Dr Natalie Borg - Researcher Profile

Biography

Natalie works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

BACHELOR OF SCIENCE

Institution: University of Melbourne

Year awarded: 2003

BACHELOR OF APPLIED BIOLOGY/BIOTECHNOLOGY HONOURS

Institution: RMIT University

Year awarded: 1997

BACHELOR OF APPLIED BIOLOGY/BIOTECHNOLOGY

Institution: RMIT University

Year awarded: 1996

Publications

Journal Articles

Reboul, C., Meyer, G.R., Porebski, B., Borg, N.A., Buckle, A.M., 2012, Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex, PLoS Computational Biology [E], vol 8, issue 3 (Art. ID: e1002404), Public Library of Science, USA, pp. 1-11.

Paxman, J.J., Borg, N., Horne, H.J., Thompson, P., Chin, K.Y., Sharma, P., Simpson, J.S., Wielens, J., Piek, S., Kahler, C.M., Sakellaris, H., Pearce, M.C., Bottomley, S.P., Rossjohn, J., Scanlon, M., 2009, The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes, Journal Of Biological Chemistry [P], vol 284, issue 26, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 17835-17845.

Wun, K.S., Borg, N., Kjer-Nielsen, L., Beddoe, T.C., Koh, R., Richardson, S.K., Thakur, M., Howell, A.R., Scott-Browne, J.P., Gapin, L., Godfrey, D.I., McCluskey, J., Rossjohn, J., 2008, A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR, The Journal of Experimental Medicine, vol 205, issue 4, Rockefeller University Press, USA, pp. 939-949.

Tynan, F.E., Reid, H.H., Kjer-Nielsen, L., Miles, J.J., Wilce, M.C.J., Kostenko, L., Borg, N., Williamson, N.A., Beddoe, T.C., Purcell, A.W., Burrows, S.R., McCluskey, J., Rossjohn, J., 2007, A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule, Nature Immunology, vol 8, issue 3, Nature Publishing Group, New York NY USA, pp. 268-276.

Henderson, K., Tye-Din, J.A., Reid, H.H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S.I., Purcell, A.W., Dudek, N.L., van Heel, D.A., McCluskey, J., Rossjohn, J., Anderson, R.P., 2007, A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease, Immunity, vol 27, issue 1, Cell Press, Cambridge MA USA, pp. 23-34.

Borg, N., Wun, K.S., Kjer-Nielsen, L., Wilce, M.C.J., Pellicci, D.G., Koh, R., Besra, G.S., Bharadwaj, M., Godfrey, D.I., McCluskey, J., Rossjohn, J., 2007, CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor, Nature, vol 448, issue 7149, Nature Publishing Group, London England UK, pp. 44-49.

Scott-Browne, J.P., Matsuda, J.L., Mallevaey, T., White, J., Borg, N., McCluskey, J., Rossjohn, J., Kappler, J., Marrack, P., Gapin, L., 2007, Germline-encoded recognition of diverse glycolipids by natural killer T cells, Nature Immunology, vol 8, issue 10, Nature Publishing Group, New York NY USA, pp. 1105-1113.

Borg, N., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., 2007, Structural insight into natural killer T cell receptor recognition of CD1d, Advances in Experimental Medicine and Biology, vol 598, Springer-Verlag Berlin, Berlin Germany, pp. 20-34.

Henderson, K., Reid, H.H., Borg, N., Broughton, S.E., Huyton, T., Anderson, R.P., McCluskey, J., Rossjohn, J., 2007, The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, vol 63, issue 12, Wiley-Blackwell Munksgaard, Denmark, pp. 1021-1025.

Kjer-Nielsen, L., Borg, N.A., Pellicci, D.G., Beddoe, T.C., Kostenko, L., Clements, C.S., Williamson, N.A., Smyth, M.J., Besra, G.S., Reid, H.H., Bharadwaj, M., Godfrey, D.I., Rossjohn, J., McCluskey, J., 2006, A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition, Journal of Experimental Medicine, vol 203, issue 3, Rockefeller University Press, New York USA, pp. 661-673.

Miles, J.J., Borg, N.A., Brennan, R.M., Tynan, F.E., Kjer-Nielsen, L., Silins, S.L., Bell, M.J., Burrows, J.M., McCluskey, J., Rossjohn, J., Burrows, S.R., 2006, TCRalpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope, Journal of Immunology, vol 177, issue 10, The American Association of Immunologists, Bethesda USA, pp. 6804-6814.

Miles, J.J., Elhassen, D., Borg, N.A., Silins, S.L., Tynan, F.E., Burrows, J.M., Purcell, A.W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S.R., McCluskey, J., 2005, CTL recognition of a bulged viral peptide involves biased TCR selection, Journal of Immunology, vol 175, issue 6, American Association of Immunologists, Bethesda USA, pp. 3826-3834.

Tynan, F.E., Borg, N., Miles, J.J., Beddoe, T.C., El-Hassen, D., Silins, S.L., van Zuylen, W.J., Purcell, A.W., Kjer-Nielsen, L., McCluskey, J., Burrows, S.R., Rossjohn, J., 2005, High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance, Journal of Biological Chemistry, vol 280, issue 25, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 23900-23909.

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide, Nature Immunology, vol 6, issue 11, Nature Publishing Group, New York USA, pp. 1114-1122.

Borg, N.A., Ely, L.K., Beddoe, T.C., Macdonald, W.A., Reid, H.H., Clements, C.S., Purcell, A.W., Kjer-Nielsen, L., Miles, J.J., Burrows, S.R., McCluskey, J., Rossjohn, J., 2005, The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition, Nature Immunology, vol 6, issue 2, Nature Publishing Group, New York USA, pp. 171-180.

Tynan, F.E., Elhassen, D., Purcell, A.W., Burrows, J.M., Borg, N.A., Miles, J.J., Williamson, N.A., Green, K.J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J., Burrows, S.R., 2005, The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation, The Journal of Experimental Medicine, vol 202, issue 9, Rockefeller University Press, New York USA, pp. 1249-1260.

Webb, A.I., Borg, N.A., Dunstone, M.A., Kjer-Nielsen, L., Beddoe, T.C., McCluskey, J., Carbone, F.R., Bottomley, S.P., Aguilar, M.I., Purcell, A.W., Rossjohn, J., 2004, The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance, The Journal of Immunology, vol 173, issue 1, American Association of Immunologists, Bethesda USA, pp. 402-409.

Conference Proceedings

Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N., Beddoe, T.C., Whisstock, J.C., Wilce, M.C.J., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Kostenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 571.

Miles, J.J., Borg, N., Tynan, F.E., Kjer-Nielsen, L., Elhassen, D., Silins, S.L., Burrows, J.M., Brennan, R.M., Purcell, A.W., McCluskey, J., Rossjohn, J., 2005, Predicting the human T cell receptor choice before viral infection; Facts learnt from primary infection, Tissue Antigens, 29 November 2005 - 3rd December 2005, Blackwell Publishing, Oxford England, p. 493.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Functional and structural study into the regulation of antiviral immunity by host and viral proteins.

Supervisors:

Borg, N (Main).