Dr Peter Janes - Researcher Profile

Biography

Peter works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY, MEDICINE

Institution: Garvan Institute, Sydney/University of NSW

Year awarded: 1997

SCIENCE

Institution: University of Sydney

Year awarded: 1989

Publications

Journal Articles

Atapattu Mudiyanselage, L.S., Saha, N., Llerena, C.O., Vail, M.E., Scott, A.M., Nikolov, D.B., Lackmann, M., Janes, P.W., 2012, Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function, Journal Of Cell Science [P], vol 125, issue Pt 24, The Company of Biologists Ltd, UK, pp. 6084-6093.

Janes, P.W., Nievergall, E., Lackmann, M., 2012, Concepts and consequences of Eph receptor clustering, Seminars In Cell & Developmental Biology [P], vol 23, issue 1, Academic Press, UK, pp. 43-50.

Janes, P.W., Griesshaber, B., Atapattu Mudiyanselage, L.S., Nievergall, E., Hii, L.L., Mensinga, A., Chheang, C., Day, B.W., Boyd, A.W., Bastiaens, P.I., Jorgensen, C., Pawson, T., Lackmann, M., 2011, Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors, Journal of Cell Biology [P], vol 195, issue 6, Rockefeller University Press, USA, pp. 1033-1045.

Nievergall, E., Lackmann, M., Janes, P.W., 2011, Eph-dependent cell-cell adhesion and segregation in development and cancer, Cellular And Molecular Life Sciences [P], vol E, Birkhaeuser Verlag AG, Switzerland, pp. 1-30.

Himanen, J., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu Mudiyanselage, L.S., Rajashankar, K.R., Mensinga, A., Lackmann, M., Dhe-Paganon, S., Nikolov, D.B., 2010, Architecture of Eph receptor clusters, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 24, National Academy of Sciences, USA, pp. 10860-10865.

Nievergall, E., Janes, P.W., Stegmayer, C., Vail, M.E., Haj, F.G., Teng, S.W., Neel, B.G., Bastiaens, P.I., Lackmann, M., 2010, PTP1B regulates Eph receptor function and trafficking, Journal of Cell Biology [P], vol 191, issue 6, Rockefeller University Press, USA, pp. 1189-1203.

Janes, P.W., Wimmer-Kleikamp, S.H., Frangakis, A.S., Treble, K., Griesshaber, B., Sabet, O., Grabenbauer, M., Ting, A.Y., Saftig, P., Bastiaens, P.I., Lackmann, M., 2009, Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10, Plos Biology [P], vol 7, issue 10, Public Library of Science, USA, pp. e1000215-1-e1000215-17.

Janes, P.W., Adikari, S.H., Lackmann, M., 2008, Eph/ephrin signalling and function in oncogenesis: Lessons from embryonic development, Current Cancer Drug Targets, vol 8, issue 6, Bentham Science Publishers Ltd., Netherlands, pp. 473-489.

Janes, P.W., Saha, N., Barton, W.A., Kolev, M.V., Wimmer-Kleikamp, S.H., Nievergall, E., Blobel, C.P., Himanen, J., Lackmann, M., Nikolov, D.B., 2005, Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans, Cell, vol 123, issue 2, Cell Press, Cambridge MA USA, pp. 291-304.

Wimmer-Kleikamp, S.H., Janes, P.W., Squire, A., Bastiaens, P.I.H., Lackmann, M., 2004, Recruitment of Eph receptors into signaling clusters does not require ephrin contact, The Journal of Cell Biology, vol 164, issue 5, Rockefeller University Press, New York USA, pp. 661-666.

Frew, I.J., Hammond, V.E., Dickins, R.A., Quinn, J.M.W., Walkley, C.R., Sims, N.A., Schnall, R., Della, N.G., Holloway, A.J., Digby, M.R., Janes, P.W., Tarlinton, D.M., Purton, L.E., Gillespie, M.T., Bowtell, D.D.L., 2003, Generation and analysis of Siah2 mutant mice, Molecular and Cellular Biology, vol 23, issue 24, American Society for Microbiology, Washington USA, pp. 9150-9161.

Habelhah, H., Frew, I.J., Laine, A., Janes, P.W., Relaix, F., Sassoon, D., Bowtell, D.D.L., Ronai, Z., 2002, Stress-induced decrease in TRAF2 stability is mediated by Siah2, EMBO Journal, vol 21, issue 21, Nature Publishing Group, New York USA, pp. 5756-5765.

DeFazio, A., Chiew, Y., Sini, R.L., Janes, P.W., Sutherland, R.L., 2000, Expression of c-erB receptors, heregulin and oestrogen receptor in human breast cell lines, International Journal of Cancer, vol 87, issue 4, Wiley-Liss, Div John Wiley & Sons Inc., Hoboken USA, pp. 487-498.

Other

Lackmann, M., Janes, P.W., Nikolov, D.B., Saha, N., 2010, Regulation of metalloprotease cleavage of cell surface proteins, Australia.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(POSTGRADUATE QUALIFYING OR PRELIMINARY).

Thesis Title:

Effects of a function-blocking mono-clonal antibody against the ADAMIO metalloprotease on oncogenic signalling mechanisms.

Supervisors:

Janes, P (Joint), Lackmann, M (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of mRNA poly (A)-tail length regulation in translational repression..

Supervisors:

Lackmann, M (Main), Devenish, R (Associate), Janes, P (Associate).

Completed Supervision

Student:

Nievergall, E.

Program of Study:

Regulation of EphA3 receptor tyrosine kinase signalling by protein tyrosine phosphatases. (PHD) 2012.

Supervisors:

Lackmann, M (Main), Janes, P (Associate).