Dr Jason Cain - Researcher Profile

Jason Cain

Address

Monash Institute of Medical Research
Monash Medical Centre, Clayton

Contact Details

Tel: +61 3 9902 4725

Email: Jason.Cain@monash.edu


Biography

Jason is a Research Fellow in the Developmental and Cancer Biology laboratory of Prof. Neil Watkins in the Centre for Cancer Research at the Monash Institute of Medical Research. Jason's research focuses on the role of critical embryonic signalling pathways in normal and abnormal development and disease. In particular Jason is interested in how aberrant activation of these pathways contrbiutes to paediatric cancers, including osteosarcoma and medulloblastoma.

Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training.  During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up his current position as a Research Fellow with Dr Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at the Monash Institute for Medical Research (MIMR).

 

Qualifications

DOCTOR OF PHILOSOPHY
Institution: Monash University
Year awarded: 2006
BACHELOR OF SCIENCE (HONOURS)
Institution: Monash University
Year awarded: 2001
BACHELOR OF SCIENCE
Institution: Monash University
Year awarded: 2000

Publications

Journal Articles

Kelleher, F.C., Cain, J., Healy, J.M., Watkins, D.N., Thomas, D.M., 2012, Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma, Pharmacology and Therapeutics [P], vol 136, issue 2, Elsevier Inc., United States, pp. 153-168.

Cain, J., Rosenblum, N., 2011, Control of mammalian kidney development by the Hedgehog signaling pathway, Pediatric Nephrology [P], vol 26, issue 9, Springer, Germany, pp. 1365-1371.

Cain, J., Islam, E., Haxho, F., Blake, J., Rosenblum, N., 2011, GLI3 repressor controls functional development of the mouse ureter, Journal of Clinical Investigation [P], vol 121, issue 3, American Society for Clinical Investigation, United States, pp. 1199-1206.

Bridgewater, D., de Giovanni, V., Cain, J., Cox, B., Jakobson, M., Sainio, K., Rosenblum, N., 2011, beta-catenin causes renal dysplasia via upregulation of Tgfbeta2 and Dkk1, Journal Of The American Society Of Nephrology [P], vol 22, issue 4, American Society of Nephrology, United States, pp. 718-731.

Cain, J., di Giovanni, V., Smeeton, J., Rosenblum, N., 2010, Genetics of renal hypoplasia: Insights into the mechanisms controlling nephron endowment, Pediatric Research [P], vol 68, issue 2, Lippincott Williams & Wilkins, United States, pp. 91-98.

Cain, J., Islam, E., Haxho, F., Chen, L., Bridgewater, D., Nieuwenhuis, E., Hui, C., Rosenblum, N., 2009, GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells, PLoS ONE [P], vol 4, issue 10, Public Library of Science, United States, pp. 1-13.

Hartwig, S., Bridgewater, D., de Giovanni, V., Cain, J., Mishina, Y., Rosenblum, N., 2008, BMP receptor ALK3 controls collecting system development, Journal Of The American Society Of Nephrology [P], vol 19, issue 1, American Society of Nephrology, United States, pp. 117-124.

Cain, J., Hartwig, S., Bertram, J.F., Rosenblum, N.D., 2008, Bone morphogenetic protein signaling in the developing kidney: Present and future, Differentiation, vol 76, issue 8, Elsevier Ltd., UK and USA, pp. 831-842.

Bridgewater, D., Cox, B., Cain, J., Lau, A., Athaide, V., Gill, P., Kuure, S., Sainio, K., Rosenblum, N., 2008, Canonical WNT/beta-catenin signaling is required for ureteric branching, Developmental Biology [P], vol 317, issue 1, Academic Press, United States, pp. 83-94.

Cain, J., Bertram, J.F., 2006, Ureteric branching morphogenesis in BMP4 heterozygous mutant mice, Journal of Anatomy, vol 209, issue 6, Blackwell Publishing, Oxford England, pp. 745-755.

Cain, J.E., Nion, T., Jeulin, D., Bertram, J.F., 2005, Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro, Kidney International, vol 67, issue 2, Blackwell Publishing, Inc., Malden USA, pp. 420-431.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Functional characterization of the tumour suppressor gene hypermethylated in cancer-1 (HIC1).
Supervisors:
Cain, J (Joint), Watkins, D (Joint-co).