Prof Graham Lieschke - Researcher Profile

Biography

Graham works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 1997

FELLOW OF THE ROYAL AUSTRALASIAN COLLEGE OF PHYSIC

Institution: Royal Australasian Centre of Physicians

Year awarded: 1991

MBBS

Institution: University of Melbourne

Year awarded: 1983

BACHELOR OF MEDICAL SCIENCE

Institution: University of Melbourne

Year awarded: 1981

Publications

Book Chapters

Ellett, F., Lieschke, G.J., 2012, Computational Quantification of fluorescent leukocyte numbers in Zebrafish embryos, in Imaging and Spectroscopic Analysis of Living CellsImaging Live Cells in Health and Disease, eds PM Conn, Academic Press, USA, pp. 425-435.

Pase, L., Nowell, C.J., Lieschke, G.J., 2012, In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay, in Imaging and Spectroscopic Analysis of Living CellsImaging Live Cells in Health and Disease, eds PM Conn, Academic Press, USA, pp. 135-156.

Pase, L., Lieschke, G., 2011, Discerning different in vivo roles of microRNAs by experimental approaches in zebrafish, in Methods in Cell Biology - The Zebrafish: Genetics, Genomics and Informatics, eds H Detrich III, M Westerfield, L Zon, Academic Press, USA, pp. 353-378.

Hogan, B.M., Verkade, H., Lieschke, G.J., Heath, J.K., 2009, Manipulation of gene expression during zebrafish embryonic development using transient approaches, in Wnt Signalling, Volume II: Pathway Models, eds Elizabeth Vincan, Humana Press, New York USA, pp. 273-300.

Pase, L., Lieschke, G., 2009, Validating microRNA target transcripts using Zebrafish assays, in Zebrafish Methods and Protocols, eds GJ Lieschke, AC Oates & K Kawakami, Springer, USA, pp. 227-240.

Journal Articles

Svahn, A.J., Graeber, M.B., Ellett, F., Lieschke, G.J., Rinkwitz, S., Bennett, M.R., Becker, T.S., 2013, Development of ramified microglia from early macrophages in the zebrafish optic tectum, Developmental Neurobiology [P], vol E-pub, John Wiley & Sons Inc, USA, pp. 1-12.

Goldshmit, Y., Matteo, R., Sztal, T.E., Ellett, F., Frisca, F., Moreno, K., Crombie, D., Lieschke, G.J., Currie, P.D., Sabbadini, R.A., Pebay, A., 2012, Blockage of lysophosphatidic acid signaling improves spinal cord injury outcomes, American Journal Of Pathology [P], vol 181, issue 3, Elsevier Inc., USA, pp. 978-992.

Cai, H., Santiago, F.S., Prado-Lourenco, L., Wang, B., Patrikakis, M., Davenport, M.P., Maghzal, G.J., Stocker, R., Parish, C.R., Chong, B.H., Lieschke, G.J., Wong, T., Chesterman, C.N., Francis, D.J., Moloney, F.J., Barnetson, R.S.C., Halliday, G.M., Khachigian, L.M., 2012, DNAzyme targeting c-jun suppresses skin cancer growth, Science Translational Medicine [P], vol 4, issue 139 (Art. No. 139ra82), American Association for the Advancement of Science, USA, pp. 1-12.

Wittmann, C., Chockley, P., Singh, S.K., Pase, L., Lieschke, G.J., Grabher, C., 2012, Hydrogen peroxide in inflammation: messenger, guide, and assassin, Advances in Hematology [P], vol 2012, issue Article No. 541471, Hindawi Publishing Corporation, USA, pp. 1-6.

Benard, E.L., van der Sar, A.M., Ellett, F., Lieschke, G.J., Spaink, H.P., Meijer, A.H., 2012, Infection of zebrafish embryos with intracellular bacterial pathogens, Journal of Visualized Experiments [E], vol 61, issue Art. No: 3781, Journal of Visualized Experiments, USA, pp. 1-8.

Dworkin, S., Darido, C., Georgy, S., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J., Lieschke, G., Jane, S., 2012, Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways, Development [P], vol 139, issue 3, The Company of Biologists Ltd, UK, pp. 525-536.

Pase, L., Layton, J.E., Wittmann, C., Ellett, F., Nowell, C.J., Reyes-Aldasoro, C.C., Varma, S., Rogers, K.L., Hall, C.J., Keightley, M., Crosier, P.S., Grabher, C., Heath, J.K., Renshaw, S.A., Lieschke, G.J., 2012, Neutrophil-delivered myeloperoxidase dampens the hydrogen peroxide burst after tissue wounding in zebrafish, Current Biology [P], vol 22, issue 19, Cell Press, USA, pp. 1818-1824.

Macheda, M.L., Sun, W.W., Kugathasan, K., Hogan, B.M., Bower, N.I., Halford, M.M., Zhang, Y.F., Jacques, B.E., Lieschke, G.J., Dabdoub, A., Stacker, S.A., 2012, The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling, Journal Of Biological Chemistry [P], vol 287, issue 35, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 29312-29323.

Fang, L., Green, S.R., Baek, J., Lee, S., Ellett, F., Deer, E., Lieschke, G.J., Witztum, J.L., Tsimikas, S., Miller, Y.I., 2011, In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish, Journal of Clinical Investigation [P], vol 121, issue 12, American Society for Clinical Investigation, USA, pp. 4861-4869.

Keightley, M., Layton, J., Hayman, J., Heath, J., Lieschke, G., 2011, Mediator subunit 12 is required for neutrophil development in zebrafish, PLoS ONE [P], vol 6, issue 8 (Art. no: e23845), Public Library of Science, USA, pp. 1-8.

Ellett, F., Pase, L., Hayman, J.W., Andrianopoulos, A., Lieschke, G., 2011, mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish, Blood [P], vol 117, issue 4, American Society of Hematology, USA, pp. e49-e56.

Berger, J., Berger, S., Hall, T.E., Lieschke, G.J., Currie, P.D., 2010, Dystrophin-deficient zebrafish feature aspects of the Duchenne muscular dystrophy pathology, Neuromuscular Disorders [P], vol 20, issue 12, Elsevier Ltd, UK, pp. 826-832.

Ellett, F., Lieschke, G., 2010, Zebrafish as a model for vertebrate hematopoiesis, Current Opinion in Pharmacology [P], vol 10, issue 5, Elsevier Ltd, UK, pp. 563-570.

de Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H., Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T., Nixon, S.J., Parton, R.G., Zon, L.I., Stainer, D.Y.R., Lieschke, G.J., Heath, J.K., 2009, Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish, Gastroenterology [P], vol 136, issue 3, Elsevier, USA, pp. 902-911.e7.

Lieschke, G., Trede, N.S., 2009, Fish immunology, Current Biology [P], vol 19, issue 16, Cell Press, USA, pp. R678-R682.

Ellett, F., Kile, B., Lieschke, G., 2009, The role of the ETS factor erg in zebrafish vasculogenesis, Mechanisms of Development [P], vol 126, issue 3-4, Elsevier Ireland Ltd, Ireland, pp. 220-229.

Pase, L., Layton, J., Kloosterman, W.P., Carradice, D., Waterhouse, P.M., Lieschke, G., 2009, miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2, Blood [P], vol 113, issue 8, American Society of Hematology, USA, pp. 1794-1804.

Cheng, K.C., Alestrom, P., Begemann, G., Crosier, K.E., Crosier, P.S., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G.J., Mione, M., Neely, M.N., Neuhauss, S., Trede, N.S., Carvan III, M.J., 2008, The Experts Speak - Views on Four Key Questions About Zebrafish Research, Zebrafish [P], vol 5, issue 1, Mary Ann Liebert Inc, Publishers, USA, pp. 9-23.

Carradice, D., Lieschke, G.J., 2008, Zebrafish in hematology: sushi or science?, Blood [P], vol 111, issue 7, American Society of Hematology, USA, pp. 3331-3342.

Lieschke, G.J., Currie, P.D., 2007, Animal models of human disease: zebrafish swim into view, Nature Reviews Genetics [P], vol 8, issue 5, Nature Publishing Group, UK, pp. 353-367.

Dworkin, S., Heath, J.K., deJong-Curtain, T.A., Hogan, B.M., Lieschke, G.J., Malaterre, J., Ramsay, R.G., Mantamadiotis, T., 2007, CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish, Developmental Biology, vol 307, issue 1, Academic Press, USA, pp. 127-141.

Yoong, S., O'Connell, B.A., Soanes, A., Crowhurst, M.O., Lieschke, G.J., Ward, A.C., 2007, Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern, Gene Expression Patterns [P], vol 7, issue 1-2, Elsevier BV, The Netherlands, pp. 39-46.

Horsfield, J.A., Anagnostou, S.H., Hu, J.K., Cho, K.H., Geisler, R., Lieschke, G.J., Crosier, K.E., Crosier, P.S., 2007, Cohesin-dependent regulation of Runx genes, Development [P], vol 134, issue 14, The Company of Biologists Ltd, UK, pp. 2639-2649.

Hogan, B.M., Pase, L., Hall, N.E., Lieschke, G.J., 2006, Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish, Development Genes And Evolution [P], vol 216, issue 9, Springer, Germany, pp. 523-529.

Kinna, G., Kolle, G., Carter, A., Key, B., Lieschke, G.J., Perkins, A.C., Little, M.H., 2006, Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development, Mechanisms of Development [P], vol 123, issue 4, Elsevier Ireland Ltd, Ireland, pp. 277-287.

Chee, L.C., Fahey, V., Juneja, S., Lieschke, G.J., Szer, J., 2006, Relapsed blastic natural killer cell leukaemia with splenic rupture, British Journal Of Haematology [P], vol 135, issue 2, Wiley-Blackwell Publishing Ltd, UK, p. 1.

Hogan, B.M., Layton, J.E., Pyati, U.J., Nutt, S.L., Hayman, J.W., Varma, S., Heath, J.K., Kimelman, D., Lieschke, G.J., 2006, Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish, Current Biology [P], vol 16, issue 5, Cell Press, USA, pp. 506-511.

Hogan, B.M., Danks, J.A., Layton, J.E., Hall, N.E., Heath, J.K., Lieschke, G., 2005, Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis, Endocrinology [P], vol 146, issue 2, The Endocrine Society, USA, pp. 547-551.

Onnebo, S.M., Condron, M.M., McPhee, D.O., Lieschke, G.J., Ward, A.C., 2005, Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion, Experimental Hematology [P], vol 33, issue 2, Elsevier Inc, USA, pp. 182-188.

Mawdsley, D., Cooper, H.M., Hogan, B.M., Cody, S., Lieschke, G.J., Heath, J.K., 2004, The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish, Developmental Biology [P], vol 269, issue 1, Academic Press, USA, pp. 302-315.

Ward, A.C., McPhee, D., Condron, M., Varma, S., Cody, S.H., Onnebo, S.M., Paw, B.H., Zon, L., Lieschke, G.J., 2003, The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish, Blood [P], vol 102, issue 9, American Society for Hematology, USA, pp. 3238-3240.

Sun, X., Elefanty, A.G., Lieschke, G.J., 2001, Comparisons of effects of the tyrosine kinase inhibitors AG957, AG490 and ST1571 on BCR-ABL-expressing cells, demonstrating synergy between AG490 and ST1571, Blood, vol 97, Amer Society Hematology, USA, pp. 2008-2015.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular study of community-acquired Acinetobacter baumannii.

Supervisors:

Lieschke, G (Joint), Peleg, A (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Regulation of leukocyte behaviour during inflammation in vivo.

Supervisors:

Lieschke, G (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Studies of neutrophil behaviour and function in vivo.

Supervisors:

Lieschke, G (Main), Hickey, M (Associate).