Thompson, P.E., 2005, A reversed-phase HPLC-based method for the assay of cyclic nucleotide phosphodiesterase activity, Analytical Biochemistry, vol 339, issue 1, Academic Press Inc, Elsevier Science, San Diego, USA, pp. 185-187.

Cranmer, S.L., Pikovski, I., Mangin, P.H., Thompson, P.E., Domagala, T., Frazzetto, M., Salem, H.H., Jackson, S.P., 2005, Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha, Biochemical Journal, vol 387, issue 3, Portland Press Ltd, London UK, pp. 849-858.

Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V.B., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H., 2005, PI 3-kinase p110beta: A new target for antithrombotic therapy, Nature Medicine, vol 11, issue 5, Nature Publishing Group, New York USA, pp. 507-514.

Manallack, D.T., Hughes, R.A., Thompson, P.E., 2005, The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases, Journal of Medicinal Chemistry, vol 48, issue 10, American Chemical Society, USA, pp. 3449-3462.

Abbott, B.M., Thompson, P., 2004, PDe2 inhibition by the PI3 kinase inhibitor LY294002 and analogues, Bioorganic & Medicinal Chemistry Letters, vol 14, issue 11, Elsevier Ltd, Australia, pp. 2847-2851.

Abbott, B.M., Thompson, P., 2003, Synthetic studies of the phosphatidylinositol 3-kinase inhibitor LY294002 and related analogues, Australian Journal of Chemistry, vol 56, issue 11, CSIRO Publishing, Australia, pp. 1099-1106.

Schoenwaelder, S.M., Hughan, S.C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P.E., Salem, H., Jackson, S.P., 2002, RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear, Journal of Biological Chemistry, vol 277, issue 17, Amer Soc for Biochemistry and Molecular Biology, Inc, Bethesda MD USA, pp. 14738-14746.

Sun, J., Whisstock, J.C., Harriott, P., Walker, B., Novak, A.J., Thompson, P., Smith, A., Bird, P.I., 2001, Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop, Journal of Biological Chemistry, vol 276, issue 18, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 15177-15184.

Cavallaro, V., Thompson, P.E., Hearn, M.T.W., 2001, Solid-phase synthesis of a dedritic peptide related to a retinoblastoma protein fragment utilizing a combined boc- and fmoc- chemistry approach, Journal of Peptide Science, vol 7, issue 5, John Wiley & Sons Ltd, West Sussex England, pp. 262-269.

Cavallaro, V., Thompson, P.E., Hearn, M.T., 2001, Solid-phase synthesis of cyclic analogues related to the hypoglycaemic peptide hGH(6-13): Comparison of two i i +4 lactam cyclization procedures, Journal of Peptide Science, vol 7, issue 10, John Wiley & Sons Ltd, West Sussex England, pp. 529-536.

Smith, R., Jenkins, A.L., Lourbakos, A., Thompson, P.E., Ramakrishnan, V., Tomlinson, J., Deshpande, U., Johnson, D.A., Jones, R., Mackie, E.J., Pike, R.N., 2000, Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes, FEBS Letters, vol 484 issue 1, Elsevier Science BV, Amsterdam Netherlands, pp. 285-290.

Konigs, C., Rowley, M.J., Thompson, P.E., Scealy, M., Davies, J.M., Wu, L., Dietrich, U., Mackay, C.R., Mackay, I.R., 2000, Monoclonal antibody screening of a phage-displayed random peptide library reveals mimotopes of chemokine receptor CCR5: implications for the tertiary structure of the receptor and for an N-terminal binding site fro HIV-1 gp120, European Journal of Immunology, vol 30 issue 4, Wiley-VCH, Germany, pp. 1162-1171.

Gomme, P.T., Thompson, P.E., Whisstock, J.C., Stanton, P., Hearn, M.T., 1999, Identification of functional regions of the thyrotropin beta-subunit recognised by two monoclonal antibodies mAb<279 and mAb<299: a chimetic peptide approach, J Peptide Research, vol 54, Munksgaard International Publishers Ltd, Copenhagen Denmark, pp. 218-229.

Gomme, P.T., Thompson, P.E., Whisstock, J.C., Stanton, P., Hearn, M.T., 1999, Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin beta-subunit, Letters in Peptide Science, vol 6, no 2-3, Kluwer Academic Publishers, Dordrecht Netherland, pp. 185-192.

Lourbakos, A., Chinni, C., Thompson, P.E., Potempa, J., Travis, J., Mackie, E.J., Pike, R.N., 1998, Cleavage and activation of preinase-activated receptor-2 on human neutrphil s by gingpain -R from Porphyromonas gingivilis, FEBS Letters, vol 435 no 1, Elsevier B.V., Amsterdam Netherlands, pp. 45-48.

Steer, D., Thompson, P.E., Blondelle, S.E., Houghton, R.A., Aguilar, M., 1998, Comparison of the binding of a-helical and beta-sheet peptides to ahydrophobic surface, Journal of Peptide Research, vol 51 no 6, Munksgaard, Copenhagen Denmark, pp. 401-412.

Cavallaro, V., Thompson, P.E., Hearn, M.T., 1998, Solid Phase Synthesis of Cyclic Peptides: Model Studies Involving 1 - (i+4) Side-Chain to Side-Chain Cyclisation, Journal of Peptide Science, vol 4, John Wiley & Sons, West Sussex UK, pp. 335-343.

Thompson, P.E., Steer, D., Aguilar, M., Hearn, M.T., 1998, Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation, Bioorganic and Medicinal Chemistry Letters, vol 8 no 19, Elsevier Science Ltd, Oxford UK, pp. 2699-2704.

Lee, T., Thompson, P.E., Hearn, M.T., Aguilar, M., 1997, Conformational stability of a type IIb- turn motif in human growth hormone [6 - 13] peptide analogues at hydrophobic surfaces, Journal of Peptide Research, vol 49, Munksgaard International Publishers Ltd., Copenhagen Denmark, pp. 394-403.

Thompson, P.E., Hearn, M.T., 1997, Fmoc-protected tropane-based amino acids for peptide structure-function studies, Tetrahedron Letts, vol 38, Elsevier Science Ltd., Oxford UK, pp. 2907-2910.

Conference Proceedings

Chai, S.Y., Yeatman, H.R., Parker, M.W., Ascher, D.B., Thompson, P., Mulvey, H.T., Albiston, A.L., 2008, Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase, 8th International Conference on Alzheimer's Disease Drug Discovery, 15-16 Oct 2007, BioMed Central, USA, p. 0.

Northfield, S., Camerino, M., Mulvey, H., Ashton, T., Chalmers, D., Kerr, K., Thompson, P., 2007, 7-Azabicycloalkane[2.2.1]heptane-2-carboxylic acids as peptidomimetic conformational restraints - NK2 antagonists as an example, Proceedings of the 4th International Peptide Symposium, 21-25 October, 2007, Australian Peptide Association, Australia, pp. 1-2.

Camerino, M., Thompson, P., Chalmers, D., 2007, New drugs for diabetes: the design and molecular modelling of alpha-amylase peptidomimetics, Proceedings of the 4th international peptide symposium, Australian Peptide Association, Australia, pp. 1-2.

Ng, N., Boyd, S.E., Bird, P.I., Thompson, P., Matthews, A.Y., Kaiserman, D., Pike, R.N., 2007, The effects of thrombomodulin on the substrate specificity of thrombin, 5th General Meeting of the International Proteolysis Society Book of Abstracts, 20 October 2007 to 24 October 2007, Novartis Pharma A, Basel Switzerland, p. 375.

Mercer, L.D., Lawrence, A.J., Cheung, N.S., Mercer, J.F.B., Thompson, P.E., Jarrott, B., Beart, P.M., 1998, Immunohistochemistry in rat brain with antibodies to the cholecystokinin-A receptor, 1st Joint Meeting of the European Neuropeptide Club and Summer Neuropeptide Conference, Gent, Belgium, May 1998, J Crawley & R Lefebvre, Gent Belgium, p. 0.

Steer, D., Aguilar, M., Hearn, M.T., Thompson, P.E., 1998, Synthesis and evaluation of Fmoc protected tropane based amino acids and their Incorporation into peptides as fibrinogen peptidomimetics, Proceedings, 23rd Lorne Annual Conference on Protein Structure and Function, Lorne VIC, 8-12 February 1998, Lorne Protein Workshop Inc, Melbourne Vic Australia, p. B40.

Thompson, P.E., Higgins, K., Hearn, M.T., 1997, Application of tropane-based peptidomimetics, Proceedings, 15th American Peptide Symposium, Nashville, TN, USA, June 14-19, 1997, American Peptide Society, Nashville TN USA, p. 2-74.

Steer, D., Thompson, P.E., Aguilar, M., 1997, Comparison of the binding behaviour of amphipathic a-helical and b-sheet peptides at hydrophobic surfaces, Proceedings, 22nd Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, Feb.10-14, 1997, Lorne Protein Workshop Inc., Lorne Australia, p. B68.

Gomme, P.T., Thompson, P.E., Whisstock, J.C., Hearn, M.T., 1997, Homology modelling of the glycoprotein hormones: receptor recognition characteristics, 1st International Peptide Symposium, Kyoto, Japan, Nov. 30-Dec. 5, 1997, Kluwer Academic Publishers B.V., Amsterdam Netherlands, p. 122.

Gomme, P.T., Fairlie, W., Thompson, P.E., Stanton, P., Hearn, M.T., 1997, Identification of the epitope site associated with receptor recognition on the thyrotropin b-subunit, Proceedings, 22nd Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, Feb. 9-13, 1997, Lorne Protein Workshop Inc., Melbourne Vic Australia, p. B36.

Cavallaro, V., Thompson, P.E., Stanton, P., Hearn, M.T., 1997, Peptides with affinity for insulin, Proceedings, 22nd Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, Feb. 9-13, 1997, Lorne Protein Workshop Inc., Melbourne Vic Australia, p. A73.

Steer, D., Aguilar, M., Hearn, M.T., Thompson, P.E., 1997, Synthesis of FMOC protected tropane based amino acids and their incorporation into fibrinogen related peptides, Proceedings of the Australian Society for Biochemistry and Molecular Biology, Melbourne, Sept. 29-Oct. 2, 1997, Australian Soc. for Biochemistry & Molecular Biol., Kent Town SA, p. B1-87.

Thompson, P.E., Steer, D., Higgins, K., Aguilar, M., Hearn, M.T., 1997, Synthesis, conformational analysis and application of tropane-based FMOC-amino acid derivatives: novel antagonists of fibrinogen receptor, GPIIb/IIIa, 1st International Peptide Symposium, Kyoto, Japan, Nov. 30-Dec. 5, 1997, Kluwer Academic Publishers B.V., Amsterdam Netherlands, p. 105.

Other

Abbott, B., Anderson, K., Goncalves, I., Jackson, S., Vijaya, K., Warwick, N., Hishani, P., Robertson, A.D., Saylik, D., Schoenwaelder, S.M., Thompson, P., 2009, Inhibition of phosphoinositide 3-kinase-beta (AU), Australia.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B.M., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2007, Inhibition of phosphoinositide 3-kinase beta, New Zealand.

Robertson, A.D., Jackson, S., Kenche, V., Yap, C.L.S., Prabaharan, H., Thompson, P., 2006, Therapeutic Morpholino-substituted compounds, Australia.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2004, Inhibition of phosphoinositide 3-kinase beta.

Robertson, A.D., Jackson, S., Kenche, V., Yaip, C., Hishani, P., Thompson, P., 2004, Therapeutic Morpholino-substituted compounds, New Zealand.

Teaching Commitment

Activities

Affiliations with research centres

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Grants

Title:

Design and synthesis of inhibitors of oncogenic forms of PI3 kinase.

Investigators:

Thompson, P, Kinzler, K

Funding:

(2005 - 2009). Basic Cancer Research Fund. $78,771.00

(2006 - 2010). Basic Cancer Research Fund. $32,726.00

Title:

Dissecting Isoform Selectivity of PI3 Kinase Inhibitors.Uncovering leads for rational drug design.

Investigators:

Thompson, P, Jennings, I, Vogelstein, B, Amzel, M

Funding:

(2009 - 2012). National Health & Medical Research Council (NHMRC). $499,500.00

(2011 - 2016). National Health & Medical Research Council (NHMRC). $0.00

Title:

Inhibition of cAMP Phosphodiesterase 3B - a novel therapeutic approach to type II diabetes.

Investigators:

Thompson, P

Funding:

(2006 - 2009). Diabetes Australia. $44,900.00

Title:

LC/MS System for peptide and protein analysis.

Investigators:

Thompson, P, Scanlon, M, Jennings, I, Graham, B, Nation, R

Funding:

(2009 - 2014). National Health & Medical Research Council (NHMRC). $70,000.00

Title:

Molecular genetic analysis of colorectal cancer.

Investigators:

Vogelstein, B, Thompson, P

Funding:

(2007 - 2011). National Institutes of Health (NIH), USA. $395,196.00

Title:

Peptide Ligands for Imaging and Therapy.

Investigators:

Thompson, P

Funding:

(2008 - 2012). Cooperative Research Centres (CRC). $180,000.00

Title:

Pipettes from John Morris; 3 x Starter Kits and 3 x Pipetman.

Investigators:

Kerr, K, Irving, H, Exintaris, B, Thompson, P, Coupar, I

Funding:

(2008 - 2011). Collier Charitable Fund. $1,715.00

Title:

Rainin PS3 Peptide Synthesizer and Mettler-Toldeo compact parallel synthesizer.

Investigators:

Thompson, P, Iskander, M, Scanlon, M, Coupar, I

Funding:

(2004 - 2008). National Health & Medical Research Council (NHMRC). $74,728.00

Title:

Structure-based Design of Phosphodiesterase Inhibitors.

Investigators:

Thompson, P, Martin, T

Funding:

(2005 - 2009). CASS Foundation Limited. $27,440.00

Title:

Studies of the PI3-kinase enzyme family using selective inhibitors.

Investigators:

Anderson, K, Thompson, P, Saylik, D, Frazzetto, M

Funding:

(2003 - 2007). Australian Research Council (ARC). $4,000.00

(2003 - 2007). Australian Research Council (ARC). $69,099.00

(2003 - 2007). Australian Research Council (ARC). $9,305.00

(2003 - 2007). Kinacia Pty. Ltd. $15,000.00

(2008 - 2012). Kinacia Pty. Ltd. $0.00

Title:

Targeting polymyxin-resistant Gram-negative 'superbugs': development of novel antimicrobial peptides.

Investigators:

Li, J, Velkov, T, Nation, R, Thompson, P

Funding:

(2010 - 2013). National Health & Medical Research Council (NHMRC). $425,000.00

(2011 - 2015). National Health & Medical Research Council (NHMRC). $212,500.00

Title:

Towards selective inhibition of oncogenic forms of PI3K - a chemical biology approach.

Investigators:

Thompson, P, Vogelstein, B

Funding:

(2007 - 2010). Cancer Council Victoria. $200,250.00

Title:

Development of small molecule inhibitors of IRAP for treating memory deficits.

Investigators:

Thompson, P

Funding:

(2008 - 2012). National Health & Medical Research Council (NHMRC). $100,000.00

Title:

X-ray Molecular Structure Elucidation Facillity (MSEF).

Investigators:

White, J, Abrahams, B, El-Kabbani, O, Scammells, P, Donnelly, P, Holmes, A, Kolev, S, O'Hair, R, Schiesser, C, Wedd, A, Young, C, Robson, R, Cheng, H, Boskovic, C, Dakternieks, D, Duthie, A, Hutton, C, Williams, S, Rizzacasa, M, Prankerd, R, Jazayeri, J, Thompson, P, Simpson, J, Wille, U

Funding:

(2007 - 2011). Australian Research Council (ARC). $132,600.00

(2007 - 2011). Monash University. $24,666.00

(2007 - 2011). Monash University. $49,334.00

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identifying the role of specific non-conserved residues on PI3K in the discovery of isoform-selective PI3K inhibitors..

Supervisors:

Thompson, P (Main), Jennings, I (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural studies of PI3 kinase catalysis and inhibitor binding.

Supervisors:

Thompson, P (Main), Jennings, I (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Synthesis of NPY/Kisspeptin analogues as models of biological imaging agents.

Supervisors:

Thompson, P (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Synthetic and preclinical studies towards the development of novel, polymyxin derived lipopeptides.

Supervisors:

Li, J (Main), Thompson, P (Associate), Velkov, T (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Targeting phosphodiesterase inhibition for novel antimalarial therapies.

Supervisors:

Manallack, D (Joint-co), Thompson, P (Joint).

Completed Supervision

Student:

Abbott, B.

Program of Study:

SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF ANTIPLATELET 2-MORPHOLINOCHROMONES. (PHD) 2003.

Supervisors:

Salem, H (Main), Thompson, P (Associate).

Student:

Agostino, M.

Program of Study:

The development and application of in silico mapping techniques for the study of carbohydrate-protein interactions. (PHD) 2011.

Supervisors:

Yuriev, E (Main), Ramsland, P (Associate), Thompson, P (Associate).

Student:

Camerino, M.

Program of Study:

Peptidomimetic techniques and their application in the design and synthesis of Kisspeptin analogues. (PHD) 2011.

Supervisors:

Chalmers, D (Joint-Co), Thompson, P (Joint).

Student:

Frazzetto, M.

Program of Study:

Studies of phosphoinositide 3-kinase isoform function using selective inhibitors and site directed mutagenesis. (PHD) 2007.

Supervisors:

Salem, H (Joint-Co), Thompson, P (Joint).

Student:

Hanna-Elias, A.

Program of Study:

Design, synthesis, and evaluation of novel 5-HT4 receptor ligands. (PHD) 2008.

Supervisors:

Iskander, M (Main), Coupar, I (Associate), Thompson, P (Associate).

Student:

Holien, J.

Program of Study:

Chromone-based PDE2 inhibitors as potential prostate cancer therapeutics. (PHD) 2010.

Supervisors:

Thompson, P (Main), Mcpherson, S (Associate).

Student:

Liu, M.

Program of Study:

Synthesis of BVDI5 analogues as models for radioligands in tumour imaging. (Masters) 2012.

Supervisors:

Thompson, P (Main).

Student:

Nankervis, J.

Program of Study:

Small molecule inhibitors of PDE4. (PHD) 2012.

Supervisors:

Thompson, P (Main), Manallack, D (Associate).

Student:

Neale, D.

Program of Study:

The design and synthesis of thiophene based phosphodiesteras 4 inhibitors. (PHD) 2012.

Supervisors:

Manallack, D (Joint-Co), Thompson, P (Joint).

Student:

Nguyen, W.

Program of Study:

Development of novel Kv1.3 ion channel blockers based upon diphenoxylate. (PHD) 2012.

Supervisors:

Manallack, D (Main), Thompson, P (Associate), White, P (Associate).

Student:

Northfield, S.

Program of Study:

Inhibition of protein-protein interactions: cyclic peptides targeting HIV-1 integrase/LEDGF binding. (PHD) 2012.

Supervisors:

Chalmers, D (Joint), Thompson, P (Joint-Co).

Student:

Pinson, J.

Program of Study:

PI3 kinase and inhibitors: targeting isoform selectivity. (PHD) 2011.

Supervisors:

Thompson, P (Main), Chalmers, D (Joint).