Dr Roland Chung - Researcher Profile

Biography

Position

Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

DOCTOR OF PHILOSOPHY

Institution: La Trobe University

Year awarded: 1991

BACHELOR OF SCIENCE

Institution: La Trobe University

Year awarded: 1986

Publications

Journal Articles

Sundaram, K., Dhagat, U., Endo, S., Chung, R., Matsunaga, T., Hara, A., El-Kabbani, O., 2011, Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 2, Pergamon, United Kingdom, pp. 801-804.

Carbone, V., Giglio, M., Chung, R., Huyton, T., Adams, J., Maccari, R., Ottana, R., Hara, A., El-Kabbani, O., 2010, Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor, European Journal of Medicinal Chemistry [P], vol 45, issue 3, Elsevier Masson, France, pp. 1140-1145.

Carbone, V., Zhao, H., Chung, R.P., Endo, S., Hara, A., El-Kabbani, O., 2009, Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase, Bioorganic & Medicinal Chemistry [P], vol 17, issue 3, Pergamon, UK, pp. 1244-1250.

Chung, R.P., Endo, S., Hara, A., El-Kabbani, O., 2009, Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14), Acta Crystallographica Section F: Structural Biology..., vol 65, issue Pt 4, Wiley-Blackwell Munksgaard, Denmark, pp. 395-397.

Zhao, H., Endo, S., Ishikura, S., Chung, R.P., Hogg, P.J., Hara, A., El-Kabbani, O., 2009, Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase, Cellular And Molecular Life Sciences [P], vol 66, issue 9, Birkhaeuser Verlag AG, Switzerland, pp. 1570-1579.

Carbone, V., Chung, R.P., Endo, S., Hara, A., El-Kabbani, O., 2008, Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity, Archives of Biochemistry and Biophysics, vol 479, issue 1, ELSEVIER SCIENCE INC, USA, pp. 82-87.

Carbone, V., Endo, S., Sumii, R., Chung, R.P., Matsunaga, T., Hara, A., El-Kabbani, O., 2008, Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis, Proteins Structure Function Bioinformatics, vol 70, issue 1, John Wiley and Sons, Inc., USA, pp. 176-187.

Dhagat, U., Carbone, V., Chung, R.P., Matsunaga, T., Endo, S., Hara, A., El-Kabbani, O., 2007, A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase, Medicinal Chemistry, vol 3, issue 6, Bentham Science Publishers Ltd, Netherlands, pp. 546-550.

Dhagat, U., Carbone, V., Chung, R.P., Schulze-Briese, C., Endo, S., Hara, A., El-Kabbani, O., 2007, Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme, Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, vol 63, Blackwell Publishing, Denmark, pp. 825-830.

Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R.P., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A., Podjarny, A.D., 2005, Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex, Journal of Medicinal Chemistry, vol 48, issue 18, American Chemical Society, Washingtong, USA, pp. 5659-5665.

El-Kabbani, O., Carbone, V., Darmanin, C., Oka, M., Mitschler, A., Podjarny, A.D., Schulze-Briese, C., Chung, R.P., 2005, Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity, Journal of Medicinal Chemistry, vol 48, issue 17, American Chemical Society, Washington, USA, pp. 5536-5542.

El-Kabbani, O., Ruiz, F., Darmanin, C., Chung, R.P., 2004, Aldose reductase structures: implications for mechanism and inhibition, Cellular and Molecular Life Sciences, vol 61, issue 7-Aug, Birkhauser Verlag AG, Switzerland, pp. 750-762.

El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P., Usami, N., Hara, A., 2004, Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis, PROTEINS: Structure, Function and Bioinformatics, vol 55, issue 3, John Wiley & Sons, Inc., USA, pp. 724-732.

El-Kabbani, O., Darmanin, C., Chung, R.P., 2004, Sorbitol Dehydrogenase: Structure, Function and Ligand Design, Current Medicinal Chemistry, vol 11, issue 4, Bentham Science Publishers Ltd, The Netherlands, pp. 465-476.

Darmanin, C., Iwata, T., Carper, D.A., Sparrow, L.G., Chung, R.P., El-Kabbani, O., 2003, Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase, Acta Crytallographica Section D: Biological Crystallography, vol D59, Blackwell Munksgaard, Denmark, pp. 558-560.

El-Kabbani, O., Ramsland, P.A., Darmanin, C., Chung, R.P., Podjarny, A.D., 2003, Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme, PROTEINS: Structure, Function, and Genetics, vol 50, issue 2, John Wiley & Sons, Inc., USA, pp. 230-238.

El-Kabbani, O., Chung, R.P., Ramsland, P.A., Asada, Y., Ishikura, S., Usami, N., Hara, A., 2002, Crystallization and preliminary X-ray diffraction analysis of monkey dimeric dihydrodiol dehydrogenase, Acta Crystallographica Section D: Biological Crystallography, vol D58, issue Part 1, Blackwell Munksgaard, Denmark, pp. 163-164.

El-Kabbani, O., Chung, R.P., Ishikura, S., Usami, N., Nakagawa, J., Hara, A., 2002, Crystallization and preliminary crystallographic analysis of human L-xylulose reductase, Acta Crystallographica. Section D: Biological Crystallography, vol D58, issue Part 8, Blackwell Munksgaard, Denmark, pp. 1379-1380.

El-Kabbani, O., Rogniaux, H., Barth, P., Chung, R.P., Fletcher, E.V., Van Dorsselaer, A., Podjarny, A., 2000, Aldose and aldehyde reductases:correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site, Proteins:Structure, Function and Genetics, vol 41 issue 3, Wiley-Liss, New York NY USA, pp. 407-414.

El-Kabbani, O., Chung, R.P., 2000, Crystallization and preliminary x-ray analysis of porcine aldehyde reductase in complex with coenzyme and quercetin, Protein and Peptide Letters, vol 7 issue 3, Bentham Science Publishers Ltd, Hilversum Netherlands, pp. 201-206.

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences