Prof Jian Li - Researcher Profile

Jian Li

Address

Faculty of Pharmacy and Pharmaceutical Sciences
381 Royal Parade, Parkville

Contact Details

Tel: +61 3 990 39702

Fax: +61 3 9903 9629

Email: Jian.Li@monash.edu

Web: http://www.pharm.monash.edu.au/research/mips/d4/index.html


Biography

Position

 

NHMRC Senior Research Fellow
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

 

The last line of defence

Professor Jian Li represents one of medical science’s last defences against the ongoing march of the bacterial ‘superbugs’.  He is a world leader in the pharmacology of polymyxin, one of the few antibiotics currently available that is still capable of successfully fighting bacteria which have become resistant to just about every other antibiotic on the market.

Jian started his research in colistin pharmacology while working as a PhD student.

The drug became clinically available in the late 1950s but led to serious side-effects and was labelled as ‘toxic’. It was surpassed by new antibiotics in the 1970s and was rarely used. Research into the drug lay dormant for almost 30 years.

However, Jian and his PhD supervisors realised that it could offer a new hope for treatment of infections caused by Gram-negative superbugs. Since then, Jian, and his team have led a relentless exploration of pharmacology of colistin and polymyxin B. Today they provide the majority of our current knowledge on this class of antibiotics.

Over the last 8 years he and his collaborators have attracted more than $15 million in competitive grant funding from Australian government (i.e. National Health and Medical Research Council), the National Institutes of Health (USA) and the pharmaceutical industry.

"If ever we attend an international conference and people are talking about colistin pharmacology, they are talking about our research," Jian says. "The majority of the pharmacology information about this drug is from our group."

His work has exposed polymyxins to the rigours of modern drug development procedure that was not in place when this old class of antibiotics was first introduced to hospitals.

His group has taken the drug from the earliest stages of microbiological evaluations and animal testing through to clinical studies. More than 250 patients across the USA, Thailand, Greece and Brazil participated in clinical studies. The samples being sent to Monash for pharmacological analyses have generated optimism that colistin could be used in the fight against superbugs. In addition, Jian is leading a very productive team at Monash to discover novel lipopeptides which are active against polymyxin-resistant superbugs.
 
"The current antibiotic discovery pipeline is dry; there’s no new antibiotic for these sorts of pathogens for many years to come," Jian says. "It’s an urgent situation, globally. As highlighted on World Health Day 2011: no action today, no cure tomorrow. We hope our discovery could be part of the solution."

Jian has established a team of cross-disciplinary experts within the Monash Institute of Pharmaceutical Sciences and Monash University to uncover the basic mechanisms of bacterial resistance and toxicity to further enhance his drug discovery program. This world-leading research will help slow the advance of bacterial resistance and minimise side-effects in patients.

"The rise of bacterial superbugs is inevitable, and has presented a global medical challenge, including in Australia. At the moment polymyxins are considered a last line therapy; they are one of the best weapons left in the fight against superbugs."

Keywords

Antimicrobials, antimicrobial resistance, drug discovery, antimicrobial pharmacology , Colistin, polymyxin B, pharmacodynamics, pharmacokinetics , polymyxin, Acinetobacter baumannii,Klebsiella pneu

Qualifications

DOCTOR OF PHILOSOPHY
Institution: University of South Australia
Year awarded: 2002
MASTER OF SCIENCE
Institution: Shandong University
Year awarded: 1999
BACHELOR OF SCIENCE
Institution: Shandong University - CHINA
Year awarded: 1996

Publications

Book Chapters

Nation, R., Li, J., 2010, Polymyxins, in Kucers' the use of antibiotics- A clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs, eds M Lindsay Grayson, Hodder Arnold, United Kingdom, pp. 955-970.

Journal Articles

Yousef, J.M., Chen, G., Hill, P.A., Nation, R.L., Li, J., 2012, Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics, Journal Of Antimicrobial Chemotherapy [P], vol 67, issue 2, Oxford University Press, Oxford, England, pp. 452-459.

Soon, R.L., Li, J., Boyce, J.D., Harper, M., Adler, B., Larson, I.C., Nation, R.L., 2012, Cell surface hydrophobicity of colistin-susceptible vs resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications, Journal Of Applied Microbiology [P], vol 113, issue 4, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 940-951.

Henry, R.M., Vithanage (Sulthanagoda), N.R., Harrison, P., Seemann, T., Coutts, S.A., Moffatt, J.H., Nation, R.L., Li, J., Harper, M., Adler, B., Boyce, J.D., 2012, Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-, Antimicrobial Agents And Chemotherapy [P], vol 56, issue 1, American Society for Microbiology, USA, pp. 59-69.

Wallace, S.J., Li, J., Nation, R.L., Boyd, B.J., 2012, Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology, Drug Delivery and Translational Research [E], vol 2, Springer, Germany, pp. 284-292.

Huang, J.X., Cooper, M.A., Baker, M.A., Azad, M.A.K., Nation, R.L., Li, J., Velkov, T., 2012, Drug-binding energetics of human a-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations, Journal Of Molecular Recognition [P], vol 25, issue 12, Wiley-Blackwell, Malden, Massachusetts USA, pp. 642-656.

Jin, L., Li, J., Nation, R.L., Nicolazzo, J., 2012, Effect of systemic infection induced by pseudomonas aeruginosa on the brain uptake of colistin in mice, Antimicrobial Agents And Chemotherapy [P], vol 56, issue 10, American Society for Microbiology, Washington DC USA, pp. 5240-5246.

Dai, C., Li, J., Lin, W., Li, G., Sun, M., Wang, F., Li, J., 2012, Electrophysiology and ultrastructural changes in mouse sciatic nerve associated with colistin sulfate exposure, Toxicology Mechanisms And Methods [P], vol 22, issue 8, Informa Healthcare, United States, pp. 592-596.

Wallace, S.J., Li, J., Nation, R.L., Prankerd, R.J., Boyd, B.J., 2012, Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, John Wiley & Sons, USA, pp. 3347-3359.

Huang, J.X., Azad, M.A.K., Yuriev, E., Baker, M.A., Nation, R.L., Li, J., Cooper, M.A., Velkov, T., 2012, Molecular characterization of lipopolysaccharide binding to human alpha-1-acid glycoprotein, Journal of Lipids [E], vol 2012, Hindawi Publishing Corporation, USA, pp. 1-15.

Bergen, P.J., Landersdorfer, C.B., Lee, H.J., Li, J., Nation, R.L., 2012, 'Old' antibiotics for emerging multidrug-resistant bacteria, Current Opinion In Infectious Diseases [P], vol 25, issue 6, Lippincott Williams & Wilkins, Philadelphia, Pennsylvania USA, pp. 626-633.

Bergen, P.J., Landersdorfer, C.B., Zhang, J., Zhao, M., Lee, H.J., Nation, R.L., Li, J., 2012, Pharmacokinetics and pharmacodynamics of 'old' polymyxins: What is new?, Diagnostic Microbiology and Infectious Disease [P], vol 74, issue 3, Elsevier Science Inc, New York, USA, pp. 213-223.

Neoh, C.F., Jacob, J., Leung, L., Li, J., Stathopoulos, A., Stewart, K., Kong, D.C.M., 2012, Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise, Antimicrobial Agents and Chemotherapy [E], vol 56, issue 6, American Society for Microbiology, Washington DC USA, pp. 3435-3437.

Azad, M.A.K., Huang, J.X., Cooper, M.A., Roberts, K.D., Thompson, P., Nation, R.L., Li, J., Velkov, T., 2012, Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein, Biochemical Pharmacology [P], vol 84, issue 3, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 278-291.

Deris, Z.Z., Yu, H., Davis, K.E., Soon, R.L., Jacob, J., Ku, K.U.C., Poudyal, A., Bergen, P.J., Tsuji, B., Bulitta, J.B., Forrest, A., Paterson, D.L., Velkov, T., Li, J., Nation, R.L., 2012, The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model, Antimicrobial Agents And Chemotherapy [P], vol 56, issue 10, American Society for Microbiology, Washington DC, USA, pp. 5103-5112.

Liang, W., Liu, X., Huang, J., Zhu, D., Li, J., Zhang, J., 2011, Activities of colistin- and minocycline-based combinations against extensive drug resistant acinetobacter baumannii isolates from intensive care unit patients, BMC Infectious Diseases [P], vol 11, issue 109, BioMed Central, England, pp. e1-e7.

Wang, J., Wong, E., Whitley, J., Li, J., Stringer, J., Short, K., Renfree, M., Belov, K., Cocks, B., 2011, Ancient antimicrobial peptides kill antibiotic-resistant pathogens: australian mammals provide new options, PLoS ONE [P], vol 6, issue 8, Public Library of Science, USA, pp. 1-8.

Sidjabat, H., Nimmo, G., Walsh, T., Binotto, E., Htin, A., Hayashi, Y., Li, J., Nation, R., George, N., Paterson, D., 2011, Carbapenem resistance in Klebsiella pneumoniae due to the new delhi metallo-alpha-lactamase, Clinical Infectious Diseases [P], vol 52, issue 4, Oxford University Press, United States, pp. 481-484.

Bergen, P., Forrest, A., Bulitta, J., Tsuji, B., Sidjabat, H., Paterson, D., Li, J., Nation, R., 2011, Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant peudomonas aeruginosa at multiple inocula, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 11, American Society for Microbiology, USA, pp. 5134-5142.

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R., Li, J., 2011, Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions, Analytical Biochemistry [P], vol 409, issue 2, Academic Press, United States, pp. 273-283.

Soon, R., Nation, R., Cockram, S., Moffatt, J., Harper, M., Adler, B., Boyce, J., Larson, I., Li, J., 2011, Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment, Journal Of Antimicrobial Chemotherapy [P], vol 66, issue 1, Oxford University Press, United Kingdom, pp. 126-133.

Bergen, P., Li, J., Nation, R., 2011, Dosing of colistin - back to basic PK/PD, Current Opinion in Pharmacology [P], vol 11, issue 5, Elsevier, England, pp. 464-469.

Soon, R., Nation, R., Harper, M., Adler, B., Boyce, J., Tan, C., Li, J., Larson, I., 2011, Effect of colistin exposure and growth phase on the surface properties of live acinetobacter baumannii cells examined by atomic force microscopy, International Journal of Antimicrobial Agents [P], vol 38, issue 6, Elsevier, Netherlands, pp. 493-501.

Moffatt, J.H., Harper, M., Adler, B., Nation, R.L., Li, J., Boyce, J.D., 2011, Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 6, American Society for Microbiology, USA, pp. 3022-3024.

Yousef, J., Chen, G., Hill, P., Nation, R., Li, J., 2011, Melatonin attenuates colistin-induced nephrotoxicity in rats, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 9, American Society for Microbiology, USA, pp. 4044-4049.

Garonzik, S., Li, J., Thamlikitkul, V., Paterson, D., Shoham, S., Jacob, J., Silveira, F., Forrest, A., Nation, R., 2011, Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients., Antimicrobial Agents And Chemotherapy [P], vol 55, issue 7, American Society for Microbiology, USA, pp. 3284-3294.

Bergen, P., Tsuji, B., Bulitta, J., Forrest, A., Jacob, J., Sidjabat, H., Paterson, D., Nation, R., Li, J., 2011, Synergistic killing of multidrug-resistant pseudomonas aeruginosa at inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 12, American Society for Microbiology, USA, pp. 5685-5695.

Vaara, M., Siikanen, O., Apajalahti, J., Fox, J., Frimodt-Moller, N., He, F.H., Poudyal, A., Li, J., Nation, R.L., Vaara, T., 2010, A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 8, American Society for Microbiology, United States, pp. 3341-3346.

Moffatt, J.H., Harper, M., Harrison, P.F., Hale, J.D., Vinogradov, E., Seemann, T., Henry, R.M., Crane, B.A., St Michael, F., Cox, A.D., Adler, B., Nation, R.L., Li, J., Boyce, J.D., 2010, Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 12, American Society for Microbiology, USA, pp. 4971-4977.

Henderson, L.C., Li, J., Nation, R.L., Velkov, T., Pfeffer, F.M., 2010, Developing an anion host for lipid A binding and antibacterial activity, Chemical Communications [P], vol 46, Royal Society of Chemistry, United Kingdom, pp. 3197-3199.

Dudhani, R., Turnidge, J.D., Coulthard, K., Milne, R., Rayner, C.R., Li, J., Nation, R.L., 2010, Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 3, American Society of Microbiology, United Stated, pp. 1117-1124.

Dudhani, R., Nation, R.L., Li, J., 2010, Evaluating the stability of colistin and colistin methanesulphonate in human plasma under different conditions of storage, Journal Of Antimicrobial Chemotherapy [P], vol 65, Oxford University Press, United Kingdom, pp. 1412-1415.

Jin, L., Li, J., Nation, R., Nicolazzo, J., 2010, Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice, Antimicrobial Agents And Chemotherapy [P], vol 55, issue 2, American Society for Microbiology, USA, pp. 502-507.

Bergen, P.J., Bulitta, J.B., Forrest, A., Tsuji, B., Li, J., Nation, R.L., 2010, Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 9, American Society for Microbiology, United States, pp. 3783-3789.

Neoh, C.F., He, F.H., Li, J., Fullinfaw, R., Leung, L., Misra, A., Vajpayee, R., Davies, G.E., Stewart, K., Kong, D.C.M., 2010, Rapid and sensitive liquid chromatography/mass spectrometry assay for caspofungin in human aqueous humor, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 10, American Society for Microbiology, United States, pp. 4467-4470.

Wallace, S.J., Li, J., Nation, R.L., Prankerd, R.J., Velkov, T., Boyd, B.J., 2010, Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization, Journal of Physical Chemistry B [P], vol 114, American Chemical Society, USA, pp. 4836-4840.

Velkov, T., Thompson, P., Nation, R.L., Li, J., 2010, Structure-Activity Relationships of Polymyxin Antibiotics, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, USA, pp. 1898-1916.

Dudhani, R., Turnidge, J., Nation, R., Li, J., 2010, fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models, Journal Of Antimicrobial Chemotherapy [P], vol 65, issue 9, Oxford University Press, United Kingdom, pp. 1984-1990.

Soon, R.L., Nation, R.L., Hartley, P., Larson, I.C., Li, J., 2009, Atomic force microscopy investigation of the morphology and topography of colistin-heteroresistant Acinetobacter baumannii strains as a function of growth phase and in response to colistin treatment, Antimicrobial Agents And Chemotherapy [P], vol 53, issue 12, American Society for Microbiology, United States, pp. 4979-4986.

Jin, L., Li, J., Nation, R.L., Nicolazzo, J., 2009, Brain penetration of colistin in mice assessed by a novel high-performance liquid chromatographic technique, Antimicrobial Agents And Chemotherapy [P], vol 53, issue 10, American Society for Microbiology, USA, pp. 4247-4251.

Yau, W., Owen, R., Poudyal, A., Bell, J.M., Turnidge, J.D., Yu, H., Nation, R.L., Li, J., 2009, Colistin hetero-resistance in multidrug-resistant Acinetobacter baumannii clinical isolates from the Western Pacific region in the SENTRY antimicrobial surveillance programme, Journal of Infection, vol 58, W.B. Saunders Co. Ltd, United Kingdom, pp. 138-144.

Nation, R.L., Li, J., 2009, Colistin in the 21st century, Current Opinion In Infectious Diseases [P], vol 22, issue 6, Lippincott Williams & Wilkins, United States, pp. 535-543.

Li, J., Nation, R.L., Cao, G., Ali, F., Chiu, F.C.K., Zavascki, A.P., 2009, Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma - authors' response, Journal Of Antimicrobial Chemotherapy [P], vol 63, issue 3, Oxford University Press, United Kingdom, pp. 628-629.

Li, J., Nation, R.L., Zavascki, A.P., 2009, Letter to the Editor: Reply to Kunin, Clinical Infectious Diseases [P], vol 48, issue 6, University of Chicago Press, United States, pp. 843-844.

Kim, B., Peleg, A., Lodise, T., Lipman, J., Li, J., Nation, R.L., Paterson, D., 2009, Management of meningitis due to antibiotic-resistant Acinetobacter species, Lancet [P], vol 9, issue 4, The Lancet Publishing Group, United Kingdom, pp. 245-255.

Ali, F., Cao, G., Poudyal, A., Vaara, T., Nation, R.L., Vaara, M., Li, J., 2009, Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration, Journal Of Antimicrobial Chemotherapy [P], vol 64, issue 5, Oxford University Press, United Kingdom, pp. 1067-1070.

Ma, Z., Wang, J., Nation, R.L., Li, J., Turnidge, J.D., Coulthard, K., Milne, R., 2009, Renal disposition of colistin in the isolated perfused rat kidney, Antimicrobial Agents And Chemotherapy [P], vol 53, issue 7, American Society for Microbiology, United States, pp. 2857-2864.

Al-Badriyeh, D.M., Li, J., Stewart, K., Kong, D.C.M., Leung, L., Davies, G., Fullinfaw, R., 2009, Stability of extemporaneously prepared voriconazole ophthalmic solution, American Journal of Health-System Pharmacy [P], vol 66, issue 16, American Journal of Health-System Pharmacists, United States, pp. 1478-1483.

Zavascki, A.P., Li, J., Nation, R.L., Superti, S.V., Barth, A.L., Lutz, L., Ramos, F., Boniatti, M.M., Goldani, L.Z., 2009, Stable polymyxin B susceptibility to Pseudomonas aeruginosa and Acinetobacter spp. despite persistent recovery of these organisms from respiratory secretions of patients with ventilator-associated pneumonia treated with this drug, Journal Of Clinical Microbiology [P], vol 47, issue 9, American Society for Microbiology, United States, pp. 3064-3065.

Bergen, P.J., Li, J., Nation, R.L., Turnidge, J.D., Coulthard, K., Milne, R., 2008, Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model, Journal of Antimicrobial Chemotherapy, vol 61, issue 3, Oxford University Press, United Kingdom, pp. 636-642.

Cao, G., Ali, F.E.A., Chiu, F.C.K., Zavascki, A.P., Nation, R.L., Li, J., 2008, Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma, Journal of Antimicrobial Chemotherapy, vol 62, issue 5, Oxford University Press, United Kingdom, pp. 1009-1014.

Poudyal, A., Howden, B., Bell, J.M., Gao, W., Owen, R., Turnidge, J.D., Nation, R.L., Li, J., 2008, In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae, Journal of Antimicrobial Chemotherapy, vol 62, issue 6, Oxford University Press, United Kingdom, pp. 1311-1318.

Sudhakaran, S., Rayner, C.R., Li, J., Kong, D.C.M., 2008, Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus, British Journal of Clinical Pharmacology, vol 65, issue 5, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 667-673.

Zavascki, A.P., Li, J., 2008, Intravenous colistimethate for multidrug-resistant gram-negative bacteria, The Lancet, vol 8, issue 7, The Lancet Publishing Group, United Kingdom, pp. 403-405.

Zavascki, A.P., Goldani, L.Z., Cao, G., Superti, S.V., Lutz, L., Barth, A.L., Ramos, F., Boniatti, M.M., Li, J., Nation, R.L., 2008, Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients, Clinical Infectious Diseases, vol 47, issue 15 November, University of Chicago Press, United States, pp. 1298-1304.

Wallace, S.J., Li, J., Rayner, C.R., Coulthard, K., Nation, R.L., 2008, Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients, Antimicrobial Agents and Chemotherapy, vol 52, issue 9, American Society for Microbiology, United States, pp. 3047-3051.

Wallace, S.J., Li, J., Nation, R.L., Rayner, C.R., Taylor, D., Middleton, D., Milne, R., Coulthard, K., Turnidge, J.D., 2008, Subacute toxicity of colistin methanesulfonate in rats: Comparison of various intravenous dosage regimens, Antimicrobial Agents and Chemotherapy, vol 52, issue 3, American Society for Microbiology, United States, pp. 1159-1161.

Tan, C., Li, J., Nation, R.L., 2007, Activity of colistin against heteroresistant Acinetobacter baumannii and emergence of resistance in an in vitro pharmacokinetic/pharmacodynamic model, Antimicrobial agents and chemotherapy, vol 51, issue 9, American Society for Microbiology, US, pp. 3413-3415.

Li, J., Nation, R.L., Owen, R., Wong, S., Spelman, D.W., Franklin, C., 2007, Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains, Clinical Infectious Diseases, vol 45, issue 5, University of Chicago Press, US, pp. 594-598.

Sudhakaran, S., Rayner, C.R., Li, J., Kong, D.C.M., Gude, N.M., Nation, R.L., 2007, Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma, British Journal of Clinical Pharmacology, vol 63, issue 3, Blackwell Publishing Ltd, UK, pp. 315-321.

Owen, R., Li, J., Nation, R.L., Spelman, D.W., 2007, In vitro pharmacodynamics of colistin against Acinetobacter baumannii clinical isolates, Journal of Antimicrobial Chemotherapy, vol 59, issue 3, Oxford University Press, UK, pp. 473-477.

Nation, R.L., Li, J., 2007, Optimizing use of colistin and polymyxin B in the critically ill, Seminars in Respiratory and Critical Care Medicine, vol 28, issue 6, Thieme Medical Publishers, US, pp. 604-614.

Boak, L.M., Li, J., Rayner, C.R., Nation, R.L., 2007, Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model, Antimicrobial Agents and Chemotherapy, vol 51, issue 4, American Society for Microbiology, US, pp. 1287-1292.

Zavascki, A.P., Goldani, L.Z., Li, J., Nation, R.L., 2007, Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review, Journal of Antimicrobial Chemotherapy, vol 60, issue 6, Oxford University Press, UK, pp. 1206-1215.

Bergen, P.J., Li, J., Rayner, C.R., Nation, R.L., 2006, Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa, Antimicrobial Agents and Chemotherapy, vol 50, issue 6, American Society for Microbiology, USA, pp. 1953-1958.

Li, J., Nation, R.L., Turnidge, J.D., Milne, R.W., Coulthard, K., Rayner, C.R., Paterson, D.L., 2006, Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections, The Lancet Infectious Diseases, vol 6, issue 9, The Lancet Publishing Group, London UK, pp. 589-601.

Li, J., Nation, R.L., 2006, Comment on: pharmacokinetics of inhaled colistin in patients with cystic fibrosis, Journal of Antimicrobial Chemotherapy, vol 58, issue 1, Oxford University Press, Oxford UK, pp. 222-223.

Li, J., Nation, R.L., Turnidge, J.D., 2006, Defining the dosage units for colistin methanesulfonate: urgent need for international harmonization, Antimicrobial Agents and Chemotherapy, vol 50, issue 12, American Society for Microbiology, USA, pp. 4231-4232.

Wang, J., Nation, R.L., Evans, A.M., Cox, S., Li, J., 2006, Determination of antiviral nucleoside analogues AM365 and AM188 in perfusate and bile of the isolated perfused rat liver using HPLC, Biomedical Chromatography, vol 20, issue 3, John Wiley & Sons Ltd., UK, pp. 244-250.

Li, J., Rayner, C.R., Nation, R.L., Owen, R.J., Spelman, D.W., Tan, K., Liolios, L.L., 2006, Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii, Antimicrobial Agents and Chemotherapy, vol 50, issue 9, American Society for Microbiology, USA, pp. 2946-2950.

Boak, L.M., Li, J., Nation, R.L., Rayner, C.R., 2006, High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma, Biomedical Chromatography, vol 20, issue 8, John Wiley & Sons Limited, West Sussex UK, pp. 782-786.

Li, J., Nation, R.L., 2006, Old polymyxins are back: Is resistance close?, Clinical Infectious Diseases, vol 43, issue 5, University of Chicago Press, Chicago USA, pp. 663-664.

Boak, L.M., Li, J., Spelman, D.W., Du Cros, P.A., Nation, R.L., Rayner, C.R., 2006, Successful treatment and cerebrospinal fluid penetration of oral linezolid in a patient with coagulase-negative Staphylococcus ventriculitis, The Annals of Pharmacotherapy, vol 40, issue 7-8, Harvey Whitney Books Company, Cincinnati USA, pp. 1451-1455.

Li, J., Nation, R.L., 2006, Three 'Cs' of colistin, Australian Society for Antimicrobials Newsletter, vol June, issue 25, Australian Society of Antimicrobials, Australia, pp. 1-5.

Li, J., Rayner, C.R., Nation, R.L., 2005, Colistin-associated acute renal failure: revisited, Southern Medical Journal, vol 98, issue 12, Southern Medical Association, USA, pp. 1229-1230.

Li, J., Nation, R.L., Milne, R.L., Turnidge, J.D., Coulthard, K., 2005, Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria, International Journal of Antimicrobial Agents, vol 25, Elsevier BV, Netherlands, pp. 11-25.

Li, J., Rayner, C.R., Nation, R.L., Deans, R., Boots, R., Widdecombe, N., Douglas, A., Lipman, J., 2005, Pharmacokinetics of colistin methanesulfonate and colistin in a critically ill patient receiving continuous venovenous hemodiafiltration [4], Antimicrobial Agents and Chemotherapy, vol 49, issue 11, American Society for Microbiology, USA, pp. 4814-4815.

Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Smeaton, T.C., Coulthard, K., 2004, Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate, Journal of Antimicrobial Chemotherapy, vol 53, issue 5, Oxford University Press, UK, pp. 837-840.

Li, J., Rayner, C.R., Nation, R.L., 2004, Simple method for the assay of eperezolid in Brain Heart Infusion broth by high-performance liquid chromatography, Journal of Pharmaceutical and Biomedical Analysis, vol 35, issue 4, Elsevier BV, Netherlands, pp. 847-851.

Li, J., Rayner, C.R., Dixson, S.D., Nation, R.L., 2004, Simple method for the assay of linezolid in Brain Heart Infusion broth by high-performance liquid chromatography, Biomedical Chromatography, vol 18, issue 1, John Wiley & Sons Ltd, UK, pp. 1-5.

Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K., 2003, Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography, Antimicrobial Agents and Chemotherapy, vol 47, issue 4, American Society for Microbiology, USA, pp. 1364-1370.

Li, J., Coulthard, K., Milne, R., Nation, R.L., Conway, S., Peckham, Etherington, C., Turnidge, J.D., 2003, Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis, Journal of Antimicrobial Chemotherapy, vol 52, Oxford University Press, UK, pp. 987-992.

Li, J., Milne, R., Nation, R.L., Turnidge, J.D., Smeaton, T., Coulthard, K., 2003, Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration, Antimicrobial Agents and Chemotherapy, vol 47, American Society for Microbiology, USA, pp. 1766-1770.

Li, J., Milne, R., Nation, R.L., Turnidge, J.D., Coulthard, K., Valentine, J., 2002, Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography, Antimicrobial Agents and Chemotherapy, vol 46, issue 10, American Society for Microbiology, USA, pp. 3304-3307.

Li, J., Milne, R., Nation, R.L., Turnidge, J.D., Coulthard, K., Johnson, D.W., 2001, A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reverse-phase high-performance liquid chromatography, Journal of Chromatography B, Biomedical Sciences and Applications, vol 761, Elsevier Science B.V., Netherlands, pp. 167-175.

Li, J., Turnidge, J.D., Milne, R., Nation, R.L., Coulthard, K., 2001, In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis, Antimicrobial Agents and Chemotherapy, vol 45, American Society for Microbiology, USA, pp. 781-785.

Hill, A.J., Macfarlane, D.R., Li, J., Jones, P.L., Forsyth, M., 1998, Plasticizer Effects in Polyether Electrolytes Studied by Positron Annihilation Lifetime Spectroscopy, Electrochimica Acta, vol . 43, nos. 10-11, Elsevier Science Ltd., Oxford UK, pp. 1481-1484.

Conference Proceedings

Jong, T., Li, J., Hale, J., Morton, D., Larson, I., 2011, Investigating the particle engineering of colistin for pulmonary delivery, ECPS 2011, 01/03-31/03/2011, MDPI open access publishing, Basel, Switzerland, pp. 1-6.

Morton, D., Jong, T., Li, J., Hale, J., Nation, R., Larson, I., 2011, Investigating the particle engineering of colistin for pulmonary delivery, Respiratory Drug Delivery Europe 2011, 03-06/05/2011, RDD Online and Aptar Pharm, USA, pp. 367-371.

Wallace, S., Li, J., Rayner, C.R., Nation, R.L., Taylor, D., Middleton, D., Milne, R.W., Coulthard, K., Turnidge, J.D., 2006, Sub-acute toxicity of colistin methanesulfonate (CMS) in rats, 46th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 2006.

Other

Li, J., Rayner, C.R., Nation, R.L., 2006, Therapy for Multi-Drug Resistant Microorganisms, USA.

Teaching Commitment

  • Supervisor of PhD and Honours students at Monash Institute of Pharmaceutical Sciences

    • Activities

    Affiliations with institutes

    Drug Delivery, Disposition and Dynamics
    Monash Institute of Pharmaceutical Sciences

    Grants

    Title:
    Combating the global medical challenge caused by Gram-negative 'superbugs': from redeveloping the polymyxins to discovering novel antibiotics.
    Investigators:
    Li, J
    Funding:
    (2011 - 2015). National Health & Medical Research Council (NHMRC). $114,128.00
    (2012 - 2015). National Health & Medical Research Council (NHMRC). $456,512.00
    Title:
    Optimizing dosing of colistin for infections resistant to all other antibiotics.
    Investigators:
    Nation, R, Li, J
    Funding:
    (2007 - 2011). National Institutes of Health (NIH), USA. $1,289,902.00
    (2012 - 2016). National Institutes of Health (NIH), USA. $0.00
    Title:
    Rescuing the last-line therapy colistin against Gram-negative ‘superbugs’: increasing the therapeutic index by attenuation of nephrotoxicity.
    Investigators:
    Li, J, Hill, P, Nation, R, Velkov, T
    Funding:
    (2012 - 2016). National Health & Medical Research Council (NHMRC). $481,300.00
    Title:
    Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.
    Investigators:
    Nation, R, Li, J, Tsuji, B, Forrest, A, Paterson, D
    Funding:
    (2008 - 2012). National Institutes of Health (NIH), USA. $2,598,893.00
    (2012 - 2016). National Institutes of Health (NIH), USA. $0.00
    Title:
    Targeting NDM-producing ‘superbugs’: optimising novel combinations with ‘old’ polymyxins using pharmacological, molecular imaging and systems biology approaches .
    Investigators:
    Li, J, Nation, R, Fu, J, Boyce, J, Butler, M
    Funding:
    (2013 - 2017). National Health & Medical Research Council (NHMRC). $563,021.17
    (2014 - 2017). National Health & Medical Research Council (NHMRC). -$20,000.00
    Title:
    Targeting Superbugs: discovery and development of new broad-spectrum lipopeptide.
    Investigators:
    Li, J, Velkov, T, Nation, R, Thompson, P, Roberts, K, Dudley, M, Hecker, S, Lomovskaya, O, Griffith, D
    Funding:
    (2012 - 2016). National Institute of Health, US. $4,548,070.00