Dr Siew Pang - Researcher Profile

Biography

Siew works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD

Institution: University of Queensland

Year awarded: 2000

Publications

Book Chapters

Duggleby, R.G., Guddat, L.W., Pang, S.S., 2003, Structure and properties of acetohydroxyacid synthase, in Thiamine - Catalytic Mechanisms in Normal and Disease States, eds Frank Jordan and Mulchand S Patel, Marcel Dekker Inc, USA, pp. 251-274.

Journal Articles

Wun, K., Cameron, G., Patel, O., Pang, S.S., Pellicci, D.G., Sullivan, L.C., Keshipeddy, S., Young, M.H., Uldrich, A.P., Thakur, M.S., Richardson, S.K., Howell, A.R., Illarionov, P.A., Brooks, A.G., Besra, G.S., McCluskey, J., Gapin, L., Porcelli, S.A., Godfrey, D.I., Rossjohn, J., 2011, A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells, Immunity [P], vol 34, issue 3, Cell Press, USA, pp. 327-339.

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, The structural basis for autonomous dimerization of the pre-T-cell antigen receptor, Nature [P], vol 467, issue 7317, Nature Publishing Group, UK, pp. 844-848.

Beddoe, T.C., Chen, Z., Clements, C.S., Ely, L.K., Bushell, S.R., Vivian, J.P., Kjer-Nielsen, L., Pang, S.S., Dunstone, M.A., Liu, Y.C., Macdonald, W.A., Perugini, M.A., Wilce, M.C.J., Burrows, S.R., Purcell, A.W., Tiganis, T., Bottomley, S.P., McCluskey, J., Rossjohn, J., 2009, Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 777-788.

Wang, J., Lee, P.K., Dong, Y., Pang, S.S., Duggleby, R.G., Li, Z., Guddat, L.W., 2009, Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase, Febs Journal [P], vol 276, issue 5, Wiley-Blackwell Publishing Ltd, UK, pp. 1282-1290.

Pellicci, D.G., Patel, O., Kjer-Nielsen, L., Pang, S.S., Sullivan, L.C., Kyparissoudis, K., Brooks, A.G., Reid, H.H., Gras, S., Lucet, I.S., Koh, R., Smyth, M.J., Mallevaey, T., Matsuda, J.L., Gapin, L., McCluskey, J., Godfrey, D.I., Rossjohn, J., 2009, Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the Vbeta8.2 and Vbeta7 Semi-invariant NKT T Cell Receptors, Immunity [P], vol 31, issue 1, Cell Press, USA, pp. 47-59.

McCourt, J.A., Pang, S.S., King-Scott, J., Guddat, L.W., Duggleby, R.G., 2006, Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase, Proceedings of the National Academy of Sciences of the United States of America, vol 103, issue 3, National Academy of Sciences, Washington USA, pp. 569-573.

Manjunatha, U.H., Boshoff, H., Dowd, C.S., Zhang, L., Albert, T.J., Norton, J.E., Daniels, L., Dick, T., Pang, S.S., Barry III, C.E., 2006, Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences of the United States of America, vol 103, issue 2, National Academy of Sciences, Washington USA, pp. 431-436.

McCourt, J.A., Pang, S.S., Guddat, L.W., Duggleby, R.G., 2005, Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase, Biochemistry, vol 44, issue 7, American Chemical Society, Washington USA, pp. 2330-2338.

Wang, J., Li, Z., Ma, N., Wang, B., Jiang, L., Pang, S.S., Lee, Y., Guddat, L.W., Duggleby, R.G., 2005, Structure-activity relationships for a new family of sulfonylurea herbicides, Journal of Computer-Aided Molecular Design, vol 19, issue 11, Springer, Dordrecht The Netherlands, pp. 801-820.

Pang, S.S., Guddat, L.W., Duggleby, R.G., 2004, Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl, ACTA Crystallographica Section D-Biological Crystallography, vol 60, issue Pt 1, Blackwell Publishing, Oxford England, pp. 153-155.

Pang, S.S., Guddat, L.W., Duggleby, R.G., 2003, Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase, The Journal of Biological Chemistry, vol 278, issue 9, American Society of Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 7639-7644.

Duggleby, R.G., Pang, S.S., Yu, H., Guddat, L.W., 2003, Systematic characterization of mutations in yeast acetohydroxyacid synthase: interpretation of herbicide-resistance data, European Journal of Biochemistry, vol 270, issue 13, Blackwell Publishing, Oxford UK, pp. 2895-2904.

Pang, S.S., Duggleby, R.G., Schowen, R.L., Guddat, L.W., 2003, The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate, Journal of Biological Chemistry, vol 279, issue 3, American Society of Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 2242-2253.

Pang, S.S., Duggleby, R.G., Guddat, L.W., 2002, Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors, Journal of Molecular Biology, vol 317, issue 2, Academic Press Ltd Elsevier Science Ltd, London England, pp. 249-262.

Pang, S.S., Guddat, L.W., Duggleby, R.G., 2002, Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae, ACTA Crystallographica Section D-Biological Crystallography, vol 58, issue Pt 7, Blackwell Publishing, Oxford England, pp. 1237-1239.

Pang, S.S., Guddat, L.W., Duggleby, R.G., 2001, Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroxyacid synthase, ACTA Crystallographica Section D-Biological Crystallography, vol 57, issue Pt 9, Blackwell Publishing, Oxford UK, pp. 1321-1323.

Pang, S.S., Duggleby, R.G., 2001, Regulation of yeast acetohydroxyacid synthase by valine and ATP, Biochemical Journal, vol 357, issue Pt 3, Portland Press Ltd, London England, pp. 749-757.

Other

Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T.C., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C., McCluskey, J., Rossjohn, J., 2010, Crucial link in immune development and regulation unearthed, Quality control mechanism that must take place for our immune system, Monash University, Clayton, Vic, Australia.