Dr Marina Harper - Researcher Profile

Biography

Marina works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

MICROBIOLOGY

Institution: Monash University

Year awarded: 2004

Publications

Book Chapters

Boyce, J.D., Harper, M., Wilkie, I., Adler, B., 2010, Pasteurella, in Pathogenesis of Bacterial Infections in Animals, eds C.L. Gyles, J.F. Prescott, J. Glenn Songer, C.O. Thoen, Blackwell Publishing (John Wiley & Sons), USA, pp. 325-346.

Journal Articles

Soon, R.L., Li, J., Boyce, J.D., Harper, M., Adler, B., Larson, I.C., Nation, R.L., 2012, Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications, Journal Of Applied Microbiology [P], vol 113, issue 4, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 940-951.

Harper, M., St Michael, F., Vinogradov, E., John, M., Boyce, J.D., Adler, B., Cox, A.D., 2012, Characterization of the lipopolysaccharide from Pasteurella multocida Heddleston serovar 9: identification of a proposed bi-functional dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis enzyme, Glycobiology [P], vol 22, issue 3, Oxford University Press, USA, pp. 332-344.

Henry, R.M., Vithanage (Sulthanagoda), N.R., Harrison, P., Seemann, T., Coutts, S.A., Moffatt, J.H., Nation, R.L., Li, J., Harper, M., Adler, B., Boyce, J.D., 2012, Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-, Antimicrobial Agents And Chemotherapy [P], vol 56, issue 1, American Society for Microbiology, USA, pp. 59-69.

Wilkie, I.W., Harper, M., Boyce, J.D., Adler, B., 2012, Pasteurella multocida: diseases and pathogenesis, Current Topics In Microbiology And Immunology [P], vol 361, Springer New York LLC, USA, pp. 1-22.

Boyce, J.D., Seemann, T., Adler, B., Harper, M., 2012, Pathogenomics of pasteurella multocida, Current Topics In Microbiology And Immunology [P], vol 361, Springer New York LLC, USA, pp. 23-38.

Harper, M., Boyce, J.D., Adler, B., 2012, The key surface components of pasteurella multocida: capsule and lipopolysaccharide, Current Topics In Microbiology And Immunology [P], vol 361, Springer New York LLC, USA, pp. 39-51.

Soon, R., Nation, R., Cockram, S., Moffatt, J., Harper, M., Adler, B., Boyce, J., Larson, I., Li, J., 2011, Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment, Journal Of Antimicrobial Chemotherapy [P], vol 66, issue 1, Oxford University Press, United Kingdom, pp. 126-133.

Soon, R., Nation, R., Harper, M., Adler, B., Boyce, J., Tan, C., Li, J., Larson, I., 2011, Effect of colistin exposure and growth phase on the surface properties of live acinetobacter baumannii cells examined by atomic force microscopy, International Journal of Antimicrobial Agents [P], vol 38, issue 6, Elsevier, Netherlands, pp. 493-501.

Moffatt, J.H., Harper, M., Adler, B., Nation, R.L., Li, J., Boyce, J.D., 2011, Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 6, American Society for Microbiology, USA, pp. 3022-3024.

Harper, M., St Michael, F., John, M., Vinogradov, E., Adler, B., Boyce, J.D., Cox, A.D., 2011, Pasteurella multocida Heddleston serovars 1 and 14 express different lipopolysaccharide structures but share the same lipopolysaccharide biosynthesis outer core locus, Veterinary Microbiology [P], vol 150, issue 3-4, Elsevier BV, The Netherlands, pp. 289-296.

Harper, M., Cox, A., Adler, B., Boyce, J., 2011, Pasteurella multocida lipopolysaccharide: The long and the short of it, Veterinary Microbiology [P], vol 153, issue 1-2, Elsevier Science BV, The Netherlands, pp. 109-115.

Moffatt, J.H., Harper, M., Harrison, P.F., Hale, J.D., Vinogradov, E., Seemann, T., Henry, R.M., Crane, B.A., St Michael, F., Cox, A.D., Adler, B., Nation, R.L., Li, J., Boyce, J.D., 2010, Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 12, American Society for Microbiology, USA, pp. 4971-4977.

Steen, J.A., Steen, J.A., Harrison, P.F., Seemann, T., Wilkie, I.W., Harper, M., Adler, B., Boyce, J.D., 2010, Fis is essential for capsule production in Pasteurella multocida and regulates expression of other important virulence factors, Plos Pathogens [P], vol 6, issue 2, Public Library of Science, USA, pp. e1000750-1-e1000750-14.

Harper, M., Cox, A.D., St Michael, F., Ford, M., Wilkie, I.W., Adler, B., Boyce, J.D., 2010, Natural selection in the chicken host identifies 3-deoxy-D-manno- octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide, Infection And Immunity [P], vol 78, issue 9, American Society for Microbiology, USA, pp. 3669-3677.

Boyce, J.D., Harper, M., St Michael, F., John, M., Aubry, A., Parnas, H., Logan, S.M., Wilkie, I.W., Ford, M.E., Cox, A.D., Adler, B., 2009, Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence, Infection and Immunity, vol 77, issue 4, American Society for Microbiology, USA, pp. 1532-1542.

St Michael, F., Harper, M., Parnas, H., John, M., Stupak, J., Vinogradov, E., Adler, B., Boyce, J.D., Cox, A.D., 2009, Structural and genetic basis for the serological differentiation of Pasteurella multocida Heddleston Serotypes 2 and 5, Journal Of Bacteriology [P], vol 191, issue 22, American Society for Microbiology, USA, pp. 6950-6959.

Lazar Adler, N.R., Govan, B., Cullinane, M., Harper, M., Adler, B., Boyce, J.D., 2009, The molecular and cellular basis of pathogenesis in melioidosis: How does Burkholderia pseudomallei cause disease?, FEMS Microbiology Reviews [P], vol 33, issue 6, Wiley-Blackwell Publishing Ltd, UK & The Netherlands, pp. 1079-1099.

Harper, M., Cox, A.D., St Michael, F., Parnas, H., Wilkie, I.W., Blackall, P.J., Adler, B., Boyce, J.D., 2007, Decoration of pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence, Journal of Bacteriology, vol 189, issue 20, American Society of Microbiology, Washington, DC, USA, pp. 7384-7391.

Harper, M., Boyce, J.D., Cox, A.D., St Michael, F., Wilkie, I.W., Blackall, P.J., Adler, B., 2007, Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: Identification of two acceptor-specific heptosyl I transferases, Infection and Immunity, vol 75, issue 8, American Society of Microbiology, Washington DC USA, pp. 3885-3893.

Harper, M., Boyce, J.D., Adler, B., 2006, Pasteurella multocida pathogenesis: 125 years after Pasteur, FEMS Microbiology Letters, vol 265, issue 1, Blackwell Publishing Ltd, OXON ENGLAND, pp. 1-10.

St.Michael, F., Li, J., Vinogradov, E., Larocque, S., Harper, M., Cox, A.D., 2005, Structural analysis of the lipopolysaccharide of Pasteurella multocida strain VP161: Identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide, Carbohydrate Research, vol 340, issue 1, Elsevier Pergamon, UK, pp. 59-68.

Harper, M., Cox, A.D., St Michael, F., Wilkie, I.W., Boyce, J.D., Adler, B., 2004, A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and Is attenuated in virulence, Infection and Immunity, vol 72, issue 6, American Society for Microbiology, Washington USA, pp. 3436-3443.

Boyce, J.D., Wilkie, I.W., Harper, M., Paustian, M.L., Kapur, V., Adler, B., 2004, Genomic-scale analysis of Pasteurella multocida gene expression during growth within liver tissue of chickens with fowl cholera, Microbes and Infection, vol 6, issue 3, Elsevier, Amsterdam The Netherlands, pp. 290-298.

Harper, M., Boyce, J.D., Wilkie, I.W., Adler, B., 2003, Signature-tagged mutagenesis of Pasteurella multocida identifies mutants displaying differential virulence characteristics in mice and chickens, Infection and Immunity, vol 71, issue 9, American Soceity for Microbiology, Washington USA, pp. 5440-5446.

Boyce, J.D., Wilkie, I., Harper, M., Paustian, M.L., Kapur, V., Adler, B., 2002, Genomic Scale Analysis of Pasteurella multocida Gene Expression during Growth within the Natural Chicken Host, Infection and Immunity, vol 70, issue 12, ASM, Washington DC USA, pp. 6871-6879.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Characterisation of a Type VI Secretion System in Acinetobacter baumannii.

Supervisors:

Boyce, J (Main), Harper, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The mechanism of colistin resistance in A.baumannii.

Supervisors:

Boyce, J (Main), Harper, M (Associate), Li, J (Associate).

Completed Supervision

Student:

Lazar Adler, N.

Program of Study:

Studies on the molecular basis of pathogenesis of melioidosis. (PHD) 2009.

Supervisors:

Boyce, J (Main), Adler, B (Associate), Harper, M (Associate).

Student:

Steen, J.

Program of Study:

Analysis of Pasteurella multocida virulence factors. (PHD) 2010.

Supervisors:

Boyce, J (Joint-Co), Adler, B (Associate), Harper, M (Associate).

Student:

Sulthanagoda Vithanage, N.

Program of Study:

TBD. 2010.

Supervisors:

Boyce, J (Joint-Co), Harper, M (Joint).