Dr Michelle Kett - Researcher Profile

Biography

Michelle works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PH.D. MEDICINE

Institution: University of Melbourne

Year awarded: 1997

SCIENCE (HONS)

Institution: UNIVERSITY OF MELBOURNE

Year awarded: 1993

Publications

Book Chapters

Denton, K.M., Kett, M., Dodic, M., 2006, Programming hypertension - animal models: causes and mechanisms, in Advances in Experimental Medicine and Biology, eds E. Marelyn Wintour and Julie A Owens, Landes Bioscience, Georgetown USA, pp. 103-120.

Journal Articles

Walker, K.A., Cai, X., Caruana, G., Thomas, M.C., Bertram, J.F., Kett, M.M., 2012, High nephron endowment protects against salt-induced hypertension, American Journal of Physiology - Renal Fluid and Electrolyte Physiology [E], vol 303, issue 2, American Physiological Society, USA, pp. F253-F258.

Iqbal, J., Tonta, M.A., Mitsui, R., Li, Q., Kett, M.M., Li, J., Parkington, H.C., Hashitani, H., Lang, R.J., 2012, Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis, British Journal of Pharmacology [P], vol 165, issue 7, John Wiley & Sons Ltd, UK, pp. 2389-2408.

Alikhan, M., Jones, C., Williams, T., Beckhouse, A., Fletcher, A., Kett, M., Sakkal, S., Samuel, C.S., Ramsay, R., Deane, J., Wells, C., Little, M., Hume, D., Ricardo, S., 2011, Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses, American Journal Of Pathology [P], vol 179, issue 3, Elsevier Inc., USA, pp. 1243-1256.

Hilliard, L.M., Nematbakhsh, M., Kett, M.M., Teichman, E., Sampson, A.K., Widdop, R.E., Evans, R.G., Denton, K.M., 2011, Gender differences in pressure-natriuresis and renal autoregulation: Role of the Angiotensin type 2 receptor, Hypertension [P], vol 57, issue 2, Lippincott Williams & Wilkins, USA, pp. 275-282.

Ruta, L.M., Dickinson, H., Thomas, M.C., Denton, K.M., Anderson, W.P., Kett, M.M., 2010, High-salt diet reveals the hypertensive and renal effects of reduced nephron endowment, American Journal of Physiology - Renal Physiology [P], vol 298, issue 6, American Physiological Society, USA, pp. F1384-F1392.

Kett, M.M., Denton, K.M., 2010, Renal programming: Cause for concern?, American Journal Of Physiology-Regulatory Integrat..., vol 300, American Physiological Society, USA, pp. 1-38.

Shweta, A., Cullen-McEwen, L.A., Kett, M.M., Evans, R.G., Denton, K.M., Fitzgerald, S.M., Anderson, W.P., Bertram, J.F., 2009, Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors, American Journal of Physiology - Renal Physiology [P], vol 296, issue 3, American Physiological Society, USA, pp. F583-F589.

Sims-Lucas, S., Caruana, G., Dowling, J.P., Kett, M.M., Bertram, J.F., 2008, Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant mice, Pediatric Research, vol 63, issue 6, Lippincott Williams & Wilkins, USA, pp. 607-612.

Abdelkader (Shweta), A., Cullen-McEwen, L.A., Kett, M.M., Evans, R.G., Denton, K.M., Fitzgerald, S.M., Anderson, W.P., Bertram, J.F., 2008, Glomerular surface area is normalized in mice born with a nephron deficit: No role for AT(1) receptors, American Journal of Physiology: Renal Physiology, vol E, American Physiological Society, USA, pp. F583-F589.

O'Connor, P.M., Anderson, W.P., Kett, M.M., Evans, R.G., 2008, Simultaneous measurement of pO2 and perfusion in the rabbit kidney in vivo, Advances in Experimental Medicine and Biology, vol 599, Springer-Verlag Berlin, Germany, pp. 93-99.

Dickinson, H., Moritz, K.M., Wintour-Coghlan, M.E., Walker, D.W., Kett, M.M., 2007, A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: Response to dietary salt load, American Journal of Physiology - Renal Physiology, vol 293, issue 4, American Physiological Society, Bethesda MD USA, pp. F1093-F1098.

Boesen, E.I., Anderson, W.P., Kett, M.M., 2007, Acute pressure-natriuresis relationship following withdrawal of chronic noradrenaline infusion, Clinical and Experimental Pharmacology & Physiology, vol 34, issue 9, Blackwell Publishing, Oxford England UK, pp. 881-883.

Wilkinson, L., Gilbert, T., Kinna, G., Ruta, L.M., Pennisi, D., Kett, M., Little, M.H., 2007, Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development, Journal of the American Society of Nephrology, vol 18, issue 6, American Society of Nephrology, Washington DC USA, pp. 1697-1708.

Boesen, E.I., Anderson, W.P., Evans, R.G., Kett, M.M., 2007, Endogenous endothelins and the response to electrical renal nerve stimulation in anaesthetized rabbits, Autonomic Neuroscience: Basic & Clinical, vol 132, issue 1-2, Elsevier BV, The Netherlands, pp. 8-15.

Singh, R.R., Cullen-McEwen, L.A., Kett, M.M., Boon, W.M., Dowling, J.P., Bertram, J.F., Moritz, K.M., 2007, Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring, The Journal of Physiology, vol 579, issue 2, Blackwell Publishing, Oxford England UK, pp. 503-513.

Maduwegedera, D.W.K., Kett, M.M., Flower, R.L., Lambert, G.W., Bertram, J.F., Wintour, M.E., Denton, K.M., 2007, Sex differences in postnatal growth and renal development in offspring of rabbit mothers with chronic secondary hypertension, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol 292, issue 2, American Physiological Society, Bethesda USA, pp. 706-714.

O'Connor, P.M., Kett, M.M., Anderson, W.P., Evans, R.G., 2006, Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow, American Journal of Physiology-Renal Physiology, vol 290, issue 3, American Physiological Society, Bethesda USA, pp. F688-F694.

O'Connor, P.M., Anderson, W.P., Kett, M.M., Evans, R.G., 2006, Renal preglomerular arterial-venous O2 shunting is a structural anti-oxidant defence mechanism of the renal cortex, Clinical and Experimental Pharmacology and Physiology, vol 33, issue 7, Blackwell Publishing, Oxford England, pp. 637-641.

Duke, L.M., Widdop, R.E., Kett, M.M., Evans, R.G., 2005, AT2 receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension, British Journal of Pharmacology, vol 144, issue 4, Nature Publishing Group, London England, pp. 486-492.

Evans, R.G., Kett, M.M., Shweta, A., Fitzgerald, S.M., Denton, K.M., Eppel, G.A., Edgley, A.J., Anderson, W.P., 2005, New physiological targets within the kidney for antihypertensive therapy, Drug Design Reviews, vol 2, Bentham Science Publishers Ltd, The Netherlands, pp. 167-178.

Shweta, A., Denton, K.M., Kett, M.M., Bertram, J.F., Lambert, G.W., Anderson, W.P., 2005, Paradoxical structural effects in the unilaterally denervated spontaneously hypertensive rat kidney, Journal of Hypertension, vol 23, Lippincott Williams & Wilkins, Philadelphia USA, pp. 851-859.

Cochrane, A.L., Kett, M.M., Samuel, C.S., Campanale, N.V., Anderson, W.P., Hume, D.A., Little, M.H., Bertram, J.F., Ricardo, S.D., 2005, Renal structural and functional repair in a mouse model of reversal of ureteral obstruction, Journal of the American Society of Nephrology, vol 16, Lippincott Williams & Wilkins, Philadelphia USA, pp. 3623-3630.

Boesen, E.I., Anderson, W.P., Kett, M.M., 2005, Role of endothelin in noradrenaline-induced hypertension in rats, Journal of Hypertension, vol 23, issue 5, Lippincott Williams & Wilkins, Ltd., Philadelphia USA, pp. 987-993.

Kett, M.M., Denton, K.M., Boesen, E.I., Anderson, W.P., 2004, Effects of early carvedilol treatment and withdrawal on the development of hypertension and renal vascular narrowing, American Journal of Hypertension, vol 17, issue 2, Elsevier, New York USA, pp. 161-166.

Black, M.J., Briscoe, T., Constantinou, M., Kett, M.M., Bertram, J.F., 2004, Is there an association between level of adult blood pressure and nephron number or renal filtration surface area?, Kidney International, vol 65, issue 2, Blackwell Publishing, Inc., Malden USA, pp. 582-588.

Kett, M.M., Bertram, J.F., 2004, Nephron endowment and blood pressure: what do we really know?, Current Hypertension Reports, vol 6, issue 2, Current Science Inc., Philadelphia USA, pp. 133-139.

Boesen, E.I., Lambert, G.W., Anderson, W.P., Kett, M.M., 2004, Pre-weaning carvedilol treatment in spontaneously hypertensive rats, European Journal of Pharmacology, vol 486, issue 2, Elsevier, Amsterdam The Netherlands, pp. 183-188.

Boesen, E.I., Lewis, T.V., Kett, M.M., Anderson, W.P., 2003, Effects of preweaning doxazosin treatment on adult pressure in the spontaneously hypertensive rat, Clinical and Experimental Pharmacology and Physiology, vol 30, issue 8, Blackwell Publishing Asia, Carlton Vic Australia, pp. 555-557.

Edgley, A.J., Kett, M.M., Anderson, W.P., 2003, Evidence for renal vascular remodeling in angiotensin II-induced hypertension, Journal of Hypertension, vol 21, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1401-1406.

Cullen-McEwen, L.A., Kett, M.M., Dowling, J.P., Anderson, W.P., Bertram, J.F., 2003, Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice, Hypertension, vol 41, issue 2, Lippincott Williams & Wilkins, Philadelphia USA, pp. 335-340.

Kett, M.M., Bergstrom, G., Alcorn, D., Bertram, J.F., Anderson, W.P., 2001, Renal vascular resistance properties and glomerular protection in early established SHR hypertension, Journal of Hypertension, vol 19, issue 8, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1505-1512.

Kett, M.M., Heideman, B.L., Bertram, J.F., Anderson, W.P., 2001, Renomedullary interstitial cell lipid droplet content is increased in spontaneously hypertensive rats and by low salt diet, Journal of Hypertension, vol 19, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1309-1313.

Edgley, A.J., Kett, M.M., Anderson, W.P., 2001, 'Slow pressor' hypertension from low-dose chronic angiotensin II infusion, Clinical and Experimental Pharmacology and Physiology, vol 28, issue 12, Blackwell Science Asia, Carlton Vic Australia, pp. 1035-1039.

Steveson, K.M., Edgley, A.J., Bergstrom, G., Worthy, K., Kett, M.M., Anderson, W.P., 2000, Angiotensin II infused intrarenally causes preglomerular vascular changes and hypertension, Hypertension, vol 36 issue 6, American Heart Association, Philadelphia PA USA, pp. 839-844.

Bergstrom, G., Johansson, I., Steveson, K.M., Kett, M.M., Anderson, W.P., 1998, Peridopril treatment affects both preglomerular renal vascular lumen dimensions and in vivo responsiveness to vasoconstrictors in spontaneously hypertensive rats, Hypertension, vol 31 (4), American Heart Association, Baltimore MD USA, pp. 1007-1013.

Conference Proceedings

Anderson, W.P., Kett, M.M., Steveson, K.M., Edgley, A.J., Denton, K.M., Fitzgerald, S.M., 2000, Renovascular Hypertension: Structural changes in the renal vasculature, Hypertension, Lorne, Victoria: 22-24 March 2000, American Heart Foundation, www.hypertensionaha.org, pp. 648-652.

Kett, M.M., Anderson, W.P., 1998, Effects of carvedilol treatment on the renal vasculature and filtration capacity of young SHR, Journal of Hypertension, Amsterdam The Netherlands 7-11 June 1998, Lippincott-Raven, London UK, p. 5189.

Kett, M.M., Anderson, W.P., 1998, Effects of carvedilol treatment on the renal vasculature of SHR: Lack of long term benefits, High Blood Pressure Research Council of Australia Inc, Melbourne Victoria 10-12 December 1998, High Blood Pressure Research Council of Australia, Melbourne Vic Australia, p. 105.

Anderson, W.P., Kett, M.M., Alcorn, D., Bertram, J.F., 1997, Angiotensin II antagonism and pre-glomerular arterial wall dimensions in the kidney of the spontaneously hypertensive rat, Clinical and Experimental Hypertension, Broome WA, September 1996, Marcel Dekker Inc, New York NY USA, pp. 965-979.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Birth Asphyxia and Acute kidney Failure: the Protective Capacity of Maternal creatine Supplements.

Supervisors:

Dickinson, H (Main), Kett, M (Associate), Walker, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Novel understanding of the consequences of rental programming.

Supervisors:

Kett, M (Main).

Completed Supervision

Student:

Boesen, E.

Program of Study:

NORADRENALINE-INDUCED HYPERTENSION, ENDOTHELIN AND THE RENAL NERVES. (PHD) 2004.

Supervisors:

Anderson, W (Main), Kett, M (Joint).

Student:

O'Connor, P.

Program of Study:

RENAL MEDULLARY OXYGENATION AND ANTIHYPERTENSIVE MECHANISMS. (PHD) 2005.

Supervisors:

Anderson, W (Joint-Co), Kett, M (Joint).

Student:

Ruta, L.

Program of Study:

Cardiovascular and renal outcomes for mice born with moderate or marked nephron deficits. (PHD) 2009.

Supervisors:

Kett, M (Main).

Student:

Walker, K.

Program of Study:

The development and function of high nephron endowment. (PHD) 2010.

Supervisors:

Bertram, J (Main), Caruana, G (Associate), Stenvers, K (Associate), Kett, M (Associate).