Assoc Prof Jackie Wilce - Researcher Profile

Biography

Jackie works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

PHD (MEDICINAL CHEMISTRY)

Institution: Monash University

Year awarded: 1993

BSC(HONS CHEMISTRY)

Institution: Monash University

Year awarded: 1988

Publications

Book Chapters

Wilce, J.A., Vivian, J.P., Wilce, M.C., 2012, Oligonucleotide binding proteins: the occurrence of dimer and multimer formation, in Advances, eds JM Matthews, Springer Science+Business Media, USA, pp. 91-104.

Journal Articles

Beckham, S.A., Brouwer, J.M., Roth, A., Wang, D., Sadler, A.J., John, M., Jahn-Hofmann, K., Williams, B.R.G., Wilce, J.A., Wilce, M.C.J., 2013, Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly, Nucleic Acids Research [P], vol 41, issue 5, Oxford University Press, UK, pp. 3436-3445.

Ambaye, N.D., Gunzburg, M.J., Lim, R.C.C., Price, J.T., Wilce, M.C.J., Wilce, J.A., 2013, The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents, Chemmedchem [P], vol 8, issue 2, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 280-288.

Gopalan, R.D., Del Borgo, M.P., Bergman, Y.E., Unabia, S., Mulder, R.J., Wilce, M.C., Wilce, J.A., Aguilar, M.[., Perlmutter, P., 2012, Conformational stability studies of a stapled hexa-beta(3)-peptide library, Organic & Biomolecular Chemistry [P], vol 10, issue 9, R S C Publications, UK, pp. 1802-1806.

Yoga, Y.M.K., Traore, D.A., Sidiqi, M., Szeto, C., Pendini, N.R., Barker, A., Leedman, P., Wilce, J.A., Wilce, M.C., 2012, Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides, Nucleic Acids Research [P], vol 40, issue 11, Oxford University Press, UK, pp. 5101-5114.

Gunzburg, M.J., Ambaye, N.D., Del Borgo, M.P., Pero, S.C., Krag, D.N., Wilce, M.C., Wilce, J.A., 2012, Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity, Journal Of Molecular Recognition [P], vol 25, issue 1, John Wiley & Sons Ltd, UK, pp. 57-67.

Barker, A., Epis, M.R., Porter, C.J., Hopkins, B.R., Wilce, M.C., Wilce, J.A., Giles, K.M., Leedman, P.J., 2012, Sequence requirements for RNA binding by HuR and AUF1, Journal of Biochemistry [P], vol 151, issue 4, Oxford University Press, UK, pp. 423-437.

Kim, H.S., Wilce, M.C.J., Yoga, Y., Pendini, N.R., Gunzburg, M.J., Cowieson, N., Wilson, G.M., Williams, B., Gorospe, M., Wilce, J.A., 2011, Different modes of interaction by TIAR and HuR with target RNA and DNA, Nucleic Acids Research [P], vol 39, issue 3, Oxford University Press, UK, pp. 1117-1130.

Yoga, Y.M.K., Traore, D.A., Wilce, J.A., Wilce, M.C., 2011, Mutation and crystallization of the first KH domain of human polycytosine-binding protein 1 (PCBP1) in complex with DNA, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 67, issue Pt 10, Wiley-Blackwell Publishing, Inc., USA, pp. 1257-1261.

Ambaye, N., Pero, S., Gunzburg, M., Yap, M., Clayton, D., Del Borgo, M., Perlmutter, P., Aguilar, M., Shukla, G., Peletskaya, E., Cookson, M., Krag, D., Wilce, M., Wilce, J., 2011, Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression, Journal of Molecular Biology [P], vol 412, issue 3, Academic Press, UK, pp. 397-411.

Ambaye, N.D., Lim, R.C.C., Clayton, D.J., Gunzburg, M.J., Price, J.T., Pero, S.C., Krag, D.N., Wilce, M.C.J., Aguilar, M.I., Perlmutter, P., Wilce, J.A., 2011, Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain, Journal Of Peptide Science [P], vol 96, issue 2, John Wiley & Sons, Inc., USA, pp. 181-188.

Ambaye, N.D., Gunzburg, M.J., Lim, R.C., Price, J.T., Wilce, M.C., Wilce, J.A., 2010, Benzopyrazine derivatives: a novel class of Growth Factor receptor bound protein 7 antagonists, Bioorganic & Medicinal Chemistry [P], vol 19, Pergamon, UK, pp. 693-701.

Theodossis, A., Guillonneau, C., Welland, A.D., Ely, L.K., Clements, C.S., Williamson, N.A., Webb, A.I., Wilce, J.A., Mulder, R.J., Dunstone, M.A., Doherty, P.C., McCluskey, J., Purcell, A.W., Turner, S.J., Rossjohn, J., 2010, Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 12, National Academy of Sciences, USA, pp. 5534-5539.

Yap, M.Y., Wilce, M.C.J., Clayton, D.J., Perlmutter, P., Aguilar, M.I., Wilce, J.A., 2010, Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide, Acta Crystallographica Section F: Structural Biology..., vol 66, issue Pt 12, Wiley-Blackwell Publishing, Inc., USA, UK, pp. 1640-1643.

Gunzburg, M.J., Ambaye, N.D., Hertzog, J.T., Del Borgo, M.P., Pero, S.C., Krag, D.N., Wilce, M.C., Aguilar, M.I., Perlmutter, P., Wilce, J.A., 2010, Use of SPR to study the interaction of G7-18NATE peptide with the Grb7-SH2 domain, International Journal Of Peptide Research And Therapeutics [P], vol 16, issue 3, Springer Netherlands, The Netherlands, pp. 177-184.

Bergman, Y.E., Del Borgo, M.P., Gopalan, R.D., Jalal, S., Unabia, S., Ciampini, M., Clayton, D.J., Fletcher, J.M., Mulder, R.J., Wilce, J.A., Aguilar, M.I., Perlmutter, P., 2009, Synthesis of stapled beta3-peptides through ring-closing metathesis, Organic Letters [P], vol 11, issue 19, American Chemical Society, United States, pp. 4438-4440.

Schmidberger, J.W., Wilce, J.A., Weightman, A.J., Wilce, M.C.J., 2008, Purification, crystallization and preliminary crystallographic analysis of DehI, a group I alpha-haloacid dehalogenase from Pseudomonas putida strain PP3, Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, vol 64, issue 7, Wiley-Blackwell Munksgaard, Denmark, USA, pp. 596-598.

Schmidberger, J.W., Wilce, J.A., Weightman, A.J., Whisstock, J., Wilce, M.C.J., 2008, The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism, Journal of Molecular Biology, vol 378, issue 1, Academic Press, UK, pp. 284-294.

Hodoniczky, J., Sims, C.G., Best, W.M., Bentel, J.M., Wilce, J.A., 2008, The intracellular and nuclear-targeted delivery of an antiandrogen drug by carrier peptides, Biopolymers, vol 90, issue 5, John Wiley & Sons Inc, USA, pp. 595-603.

Vivian, J.P., Porter, C.J., Wilce, J.A., Wilce, M.C.J., 2007, An asymmetric structure of the bacillus subtilis replication terminator protein in complex with DNA, Journal of Molecular Biology, vol 370, issue 3, Academic Press Ltd Elsevier Science Ltd, London England UK, pp. 481-491.

Schmidberger, J.W., Wilce, J.A., Tsang, J.S., Wilce, M.C.J., 2007, Crystal Structures of the Substrate Free-enzyme, and Reaction Intermediate of the HAD Superfamily Member, Haloacid Dehalogenase DehIVa from Burkholderia cepacia MBA4, Journal of Molecular Biology, vol 368, issue 3, Academic Press Elsevier Science Ltd, London England UK, pp. 706-717.

Kim, H., Kuwano, Y., Zhan, M., Pullmann Jr, R., Mazan-Mamczarz, K., Li, H., Kedersha, N., Anderson, P., Wilce, M.C.J., Gorospe, M., Wilce, J.A., 2007, Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR, Molecular and Cellular Biology, vol 27, issue 19, American Society of Microbiology, Washington DC USA, pp. 6806-6817.

Porter, C.J., Matthews, J.M., Mackay, J.P., Pursglove, S.E., Schmidberger, J., Leedman, P., Pero, S.C., Krag, D., Wilce, M.C.J., Wilce, J.A., 2007, Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation, BMC Structural Biology, vol 7, issue 58, Biomed Central Ltd, London England UK, pp. 1-15.

Porter, C.J., Wilce, J.A., 2007, NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein, Biopolymers, vol 88, issue 2, John Wiley & Sons Inc, Hoboken NJ USA, pp. 174-181.

Vivian, J.P., Porter, C.J., Wilce, J.A., Wilce, M.C.J., 2006, Crystallization and preliminary X-ray diffraction analysis of the Bacillus subtilis replication termination protein in complex with the 37-base-pair TerI-binding site, Acta Crystallographica Section F - Structural Biology and Crystallization Communications, vol 62, issue 11, Blackwell Publishing, UK, pp. 1104-1107.

Hatchell, E.C., Colley, S.M., Beveridge, D.J., Epis, M.R., Stuart, L.M., Giles, K.M., Redfern, A.D., Miles, L.E., Barker, A., MacDonald, L.M., Arthur, P.G., Liu, J.C., Golding, J.L., McCulloch, R., Metcalf, C.B., Wilce, J.A., Wilce, M.C., Lanz, R.B., O'Malley, B.W., Leedman, P.J., 2006, SLIRP, a small SRA binding protein, is a nuclear receptor corepressor, Molecular Cell [P], vol 22, issue 5, Cell Press, USA, pp. 657-668.

Judge, R.K., Henry, P.J., Mirtschin, P., Jelinek, G., Wilce, J.A., 2006, Toxins not neutralized by brown snake antivenom, Toxicology and Applied Pharmacology, vol 213, issue 24 October 2005, Elsevier, San Diego USA, pp. 117-125.

Bailey, P.M., Bakker, A.J., Seymour, J.E., Wilce, J.A., 2005, A functional comparison of the venom of three Australian jellyfish: Chironex fleckeri, Chiropsalmus sp., and Carybdea xaymacana - On cytosolic Ca2+, haemolysis and Artemia sp. lethality, Toxicon : official journal of the International Society on Toxinology [P], vol 45, issue 2, Pergamon, UK, pp. 233-242.

Sharpe, B.K., Liew, C.K., Kwan, A.H., Wilce, J.A., Crossley, M., Matthews, J.M., Mackay, J.P., 2005, Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting, Structure, vol 13, issue 2, Cell Press, Cambridge USA, pp. 257-266.

Sidiqi, M., Wilce, J.A., Porter, C.J., Barker, A., Leedman, P.J., Wilce, M.C., 2005, Formation of an alphacP1-KH3 complex with UC-rich RNA, European Biophysics Journal, vol 34, issue 5, Springer, New York USA, pp. 423-429.

Porter, C.J., Wilce, M.C., Mackay, J.P., Leedman, P.J., Wilce, J.A., 2005, Grb7-SH2 domain dimerisation is affected by a single point mutation, European Biophysics Journal, vol 34, issue 5, Springer, New York USA, pp. 454-460.

Hastings, A.F., Otting, G., Folmer, R.H., Duggin, I.G., Wake, R.G., Wilce, M.C.J., Wilce, J.A., 2005, Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy, Biochemical and Biophysical Research Communications, vol 335, issue 2, Academic Press, San Diego USA, pp. 361-366.

Sidiqi, M., Wilce, J.A., Vivian, J.P., Porter, C.J., Barker, A., Leedman, P.J., Wilce, M.C.J., 2005, Structure and RNA binding of the third KH domain of poly(C)-binding protein 1, Nucleic Acids Research, vol 33, issue 4, Oxford University Press, Oxford England, pp. 1213-1221.

Finnegan, P.M., Umbach, A.L., Wilce, J.A., 2003, Prokaryotic origins for the mitochondrial alternative oxidase and plastid terminal oxidase nuclear genes, FEBS Letters, vol 555, issue 3, Elsevier Science BV, The Netherlands, pp. 425-430.

Yeap, B.B., Voon, D.C., Vivian, J.P., McCulloch, R.K., Thomson, A.M., Giles, K.M., Czyzyk-Krzeska, M.F., Furneaux, H., Wilce, M.C.J., Wilce, J.A., Leedman, P., 2002, Novel Binding of HuR and Poly(C)-binding Protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA, Journal of Biological Chemistry, vol 277, issue 30, American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 27183-27192.

Boysen, R.I., Jong, A., Wilce, J.A., King, G.F., Hearn, M.T.W., 2002, Role of Interfacial Hydrophobic Residues in the Stabilization of the Leucine Zipper structures of the transcription Factors c-Fos and c-Jun, The Journal of Biological Chemistry, vol 277, issue 1, The American Society for Biochemistry and Molecular Biology I, Bethesda MD USA, pp. 23-31.

Wilce, J.A., Vivian, J.P., Hastings, A.F., Otting, G., Folmer, R.H., Duggin, I.G., Wake, R.G., Wilce, M.C.J., 2001, Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest, Nature Structural & Molecular Biology, vol 8, issue 3, Nature Publishing Group, New York USA, pp. 206-210.

Wilce, J.A., Love, S.G., Richardson, S.J., Alewood, P., Craik, D.J., 2001, Synthesis of an analog of the thyroid hormone-binding protein transthyretin via regioselective chemical ligation, Journal of Biological Chemistry, vol 276, issue 28, American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 25997-26003.

Muratovska, A., Lightowlers, R.N., Taylor, R.W., Wilce, J.A., Murphy, M.P., 2001, Targeting large moleculars to mitochondria, Advanced Drug Delivery Reviews, vol 49, issue 1-2, Elsevier Science BV, The Netherlands, pp. 189-198.

Muratovska, A., Lightowlers, R.N., Taylor, R.W., Turnbull, D.M., Smith, R.A., Wilce, J.A., Martin, S.W., Murphy, M.P., 2001, Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease, Nucleic Acids Research, vol 29, issue 9, Oxford University Press, Oxford England, pp. 1852-1863.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Grb7 inhibitor development and characterization..

Supervisors:

Wilce, J (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Understanding Poly-C Binding Protein Specificity and Affinity for C-rich oligonucleotides.

Supervisors:

Wilce, J (Joint), Wilce, M (Joint-co).

Completed Supervision

Student:

Ambaye, N.

Program of Study:

Discovery and optimization of Grb7 antagonists as potential antitumour therapeutics. (PHD) 2010.

Supervisors:

Wilce, J (Main), Wilce, M (Associate).

Student:

Kim, H.

Program of Study:

Biophyiscal and structural investigation into the RNA-binding properties of TIAR. (PHD) 2010.

Supervisors:

Wilce, J (Joint-Co), Wilce, M (Joint).

Student:

Yoga, Y.

Program of Study:

. 2008.

Supervisors:

Wilce, J (Joint-Co), Wilce, M (Joint).