Prof Stephen Jane - Researcher Profile

Biography

Professor Jane is the Head of Central Clinical School, Professor of Medicine, Monash University and Director of Research for Alfred Hospital. He is also a member of the Clinical Haematology Service.

Professor Jane has a range of research interests investigating both developmental and acquired disorders of the blood and skin in mouse models. At a basic level, this involves the study of gene transcription. He currently holds a number of NH&MRC and other competitive grants. He has published over 90 papers including articles in Science, Nature Medicine and Developmental Cell.

Qualifications

MEDICINE

Institution: Monash University

Year awarded: 1990

FRACP FRCPA

Institution: Colleges of Physicians / Pathologists

Year awarded: 1990

MBBS

Institution: Monash University

Year awarded: 1981

Publications

Journal Articles

Brown, F., Scott, N., Rank, G., Collinge, J.E., Vadolas, J., Vickaryous, N., Whitelaw, N.C., Whitelaw, E., Kile, B., Jane, S.M., Curtis, D.J., 2013, ENU mutagenesis identifies the first mouse mutants reproducing human ?-thalassemia at the genomic level, Blood Cells Molecules And Diseases [P], vol 50, issue 2, Academic Press, Maryland Heights, MO 63043 United States, pp. 86-92.

Darido, C., Jane, S., 2013, Golgi feels its own wound, Advances in Wound Care, vol 2, issue 3, Liber, New Rochelle, NY 10801 United States, pp. 87-92.

Slape, C.I., Saw, J.M.Y., Jowett, J.B., Aplan, P.D., Strasser, A., Jane, S.M., Curtis, D.J., 2012, Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome, Blood [P], vol 120, issue 12, American Society of Hematology, United States, pp. 2475-2483.

Dworkin, S., Darido, C., Georgy, S., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J., Lieschke, G., Jane, S., 2012, Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways, Development [P], vol 139, issue 3, The Company of Biologists Ltd, UK, pp. 525-536.

Desgardin, A.D., Abramova, T., Rosanwo, T.O., Kartha, S., Shim, E., Jane, S.M., Cunningham, J., 2012, Regulation of delta-aminolevulinic acid dehydratase by kruppel-like factor 1, PLoS ONE [P], vol 7, issue 10 (Art. No.: e46482), Public Library of Science, United States, pp. 1-11.

Xu, Z., He, Y., Ju, J., Rank, G., Cerruti, L., Ma, C., Simpson, R.J., Moritz, R.L., Jane, S.M., Zhao, Q., 2012, The role of WDR5 in silencing human fetal globin gene expression, Haematologica-The Hematology Journal [P], vol 97, issue 11, Fondazione Ferrata Storti, Italy, pp. 1632-1640.

Nguyen, N., Maxwell, M., Ooms, L., Davies, E.M., Hilton, A., Collinge, J., Hilton, D., Kile, B., Mitchell, C., Hibbs, M., Jane, S., Curtis, D., 2011, An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation, Blood [P], vol 117, issue 20, American Society of Hematology, United States, pp. 5362-5371.

Darido, C., Jane, S., 2011, Grhl3 and GEF19 in the front rho, Small GTPases [P], vol 1, issue 2, Landes Bioscience, Austin, TX 78701 United States, pp. 104-107.

Darido, C., Georgy, S.R., Wilanowski, T., Dworkin, S., Auden, A., Zhao, Q., Rank, G., Srivastava, S., Finlay, M.J., Papenfuss, A.T., Pandolfi, P.P., Pearson, R.B., Jane, S., 2011, Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis, Cancer Cell [P], vol 20, issue 5, Cell Press, USA, pp. 635-648.

Dworkin, S., Jane, S., Darido, C., 2011, The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair, Organogenesis [P], vol 7, issue 3, Landes Bioscience, USA, pp. 202-208.

Boglev, Y., Wilanowski, T., Caddy, J., Parekh, V., Auden, A., Darido, C., Hislop, N., Cangkrama, M., Ting, S., Jane, S., 2011, The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity, Developmental Biology [P], vol 349, issue 2, Academic Press, USA, pp. 512-522.

Caddy, J., Wilanowski, T., Darido, C., Dworkin, S., Ting, S., Zhao, Q., Rank, G., Auden, A., Srivastava, S., Cunningham, J., Jane, S., 2010, Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway, Developmental Cell [P], vol 19, issue 1, Cell Press, United States, pp. 138-147.

Rank, G., Cerruti, L., Simpson, R., Moritz, R., Jane, S., Zhao, Q., 2010, Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression, Blood [P], vol 116, issue 9, American Society of Hematology, United States, pp. 1585-1592.

Rifat, Y., Parekh, V., Wilanowski, T., Hislop, N., Auden, A., Ting, S., Cunningham, J., Jane, S., 2010, Regional neural tube closure defined by the Grainy head-like transcription factors, Developmental Biology [P], vol 345, Academic Press, United States, pp. 237-245.

McCormack, M., Young, L., Vasudevan, S., de Graaf, C., Codrington, R., Rabbitts, T., Jane, S., Curtis, D., 2010, The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal, Science [P], vol 327, issue 12, American Association for the Advancement of Science, United States, pp. 879-883.

Dey, S., Curtis, D., Jane, S., Brandt, S., 2010, The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors, Molecular and Cellular Biology [P], vol 30, issue 9, American Society for Microbiology, United States, pp. 2181-2192.

Rank, G., Sutton, R., Marshall, V., Lundie, R.J., Caddy, J., Romeo, T., Fernandez, K.M., McCormack, M.P., Cooke, B.M., Foote, S.J., Crabb, B.S., Curtis, D.J., Hilton, D.J., Kile, B.T., Jane, S.M., 2009, Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant, Blood, vol 113, issue 14, American Society of Hematology, USA, pp. 3352-3362.

Zhao, Q., Rank, G., Tan, Y., Moritz, R., Simpson, R., Cerruti, L., Curtis, D., Jane, S., 2009, PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing, Nature Structural and Molecular Biology [E], vol 16, issue 3, Nature Publishing Group, United States, pp. 304-311.

Siggins, S., Nguyen, N., McCormack, M., Vasudevan, S., Vilani, R., Jane, S., Wainwright, B., Curtis, D., 2009, The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms, Blood [P], vol 114, issue 5, American Society of Hematology, United States, pp. 995-1004.

Hislop, N., Caddy, J., Ting, S., Auden, A., Vasudevan, S., King, S., Lineman, G., Visvader, J., Cunningham, J., Jane, S., 2008, Grhl3 and Lmo4 play coordinate roles in epidermal migration, Developmental Biology [P], vol 321, Academic Press, United States, pp. 263-272.

Wilanowski, T., Caddy, J., Ting, S., Cerruti, L., Auden, A., Zhao, L., Jane, S., 2008, Perturbed desmosomal cadherin expression in grainy head-like 1-null mice, Embo Journal [P], vol 27, Nature Publishing Group, United Kingdom, pp. 886-897.

Salmon, J., Slater, N., Hall, M., McCormack, M., Jane, S., Curtis, D., 2007, Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene, Blood [P], vol 110, issue 10, American Society of Hematology, United States, pp. 3573-3581.

Dow, L., Kauffman, J., Caddy, J., Peterson, A., Jane, S., Russell, S., Humbert, P., 2007, The tumour-suppressor scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge, Oncogene [P], vol 26, Nature Publishing Group, United Kingdom, pp. 2272-2282.

McCormack, M.P., Hall, M.A., Schoenwaelder, S.M., Zhao, Q., Ellis, S., Prentice, J.A., Clarke, A.J., Slater, N.J., Salmon, J.M., Jackson, S.P., Jane, S.M., Curtis, D.J., 2006, A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis, Blood, vol 108, issue 7, American Society of Hematology, Washington DC USA, pp. 2248-2256.

Bose, F., Fugazza, C., Casalgrandi, M., Capelli, A., Cunningham, J., Zhao, Q., Jane, S., Ottolenghi, S., Ronchi, A., 2006, Functional Interaction of CP2 with GATA-1 in the Regulation of Erythroid Promoters, Molecular and Cellular Biology [P], vol 26, issue 10, American Society for Microbiology, United States, pp. 3942-3954.

Zhao, Q., Cerruti, L., Cunningham, J., Jane, S., 2006, Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter, Blood [P], vol 107, issue 5, American Society of Hematology, United States, pp. 2138-2145.

Auden, A., Caddy, J., Wilanowski, T., Ting, S., Cunningham, J., Jane, S., 2006, Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development, Gene Expression Patterns [P], vol 6, issue 8, ELSEVIER SCIENCE BV, AMSTERDAM, NETHERLANDS, pp. 964-970.

Ting, S., Caddy, J., Hislop, N., Wilanowski, T., Auden, A., Zhao, L., Ellis, S., Kaur, P., Cunningham, J., Jane, S., 2005, A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice, Science [P], vol 308, American Association for the Advancement of Science, United States, pp. 411-413.

Moeller, M., Haynes, N., Kershaw, M., Jackson, J., Teng, M., Street, S., Cerruti, L., Jane, S., Trapani, J., Smyth, M., Darcy, P., 2005, Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection, Blood [P], vol 106, issue 9, American Society of Hematology, United States, pp. 2995-3003.

Tao, J., Kuliyer, E., Wang, X., Li, X., Wilanowsk, T., Jane, S., Mead, P., Cunningham, J., 2005, BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation, Disease Models and Mechanisms [P], vol 132, issue 5, The Company of Biologists' Principles, United Kingdom, pp. 1021-1034.

Jane, S., Cunningham, J., Ting, S., 2005, Epidermal impermeable barriers in mouse and fly, Current Opinion in Genetics and Development [P], vol 15, issue 4, Elsevier Ltd. * Current Opinion Journals, United Kingdom, pp. 447-453.

Hall, M., Slater, N., Begley, C., Salmon, J., Stekelenburg, L., McCormack, M., Jane, S., Curtis, D., 2005, Functional but Abnormal Adult Erythropoiesis in the Absence of the Stem Cell Leukemia Gene, Molecular and Cellular Biology [P], vol 25, issue 15, American Society for Microbiology, United States, pp. 6355-6362.

Teng, M., Kershaw, M., Hayakawa, Y., Cerruti, L., Jane, S., Darcy, P., Smyth, M., 2005, T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner, Journal Of Biological Chemistry [P], vol 280, issue 46, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 38235-38241.

Ting, S., Caddy, J., Auden, A., Wilanowski, T., Cunningham, J., Elias, P., Holleran, W., Jane, S., 2005, The Epidermis of Grhl3-Null Mice Displays Altered Lipid Processing and Cellular Hyperproliferation, Organogenesis [P], vol 2, issue 2, Landes Bioscience, United States, pp. 33-35.

Zhao, Q., Cumming, H.E., Cerruti, L., Cunningham, J.M., Jane, S.M., 2004, Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase HDAC1, The Journal of Biological Chemistry, vol 279, issue 40, The American Society for Biochemistry and Molecular Biology Inc., USA, pp. 41477-41486.

Zhou, W., Zhao, Q., Sutton, R., Cumming, H.E., Wang, X., Cerruti, L., Hall, M., Wu, R., Cunningham, J.M., Jane, S.M., 2004, The role of p22 NF-E4 in human globin gene switching, The journal of biological chemistry, vol 279, issue 25, The american society for biochemistry and molecular biology, pp. 26227-26232.

Ting, S.B.N., Wilanowski, T., Auden, A., Hall, M.A., Voss, A.K., Thomas, T., Parekh, V., Cunningham, J.M., Jane, S.M., 2003, Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3, Nature Medicine [P], vol 9, issue 12, Nature Publishing Group, New York, NY 10013 United States, pp. 1513-1519.

Hall, M., Curtis, D.J., Metcalf, D., Elefanty, A.G., Sourris, K., Robb, L., Gothert, J.R., Jane, S.M., Begley, C.G., 2003, The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erthropoiesis and lineage choice in CFU-S12. IF 10.542, A Proceedings of the National Academy of Sciences USA, vol 100, Natl Acad Sciences, USA, pp. 992-997.

Ting, S.B.N., Wilanowski, T., Cerruti, L., Zhao, L., Cunningham, J.M., Jane, S.M., 2003, The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors, Biochemical Journal [P], vol 370, issue 3, Portland Press Ltd., London, WC1N 2JU United Kingdom, pp. 953-962.

Coghill, E.K., Eccleston, S.E., Fox, V., Cerruti, L., Brown, C., Cunningham, J.M., Jane, S., Perkins, A.C., 2001, Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines dervied from EKLF null mice, Blood, vol 97, issue 6, American Society of Hematology, Washington DC USA, pp. 1861-1868.

Conference Proceedings

Coghill, E., Eccleston, S., Fox, V., Perkins, A.C., Jane, S.M., 1999, Erythroid Kruppel like factor (EKLF) coordinates proliferation haemglobinisation and activation of the human beta-globin gene in cell lines derived from EKLF^-^/^- mice, 11th Lorne Cancer Conference, Lorne, Victoria, 11-14 February 1999, Pink Panther Printing, Australia, p. 1001.

Brown, R.C., Pattinson, S., Barbour, V., Perkins, A.C., Jane, S.M., Cunningham, J.M., 1999, Two distinct domains of the erythnoid transcription factor EKLF are required for maximal activation of the endogenous murine beta-globin gene promoter, Blood, New Orleans, LA, USA, 3-7 December 1999, WB Saunders Company, Philadelphia PA USA, p. 582a.

Other

Jane, S., Wilanowski, T., Ting, S., 2008, Mammalian grainyhead transcription factors, USA.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Analysis of Inositol compounds as a novel therapeutic intervention in squamous cell carcinoma .

Supervisors:

Jane, S (Main), Darido, C (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Analysis of the Grainyhead-like genes in mammalian development and disease.

Supervisors:

Darido, C (Joint), Jane, S (Joint-co).