Assoc Prof Margaret Hibbs - Researcher Profile

Biography

Margaret works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Melbourne University

Year awarded: 1991

BACHELOR OF SCIENCE

Institution: University of Melbourne

Year awarded: 1984

Publications

Journal Articles

Maxwell, M.J., Tsantikos, E., Kong, A.M., Vanhaesebroeck, B., Tarlinton, D.M., Hibbs, M., 2012, Attenuation of phosphoinositide 3-kinase delta signaling restrains autoimmune disease, Journal Of Autoimmunity [P], vol 38, issue 4, Academic Press, United Kingdom, pp. 381-391.

Duan, M., Li, W.C., Vlahos, R., Maxwell, M.J., Anderson, G., Hibbs, M., 2012, Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease, Journal Of Immunology [P], vol 189, issue 2, American Association of Immunologists, United States, pp. 946-955.

Tsantikos, E., Maxwell, M.J., Kountouri, N., Harder, K.W., Tarlinton, D.M., Hibbs, M., 2012, Genetic interdependence of lyn and negative regulators of B cell receptor signalling in autoimmune disease development, Journal Of Immunology [P], vol 189, issue 4, American Association of Immunologists, United States, pp. 1726-1736.

Lau, M., Tsantikos, E., Maxwell, M.J., Tarlinton, D.M., Anderson, G., Hibbs, M., 2012, Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background, Journal Of Autoimmunity [P], vol 39, issue 4, Academic Press, United Kingdom, pp. 388-397.

Krebs, D.L., Chehal, M.K., Sio, A., Huntington, N.D., Da, M., Ziltener, P., Inglese, M., Kountouri, N., Priatel, J.J., Jones, J., Tarlinton, D.M., Anderson, G.P., Hibbs, M., Harder, K.W., 2012, Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells, Journal Of Immunology [P], vol 188, issue 10, American Association of Immunologists, United States, pp. 5094-5105.

Xu, Y., Huntington, N.D., Harder, K.W., Nandurkar, H., Hibbs, M., Tarlinton, D.M., 2012, Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase, Immunology And Cell Biology [P], vol 90, issue 9, Nature Publishing Group, United Kingdom, pp. 903-911.

Nguyen, N., Maxwell, M., Ooms, L., Davies, E.M., Hilton, A., Collinge, J., Hilton, D., Kile, B., Mitchell, C., Hibbs, M., Jane, S., Curtis, D., 2011, An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation, Blood [P], vol 117, issue 20, American Society of Hematology, United States, pp. 5362-5371.

Maxwell, M., Duan, M., Armes, J., Anderson, G., Tarlinton, D., Hibbs, M., 2011, Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice, Journal Of Immunology [P], vol 186, issue 12, American Association of Immunologists, USA, pp. 7164-7175.

Perugini, M., Brown, A., Salerno, D., Booker, G., Stojkoski, C., Hercus, T., Lopez, A., Hibbs, M., Gonda, T., D'Andrea, R., 2010, Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit, Blood [P], vol 115, issue 16, American Society of Hematology, United States, pp. 3346-3353.

Tsantikos, E., Oracki, S., Quilici, C., Anderson, G., Tarlinton, D., Hibbs, M., 2010, Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6, Journal Of Immunology [P], vol 184, issue 3, The American Association of Immunologists, United States, pp. 1348-1360.

Mackay-Fisson, F., Figgett, W., Saulep, D., Le Page, M., Hibbs, M., 2010, B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor, Immunological Reviews [P], vol 237, issue 1, Wiley-Blackwell Publishing, Inc., United States, pp. 205-225.

Oracki, S., Tsantikos, E., Quilici, C., Light, A., Schmidt, T., Lew, A., Martin, J., Smith, K., Hibbs, M., Tarlinton, D., 2010, CTLA4Ig alters the course of autoimmune disease development in Lyn -/- mice, Journal Of Immunology [P], vol 184, issue 2, The American Association of Immunologists, United States, pp. 757-763.

Oracki, S., Walker, J., Hibbs, M., Corcoran, L., Tarlinton, D., 2010, Plasma cell development and survival, Immunological Reviews [P], vol 237, issue 1, Wiley-Blackwell Publishing, Inc., United States, pp. 140-159.

Verhagen, A., Wallace, M., Goradia, A., Jones, S., Croom, H., Metcalf, D., Collinge, J., Maxwell, M., Hibbs, M., Alexander, W., Hilton, D., Kile, B., Starr, R., 2009, A kinase-dead allele of lyn attenuates autoimmune disease normally associated with lyn deficiency, Journal Of Immunology [P], vol 182, American Association of Immunologist, 9650 Rockville Pike, Bethersda MD 20814 USA, pp. 2020-2029.

Liu, K., Gualano, R.C., Hibbs, M., Anderson, G., Bozinovski, S., 2008, Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection, Journal Of Biological Chemistry [P], vol 283, issue 15, American Society for Biochemistry and Molecular Biology Inc, United States, pp. 9977-9985.

McColl, B.K., Paavonen, K., Karnezis, T., Harris, N.C., Davydova, N., Rothacker, J., Nice, E., Harder, K.W., Roufail, S., Hibbs, M.L., Rogers, P.A.W., Alitalo, K., Stacker, S.A., Achen, M.G., 2007, Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2, Faseb Journal [P], vol 21, issue 4, Federation of American Societies for Experimental Biology, USA, pp. 1088-1098.

Beavitt, S.E., Harder, K.W., Kemp, J.M., Jones, J., Quilici, C., Casagranda, F., Lam, E., Turner, D., Brennan, S., Sly, P.D., Tarlinton, D.M., Anderson, G.P., Hibbs, M.L., 2005, Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity, The Journal of Immunology, vol 175, American Association of Immunologists, Bethesda USA, pp. 1867-1875.

Maxwell, M.J., Yuan, Y., Anderson, K.E., Hibbs, M.L., Salem, H.H., Jackson, S.P., 2004, SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets, The Journal of Biological Chemistry, vol 279, issue 31, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 32196-32204.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identifying and targeting signaling pathways in lupus using a clinically relevant model.

Supervisors:

Hibbs, M (Main), Mackay, F (Associate).