Assoc Prof Ashley Buckle - Researcher Profile

Biography

Ashley works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

CHEMISTRY

Institution: Cambridge University

Year awarded: 2004

Publications

Book Chapters

Kass, I., Reboul, C.F., Buckle, A.M., 2011, Computational methods for studying serpin conformational change and structural plasticity, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whissstock and Philliip I Bird, Academic Press, USA, pp. 295-323.

Phan, J., Yamout, N., Schmidberger, J., Bottomley, S., Buckle, A., 2011, Refolding Your Protein with a Little Help from REFOLD, in Protein Folding, Misfolding, and Disease, eds AF Hill, KJ Barnham, SP Bottomley and R Cappai, Springer Science+Business Media, UK, pp. 45-57.

Church, F., Pike, R.N., Tollefsen, D.M., Buckle, A.M., Ciaccia, A.V., Olson, S.T., 2007, Regulation of hemostasis by heparin-binding serpins, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 509-554.

Zhang, Q., Law, R.H.P., Buckle, A.M., Cabrita, L., McGowan, S., Irving, J.A., Faux, N.G., Lesk, A.M., Bottomley, S.P., Whisstock, J., 2007, Serpins in Prokaryotes, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 131-162.

Journal Articles

Langendorf, C.G., Tuck, K.L., Key, T., Fenalti, G., Pike, R.N., Rosado, C.J., Wong, A.S., Buckle, A.M., Law, R.H.P., Whisstock, J., 2013, Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates, Bioscience Reports [P], vol 33, issue 1, Portland Press Ltd, UK, pp. 137-149.

Kass, I., Knaupp, A., Bottomley, S.P., Buckle, A.M., 2012, Conformational properties of the disease-causing Z variant of a1-antitrypsin revealed by theory and experiment, Biophysical Journal [P], vol 102, issue 12, Cell Press, USA, pp. 2856-2865.

Atkinson, S.C., Dogovski, C., Downton, M.T., Pearce, F.G., Reboul, C.F., Buckle, A.M., Gerrard, J.A., Dobson, R.C., Wagner, J., Perugini, M.A., 2012, Crystal, sSolution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine, PLoS ONE [P], vol 7, issue 6 (Art. ID: e38318), Public Library of Science, USA, pp. 1-9.

Reboul, C., Meyer, G.R., Porebski, B., Borg, N.A., Buckle, A.M., 2012, Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex, PLoS Computational Biology [E], vol 8, issue 3 (Art. ID: e1002404), Public Library of Science, USA, pp. 1-11.

Ho, B.K., Perahia, D., Buckle, A.M., 2012, Hybrid approaches to molecular simulation, Current Opinion in Structural Biology [P], vol 22, issue 3, Elsevier Ltd. * Current Opinion Journals, UK, pp. 386-393.

Reboul, C.F., Porebski, B.T., Griffin, M.D., Dobson, R.C., Perugini, M.A., Gerrard, J.a., Buckle, A.M., 2012, Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase, PLoS Computational Biology [E], vol 8, issue 6 (Art. ID: e1002537), Public Library of Science, USA, pp. 1-12.

McGowan, S., Buckle, A.M., Mitchell, M.S., Hoopes, J.T., Gallagher, D.T., Heselpoth, R.D., Shen, Y., Reboul, C.F., Law, R.H., Fischetti, V.A., Whisstock, J.C., Nelson, D.C., 2012, X-ray crystal structure of the streptococcal specific phage lysin PlyC, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 31, National Academy of Sciences, USA, pp. 12752-12757.

Jayakrishnan, B., Hoke, D.E., Langendorf, C.G., Buckle, A.M., Rowley, M.J., 2011, An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes, PLoS ONE [P], vol 6, issue 4 (Art. No: e18411), Public Library of Science, USA, pp. 1-6.

Reboul, C., Andrews, D., Nahar, M., Buckle, A., Roujeinikova, A., 2011, Crystallographic and molecular dynamics analysis of loop motions unmasking the peptidoglycan-binding site in stator protein MotB of flagellar motor, PLoS ONE [P], vol 6, issue 4 (Art. No: e18981), Public Library of Science, USA, pp. 1-7.

Swedberg, J., de Veer, S., Sit, K., Reboul, C., Buckle, A., Harris, J., 2011, Mastering the canonical loop of serine protease inhibitors: Enhancing potency by optimising the internal hydrogen bond network, PLoS ONE [P], vol 6, issue 4 (Art. No: e19302), Public Library of Science, USA, pp. 1-11.

Hoke, D.E., Zhang, K., Egan, S., Hatfaludi, T.Z., Buckle, A.M., Adler, B., 2011, Membrane proteins of Pseudoalteromonas tunicata during the transition from planktonic to extracellular matrix-adherent state, Environmental Microbiology Reports [E], vol 3, issue 3, Wiley-Blackwell Publishing Ltd, UK, pp. 405-413.

Buckle, A.M., Bate, M.A., Androulakis, S.G., Cinquanta, M., Basquin, J., Bonneau, F., Chatterjee, D.K., Cittaro, D., Graslund, S., Gruszka, A., Page, R., Suppmann, S., Wheeler, J.X., Agostini, D., Taussig, M., Taylor, C.F., Bottomley, S.P., Villaverde, A., de Marco, A., 2011, Recombinant protein quality evaluation: proposal for a minimal information standard, Standards in Genomic Sciences [E], vol 5, issue 2, Michigan State University * Genomic Standards Consortium, USA, pp. 195-197.

Robertson, A., Bate, M., Buckle, A., Bottomley, S., 2011, The rate of polyQ-mediated aggregation is dramatically affected by the number and location of surrounding domains, Journal of Molecular Biology [P], vol 413, issue 4, Academic Press, UK, pp. 879-887.

Nogues, C., Leh, H., Langendorf, C.G., Law, R.H.P., Buckle, A.M., Buckle, M., 2010, Characterisation of peptide microarrays for studying antibody-antigen binding using surface plasmon resonance imagery, PLoS ONE [P], vol 5, issue 8 (e12152), Public Library of Science, USA, pp. 1-6.

Mahmood, K., Konagurthu, A.S., Song, J., Buckle, A.M., Webb, G.I., Whisstock, J.C., 2010, EGM: Encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes, Bioinformatics [P], vol 26, issue 17, Oxford University Press, UK, USA, pp. 2076-2084.

Konagurthu, A.S., Reboul, C.F., Schmidberger, J.W., Irving, J.A., Lesk, A.M., Stuckey, P.J., Whisstock, J.C., Buckle, A.M., 2010, MUSTANG-MR structural sieving server: Applications in protein structural analysis and crystallography, PLoS ONE [P], vol 5, issue 4 (e10048), Public Library of Science, USA, pp. 1-7.

Schmidberger, J.W., Bate, M., Reboul, C.F., Androulakis, S.G., Phan, J.M.N., Whisstock, J., Goscinski, W., Abramson, D.A., Buckle, A.M., 2010, Mrgrid: A portable grid based molecular replacement pipeline, PLoS ONE [P], vol 5, issue 4 (e10049), Public Library of Science, USA, pp. 1-6.

Robertson, A.L., Bate, M.A., Androulakis, S.G., Bottomley, S.P., Buckle, A.M., 2010, PolyQ: A database describing the sequence and domain context of polyglutamine repeats in proteins, Nucleic Acids Research [P], vol 39, issue Database issue, Oxford University Press, UK, pp. D272-D276.

Fenalti, G., Buckle, A.M., 2010, Structural biology of the GAD autoantigen, Autoimmunity Reviews [P], vol 9, Elsevier Inc., USA, pp. 148-152.

McGowan, S., Oellig, C., Birru, W.A., Caradoc-Davies, T.T., Stack, C.M., Lowther, J., Skinner-Adams, T.S., Mucha, A., Kafarski, P., Grembecka, J., Trenholme, K.R., Buckle, A.M., Gardiner, D.L., Dalton, J.P., Whisstock, J., 2010, Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 6, National Academy of Sciences, USA, pp. 2449-2454.

Langendorf, C., Key, T., Fenalti, G., Kan, W., Buckle, A.M., Caradoc-Davies, T.T., Tuck, K.L., Law, R.H.P., Whisstock, J., 2010, The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions, PLoS ONE [P], vol 5, issue 2, Pubic Library of Science, USA, pp. 1-12.

Song, J., Tan, H., Mahmood, K., Law, R.H.P., Buckle, A.M., Webb, G., Akutsu, T., Whisstock, J., 2009, Prodepth: Predict residue depth by support vector regression approach from protein sequences only, PLoS ONE [P], vol 4, issue 9 (e7072), Public Library of Science, USA, pp. 1-14.

Bergstrom, F.C., Reynolds, S., Johnstone, M., Pike, R.N., Buckle, A.M., Kemp, D.J., Fischer, K., Blom, A.M., 2009, Scabies mite inactivated serine protease paralogs inhibit the human complement system, Journal Of Immunology [P], vol 182, issue 12, American Association of Immunologists, USA, pp. 7809-7817.

McGowan, S., Porter, C.J., Lowther, J., Stack, C.M., Golding, S.J., Skinner-Adams, T.S., Trenholme, K.R., Teuscher, F., Donnelly, S.M., Grembecka, J., Mucha, A., Kafarski, P., DeGori, R., Buckle, A.M., Gardiner, D.L., Whisstock, J.C., Dalton, J.P., 2009, Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 8, National Academy of Sciences, USA, pp. 2537-2542.

Arafat, Y., Fenalti, G., Whisstock, J., Mackay, I.R., Garcia De La Banda, M.J., Rowley, M.J., Buckle, A.M., 2009, Structural determinants of GAD antigenicity, Molecular Immunology [P], vol 47, issue 2-3, Pergamon, UK, pp. 493-505.

Fischer, K., Langendorf, C., Irving, J.A., Reynolds, S., Willis, C., Beckham, S.A., Law, R.H.P., Yang, S., Bashtannyk-Puhalovich, T.A., McGowan, S., Whisstock, J., Pike, R.N., Kemp, D.J., Buckle, A.M., 2009, Structural mechanisms of inactivation in scabies mite serine protease paralogues, Journal of Molecular Biology [P], vol 390, issue 4, Academic Press, UK, pp. 635-645.

Kaiserman, D., Buckle, A.M., Van Damme, P., Irving, J.A., Law, R.H.P., Matthews, A.Y., Bashtannyk-Puhalovich, T.A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J.C., Bird, P.I., 2009, Structure of granzyme C reveals an unusual mechanism of protease autoinhibition, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 14, National Academy of Sciences, USA, pp. 5587-5592.

Swedberg, J.E., Nigon, L.V., Reid, J.C., de Veer, S.J., Walpole, C.M., Stephens, C.R., Walsh, T., Takayama, T.K., Hooper, J.D., Clements, J.A., Buckle, A.M., Harris, J.M., 2009, Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4, Chemistry and Biology [P], vol 16, issue 6, Cell Press, USA, pp. 633-643.

Zhang, Q., Law, R.H.P., Bottomley, S.P., Whisstock, J., Buckle, A.M., 2008, A structural basis for Loop C-sheet polymerization in serpins, Journal of Molecular Biology, vol 376, issue 5, Academic Press, United Kingdom, pp. 1348-1359.

Fenalti, G., Hampe, C.S., Arafat, Y., Law, R.H.P., Banga, J.P., Mackay, I.R., Whisstock, J., Buckle, A.M., Rowley, M.J., 2008, COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity, Diabetes, vol 57, issue 5, American Diabetes Association, United States, pp. 1293-1301.

Androulakis, S.G., Schmidberger, J., Bate, M.A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C.J., Harrison, A., Hunter, J., Martin, J.L., Kobe, B., Dobson, R.C., Parker, M.W., Whisstock, J., Gray, J., Treloar, A.E., Groenewegen, D., Dickson, N., Buckle, A.M., 2008, Federated repositories of X-ray diffraction images, Acta Crystallographica. Section D: Biological Crystallography, vol 64, issue 7, Wiley-Blackwell Munksgaard, Denmark, pp. 810-814.

Rosado, C.J., Kondos, S., Bull, T.E., Kuiper, M., Law, R.H.P., Buckle, A.M., Voskoboinik, I., Bird, P.I., Trapani, J.A., Whisstock, J., Dunstone, M.A., 2008, The MACPF/CDC family of pore-forming toxins, Cellular Microbiology, vol 10, issue 9, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 1765-1774.

Law, R.H.P., Sofian, T., Kan, W., Horvath, A.J., Hitchen, C.R., Langendorf, C., Buckle, A.M., Whisstock, J., Coughlin, P.B., 2008, X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin, Blood, vol 111, American Society of Hematology, Washington, DC, USA, pp. 2049-2052.

Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J., 2007, A common fold mediates vertebrate defense and bacterial attack, Science, vol 317, issue 5844, American Association of Advancement in Science, Washington, DC, USA, pp. 1548-1551.

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K.L., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M.C.J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J., 2007, GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop, Nature Structural & Molecular Biology, vol 14, issue 4, Nature Publishing Group, New York NY USA, pp. 280-286.

Fulton, K.F., Bate, M., Faux, N.G., Mahmood, K., Betts, C., Buckle, A.M., 2007, Protein folding database (PFD 2.0): an online environment for the international foldeomics consortium, Nucleic Acids Research, vol 35, issue Suppl 1, Oxford University Press, Oxford England UK, pp. D304-D307.

Porter, C.J., Schuch, R., Pelzek, A.J., Buckle, A.M., McGowan, S., Wilce, M.C.J., Rossjohn, J., Russell, R., Nelson, D., Fischetti, V.A., Whisstock, J.C., 2007, The 1.6 angstrom crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis, Journal of Molecular Biology, vol 366, issue 2, Academic Press Ltd, Elsevier Science Ltd, London UK, pp. 540-550.

Zhang, Q., Buckle, A.M., Law, R.H.P., Pearce, M.C., Cabrita, L., Lloyd, G., Irving, J.A., Smith, A.I., Ruzyla, K., Rossjohn, J., Bottomley, S.P., Whisstock, J., 2007, The N terminus of the serpin, tengpin, functions to trap the metastable native state, EMBO Reports, vol 8, issue 7, Nature Publishing Group, UK, pp. 658-663.

Law, R.H.P., Zhang, Q., McGowan, S., Buckle, A.M., Silverman, G.A., Wong, W., Rosado, C.J., Langendorf, C., Pike, R.N., Bird, P.I., Whisstock, J., 2006, An overview of the serpin superfamily, Genome Biology, vol 7, issue 5, Biomed Central Ltd, London UK, pp. 216-1-216-11.

Amin, A.A., Faux, N.G., Fenalti, G., Williams, G.N., Bernadou, A., Daglish, B., Keefe, K., Middleton, S., Rae, J., Tetis, K., Law, R.H.P., Fulton, K.F., Rossjohn, J., Whisstock, J.C., Buckle, A.M., 2006, Managing and mining protein crystallization data, Proteins: Structure Function, and Bioinformatics, vol 62, issue 1, Wiley-Liss, Hoboken USA, pp. 4-7.

Chow, M.K., Amin, A.A., Fulton, K.F., Whisstock, J.C., Buckle, A.M., Bottomley, S.P., 2006, REFOLD: an analytical database of protein refolding methods, Protein Expression and Purification, vol 46, issue 1, Academic Press Inc Elsevier Science, San Diego USA, pp. 166-171.

Chow, M.K.M., Amin, A.A., Fulton, K.F., Fernando, T., Kamau, L., Batty, C., Louca, M., Ho, S., Whisstock, J.C., Bottomley, S.P., Buckle, A.M., 2006, The REFOLD database: a tool for the optimization of protein expression and refolding., Nucleic Acids Research, vol 34, issue D-Base Issue, Oxford University Press, Oxford UK, pp. D207-D212.

Hennebry, S.C., Law, R.H.P., Richardson, S.J., Buckle, A.M., Whisstock, J.C., 2006, The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase, Journal of Molecular Biology, vol 359, issue 5, Academic Press Ltd Elseiver Science Ltd, London UK, pp. 1389-1399.

McGowan, S., Buckle, A.M., Irving, J.A., Ong, P.C., Bashtannyk-Puhalovich, T.A., Kan, W., Henderson, K., Bulynko, Y.A., Popova, E.Y., Smith, A.I., Bottomley, S.P., Rossjohn, J., Grigoryev, S.A., Pike, R.N., Whisstock, J.C., 2006, X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation, The EMBO Journal, vol 25, issue 13, Nature Publishing Group, New York USA, pp. 3144-3155.

Pike, R.N., Buckle, A.M., Le Bonniec, B., Church, F., 2005, Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans, FEBS Journal, vol 272, issue 19, Blackwell Publishing, Oxford UK, pp. 4842-4851.

Fulton, K.F., Devlin, G.L., Jodun, R.A., Silvestri, L., Bottomley, S.P., Ferscht, A.R., Buckle, A.M., 2005, PFD: a database for the investigation of protein folding kinetics and stability, Nucleic Acids Research, vol 33, issue suppl 1, Oxford University Press, Oxford UK, pp. D279-D283.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide, Nature Immunology, vol 6, issue 11, Nature Publishing Group, New York USA, pp. 1114-1122.

Wilmann, P.G., Petersen, J., Pettikiriarachchi, A., Buckle, A.M., Smith, S.C., Olsen, S., Perugini, M.A., Devenish, R.J., Prescott, M., Rossjohn, J., 2005, The 2.1 Angstrom Crystal Structure of the Far-red Fluorescent Protein HcRed: Inherent Conformational Flexibility of the Chromophore, Journal of Molecular Biology, vol 349, issue 1, Academic Press Ltd Elsevier Science Ltd, London England, pp. 223-237.

Fulton, K.F., Buckle, A.M., Cabrita, L.D., Irving, J.A., Butcher, R.E., Smith, A.I., Reeve, S.B., Lesk, A.M., Bottomley, S.P., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition, Journal of Biological Chemistry, vol 280, issue 9, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 8435-8442.

Law, R.H.P., Irving, J.A., Buckle, A.M., Ruzyla, K., Buzza, M.S., Bashtannyk-Puhalovich, T.A., Beddoe, T.C., Nguyen, K., Worrall, M.D., Bottomley, S.P., Bird, P.I., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix, Journal of Biological Chemistry, vol 280, issue 23, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 22356-22364.

Buckle, A.M., Devlin, G.L., Jodun, R.A., Fulton, K.F., Faux, N.G., Whisstock, J.C., Bottomley, S.P., 2005, The matrix refolded, Nature Methods, vol 2, issue 1, Nature Publishing Group, London UK, p. 3.

Fulton, K.F., Ervine, S., Faux, N.G., Forster, R., Ly, W., Robilliard, L., Sonsini, J., Whelan, D., Whisstock, J.C., Buckle, A.M., 2004, CLIMS: Crystallography Laboratory Information Management System, Acta Crystallographica Section D - Biological Crystallography, vol 60, issue 9, Blackwell Munksgaard, Copenhagen Denmark, pp. 1691-1693.

Fulton, K.F., Jackson, S.E., Buckle, A.M., 2003, Energetic and structural analysis of the role of tryptophan 59 in FKBP12, Biochemistry, vol 42, issue 8, American Chemical Society, Washington USA, pp. 2364-2372.

Allen, M.D., Buckle, A.M., Cordell, S.C., Lowe, J., Bycroft, M., 2003, The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A, Journal of Molecular Biology, vol 330, issue 3, Academic Press Ltd Elsevier Science Ltd, London England, pp. 503-511.

Kazmirski, S.L., Isaacson, R.L., An, C., Buckle, A.M., Johnson, C.M., Daggett, V., Fersht, A.R., 2002, Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type, Nature Structural & Molecular Biology, vol 9, issue 2, Nature Publishing Group, New York USA, pp. 112-116.

Wang, Q., Buckle, A.M., Fersht, A.R., 2000, Stabilization of GroEL minichaperones by core and surface mutations, Journal of Molecular Biology, vol 298, issue 5, Academic Press Ltd Elsevier Science Ltd, London England, pp. 917-926.

Conference Proceedings

Bethwaite, B., Abramson, D.A., Buckle, A.M., 2008, Grid interoperability: An experiment in bridging grid islands, Proceedings of the Fourth IEEE International Conference on eScience, 07 December 2008 to 12 December 2008, IEEE Computer Society, Los Alamitos CA USA, pp. 590-596.

Faux, N.G., Beitz, A., Bate, M., Amin, A.A., Atkinson, I.M., Enticott, C.M., Mahmood, K., Swift, M.J., Treloar, A.E., Abramson, D.A., Whisstock, J., Buckle, A.M., 2007, eResearch solutions for high throughput structural biology, Third IEEE International Conference on e-Science and Grid Computing, 10-13 December, 2007, IEEE Computer Society, India, pp. 221-227.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 571.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A Bioinformatics study of protein folding aggregation and disease.

Supervisors:

Buckle, A (Main), Song, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A Probabilistic Approach to In Silico Protein Design.

Supervisors:

Webb, G (Main), Buckle, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Dynamic characterisation of motility protein B.

Supervisors:

Roujeinikova, A (Main), Buckle, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of sequence based methods for the engineering of protein stability..

Supervisors:

Buckle, A (Main), Webb, G (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular dynamics studies of disease causing mutations of the serpin a-1 antitrypsin.

Supervisors:

Buckle, A (Main), Webb, G (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural aspects of the pore forming protein perforin.

Supervisors:

Buckle, A (Joint), Whisstock, J (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural basis of autoimmunity to glutamic acid decarboxylase..

Supervisors:

Buckle, A (Main), Rowley, M (Associate).

Completed Supervision

Student:

Arafat, Y.

Program of Study:

A computational investigation of the structural and physichochemical basis of autoantigenicity. (PHD) 2009.

Supervisors:

Buckle, A (Main), Garcia De La Banda, M (Associate).