Dr James Deane - Researcher Profile

Biography

Dr Deane studies the biology of epithelial cells in the uterus and the kidney. Epithelial cells form a layer lining glandular and tubular strucutres in these organs and are involved in regenerative processes after injury and during the normal female reproductive cycle. Understanding the regenerative capacity of epithelial cells in the uterus will aid the treatment of infertility and conditions such as endometriosis. Characterising epithelial regeneration mechanisms in the kidney may identify methods of hastening recovery from acute renal injury and provide insight into the epithelial defects causing polycystic kidney disease.

Qualifications

PHD

Institution: University of Melbourne

Year awarded: 2000

SCIENCE (HONS)

Institution: UNIVERSITY OF MELBOURNE

Year awarded: 1992

Publications

Journal Articles

Yang, Y.H., Song, W., Deane, J.A., Kao, W., Ooi, J., Ngo, D., Kitching, A.R., Morand, E.F., Hickey, M.J., 2013, Deficiency of annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation, Journal Of Immunology [P], vol 90, issue 3, American Association of Immunologists, United States, pp. 997-1007.

Deane, J., Ricardo, S., 2012, Emerging roles for renal primary cilia in epithelial repair, International Review of Cell and Molecular Biology [P], vol 293, Academic Press, United States, pp. 169-193.

Deane, J., Abeynaike, L., Norman, M., Wee, J., Kitching, A., Kubes, P., Hickey, M., 2012, Endogenous regulatory T cells adhere in inflamed dermal vessels via ICAM-1: association with regulation of effector leukocyte adhesion, Journal Of Immunology [P], vol 188, issue 5, American Association of Immunologists, United States, pp. 2179-2188.

Verghese, E., Johnson, C.J., Bertram, J.F., Ricardo, S.D., Deane, J.A., 2012, The fate of bone marrow-derived cells carrying a polycystic kidney disease mutation in the genetically normal kidney, BMC Nephrology [P], vol 13, issue 1 (Art. No.: 91), BioMed Central Ltd, United Kingdom, pp. 1-11.

Alikhan, M., Jones, C., Williams, T., Beckhouse, A., Fletcher, A., Kett, M., Sakkal, S., Samuel, C.S., Ramsay, R., Deane, J., Wells, C., Little, M., Hume, D., Ricardo, S., 2011, Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses, American Journal Of Pathology [P], vol 179, issue 3, Elsevier Inc., USA, pp. 1243-1256.

Verghese, E., Zhuang, J., Saiti, D., Ricardo, S.D., Deane, J.A., 2011, In vitro investigation of renal epithelial injury suggests that primary cilium length is regulated by hypoxia-inducible mechanisms, Cell Biology International [P], vol 35, issue 9, Portland Press Ltd, UK, pp. 909-913.

Zhuang, J., Deane, J.A., Yang, R., Li, J., Ricardo, S.D., 2010, SCUBE1, a novel developmental gene involved in renal regeneration and repair, Nephrology Dialysis Transplantation [P], vol 25, Oxford University Press, UK, pp. 1421-1428.

Deane, J.A., Hickey, M.J., 2009, Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging., Expert Reviews in Molecular Medicine [P], vol 11, issue e25, Cambridge University Press, United Kingdom, pp. 1-21.

Verghese, E., Ricardo, S.D., Weidenfeld, R., Zhuang, J., Hill, P.A., Langham, R.G., Deane, J.A., 2009, Renal primary cilia lengthen after acute tubular necrosis, Journal Of The American Society Of Nephrology [P], vol 20, issue 10, American Society of Nephrology, USA, pp. 2147-2153.

Wang, L., Weidenfeld, R., Verghese, E., Ricardo, S.D., Deane, J.A., 2008, Alterations in renal cilium length during transient complete ureteral obstruction in the mouse, Journal of Anatomy, vol 213, issue 2, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 79-85.

Verghese, E., Weidenfeld, R., Bertram, J.F., Ricardo, S.D., Deane, J.A., 2008, Renal Cilia display length alterations following tubular injury and are present early in epithelial repair, Nephrology Dialysis Transplantation, vol 23, Oxford University Press, Oxford England UK, pp. 834-841.

Deane, J.A., Ricardo, S.D., 2007, Polycystic kidney disease and the renal cilium (Review Article), Nephrology (Carlton), vol 12, issue 6, Blackwell Publishing Asia, Carlton, Victoria, Australia, pp. 559-564.

Li, J., Deane, J.A., Campanale, N.V., Bertram, J.F., Ricardo, S.D., 2007, The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis, Stem Cells, vol 25, issue 3, Alphamed Press, Durham USA, pp. 697-706.

Li, J., Deane, J.A., Campanale, N.V., Bertram, J.F., Ricardo, S.D., 2006, Blockade of p38 mitogen-activated protein kinase and TGF-beta1/Smad signaling pathways rescues bone marrow-derived peritubular capillary endothelial cells in adriamycin-induced nephrosis, Journal of the American Society of Nephrology, vol 17, issue 10, American Society Nephrology, Washington USA, pp. 2799-2811.

Li, J., Campanale, N.V., Liang, R., Deane, J.A., Bertram, J.F., Ricardo, S.D., 2006, Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy, The American Journal of Pathology, vol 169, issue 5, American Society for Investigative Pathology, Bethesda USA, pp. 1527-1540.

Challen, G., Bertoncello, I., Deane, J., Ricardo, S., Little, M., 2006, Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity, Journal Of The American Society Of Nephrology [P], vol 17, issue 7, American Society of Nephrology, USA, pp. 1896-1912.

Guo, M., Ricardo, S.D., Deane, J.A., Shi, M., Cullen-McEwen, L.A., Bertram, J.F., 2005, A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy, Journal of Anatomy, vol 207, issue 6, Blackwell Publishing, Oxford England, pp. 813-821.

Ricardo, S.D., Deane, J.A., 2005, Adult stem cells in renal injury and repair, Nephrology, vol 10, issue 3, Blackwell Publishing Asia, Cartlon Vic Australia, pp. 276-282.

Deane, J.A., Hill, D.R., Brett, S.J., McFadden, G.I., 1998, Hanusia phi gen.etsp.nov.(Cryptophoyeaa): characterization of 'Cryptomona s sp.phi, European Journal of Phycology, vol 33, Academic Press, London UK, pp. 149-154.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms of T-cell recruitment in dermal inflammation.

Supervisors:

Hickey, M (Main), Deane, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Mechanisms of regulatory T cell recruitment and migration in contact sensitivity.

Supervisors:

Hickey, M (Main), Deane, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Regulatory T Cell Function in Contact Sensitivity.

Supervisors:

Hickey, M (Main), Deane, J (Associate).

Completed Supervision

Student:

Alikhan, M.

Program of Study:

Regenerative potential of colony-stimulating factor-1 therapy and macrophages in renal disease. (PHD) 2012.

Supervisors:

Ricardo, S (Main), Deane, J (Associate).

Student:

Verghese, E.

Program of Study:

Using polycystic kidney disease to understand cilium mediated endogenous repair and bone marrow mediated exogenous repair. (PHD) 2010.

Supervisors:

Deane, J (Joint), Ricardo, S (Joint-Co).