Adj Assoc Prof Peter Tipping - Researcher Profile

Qualifications

PHD MEDICINE

Institution: Monash University

Year awarded: 1986

MBBS (HONS) - BACHELOR OF MEDICINE & SURGERY

Institution: Monash University

Year awarded: 1975

BACHELOR OF BIOMEDICAL SCIENCE

Institution: Monash University

Year awarded: 1974

Publications

Book Chapters

Holdsworth, S., Tipping, P., 2011, Pathways of cellular adaptive immunity in autoimmune crescentic glomerulonephritis and lupus nephritis, in Lupus Nephritis, eds Edmund J.Lewis, Melvin M. Schwartz, Stephen M. Korbet, Daniel Tak Mao Chan, Oxford University Press, United States, pp. 105-128.

Tipping, P.G., Kitching, A.R., Holdsworth, S.R., 2001, The formation of glomerular crescents, in Immunologic Renal Diseases, eds Eric G. Neilson, William G. Couser, Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 633-656.

Holdsworth, S.R., Erlich, J.H., Tipping, P.G., 1998, Immunopathogenesis of crescentic glomerulonephritis, in Rapidly Progressive Glomerulonephritis, Oxford University Press, Oxford University Press New York NY USA, pp. 12-42.

Journal Articles

Dinh, T.N., Kyaw, T.S., Kanellakis, P., To, K.Y., Tipping, P.G., Toh, B., Bobik, A., Agrotis, A., 2012, Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis, Circulation [P], vol 126, issue 10, Lippincott Williams & Wilkins, Ltd., United States, pp. 1256-1266.

Kyaw, T.S., Tay, C., Hosseini, H., Kanellakis, P., Gadowski, T., Mackay-Fisson, F., Tipping, P.G., Bobik, A., Toh, B., 2012, Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE-/- mice attenuates atherosclerosis by potently ameliorating arterial inflammation, PLoS ONE [P], vol 7, issue 1, Public Library of Science, United States, p. e29371.

Knight, V., Tchongue, J., Dowling, D., Tipping, P., Sievert, W., 2012, Protease-activated receptor 2 promotes experimental liver fibrosis in mice and activates human hepatic stellate cells, Hepatology [P], vol 55, issue 3, John Wiley & Sons, Inc., United States, pp. 879-887.

Kyaw, T.S., Tipping, P.G., Bobik, A., Toh, B., 2012, Protective role of natural IgM-producing B1a cells in atherosclerosis, Trends in Cardiovascular Medicine [P], vol 22, issue 2, Elsevier Inc., United States, pp. 48-53.

Kyaw, T., Tay, C., Krishnamurthi, S., Kanellakis, P., Agrotis, A., Tipping, P., Bobik, A., Toh, B., 2011, B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions, Circulation Research [P], vol 109, issue 8, Lippincott Williams & Wilkins, United States, pp. 830-840.

Kyaw, T., Tipping, P., Toh, B., Bobik, A., 2011, Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis, Current Opinion In Lipidology [P], vol 22, issue 5, Lippincott Williams & Wilkins, Ltd, United Kingdom, pp. 373-379.

Kyaw, T., Tay, C., Khan, A., Dumouchel, V., Cao, A., To, K., Kehry, M., Dunn, R., Agrotis, A., Tipping, P., Bobik, A., Toh, B., 2010, Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis, Journal Of Immunology [P], vol 185, issue 7, American Association of Immunologists, United States of America, pp. 4410-4419.

Apostolopoulos, J., Moussa, L., Tipping, P.G., 2010, The cytoplasmic domain of tissue factor restricts physiological albuminuria and pathological proteinuria associated with glomerulonephritis in mice, Nephron - Experimental Nephrology [P], vol 116, issue 4, S. Karger AG, Switzerland, pp. 72-83.

Tipping, P.G., 2008, Are podocytes passive or provocative in proteinuric glomerular pathology?, American Society of Nephrology. Journal, vol 19, issue 4, American Society of Nephrology, United States, pp. 651-653.

Tipping, P.G., 2008, Crescentic nephritis--is it in your genes?, Nephrology, Dialysis, Transplantation, vol 23, issue 10, Oxford University Press, United Kingdom, pp. 3065-3066.

Apostolopoulos, J., Hickey, M.J., Sharma, L., Davenport, P.R., Moussa, L., James, W.G.M., Gregory, J.L., Kitching, A.R., Li, M., Tipping, P.G., 2008, The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity, Journal of Leukocyte Biology, vol 83, issue 4, Federation of American Societies for Experimental Biology, United States, pp. 902-911.

Haase, M., Silvester, W., Uchino, S., Goldsmith, D., Davenport, P., Tipping, P., 2007, A pilot study of high-adsorption hemofiltration in human septic shock, International Journal of Artificial Organs [P], vol 30, issue 2, Wichtig Editore Srl, Italy, pp. 108-117.

Tipping, P.G., Holdsworth, S.R., 2007, Cytokines in glomerulonephritis, Seminars in Nephrology, vol 27, issue 3, W.B. Saunders Co, UK, pp. 275-285.

Holdsworth, S.R., Tipping, P.G., 2007, Leukocytes in glomerular injury, Seminars in Immunopathology, vol 29, issue 4, Springer, Germany, pp. 355-374.

Moussa, L., Apostolopoulos, J., Davenport, P.R., Tchongue, J., Tipping, P.G., 2007, Protease-activated receptor-2 augments experimental crescentic glomerulonephritis, The American Journal of Pathlogy, vol 171, issue 3, American Society for Investigative Pathology, USA, pp. 800-808.

Timoshanko, J.R., Kitching, A.R., Semple, T.J., Tipping, P.G., Holdsworth, S.R., 2006, A pathogenetic role for mast cells in experimental crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 17, issue 1, Americal Society of Nephrology, USA, pp. 150-159.

Tipping, P.G., Holdsworth, S.R., 2006, T cells in crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 17, issue 5, Lippincott Williams & Wilkins, USA, pp. 1253-1263.

Tipping, P.G., 2006, Toll-like receptors: the interface between innate and adaptive immunity, Journal of the American Society of Nephrology, vol 17, issue 7, Lippincott Williams & Wilkins, USA, pp. 1769-1771.

Odobasic, D., Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 2005, CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms, Kidney International, vol 68, issue 2, Blackwell Publishing, Inc., USA, pp. 584-594.

Duffield, J.S., Tipping, P.G., Kipari, T., Cailhier, J., Clay, S., Lang, R., Bonventre, J.V., Hughes, J., 2005, Conditional ablation of macrophages halts progression of crescentic glomerulonephritis, American Journal of Pathology, vol 167, issue 5, American Society for Investigative Pathology, USA, pp. 1207-1219.

Tipping, P.G., Timoshanko, J.R., 2005, Contributions of intrinsic renal cells to crescentic glomerulonephritis., Nephron experimental Nephrology, vol 101, issue 4, S. Karger AG, Switzerland, pp. e173-e178.

Odobasic, D., Kitching, A.R., Semple, T.J., Timoshanko, J.R., Tipping, P.G., Holdsworth, S.R., 2005, Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 16, issue 7, Lippincott Williams & Wilkins, USA, pp. 2012-2022.

Tipping, P.G., Kitching, A.R., 2005, Glomerulonephritis, Th1 and Th2: what's new?, Clinical and Experimental Immunology, vol 142, issue 2, Blackwell Publishing Ltd., UK, pp. 207-215.

Timoshanko, J.R., Kitching, A.R., Semple, T.J., Holdsworth, S.R., Tipping, P.G., 2005, Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 16, issue 9, Lippincott Willimas & Wilkins, USA, pp. 2646-2656.

Kitching, A.R., Turner, A.L., Wilson, G.R.A., Semple, T.J., Odobasic, D., Timoshanko, J.R., O'Sullivan, K.M., Tipping, P.G., Takeda, K., Akira, S., Holdsworth, S.R., 2005, IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment, Journal of the American Society of Nephrology, vol 16, issue 7, Lippincott Williams & Wilkins, USA, pp. 2023-2033.

Yang, Y.H., Hall, P.H., Little, C.B., Fosang, A.J., Milenkovski, G., Santos, L.L., Xue, J.R., Tipping, P.G., Morand, E.F., 2005, Reduction of Arthritis severity in Protease-activated receptor-deficient mice, Arthritis & Rheumatism, vol 52, issue 4, John Wiley & Sons, Inc., USA, pp. 1325-1332.

Timoshanko, J.R., Tipping, P.G., 2005, Resident kidney cells and their involvement in glomerulonephritis, Current Drug Targets - Inflammation & Allergy, vol 4, Bentham Science Publishers Ltd, The Netherlands, pp. 353-362.

Ruth, A., Kitching, A.R., Li, M., Semple, T.J., Timoshanko, J.R., Tipping, P.G., Holdsworth, S.R., 2004, An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity, The Journal of Immunology, vol 173, issue 1, The American Association of Immunologists, Inc, United, pp. 136-144.

Timoshanko, J.R., Kitching, A.R., Iwakura, Y., Holdsworth, S.R., Tipping, P.G., 2004, Contributions of IL-1 and IL-1to crescentic glomerulonephritis in mice, Journal of the American Society of Nephrology, vol 15, issue 4, Lippincott Williams and Wilkins, USA, pp. 910-918.

Cole, L., Bellomo, R., Davenport, P.R., Tipping, P.G., Ronco, C., 2004, Cytokine removal during continuous renal replacement therapy: an ex vivo comparison of convection and diffusion, The International Journal of Artificial Organs, vol 27, issue 5, Wichtig Editore, Italy, pp. 388-397.

Kitching, A.R., Turner, A.L., Wilson, G.R.A., Edgtton, K.L., Tipping, P.G., Holdsworth, S.R., 2004, Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis, Journal of the American Society of Nephrology, vol 15, issue 9, Lippincott Williams and Wilkins, USA, pp. 2373-2382.

Cunningham, M.A., Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 2004, Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis, Kidney International, vol 66, issue 2, Blackwell Publishing Inc, USA, pp. 647-654.

Timoshanko, J.R., Kitching, A.R., Iwakura, Y., Holdsworth, S.R., Tipping, P.G., 2004, Leukocyte-derived interleukin-1 interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis, American Journal of Pathology, vol 164, issue 6, American Society for Investigative Pathology, USA, pp. 1967-1977.

Yang, Y.H., Hall, P.H., Milenkovski, G., Sharma, L., Hutchinson, P., Melis, E., Carmeliet, P., Tipping, P.G., Morand, E.F., 2004, Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice, American Journal of Pathology, vol 164, issue 1, American Society for Investigative Pathology, Inc, USA, pp. 109-117.

Sharma, L., Melis, E., Hickey, M.J., Clyne, C.D., Erlich, J., Khachigian, L.M., Davenport, P.R., Morand, E.F., Carmeliet, P., Tipping, P.G., 2004, The Cytoplasmic Domain of Tissue Factor Contributes to Leukocyte Recruitment and Death in Endotoxemia, American Journal of Pathology, vol 165, issue 1, American Society for Investigative Pathology, USA, pp. 331-340.

Ruth, A., Kitching, A.R., Semple, T.J., Tipping, P.G., Holdsworth, S.R., 2003, Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 14, issue 11, Lippincott Williams & Wilkins, Philadelphia USA, pp. 2813-2822.

Timoshanko, J.R., Sedgwick, J.D., Holdsworth, S.R., Tipping, P.G., 2003, Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 14, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1785-1793.

Kitching, A.R., Kong, Y.Z., Huang, X.R., Davenport, P.R., Edgtton, K.L., Carmeliet, P., Holdsworth, S.R., Tipping, P.G., 2003, Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 14, issue 6, Lippincott Williams & Wilkins, Philadeplphia USA, pp. 1487-1495.

Tipping, P.G., Holdsworth, S.R., 2003, T cells in glomerulonephritis, Springer Seminars in Immunopathology, vol 24, issue 4, Springer-Verlag, New York USA, pp. 377-393.

Davenport, P.R., Tipping, P.G., 2003, The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice, American Journal of Pathology, vol 163, issue 3, American Society for Investigative Pathology, Bethesda USA, pp. 1117-1125.

Yuan, H.T., Tipping, P.G., Li, X., Long, D.A., Woolf, A.S., 2002, Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis, Kidney International, vol 61, issue 6, Nature Publishing Group, UK/USA, pp. 2078-2089.

Timoshanko, J.R., Holdsworth, S.R., Kitching, A.R., Tipping, P., 2002, IFN-g Production by Intrinsic Renal Cells and Bone Marrow-Derived Cells is Required for Full Expression of Crescentic Glomerulonephritis in Mice, Journal of Immunology, vol 168, American Association of Immunologists, Bethesda MD USA, pp. 4135-4141.

Kitching, A.R., Katerelos, M., Mudge, S.J., Tipping, P., Power, D.A., Holdsworth, S.R., 2002, Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis, Clinical and Experimental Immunology, vol 128, issue 1, Blackwell Publishing Ltd, Oxford UK, pp. 36-43.

Kitching, A.R., Huang, X., Turner, A.L., Tipping, P., Dunn, A.R., Holdsworth, S.R., 2002, The Requirement for Granulocyte-Macrophage Colony-Stimulating Factor and Granulocyte Colony-Stimulating Factor in Leukocyte-Mediated Immune Glomerular Injury, Journal of American Society of Nephrology, vol 13, issue 2, Lippincott Williams and Wilkins, Philadelphia PA USA, pp. 350-358.

Kitching, A.R., Huang, X., Tipping, P., Holdsworth, S.R., 2002, effects of CRLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice, Clinical and Experimental Immunology, vol 128, Blackwell Publishing Ltd, Oxford England, pp. 429-435.

Peverill, R., Teede, H.J., Smolich, J., Malan, E., Kotsopoulos, D., Tipping, P., McGrath, B.P., 2001, Effects of combined oral hormone replacement therapy on tissue factor pathway inhibitor and factor VII, Clinical Science, vol 101, Portland Press, London England, pp. 93-99.

Timoshanko, J.R., Kitching, A.R., Holdsworth, S., Tipping, P., 2001, Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis, Journal of the American Society of Nephrology, vol 12, Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 464-471.

Holdsworth, S.R., Kitching, A.R., Tipping, P.G., 2000, Chemokines as therapeutic targets in renal disease, Current Opinion in Nephrology and Hypertension, vol 9 issue 5, Lippincott Williams and Wilkins, Philadelphia PA USA, pp. 505-511.

Kitching, A.R., Holdsworth, S.R., Tipping, P.G., 2000, Crescentic glomerulonephritis - a manifestation of a nephritogenic Th1 response?, Histology and Histopathology, vol 15, F. Hernandez, Murcia Spain, pp. 993-1003.

Kitching, A.R., Tipping, P.G., Timoshanko, J.R., Holdsworth, S.R., 2000, Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis, Kidney International, vol 57, Blackwell Science Inc, Malden MA USA, pp. 518-525.

Kitching, A.R., Tipping, P.G., Kurimoto, M., Holdsworth, S.R., 2000, IL-18 Has IL-12-Independent Effects in Delayed-Type Hypersensitivity: Studies in Cell-Mediated Crescentic Glomerulonephritis, Journal of Immunology, vol 165 issue 8, American Association of Immunologists, USA, pp. 4649-4657.

Huang, X.R., Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 2000, Interleukin-10 Inhibits Macrophage-Induced Glomerular Injury, Journal of the American Society of Nephrology, vol 11, Lippincott Williams and Wilkins, Philadelphia PA USA, pp. 262-269.

Li, S., Holdsworth, S.R., Tipping, P.G., 2000, MHC class I pathway is not required for the development of crescentic glomerulonephritis in mice, Clinical and Experimental Immunology, vol 122, Blackwell Science Ltd, Oxford England, pp. 453-458.

Cunningham, M.A., Rondeau, E., Chen, X., Coughlin, S.R., Holdsworth, S.R., Tipping, P.G., 2000, Protease-activated Receptor 1 Mediates Thrombin-dependent, Cell-mediated Renal Inflammation in Crescentic Glomerulonephritis, Journal of Experimental Medicine, vol 191 issue 3, The Rockefeller University Press, New York NY USA, pp. 455-461.

Harris, G.M., Stendt, C.L., Vollenhoven, B., Eng Gan, T., Tipping, P.G., 1999, Decreased plasma tissue factor pathway inhibitor in women taking combined oral contraceptives, American Journal of Hematology, vol 60, Wiley-Liss, New York NY USA, pp. 175-180.

Kitching, A.R., Holdsworth, S.R., Tipping, P.G., 1999, IFN-gamma Mediates Crescentic Formation and Cell-Mediated Immune Injury in Murine Glomerulonephritis, Journal of the American Society of Nephrology, vol 10 (4), Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 752-759.

Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 1999, IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis, European Journal of Immunology, vol 29, Wiley-VCH Verlag GmbH, Berlin Germany, pp. 1-10.

Tipping, P.G., Kitching, A.R., Cunningham, M.A., Holdsworth, S.R., 1999, Immunopathogenesis of crescentic glomerulonephritis, Current Opinion in Nephrology and Hypertension, vol 8, Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 281-286.

D'Souza, M., Oettinger, C., Shah, A., Tipping, P.G., Huang, X., Milton, G., 1999, Macrophage Depletion by Albumin Microencapsulated Clodronate: Attenuation of Cytokine Release in Macrophage-Dependent Glomerulonephritis, Drug Development and Industrial Pharmacy, vol 25(5), Marcel Dekker Inc, New York NY USA, pp. 591-596.

Cunningham, M.A., Huang, X., Dowling, J.P., Tipping, P.G., Holdsworth, S.R., 1999, Prominence of Cell-Mediated Immunity Effectors in "Pauci-Immune" Glomerulonephritis, Journal of the American Society of Nephrology, vol 10, Lippincott Williams & Wilkins, Philadelphia PA USA, pp. 499-506.

Holdsworth, S.R., Kitching, A.R., Tipping, P.G., 1999, Th1 and Th2 helper cell subsets affect patterns of injury and outcomes in glomerulonephritis, Kidney International, vol 55, Blackwell Science, Malden MA USA, pp. 1198-1216.

Cunningham, M.A., Ono, T., Hewitson, T.D., Tipping, P.G., Becker, G.J., Holdsworth, S.R., 1999, Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis, Kidney International, vol 55, Blackwell Science, Malden MA USA, pp. 1311-1318.

Tipping, P.G., Huang, X., Qi, M., Van, G.Y., Tang, W.W., 1998, Crescentic Glomerulonephritis in CD4- and CD8-Deficient Mice, American Journal of Pathology, vol 152 no 6, American Society for Investigative Pathology, www.amjpathol.org, pp. 1541-1548.

Kitching, A.R., Tipping, P.G., Mutch, D.A., Huang, X., Holdsworth, S.R., 1998, Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice, Kidney International, vol 53, Blackwell Science Inc, 350 Main St Malden MA 02148 USA, pp. 112-118.

Gallicchio, M., McFarlane, J.R., Hufnagl, P., Holdsworth, S.R., Tipping, P.G., 1998, Stimulation of PAI-1 in rabbit anti-GBM glomerulonephritis, Nephrology, vol 4, Blackwell Science, Carlton Vic Australia, pp. 65-74.

Huang, X., Tipping, P.G., Holdsworth, S.R., 1998, T cells direct macrophage recruitment and giant cell formation but not proliferation in experimental crescentic glomerulonephritis, Nephrology, vol 4, Blackwell Science, Carlton Vic Australia, pp. 151-156.

Shuo, L., Holdsworth, S.R., Tipping, P.G., 1997, Antibody independent crescentic glomerulonephritis in m chain deficient mice, Kidney International, vol 51, Blackwell Science Inc., 350 Main St Malden MA 02148 USA, pp. 672-678.

Tipping, P.G., Kitching, A.R., Huang, X.R., Mutch, D.A., Holdsworth, S.R., 1997, Immune modulation with interleukin-4 and interleukin-10 prevents crescent formation and glomerular injury in experimental glomerulonephritis, European Journal of Immunology, vol 27, Wiley-VCH, Germany, pp. 530-537.

Kitching, A.R., Tipping, P.G., Huang, X.R., Mutch, D.A., Holdsworth, S.R., 1997, Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice, Kidney International, vol 52, Blackwell Science Inc., 350 Main St Malden MA 02148 USA, pp. 52-59.

Huang, X.R., Tipping, P.G., Apostolopoulos, J., Oettinger, C., D'Souza, M., Milton, G., Holdsworth, S.R., 1997, Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats, Clinical and Experimental Immunology, vol 109, Blackwell Science, UK, pp. 134-142.

Kitching, A.R., Holdsworth, S.R., Ploplis, V., Plow, E., Collen, D., Carmeliet, P., Tipping, P.G., 1997, Plasminogen and Plasminogen Activators Protect against Renal Injury in Crescentic Glomerulonephritis, Journal of Experimental Medicine, vol 185, The Rockefeller University Press, USA, pp. 963-968.

Huang, X.R., Tipping, P.G., Shuo, L., Holdsworth, S.R., 1997, Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice, Kidney International, vol 51, Blackwell Science Inc., 350 Main St Malden MA 02148 USA, pp. 94-103.

Huang, X.R., Holdsworth, S.R., Tipping, P.G., 1997, Th2 Responses Induce Humorally Mediated Injury in Experimental Anti-Glomerular Membrane Glomerulonephritis, Journal of the American Society of Nephrology, vol 8, American Society of Nephrology, University of Florida Gainesville Florida USA, pp. 1101-1108.

Erlich, J.H., Holdsworth, S.R., Tipping, P.G., 1997, Tissue Factor Initiates Glomerular Fibrin Deposition and Promotes Major Histocompatibility Complex Class II Expression in Crescentic Glomerulonephritis, American Journal of Pathology, vol 150, American Assoc.of Pathologist, Philadelphia PA USA, pp. 873-880.

Drew, A.F., Davenport, P., Apostolopoulos, J., Tipping, P.G., 1997, Tissue Factor Pathway Inhibitor Expression in Atherosclerosis, Laboratory Investigation, vol 77, US & Canadian Academy of Pathology Inc., USA, pp. 291-298.

Carmeliet, P., Moons, L., Lijnen, R., Baes, M., Lemaitre, V., Tipping, P.G., Drew, A.F., Shapiro, S., Lupu, F., Collen, D., 1997, Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation, Nature Genetics, vol 17, Nature America Inc, New York NY USA, pp. 439-444.

Conference Proceedings

Cunningham, M.A., Rondeau, E., Holdsworth, S.R., Tipping, P.G., 1998, Attenuation of Proliferative Glomerulonephritis in Thrombin Receptor (PAR-1) Deficient Mice: Evidence For A Non-Coagulant Role of Thrombin in Glomerular Injury, Nephrology, Auckland NZ, Blackwell Science Asia, Carlton Vic Australia, p. A2.

Kitching, A.R., Holdsworth, S.R., Tipping, P.G., 1998, Endogenous Interferon-y is an Important Mediator of Glomerular Cresent Formation and Cell Mediated Glomerular injury, Nephrology, Auckland NZ, Blackwell Science Asia, Carlton Vic Australia.

Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 1998, Interleukin-12 Directs Th1 Responses and Crescent Formation in Glomerulonephritis, Journal of the American Society of Nephrology, Philadelphia USA October 25-28, Williams and Wilkins, Philadelphia USA, p. A17.

Kitching, A.R., Tipping, P.G., Holdsworth, S.R., 1998, Interleukin-4 Is Not A Crucial Mediator of Renal Injury in Th2 Prone Mice With Glomerulonephritis, Nephrology, Auckland NZ, Blackwell Science Asia, Carlton Vic Australia, p. A4.

Tipping, P.G., Li, S., Kurts, C., Kontgen, F., Holdsworth, S.R., 1998, Major Histocompatibility Complex Class II (MHC II) Expression by Intrinsic Glomerular Cells is Required for Antigen Recognition in Crescentic Glomerulonephritis, Journal of the American Society of Nephrology, Philadelphia Pennsylvania Oct 25-28 1998, Williams & Wilkins, Philadelphia Pennsylvania, p. A13.

Holdsworth, S.R., Kitching, A.R., Huang, X., Tipping, P.G., 1998, Modulation of Experimental Crescentic Glomerulonephritis by TH2 Cytokines, Blood Purification, June 10-11 Chicago USA, International Society of Blood Purification, Chicago USA, pp. 26-28.

Cunningham, M.A., Huang, X., Tipping, P.G., Dowling, J.P., Holdsworth, S.R., 1998, Prominence of Cell-Mediated Immunity in "Pauci-immune" Glomerulonephritis (GN), Nephrology, Auckland NZ, Blackwell Science Asia, Carlton Vic Australia, p. A4.

Huang, X., Tipping, P.G., Holdsworth, S.R., 1998, The Effects of CTLA4-Ig Treatment on Anti-GBM Glomerulonephritis In Th2 Prone Balb/c Mice, Journal of the American Society of Nephrology, Philadelphia Pennsylvania Oct 25-28 1998, Williams and Wilkins, Philadelphia Pennsylvania, p. A13.

Cunningham, M.A., Huang, X., Ono, T., Tipping, P.G., Becker, G.J., Holdsworth, S.R., 1998, Tissue Factor Pathway Inhibitor and Its Correlation with Tissue Factor and Fibrin in Human Crescentic Glomerulonephritis, Nephrology, Auckland NZ, Blackwell Science Asia, Carlton Vic Australia, p. A4.

Cunningham, M.A., Hutchinson, P., Holdsworth, S.R., Tipping, P.G., 1998, Tissue Factor/Factor VIIA Receptor/Ligand Interactions Augment Macrophage Activation, Journal of the American Society of Nephrology, Philadelphia Pennsylvania Oct 25-28 1998, Williams and Wilkins, Philadelphia Pennsylvania.

Tipping, P.G., 1997, Progress In Microcirculation Research, The role of the extrinsic coagulation pathway in inflammatory tissue injury, 31 January to 2 February 1997, The Australian & NZ Microcirculation Society, Melbourne Monash Print Services Monash Universit, pp. 65-67.

Grants

Title:

Antigen Presentation by Intrinsic Glomerular Cells in Glomerulonephritis.

Investigators:

Tipping, P

Funding:

(1997 - 2016). Kidney Health Australia.

Title:

Atherosclerosis: Molecular action and suppression of NKT cell subsets.

Investigators:

Toh, B, Agrotis, A, Tipping, P

Funding:

(2007 - 2011). National Health & Medical Research Council (NHMRC).

Title:

Aust Tea Tree Oil Res Inst-Dr P Tipping.

Investigators:

Tipping, P

Funding:

(1999 - ). Australian Tea Tree Oil Research Institute.

Title:

BAFF and its receptors:contribution and therapeutic potential in atherosclerosis.

Investigators:

Toh, B, Tipping, P, Bobik, A

Funding:

(2012 - 2016). National Health & Medical Research Council (NHMRC).

Title:

Bio-Rad Whole gel eluter.

Investigators:

Apostolopoulos, J, Tipping, P

Funding:

(2005 - 2009). Collier Charitable Fund.

(2005 - 2009). Monash University.

Title:

Computer image analysis system.

Investigators:

Tipping, P

Funding:

Title:

Computerised image analysis system.

Investigators:

Tipping, P, Hedger, M, Risbridger, G, Nikolic-Paterson, D

Funding:

(1995 - 1999). National Health & Medical Research Council (NHMRC).

Title:

Contributions of Intrinsic Renal Cells to Inflammatory Renal Injury (gms Id 000419).

Investigators:

Tipping, P

Funding:

(2000 - 2002). National Health & Medical Research Council (NHMRC).

Title:

Cryptome TF experiments.

Investigators:

Tipping, P

Funding:

(2004 - 2008). Cryptome Pharmaceuticals.

Title:

Expression and regulation of fibrinolytic mechanisms in glomerulonephritis.

Investigators:

Tipping, P, Holdsworth, S

Funding:

Title:

Fluorescence activated cell sorting module.

Investigators:

Tipping, P, Hertzog, P, Kola, I, Hedger, M

Funding:

(1997 - 2001). National Health & Medical Research Council (NHMRC).

Title:

Initiation of Inflammatory Glomerular Injury By Extrinsic Pathway Activation.

Investigators:

Tipping, P, Holdsworth, S

Funding:

(1998 - 2002). National Health & Medical Research Council (NHMRC).

Title:

Mechanisms Underlying the Prethrombotic State in Mitral Valve Disease and Non-valvular Atrial Fibrillation.

Investigators:

Smolich, J, Peverill, R, Tipping, P

Funding:

(2000 - 2001). Heart Foundation of Australia.

Title:

Mechanisms of t lymphocyte directed injury in proliferative glomerulonephritis.

Investigators:

Tipping, P, Holdsworth, S

Funding:

(1994 - 2016). National Health & Medical Research Council (NHMRC).

Title:

Medical Research Equipment Grant 99 - Microplate Reader.

Investigators:

Tipping, P, Holdsworth, S, Kitching, A

Funding:

(2000 - 2000). Kidney Health Australia.

Title:

Molecular mechanisms and cellular interactions of proatherogenic NK cells.

Investigators:

Toh, B, Agrotis, A, Bobik, A, Tipping, P, Smyth, M

Funding:

(2008 - 2011). Heart Foundation.

Title:

Molecular mechanisms of macrophage initiated fibrin deposition in glomerulonephritis.

Investigators:

Tipping, P, Holdsworth, S

Funding:

(1995 - 1999). National Health & Medical Research Council (NHMRC).

Title:

NHMRC 1994 Project- Tipping/Holdsworth- Tipping/Holdsworth.

Investigators:

Tipping, P, Holdsworth, S

Funding:

(1999 - ). National Health & Medical Research Council (NHMRC).

Title:

NHMRC 1995 Project - Dr P G Tipping.

Investigators:

Tipping, P

Funding:

(1999 - ). National Health & Medical Research Council (NHMRC).

Title:

Nhmrc Research Fellowship - Continuing 143806.

Investigators:

Tipping, P

Funding:

(2001 - 2005). National Health & Medical Research Council (NHMRC).

Title:

Pathogenic mechanisms of inflammatory diseases. ID:334067.

Investigators:

Holdsworth, S, Tipping, P, Morand, E, Kitching, A, Hickey, M

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

Title:

Phospor Imager - phospho image analyser.

Investigators:

Kola, I, Tipping, P, Hearn, M, de Kretser, D

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Potential of TFPI to prevent fibrin deposition and preserve renal function in your crescentic rabbit model of glomerulonephritis.

Investigators:

Tipping, P

Funding:

(1994 - 1998). G D Searle and Co (us).

Title:

Regulation of leukocyte trafficking by macrophage migration inhibitory factor.

Investigators:

Leech, M, Hickey, M, Yang, Y, Tipping, P

Funding:

(2004 - 2008). National Health & Medical Research Council (NHMRC).

Title:

Roche "Light Cycler reg." Real-time PCR.

Investigators:

Tipping, P, Holdsworth, S, Kitching, A, Leech, M, Hickey, M, Morand, E

Funding:

(2003 - 2007). National Health & Medical Research Council (NHMRC).

Title:

Role of B lymphocytes in atherosclerosis.

Investigators:

Toh, B, Bobik, A, Tipping, P

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Sequential NKT and NK activation and regulatory T cell suppression in atherosclerosis.

Investigators:

Toh, B, Tipping, P, Agrotis, A

Funding:

(2010 - 2013). Heart Foundation.

Title:

T Cell Subsets Direct Immunopathological Features and Outcomes of Immune Glomerular Injury.

Investigators:

Holdsworth, S, Tipping, P

Funding:

(1998 - 2000). National Health & Medical Research Council (NHMRC).

Title:

T cell Cytokines in crescentic glomerulonephritis.

Investigators:

Holdsworth, S, Tipping, P

Funding:

(1996 - 2000). Baxter Healthcare Corporation.

Title:

T cells and T cell derived cytokines in atherosclerosis.

Investigators:

Tipping, P

Funding:

(1997 - 2001). Heart Foundation of Australia.

Title:

Techne MCS-104L Cell Culture Stirrer System.

Investigators:

Tipping, P, Apostolopoulos, J

Funding:

(2004 - 2008). Collier Charitable Fund.

(2004 - 2008). Monash University.

Title:

The Regulation of Organ Specific Inflammatory Disease.

Investigators:

Holdsworth, S, Tipping, P, Morand, E

Funding:

(2001 - 2005). National Health & Medical Research Council (NHMRC).

Title:

The effect of celery seed extract on lymphocyte function.

Investigators:

Tipping, P

Funding:

(1998 - 2002). Australian Tea Tree Oil Research Institute.

Title:

Tissue Factor Pathway Inhibitor (tfpi).

Investigators:

Tipping, P

Funding:

(1997 - 1997). G D Searle and Co (us).

Title:

Tissue factor pathway inhibitor (TFPI) - A potential new therapy for crescentic glomerulonephritis.

Investigators:

Tipping, P

Funding:

(1995 - 1999). Kidney Health Australia.

Title:

Treatment of severe kindney disease with bone marrow derived stem cells.

Investigators:

Apostolopoulos, J, Timoshanko, J, Tipping, P

Funding:

(2005 - 2008). The Eirene Lucas Foundation.

Title:

the role of the cytoplasmic domain of tissue factor in maintenance of the glomerular filtration barrier.

Investigators:

Tipping, P, Apostolopoulos, J

Funding:

(2009 - 2013). National Health & Medical Research Council (NHMRC).

Title:

Nhmrc - Application for Promotion to Principal Research Fellow.

Investigators:

Tipping, P

Funding:

(2002 - 2006). National Health & Medical Research Council (NHMRC).

(2007 - 2011). National Health & Medical Research Council (NHMRC).

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:

Moussa, L.

Program of Study:

Coagulant proteins in glomerulonephritis. (PHD) 2007.

Supervisors:

Tipping, P (Main).

Student:

Sharma, L.

Program of Study:

CONTRIBUTION OF TISSUE FACTOR TO INFLAMMATORY RESPONSES. (PHD) 2004.

Supervisors:

Tipping, P (Main).

Student:

Timoshanko, J.

Program of Study:

THE CONTRIBUTION OF INTRINSIC RENAL CELLS TO CRESCENTIC GLOMERULONEPHRITIS. (PHD) 2003.

Supervisors:

Tipping, P (Main).