Dr Mitchell Lawrence - Researcher Profile

Biography

Dr Mitchell Lawrence joined Monash University to work with Dr Caroline Gargett and Prof Gail Risbridger. Dr Lawrence is funded by an NH&MRC Early Career Fellowship and a Movember Young Investigator Grant awarded through Prostate Cancer Foundation of Australia’s Research Program. The focus of Dr Lawrence’s research is the tumour microenvironment, in particular defining the differences between normal prostate fibroblasts and cancer-associated fibroblasts.

Keywords

Hormones, Prostate Cancer, Tumour Microenvironment, Stem cells

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Queensland University of technology

Year awarded: 2009

BACHELOR OF APPLIED SCIENCE-HONOURS

Institution: Queensland University of Technology

Year awarded: 2004

BACHELOR OF APPLIED SCIENCE

Institution: Queensland University of Technology

Year awarded: 2003

Publications

Book Chapters

Niranjan, B., Lawrence, M.G., Papargiris, M., Richards, M.G., Hussain, S., Frydenberg, M., Pedersen, J.S., Taylor, R.A., Risbridger, G.P., 2013, Primary culture and propagation of human prostate epithelial cells, in Methods in Molecular Biology - Epithelial Cell Culture Protocols V945, eds SH Randell and ML Fulcher, Humana Press, USA, pp. 365-382.

Journal Articles

Hussain, S., Lawrence, M.G., Taylor, R.A., Lo, C.Y., APC BioResource, Frydenberg, M., Ellem, S.J., Furic, L., Risbridger, G.P., 2012, Estrogen Receptor beta Activation Impairs Prostatic Regeneration by Inducing Apoptosis in Murine and Human Stem/Progenitor Enriched Cell Populations, PLoS ONE [P], vol 7, issue 7, Public Library of Science, USA, pp. e40732-1-e40732-9.

Lawrence, M.G., Stephens, C.R., Need, E.F., Lai, J., Buchanan, G., Clements, J.A., 2012, Long terminal repeats act as androgen-responsive enhancers for the PSA-kallikrein locus, Endocrinology [P], vol 153, issue 7, The Endocrine Society, USA, pp. 3199-3210.

Lose, F., Lawrence, M.G., Srinivasan, S., O'Mara, T., Marquart, L., Chambers, S., Gardiner, R.A., Aitken, J.F., Spurdle, A.B., Batra, J., Clements, J.A., 2012, The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness, Biological Chemistry [P], vol 393, issue 5, Walter de Gruyter GmbH & Co. KG, Germany, pp. 403-412.

Lawrence, M.G., Margaryan, N.V., Loessner, D., Collins, A., Kerr, K.M., Turner, M., Seftor, E.A., Stephens, C.R., Lai, J., APC BioResource, Postovit, L., Clements, J., Hendrix, M.J., 2011, Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells, Prostate [P], vol 71, issue 11, John Wiley & Sons, Inc., USA, pp. 1198-1209.

Grants

Title:

Cancer-associated fibroblast stem cells.

Investigators:

Lawrence, M

Funding:

(2012 - 2015). National Health & Medical Research Council (NHMRC).

Title:

Sorting wheat from chaff: Isolating stromal stem cells in Prostate Cancer.

Investigators:

Lawrence, M, Gargett, C, Risbridger, G, Taylor, R

Funding:

(2012 - 2015). Prostate Cancer Foundation of Australia.