Dr David Nikolic-Paterson - Researcher Profile

David Nikolic-Paterson

Address

Faculty of Medicine, Nursing & Health Sciences
Monash University, Clayton

Contact Details

Email: David.Nikolic-Paterson@monash.edu


Biography

Inflammation and fibrosis in kidney disease

Kidney disease caused by type 2 diabetes is an emerging epidemic in the developing world. It accounts for 40 per cent of all cases, requiring dialysis or transplants as treatment. Yet many people are not aware that they may be in the early stages of the disease. Doctor David Nikolic-Paterson is helping to find new ways to identify and treat the damage wrought on our kidneys. 

 

"There are many different types of kidney disease, which vary in both the underlying cause and in the speed with which they progress to end-stage kidney failure – at which point you require dialysis or a kidney transplant to survive," notes David. 

"Our research is focused on understanding the disease mechanisms that drive progressive kidney damage, in particular inflammation and fibrosis, and to identify new therapeutic approaches in the treatment of this major health problem.

“We’re working in two areas. The first is basic research into the mechanisms of inflammation and fibrosis that underlie the development of many forms of kidney disease. The second area is translation of this basic research towards new clinical therapies. 

"Our group has done a lot of work with a signalling pathway (termed JNK) which we have shown promotes both inflammation and fibrosis in different types of the kidney injury. Using a JNK inhibitor compound, we have found that pharmacologic blockade of this pathway is effective in experimental models of kidney disease, and we’re trying to translate these exciting findings into clinical trials. 

"Another signalling pathway that we are working on (called c-fms) is required for the function of monocytes, a cell type involved in the immune response. Our previous work established that monocytes can cause acute renal injury."

Together with Dr Greg Tesch and Dr Frank Ma, David has been been able to block the action of monocytes and  ease acute renal injury in several types of kidney disease, including kidney transplant rejection. These promising preclinical studies using a pharmacologic inhibitor of the c-fms pathway have potential for translation into clinical treatment for acute forms of renal injury.

A kidney transplant is the most effective treatment for patients with end-stage renal failure. There are many more patients awaiting transplants than there are available kidneys. 

“Here at Monash Medical Centre we are doing around 75 transplants per year, and this has been increasing in part due to greater community awareness - with more people signing up to organ donation programs and improvements throughout the whole system. 

"However, one area of concern is those patients who have pre-existing antibodies against potential donor kidneys, making them unsuitable as a recipient for many of the possible donor organs, for they may experience significant problems with rejecting the transplant.

"This is an important area in which I am working with Drs John Kanellis and Bill Mulley to examine the mechanisms of antibody-mediated rejection and developing the therapeutic options.”

 

Publications

Book Chapters

Ikezumi, Y., Nikolic-Paterson, D.J., 2009, Monocytes and macrophages, in Recent Advances in IgA Nephropathy, eds Kar Neng Lai, World Scientific Publishing Co. Pte. Ltd, Singapore, pp. 267-288.

Kerr, P., Nikolic-Paterson, D.J., Atkins, R.C., 2007, Idiopathic Rapidly Progressive Glomerulonephritis, in Diseases of the Kidney and Urinary Tract, Lippincott Williams & Wilkins, USA, pp. 1511-1535.

Tesch, G.H., Atkins, R.C., Nikolic-Paterson, D.J., 2007, MIF in the pathogenesis of kidney disease, in MIF: Most Interesting Factor, eds Richard Bucala, World Scientific Publishing Co. Pte. Ltd, Singapore, pp. 153-168.

Tesch, G.H., Lan, H.Y., Nikolic-Paterson, D.J., 2006, Treatment of tissue sections for in situ hybridization, in Methods in Molecular Biology: In Situ Hybridization Protocols, eds Ian A Darby and Tim D Hewitson, Humana Press, Totowa USA, pp. 1-8.

Journal Articles

Summers, S.A., Gan, P., Dewage, L.T., Ma, F., Ooi, J., O'Sullivan, K., Nikolic-Paterson, D.J., Kitching, A.R., Holdsworth, S.R., 2013, Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction, Kidney International [P], vol 82, Nature Publishing Group, United Kingdom, pp. 676-685.

Huang, L., Nikolic-Paterson, D.J., Ma, F., Tesch, G.H., 2012, Aldosterone induces kidney fibroblast proliferation via activation of growth factor receptors and PI3K/MAPK signalling, Nephron Clinical Practice [P], vol 120, issue 4, S. Karger AG, Switzerland, pp. e115-e122.

Nozaki, Y., Nikolic-Paterson, D., Snelgrove, S., Akiba, H., Yagita, H., Holdsworth, S., Kitching, A., 2012, Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis, Kidney International [P], vol 81, issue 9, Nature Publishing Group, United Kingdom, pp. 844-855.

Abraham, A.P., Ma, F., Mulley, W., Ozols, E., Nikolic-Paterson, D.J., 2012, Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney, Nephrology [P], vol 17, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 322-329.

Qu, X., Zhang, X., Yao, J., Song, J., Nikolic-Paterson, D.J., Li, J., 2012, Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation, Journal Of Pathology [P], vol 228, issue 4, John Wiley & Sons Ltd, UK, pp. 506-519.

Leng, L., Chen, L., Fan, J., Greven, D., Arjona, A., Du, X., Austin, D., Kashgarian, M., Yin, Z., Huang, X., Lan, H., Lolis, E., Nikolic-Paterson, D., Bucala, R., 2011, A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice, Journal Of Immunology [P], vol 186, issue 1, American Association of Immunologists, Untied States, pp. 527-538.

Lim, A., Ma, F., Nikolic-Paterson, D., Ozols, E., Young, M., Bennett, B., Friedman, G., Tesch, G., 2011, Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats, American Journal Of Nephrology [P], vol 34, issue 4, S. Karger AG, Switzerland, pp. 337-346.

Ikezumi, Y., Suzuki, T., Karasawa, T., Hasegawa, H., Yamada, T., Imai, N., Narita, I., Kawachi, H., Polkinghorne, K., Nikolic-Paterson, D., Uchiyama, M., 2011, Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: Potential role in mesangial matrix expansion, Histopathology [P], vol 58, issue 2, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 198-210.

Kanellis, J., Ma, F., Kandane, R., Dowling, J., Polkinghorne, K., Bennett, B., Friedman, G., Nikolic-Paterson, D., 2011, JNK signalling in human and experimental renal ischaemia/reperfusion injury, Nephrology Dialysis Transplantation [P], vol 25, issue 9, Oxford University Press, United Kingdom, pp. 2898-2908.

Summers, S., Chan, J., Gan, P., Dewage, L., Nozaki, Y., Steinmetz, O., Nikolic-Paterson, D., Kitching, A., Holdsworth, S., 2011, Mast cells mediate acute kidney injury through the production of TNF, Journal Of The American Society Of Nephrology [P], vol 22, issue 12, American Society of Nephrology, United States, pp. 2226-2236.

Greenall, J., Ma, F., Kanellis, J., Delgado, M., Blease, K., Nikolic-Paterson, D., 2011, Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis, Laboratory Investigation [P], vol 91, issue 12, Nature Publishing Group, United Kingdom, pp. 1727-1738.

Ma, F., Tesch, G., Ozols, E., Xie, M., Schneider, M., Nikolic-Paterson, D., 2011, TGF-ß1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney, American Journal of Physiology - Renal Fluid and Electrolyte Physiology [E], vol 300, issue 6, American Physiological Society, United States, pp. F1410-F1421.

Nozaki, Y., Nikolic-Paterson, D., Yagita, H., Akiba, H., Holdsworth, S., Kitching, A., 2011, Tim-1 promotes cisplatin nephrotoxicity, American Journal of Physiology - Renal Fluid and Electrolyte Physiology [E], vol 301, issue 5, American Physiological Society, United States, pp. F1098-F1104.

Han, Y., Ma, F., Tesch, G., Manthey, C., Nikolic-Paterson, D., 2011, c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat, Laboratory Investigation [P], vol 91, issue 7, Nature Publishing Group, United Kingdom, pp. 978-991.

Nikolic-Paterson, D.J., 2010, CD4+ T cells: a potential player in renal fibrosis., Kidney International [P], vol 78, issue 4, Nature Publishing Group, United Kingdom, pp. 333-335.

Ikezumi, Y., Suzuki, T., Karasawa, T., Hasegawa, H., Kawachi, H., Nikolic-Paterson, D.J., Uchiyama, M., 2010, Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat Thy-1 mesangial proliferative glomerulonephritis, American Journal Of Nephrology [P], vol 31, issue 3, S. Karger AG, Switzerland, pp. 273-282.

Mariasegaram, M., Tesch, G.H., Verhardt, S.L., Hurst, L.A., Lan, H., Nikolic-Paterson, D.J., 2010, Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells, Biochemical And Biophysical Research Communications [P], vol 393, issue 4, Academic Press, United States, pp. 855-859.

Lim, A., Ma, F., Nikolic-Paterson, D., Kitching, A., Thomas, M., Tesch, G., 2010, Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury, Diabetologia [P], vol 53, issue 8, Springer, Germany, pp. 1772-1782.

Ma, F., Ikezumi, Y., Nikolic-Paterson, D.J., 2010, Macrophage signaling pathways: A novel target in renal disease, Seminars in Nephrology [P], vol 30, issue 3, WB Saunders Co., United States, pp. 334-344.

Li, J., Qu, X., Ricardo, S.D., Bertram, J.F., Nikolic-Paterson, D.J., 2010, Resveratrol inhibits renal fibrosis in the obstructed kidney: Potential role in deacetylation of Smad3, American Journal Of Pathology [P], vol 177, issue 3, American Society for Investigative Pathology, USA, pp. 1065-1071.

Lim, A.K.H., Nikolic-Paterson, D.J., Ma, F., Ozols, E., Thomas, M.C., Flavell, R.A., Davis, R.J., Tesch, G.H., 2009, Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice, Diabetologia, vol 52, issue 2, Springer, Germany, pp. 347-358.

Ma, F., Liu, J., Kitching, A.R., Manthey, C.L., Nikolic-Paterson, D.J., 2009, Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney, American Journal of Physiology: Renal Physiology, vol 296, American Physiological Society, United States, pp. 0-1.

Ma, F., Liu, J., Nikolic-Paterson, D.J., 2009, The role of stress-activated protein kinase signaling in renal pathophysiology, Brazilian Journal of Medical and Biological Research, vol 42, issue 1, Associacao Brasileira de Divulgacao Cientifica, Brazil, pp. 29-37.

Ikezumi, Y., Suzuki, T., Karasawa, T., Kawachi, H., Nikolic-Paterson, D.J., Uchiyama, M., 2008, Activated macrophages down-regulate podocyte nephrin and podocin expression via stress-activated protein kinases, Biochemical and Biophysical Research Communications, vol 376, issue 4, Academic Press, USA, pp. 706-711.

Comper, W.D., Hilliard, L.M., Nikolic-Paterson, D.J., Russo, L.M., 2008, Disease-dependent mechanisms of albuminuria, American Journal of Physiology - Renal Physiology [P], vol 295, issue 6, American Physiological Society, USA, pp. F1589-F1600.

Han, Y., Masaki, T., Hurst, L.A., Ikezumi, Y., Trzaskos, J.M., Atkins, R.C., Nikolic-Paterson, D.J., 2008, Extracellular signal-regulated kinase-dependent interstitial macrophage proliferation in the obstructed mouse kidney, Nephrology, vol 13, issue 5, Wiley-Blackwell Publishing Asia, Australia, pp. 411-418.

Slattery, C., Lee, A., Zhang, Y., Kelly, D.J., Thorn, P., Nikolic-Paterson, D.J., Tesch, G.H., Poronnik, P., 2008, In vivo visualization of albumin degradation in the proximal tubule, Kidney International, vol 74, issue 11, Nature Publishing Group, United Kingdom, pp. 1480-1486.

Mulley, W., Nikolic-Paterson, D.J., 2008, Indoleamine 2,3-dioxygenase in transplantation, Nephrology, vol 13, issue 3, Wiley-Blackwell Publishing Asia, Australia, pp. 204-211.

Fukuda, K., Tesch, G.H., Yap, F., Forbes, J.M., Flavell, R.A., Davis, R., Nikolic-Paterson, D.J., 2008, MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model, Laboratory Investigation, vol 88, issue 4, Nature Publishing Group, UK, USA, pp. 398-407.

Tokuyama, H., Kelly, D.J., Cox, A., Zhang, Y., Thai, K., Nikolic-Paterson, D.J., Gilbert, R.E., 2008, Tranilast ameliorates experimental mesangial proliferative glomerulonephritis, Nephron Experimental Nephrology, vol 109, issue 1, S. Karger AG, Switzerland, USA, pp. 1-7.

Ikezumi, Y., Suzuki, T., Karasawa, T., Kawachi, H., Nikolic-Paterson, D.J., Uchiyama, M., 2008, Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy, Pediatric Nephrology, vol 23, issue 4, Springer, Germany, pp. 645-650.

Fukuda, K., Tesch, G.H., Nikolic-Paterson, D.J., 2008, c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury, Biochemical and Biophysical Research Communications, vol 366, issue 3, Academic Press, United States, pp. 710-716.

Flanc, R., Ma, F., Tesch, G.H., Han, Y., Atkins, R.C., Bennett, B.L., Friedman, G.C., Fan, J., Nikolic-Paterson, D.J., 2007, A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis, Kidney International, vol 72, issue 6, Nature Publishing Group, United Kingdom, pp. 698-708.

Ma, F., Flanc, R., Tesch, G.H., Han, Y., Atkins, R.C., Bennett, B.L., Friedman, G.C., Fan, J., Nikolic-Paterson, D.J., 2007, A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis, Journal of the American Society of Nephrology, vol 18, issue 2, Lippincott Williams & Wilkins, US, pp. 472-484.

Tee, M.M., Tesch, G.H., Nikolic-Paterson, D.J., Brown, F.G., 2007, Human peritoneal mesothelial cells isolated from spent dialysate fluid maintain contaminating macrophages via production of macrophage colony stimulating factor, Nephrology, vol 12, issue 2, Blackwell Publishing Asia, Australia, pp. 160-165.

Ma, F., Tesch, G.H., Flavell, R.A., Davis, R., Nikolic-Paterson, D.J., 2007, MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney, American Journal of Physiology: Renal Physiology, vol 293, issue 5, American Physiological Society, United States, pp. 1556-1563.

Chow, F.Y., Nikolic-Paterson, D.J., Ma, F., Ozols, E., Rollins, B.J., Tesch, G.H., 2007, Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice., Diabetologia, vol 50, issue 2, Springer, Germany, pp. 471-480.

Laslett, A.L., Grimmond, S.M., Gardiner, B., Stamp, L., Lin, S.A., Hawes, S.M., Wormald, S., Nikolic-Paterson, D.J., Haylock, D.N., Pera, M.F., 2007, Transcriptional analysis of early lineage commitment in human embryonic stem cells, BMC Developmental Biology, vol 7, issue 12, BioMed Central Ltd, UK, pp. 1-18.

Hilliard, L.M., Osicka, T.M., Clavant, S.P., Robinson, P.J., Nikolic-Paterson, D.J., Comper, W.D., 2006, Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney, Journal of Laboratory and Clinical Medicine, vol 147, issue 1, Mosby Inc, St Louis USA, pp. 36-44.

Ikezumi, Y., Suzuki, T., Imai, N., Ueno, M., Narita, I., Kawachi, H., Shimizu, F., Nikolic-Paterson, D.J., Uchiyama, M., 2006, Histological differences in new-onset IgA nephropathy between children and adults, Nephrology, Dialysis, Transplantation, vol 21, issue 12, Oxford University Press, UK, pp. 3466-3474.

Lam, E., Funder, J.W., Nikolic-Paterson, D.J., Fuller, P.J., Young, M.J., 2006, Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats, Endocrinology, vol 147, issue 7, The Endocrine Society, USA, pp. 3623-3629.

Chow, F., Nikolic-Paterson, D.J., Ozols, E., Atkins, R.C., Rollins, B.J., Tesch, G.H., 2006, Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice, Kidney International, vol 69, issue 1, Nature Publishing Group, UK, pp. 73-80.

Tesch, G.H., Nikolic-Paterson, D.J., 2006, Recent Insights into experimental mouse models of diabetic nephropathy, The Nephron Journals, vol 104, issue 2, S. Karger AG, Switzerland, pp. 57-62.

O'Bryan, M.K., Gerdprasert, O., Nikolic-Paterson, D.J., Meinhardt, A., Muir, J.A., Foulds, L.M., Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2005, Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 288, issue 6, Amercan Physiological Society, USA, pp. R1744-R1755.

Chow, F.Y., Nikolic-Paterson, D.J., Ozols, E., Atkins, R.C., Tesch, G.H., 2005, Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice, Journal of the American Society of Nephrology, vol 16, issue 6, Lippincott Williams & Wilkins, USA, pp. 1711-1722.

De Haan-Klein, J.B., Stefanovic, N., Nikolic-Paterson, D.J., Scurr, L.L., Croft, K.D., Mori, T.A., Hertzog, P.J., Kola, I., Atkins, R.C., Tesch, G.H., 2005, Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy, American Journal of Physiology: Renal Physiology, vol 289, issue 3, American Physiological Society, USA, pp. F544-F551.

Koltun, M., Nikolovski, J., Strong, K., Nikolic-Paterson, D.J., Comper, W.D., 2005, Mechanism of hypoalbuminemia in rodents, American Journal of Physiology: Heart and Circulatory Physiology, vol 288, issue 4, American Physiological Society, USA, pp. H1604-H1610.

Ikezumi, Y., Suzuki, T., Hayafuji, S., Okubo, S., Nikolic-Paterson, D.J., Kawachi, H., Shimizu, F., Uchiyama, M., 2005, The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis, Nephrology, Dialysis, Transplantation, vol 20, issue 12, Oxford University Press, UK, pp. 2704-2713.

Adhikary, L., Chow, F.Y., Nikolic-Paterson, D.J., Stambe, C., Dowling, J.P., Atkins, R.C., Tesch, G.H., 2004, Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy, Diabetologia, vol 47, issue 7, Springer-Verlag, Germany, pp. 1210-1222.

Masaki, T., Stambe, C., Hill, P.A., Dowling, J.P., Atkins, R.C., Nikolic-Paterson, D.J., 2004, Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies, Journal of the American Society of Nephrology, vol 15, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1835-1843.

Osicka, T., Strong, K., Nikolic-Paterson, D.J., Atkins, R.C., Comper, W.D., 2004, Albumin and glomerular permselectivity, Nephrology, Dialysis, Transplantation, vol 19, issue 2, Oxford University Press, United Kingdom, pp. 511-512.

Naito, T., Masaki, T., Nikolic-Paterson, D.J., Tanji, C., Yorioka, N., Kohno, N., 2004, Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-1, American Journal of Physiology-Renal Physiology, vol 286, American Physiological Society, USA, pp. 278-287.

Rice, E.K., Nikolic-Paterson, D.J., David, J.R., Bucala, R., Metz, C.N., Atkins, R.C., Tesch, G.H., 2004, Macrophage accumulation and renal fibrosis are independent of macrophage migration inhibitory factor in mouse obstructive nephropathy, Nephrology, vol 9, issue 5, Blackwell Publishing Asia, Australia, pp. 278-287.

Ikezumi, Y., Hurst, L.A., Atkins, R.C., Nikolic-Paterson, D.J., 2004, Macrophage-mediated renal injury is dependent on signaling via the JNK pathway, Journal of the American Society of Nephrology, vol 15, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1775-1784.

Chow, F.Y., Ozols, E., Nikolic-Paterson, D.J., Atkins, R.C., Tesch, G.H., 2004, Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury, Kidney International, vol 65, issue 1, Blackwell Publishing Inc, Malden USA, pp. 116-128.

Chow, F.Y., Nikolic-Paterson, D.J., Atkins, R.C., Tesch, G.H., 2004, Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis, Nephrology Dialysis Transplantation, vol 19, issue 12, Oxford University Press, UK, pp. 2987-2996.

Osicka, T.M., Strong, K.J., Nikolic-Paterson, D.J., Atkins, R.C., Jerums, G., Comper, W.D., 2004, Renal processing of serum proteins in an albumin-deficient environment: an in vivo study of glomerulonephritis in the Nagase analbuminaemic rat, Nephrology Dialysis Transplantation, vol 19, issue 2, Oxford University Press, Oxford England, pp. 320-328.

Stambe, C., Atkins, R.C., Tesch, G.H., Masaki, T., Schreiner, G.F., Nikolic-Paterson, D.J., 2004, The role of p38 mitogen-activated protein kinase activation in renal fibrosis, Journal of the American Society of Nephrology, vol 15, issue 2, Lippincott Williams & Wilkins, Philadelphia USA, pp. 370-379.

Stambe, C., Nikolic-Paterson, D.J., Hill, P.A., Dowling, J.P., Atkins, R.C., 2004, p38 Mitogen-Activated Protein Kinase Activation and Cell Localization in Human Glomerulonephritis: Correlation with Renal Injury, Journal of the American Society of Nephrology, vol 15, issue 2, Lippincott Williams and Wilkins, USA, pp. 326-336.

Nikolic-Paterson, D.J., 2003, A role for macrophages in mediating tubular cell apoptosis?, Kidney International [P], vol 63, issue 4, Nature Publishing Group, United Kingdom, pp. 1582-1583.

Stambe, C., Atkins, R.C., Hill, P.A., Nikolic-Paterson, D.J., 2003, Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis, Kidney International, vol 64, issue 6, Blackwell Publishing Inc., Malden USA, pp. 2121-2132.

Masaki, T., Foti, R., Hill, P.A., Ikezumi, Y., Atkins, R.C., Nikolic-Paterson, D.J., 2003, Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney, Kidney International, vol 63, issue 4, Nature Publishing Group, United Kingdom, pp. 1256-1264.

Ikezumi, Y., Hurst, L.A., Masaki, T., Atkins, R.C., Nikolic-Paterson, D.J., 2003, Adoptive transfer studies demonstrate that macrophages can induce proteinuria and esangial cell proliferation, Kidney International, vol 63, issue 1, Blackwell Publishing Inc., Malden USA, pp. 83-95.

Stambe, C., Atkins, R.C., Tesch, G.H., Kapoun, A.M., Hill, P.A., Schreiner, G.F., Nikolic-Paterson, D.J., 2003, Blockade of p38 MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis, Journal of the American Society of Nephrology, vol 14, Lippincott Williams & Wilkins, Philadelphia USA, pp. 338-351.

Masaki, T., Chow, F.Y., Nikolic-Paterson, D.J., Atkins, R.C., Tesch, G.H., 2003, Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis, Nephrology, Dialysis, Transplantation, vol 18, issue 1, Oxford University Press, United Kingdom, pp. 178-181.

Rice, E.K., Tesch, G.H., Cao, Z., Cooper, M.E., Metz, C.N., Bucala, R., Atkins, R.C., Nikolic-Paterson, D.J., 2003, Induction of MIF synthesis and secretion by tubular epithelial cells - a novel action of angiotensin II, Kidney International, vol 63, issue 4, Blackwell Publishing Inc., Malden USA, pp. 1265-1275.

Ikezumi, Y., Atkins, R.C., Nikolic-Paterson, D.J., 2003, Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism, Journal of the American Society of Nephrology, vol 14, issue 4, American Society of Nephrology, USA, pp. 888-898.

Rice, E.K., Nikolic-Paterson, D.J., Hill, P.A., Metz, C.N., Bucala, R., Atkins, R.C., Tesch, G.H., 2003, Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells, Nephrology, vol 8, issue 3, Wiley-Blackwell Publishing Asia, Australia, pp. 156-161.

Robertson, T.E., Nikolic-Paterson, D.J., Tesch, G.H., Foti, R., Atkins, R.C., Chadban, S.J., 2003, Role of interleukin-10 in rat mesangioproliferative glomerulonephritis, Nephrology, vol 8, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 33-41.

Gerdprasert, O., O'Bryan, M.K., Nikolic-Paterson, D.J., Sebire, K.L., de Kretser, D.M., Hedger, M.P., 2002, Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis, Molecular Human Reproduction, vol 8, issue 6, Oxford University Press, Oxford UK, pp. 518-524.

Robertson, T.E., Nikolic-Paterson, D.J., Hurst, L.A., Atkins, R.C., Chadban, S.J., 2002, IL-10 induces mesangial cell proliferation via a PDGF-dependent mechanism, Clinical Experimental Immunology, vol 130, issue 2, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 241-244.

Le Meur, Y., Tesch, G.H., Hill, P.A., Mu, W., Foti, R., Nikolic-Paterson, D.J., Atkins, R., 2002, Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathway, Journal of Leukocyte Biology, vol 72, issue 3, Federation of American Societies for Experimental Biology, USA, pp. 530-537.

Brown, F.G., Nikolic-Paterson, D.J., Hill, P.A., Isbel, N.M., Dowling, J.P., Metz, C.N., Atkins, R., 2002, Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritis., Journal of American Society of Nephrology, vol 13, issue Suppl 1, American Society of Nephrology, USA, pp. 7-13.

Oldfield, M.D., Bach, L.A., Forbes, J.M., Nikolic-Paterson, D.J., McRobert, A., Thallas, V., Atkins, R.C., Osicka, T., Jerums, G., Cooper, M.E., 2001, Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products(RAGE), Journal of Clinical Investigation, vol 108, issue 12, American Socity of Clinical Investigation Inc, USA, pp. 1853-1863.

Greive, K.A., Nikolic-Paterson, D.J., Guimaraes, M., Nikolovski, J., Pratt, L.M., Mu, W., Atkins, R.C., Comper, W., 2001, Glomerular permselectivity factors are not responsible for the increase in fractional clearance of albumin in rat glomerulonephritis, American Journal of Pathology, vol 159, issue 3, American Society of Investigative Pathology, Bethesda MD USA, pp. 1159-1170.

Tesch, G.H., Hill, P.A., Wei, M., Nikolic-Paterson, D.J., Dutartre, P., Atkins, R.C., 2001, LF15-0195 prevents the induction and inhibits the progression of rat anti-GBM disease, Kidney International, vol 60, issue 4, Nature Publishing Group, USA, pp. 1354-1365.

Nikolic-Paterson, D.J., Hurst, L.A., Comper, W., 2001, Variable toxicity of dyes used in micropuncture studies, Nephrology, vol 6, issue 1, Blackwell Science Asia, Carlton Vic Australia, pp. 221-222.

Takazoe, K., Tesch, G.H., Hill, P.A., Hurst, L.A., Jun, Z., Lan, H.Y., Atkins, R.C., Nikolic-Paterson, D.J., 2000, CD44-mediated neutrophil apoptosis in the rat, Kidney International, vol 58, Blackwell Science Inc, Malden MA USA, pp. 1920-1930.

Eppel, G.A., Takazoe, K., Nikolic-Paterson, D.J., Lan, H.Y., Atkins, R.C., Comper, W.D., 2000, Characteristics of albumin processing during renal passage in anti-thy1 and anti-glomerular basement membrane glomerulonephritis, American Journal of Kidney Diseases, vol 35 issue 3, WB Saunders Co, Philadelphia USA, pp. 418-426.

Takazoe, K., Foti, R., Tesch, G.H., Hurst, L.A., Lan, H.Y., Atkins, R.C., Nikolic-Paterson, D.J., 2000, Up-regulation of the tumour-associated marker CD44V6 in experimental kidney disease, Clinical and Experimental Immunology, vol 121, Blackwell Science Ltd, Oxford England, pp. 523-532.

Hedger, M., Nikolic-Paterson, D.J., Hutchinson, P., Atkins, R.C., de Kretser, D.M., 1998, Immunoregulatory activity in adult rat testicular interstitial fluid: roles of interleukin-1 and transforming growth factor beta1, BIOLOGY OF REPRODUCTION, vol 58, Society for the Study of Reproduction, MADISON WI USA, pp. 927-934.

Grants

Title:
Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease. .
Investigators:
Nikolic-Paterson, D, Tesch, G
Funding:
(2013 - 2017). National Health & Medical Research Council (NHMRC).
Title:
Computerised image analysis system.
Investigators:
Tipping, P, Hedger, M, Risbridger, G, Nikolic-Paterson, D
Funding:
(1995 - 1999). National Health & Medical Research Council (NHMRC).
Title:
Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease.
Investigators:
Nikolic-Paterson, D
Funding:
(2011 - 2015). National Health & Medical Research Council (NHMRC).
Title:
NHMRC Senior Research Fellowship.
Investigators:
Nikolic-Paterson, D
Funding:
(2009 - 2013). National Health & Medical Research Council (NHMRC).
(2010 - 2015). National Health & Medical Research Council (NHMRC).
Title:
New roles for the spleen tyrosine kinase in antibody-independent renal injury.
Investigators:
Nikolic-Paterson, D, Ma, F
Funding:
(2011 - 2015). National Health & Medical Research Council (NHMRC).
Title:
Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney desease.
Investigators:
Li, J, Nikolic-Paterson, D
Funding:
(2010 - 2013). National Health & Medical Research Council (NHMRC).
Title:
Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase , c-fms.
Investigators:
Nikolic-Paterson, D, Tesch, G, Ma, F
Funding:
(2010 - 2013). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:
Flanc, R.
Program of Study:
A pathogenic role for the JNK signalling pathway in kidney disease. (PHD) 2006.
Supervisors:
Nikolic-Paterson, D (Main), Atkins, R (Associate).
Student:
Han, Y.
Program of Study:
Cell signalling pathways in experimental kidney disease. (PHD) 2012.
Supervisors:
Nikolic-Paterson, D (Main).
Student:
Rice, E.
Program of Study:
MACROPHAGE MIGRATION INHIBITORY FACTOR AND RENAL INJURY. (PHD) 2002.
Supervisors:
Atkins, R (Main), Nikolic-Paterson, D (Associate).
Student:
Stambe, C.
Program of Study:
THE ROLE OF THE P38 MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) PATHWAY IN INFLAMMATORY AND FIBROTIC RENAL DISEASE. (PHD) 2003.
Supervisors:
Nikolic-Paterson, D (Main), Atkins, R (Associate).