Mr Antony Vinh - Researcher Profile

Biography

Dr Antony Vinh is a research fellow within the Department of Pharmacology. Dr Vinh completed his PhD in pharmacology, focusing on the role of the hexapeptide angiotensin fragment, angiotensin IV, in atherosclerosis and endothelial dysfunction at Monash University. He then pursued postdoctoral training at Emory University, Atlanta, USA, under the mentorship of Prof David Harrison, investigating the role of adaptive immunity and T cells during the development of hypertension.

In 2010, Dr Vinh was recruited back to Monash Pharmacology as a Monash Larkins Fellow to continue his research on the expanding field of T cells and hypertension, with a particular focus on identifying the functional contribution of T cells to organ dysfunction associated with hypertension. The ultimate goal of his research is to understand how hypertension becomes an immunologic disorder, and identify novel immune targets to treat inflammation associated with hypertension. Dr Vinh currently holds a Monash Larkin Fellowship and Heart Foundation Postdoctoral Fellowship and is funded by the Ramaciotti Foundation and Monash University.

Qualifications

PHD

Institution: Monash University

Year awarded: 2008

BACHELOR OF BIOMEDICAL SCIENCE (HONS)

Institution: Monash University

Year awarded: 2003

Publications

Journal Articles

McCarthy, C.A., Vinh, A., Broughton, B.R., Sobey, C.G., Callaway, J.K., Widdop, R.E., 2012, Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats, Hypertension [P], vol 60, issue 6, Lippincott Williams & Wilkins, USA, pp. 1531-1537.

Gaspari, T.A., Vinh, A., Jones, E.S., Widdop, R.E., 2012, Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling, Hypertension [P], vol 60, issue 1, Lippincott Williams & Wilkins, USA, pp. 17-19.

Coso, S., Harrison, I., Harrison, C., Vinh, A., Sobey, C., Drummond, G., Williams, E., Selemidis, S., 2012, NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts, Antioxidants and Redox Signaling [P], vol 16, issue 11, Mary Ann Liebert Inc Publishers, United States, pp. 1229-1247.

Chan, C., Moore, J., Budzyn, K., Guida, E., Diep, H., Vinh, A., Jones, E.S., Widdop, R.E., Armitage, J.A., Sakkal, S., Ricardo, S.D., Sobey, C.G., Drummond, G.R., 2012, Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice, Hypertension [P], vol 60, issue 5, Lippincott Williams & Wilkins, USA, pp. 1207-1212.

Marvar, P.J., Vinh, A., Thabet, S., Lob, H.E., Geem, D., Ressler, K.J., Harrison, D.G., 2012, T lymphocytes and vascular inflammation contribute to stress-dependent hypertension, Biological Psychiatry [P], vol 71, issue 9, Elsevier Inc, USA, pp. 774-782.

Libinaki, R., Tesanovic, S., Heal, A., Nikolovski, B., Vinh, A., Widdop, R.E., Gaspari, T.A., Devaraj, S., Ogru, E., 2010, Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model, Clinical And Experimental Pharmacology And Physio..., vol 37, issue 5-6, Wiley-Blackwell Publishing Asia, Australia, pp. 587-592.

Vinh, A., Chen, W., Blinder, Y., Weiss, D., Taylor, W., Goronzy, J.J., Weyand, C.M., Harrison, D., Guzik, T.J., 2010, Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension, Circulation [P], vol 122, issue 24, Lippincott Williams & Wilkins, USA, pp. 2529-2537.

Harrison, D.G., Vinh, A., Lob, H., Madhur, M.S., 2010, Role of the adaptive immune system in hypertension, Current Opinion in Pharmacology [P], vol 10, issue 2, Elsevier Sci Ltd, UK, pp. 203-207.

Tesanovic Kljajic, S., Vinh, A., Gaspari, T.A., Casley, D., Widdop, R.E., 2010, Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 30, issue 8, Lippincott Williams & Wilkins, USA, pp. 1606-1613.

McCarthy, C.A., Vinh, A., Callaway, J.K., Widdop, R.E., 2009, Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke, Stroke, vol 40, issue 4, Lippincott Williams & Wilkins, USA, pp. 1482-1489.

Vinh, A., Gaspari, T.A., Jones, E.S., Widdop, R.E., 2009, Functional Cardiovascular Effects of Angiotensin Peptides: Focus on Atherosclerosis and Hypertension, Current Hypertension Reviews [P], vol 5, issue 3, Bentham Science Publishers Ltd, The Netherlands, pp. 227-236.

Vinh, A., Gaspari, T.A., Liu, H., Dousha, L., Widdop, R.E., Dear, A.E., 2008, A novel histone deacetylase inhibitor reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice, Journal of Vascular Research, vol 45, Karger, Switzerland, pp. 143-152.

Jones, E.S., Vinh, A., McCarthy, C.A., Gaspari, T.A., Widdop, R.E., 2008, AT2 receptors: Functional relevance in cardiovascular disease, Pharmacology & Therapeutics, vol 120, issue 3, Elsevier Inc., United States, pp. 292-316.

Vinh, A., Widdop, R.E., Chai, S.Y., Gaspari, T.A., 2008, Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma, Atherosclerosis, vol 200, issue 1, Elsevier Ireland Ltd, Ireland, pp. 37-44.

Vinh, A., Widdop, R.E., Drummond, G.R., Gaspari, T.A., 2008, Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice, Cardiovascular Research, vol 77, Elsevier Science BV, Amsterdam, The Netherlands, pp. 178-187.

Widdop, R.E., Vinh, A., Henrion, D., Jones, E.S., 2008, Vascular angiotensin AT2 receptors in hypertension and ageing, Clinical and Experimental Pharmacology & Physiology, vol 35, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 386-390.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identify the specific functional roles of T cell and leukocytes during hypertension.

Supervisors:

Widdop, R (Main), Vinh, A (Associate).