Prof Ian Smith - Researcher Profile

Biography

Ian is Pro-Vice Chancellor (Research & Research Infrastructure) and as such he has responsibility for the oversight and management of the universities research infrastructure as well as developing and implementing strategies to meet current future university infrastructure needs

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Keywords

ECE, Vascular peptides, vascular tone, Protease inhibitors, Endothelin, Angiotensin, ACE,, Proteomics, proteases, Peptides, Mass Spectrometry

Publications

Book Chapters

Smith, A.I., Warner, F.J., Lew, R.A., Yarski, M.A., McGrath, B., Burrell, L.M., 2009, Quenched fluorescent peptide substrates as tools for the discovery of novel cardiovascular disease biomarkers, in Peptides for Youth: The Proceedings of the 20th American Peptide Symposium, eds Susan Del Valle, Emanuel Escher and William D Lubell, Springer, USA, pp. 419-422.

Clayton, D.J., Hanchapola, I., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2009, The active site specificity of angiotensin II converting Enzyme 2 investigated through single and multiple residue changes and {beta}-amino acid substrate analogs, in Peptides for Youth: The Proceedings of the 20th American Peptide Symposium, eds S Del Valle, E Escher & WD Lubell, Springer, USA, pp. 559-560.

Lew, R.A., Tochon-Danguy, N., Hamilton, C.A., Stewart, K.M., Aguilar, M.I., Smith, A.I., 2005, Quenched fluorescent substrate-based peptidase assays, in Methods in Molecular Biology, eds John Howl, Humana Press, Totowa USA, pp. 143-150.

Journal Articles

Kuruppu, D.S., Tochon-Danguy, N., Smith, A.I., 2013, Applicability of green fluorescence protein in the study of endothelin converting enzyme-1c trafficking, Protein Science [P], vol 22, issue 3, Wiley-Blackwell Publishing Inc, USA, pp. 306-313.

Kuruppu, D.M.S., Rajapakse, N.W., Smith, A.I., 2013, Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal disease, Pflugers Archiv-European Journal Of Physiology [P], vol E-pub, Springer, Germany, pp. 1-6.

Yan, X., Porter, C.J., Hardy, S.P., Steer, D.L., Smith, A.I., Quinsey, N.S., Hughes, V.A., Cheung, K.J., Keyburn, A., Kaldhusdal, M., Moore, R., Bannam, T.L., Whisstock, J., Rood, J.I., 2013, Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens, mBio [E], vol 4, issue 1, American Society for Microbiology, USA, pp. 1-9.

Goode, R.J., Yu, S., Kannan, A., Christiansen, J.H., Beitz, A., Hancock, W.S., Nice, E.C., Smith, A.I., 2013, The proteome browser web portal, Journal Of Proteome Research [P], vol 12, issue 1, American Chemical Society, USA, pp. 172-178.

Gatsos, X., Steer, D.L., Junaid, T.A., Smith, A.I., Adler, B., Albert, M.J., 2012, Application of protein purification methods for the enrichment of a cytotoxin from Campylobacter jejuni, BMC Microbiology [P], vol 12, issue Art No.:303, BioMed Central Ltd, UK, pp. 1-10.

Kuruppu, D.S., Smith, A.I., 2012, Endothelin converting Enzyme-1 phosphorylation and trafficking, FEBS Letters [P], vol 586, issue 16, Elsevier BV, The Netherlands, pp. 2212-2217.

Rajapakse, N.W., Kuruppu, D.M.S., Hanchapola, I., Venardos, K.M., Mattson, D.L., Smith, A.I., Kaye, D.M., Evans, R.G., 2012, Evidence that renal arginine transport is impaired in spontaneously hypertensive rats, American Journal of Physiology - Renal Fluid and Electrolyte Physiology [E], vol 302, issue 12, American Physiological Society, USA, pp. F1554-F1562.

Kuruppu, D.S., Tochon-Danguy, N., Smith, A.I., 2012, Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c, Biochemical And Biophysical Research Communications [P], vol 427, issue 3, Elsevier Inc., USA, pp. 606-610.

Stanton, P.G., Sluka, P., Foo, C.F., Stephens, A.N., Smith, A.I., McLachlan, R.L., O'Donnell, L., 2012, Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells, PLoS ONE [P], vol 7, issue 7 (Art. ID: e41718), Public Library of Science, USA, pp. 1-19.

Han, X.Y., Kennan, R.M., Steer, D.L., Smith, A.I., Whisstock, J.C., Rood, J.I., 2012, The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus, PLoS ONE [P], vol 7, issue 10 (Art. No.: e47932), Public Library of Science, USA, pp. 1-8.

Law, R.H., Caradoc-Davies, T.T., Cowieson, N.P., Horvath, A.J., Quek, A.J., Amarante Da Encarnacao, J., Steer, D.L., Cowan, A.D., Zhang, Q., Lu, B.G., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C., 2012, The x-ray crystal structure of full-length human plasminogen, Cell Reports [E], vol 1, issue 3, Cell Press, USA, pp. 185-190.

Pycroft, K., Fry, B.G., Isbister, G.K., Kuruppu, D.M., Lawrence, J.M., Smith, A.I., Hodgson, W.C., 2012, Toxinology of Venoms from Five Australian Lesser Known Elapid Snakes, Basic and Clinical Pharmacology and Toxicology [P], vol 111, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 268-274.

Noor, N.M., Steer, D.L., Wheaton, B.J., Ek, C.J., Truettner, J.S., Dietrich, W.D., Dziegielewska, K.M., Richardson, S.J., Smith, A.I., VandeBerg, J.L., Saunders, N.R., 2011, Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica), PLoS ONE [P], vol 6, issue 11, Public Library of Science, USA, pp. e27465-1-e27465-16.

Lai, Z., Hanchapola, I., Steer, D., Smith, A., 2011, Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: Determinants and constraints, Biochemistry [P], vol 50, issue 23, American Chemical Society, USA, pp. 5182-5194.

Wong, W., Wijeyewickrema, L.C., Kennan, R.M., Reeve, S.B., Steer, D.L., Reboul, C., Smith, A.I., Pike, R.N., Rood, J.I., Whisstock, J.C., Porter, C.J., 2011, S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction, Journal Of Biological Chemistry [P], vol 286, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 42180-42187.

Clayton, D., Hanchapola, I., Hausler, N., Unabia, S., Lew, R.A., Widdop, R.E., Smith, A.I., Perlmutter, P., Aguilar, M.-., 2010, Beta-amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2), Journal Of Molecular Recognition [P], vol 24, issue 2, John Wiley & Sons Ltd, UK & USA, pp. 235-244.

Chaisakul, J., Konstantakopoulos, N., Smith, A.I., Hodgson, W.C., 2010, Isolation and characterisation of P-EPTX-Ap1a and P-EPTX-Ar1a: Pre-synaptic neurotoxins from the venom of the northern (Acanthophis praelongus) and Irian Jayan (Acanthophis rugosus) death adders, Biochemical Pharmacology [P], vol 80, issue 6, Elsevier Inc., USA, pp. 895-902.

Velkoska, E., Warner, F.J., Cole, T.J., Smith, A.I., Morris, M.J., 2010, Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat, Nutrition, Metabolism & Cardiovascular Diseases, vol 20, Elsevier Ltd, UK & Italy, pp. 49-55.

Kuruppu, S., Tochon-Danguy, N., Smith, A.I., 2010, Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells, Biochemical And Biophysical Research Communications [P], vol 398, issue 2, Academic Press, USA, pp. 173-177.

Grubman, A., Liaskos, M.(., Viala, J., Allison, C.C., Badea, L., Karrar, A., Boneca, I.G., Le Bourhis, L., Reeve, S.B., Smith, A.I., Hartland, E.L., Philpott, D.J., Ferrero, R.L., 2010, The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides, Cellular Microbiology [P], vol 12, Wiley-Blackwell Publishing Ltd, UK, pp. 626-639.

Kennan, R.M., Wong, W., Dhungyel, O., Han, X., Wong, D.M., Parker, D., Rosado, C.J., Law, R.H., McGowan, S., Reeve, S.B., Levina, V., Powers, G.A., Pike, R.N., Bottomley, S.P., Smith, A.I., Marsh, I., Whittington, R.J., Whisstock, J., Porter, C.J., Rood, J.I., 2010, The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates, Plos Pathogens [P], vol 6, issue 11, Public Library of Science, USA, pp. 1-12.

Kornhauser, R., Hart, A.J., Reeve, S.B., Smith, A.I., Fry, B.G., Hodgson, W.C., 2010, Variations in the pharmacological profile of post-synaptic neurotoxins isolated from the venoms of the Papuan (Oxyuranus scutellatus canni) and coastal (Oxyuranus scutellatus scutellatus) taipans, NeuroToxicology [P], vol 31, issue 2, Elsevier BV, The Netherlands, pp. 239-243.

Giannakis, E., Samuel, C., Hewitson, T.D., Boon, W.M., Macris, M., Reeve, S.B., Lawrence, J.M., Smith, A.I., Tregear, G.W., Wade, J.D., 2009, Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy, Proteomics - Clinical Applications [P], vol 3, issue 10, Wiley - VCH Verlag GmbH & CO. KGaA, Germany, pp. 1211-1224.

Beckham, S.A., Boyd, S.E., Reynolds, S., Willis, C., Johnstone, M., Mika, A., Simerska, P., Wijeyewickrema, L.C., Smith, A.I., Kemp, D.J., Pike, R.N., Fischer, K., 2009, Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite sarcoptes scabiei, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 34413-34422.

Lai, Z.W., Steer, D.L., Smith, A.I., 2009, Membrane proteomics: The development of diagnostics based on protein shedding, Current Opinion in Molecular Therapeutics [P], vol 11, issue 6, Current Drugs Ltd., UK, pp. 623-631.

Smith, A.I., Thompson, P.R., Gearing, D.P., 2009, Monash at the academic industrial interface: Trains and platforms, Journal of Molecular Medicine [P], vol 87, issue 11, Springer, Germany, pp. 1041-1044.

Lai, Z.W., Lew, R.A., Yarski, M.A., Mu, F., Andrews, R.K., Smith, A.I., 2009, The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2, Endocrinology, vol 150, issue 5, The Endocrine Society, USA, pp. 2376-2381.

Burchill, L., Velkoska, E., Dean, R.G., Lew, R.A., Smith, A.I., Levidiotis, V., Burrell, L.M., 2008, Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression, Experimental Physiology, vol 93, issue 5, Wiley-Blackwell Publishing Ltd, UK, pp. 622-630.

Jokubaitis, V.J., Sinka, L., Driessen, R., Whitty, G., Haylock, D.N., Bertoncello, I., Smith, A.I., Peault, B., Tavian, M., Simmons, P.J., 2008, Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues, Blood [P], vol 111, issue 8, American Society of Hematology, USA, pp. 4055-4063.

Lew, R.A., Warner, F.J., Hanchapola, I., Yarski, M.A., Manohar, J., Burrell, L.M., Smith, A.I., 2008, Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor, Experimental Physiology, vol 93, issue 5, Wiley-Blackwell Publishing Ltd, UK, pp. 685-693.

Foulds, L.M., Boysen, R.I., Crane, M., Yang, Y., Muir, J.A., Smith, A.I., de Kretser, D.M., Hearn, M.T.W., Hedger, M.P., 2008, Molecular Identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids, Biology of Reproduction, vol 79, issue 3, Society for the Study of Reproduction, United States, pp. 525-536.

Kuruppu, D.M.S., Smith, A.I., Isbister, G.K., Hodgson, W.C., 2008, Neurotoxins from Australo-Papuan elapids: A biochemical and pharmacological perspective, Critical Reveiws in Toxicology, vol 38, issue 1, Informa Healthcare, United States, pp. 73-86.

Lai, Z.W., Hanchapola, I., Smith, A.I., 2008, Quenched fluorescent peptide substrates tools for the discovery of novel biomarkers, Chimica Oggi [P], vol 26, issue 2, Tekno Scienze, Italy, pp. 18-21.

Dean, B., Pavey, G., Smith, A.I., 2008, Using differential solubilization and 2-D gel electrophoresis to visualize increased numbers of proteins in the human cortex and caudate nucleus and putamen, Proteomics - Clinical Applications [P], vol 2, issue 9, Wiley-VCH Verlag GmbH & Co. KGaA, Germany, pp. 1281-1289.

Aguilar, M.I., Purcell, A.W., Devi, R., Lew, R.A., Rossjohn, J., Smith, A.I., Perlmutter, P., 2007, ?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics, Organic & Biomolecular Chemistry, vol 5, issue 18, Royal Society of Chemistry, Cambridge England UK, pp. 2884-2890.

Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J., 2007, A common fold mediates vertebrate defense and bacterial attack, Science, vol 317, issue 5844, American Association of Advancement in Science, Washington, DC, USA, pp. 1548-1551.

Kuruppu, D.M.S., Reeve, S.B., Smith, A.I., 2007, Characterisation of endothelin converting enzyme-1 shedding from endothelial cells, FEBS Letters [P], vol 581, issue 23, Elsevier BV, Netherlands, Denmark, pp. 4501-4506.

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K.L., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M.C.J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J., 2007, GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop, Nature Structural & Molecular Biology, vol 14, issue 4, Nature Publishing Group, New York NY USA, pp. 280-286.

Albert, M.J., Haridas, S., Steer, D.L., Dhaunsi, G.S., Smith, A.I., Adler, B., 2007, Identification of a Campylobacter jejuni protein that cross-reacts with cholera toxin, Infection and Immunity, vol 75, issue 6, American Society of Microbiology, Washington DC USA, pp. 3070-3073.

Zhang, Q., Buckle, A.M., Law, R.H.P., Pearce, M.C., Cabrita, L., Lloyd, G., Irving, J.A., Smith, A.I., Ruzyla, K., Rossjohn, J., Bottomley, S.P., Whisstock, J., 2007, The N terminus of the serpin, tengpin, functions to trap the metastable native state, EMBO Reports, vol 8, issue 7, Nature Publishing Group, UK, pp. 658-663.

Herath, C.B., Warner, F.J., Lubel, J.S., Dean, R.G., Jia, Z., Lew, R.A., Smith, A.I., Burrell, L.M., Angus, P.W., 2007, Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis, Journal of Hepatology, vol 47, issue 3, Elsevier Science BV, Amsterdam Netherlands, pp. 387-395.

Lew, R.A., Warner, F.J., Hanchapola, I., Smith, A.I., 2006, Characterization of angiotensin converting enzyme-2 (ACE2) in human urine, International Journal of Peptide Research and Therapeutics, vol 12, issue 3, Springer, New York USA, pp. 283-289.

Tan, L.C., Kuruppu, D.M.S., Smith, A.I., Reeve, S.B., Hodgson, W.C., 2006, Isolation and pharmacological characterisation of hostoxin-1, a postsynaptic neurotoxin from the venom of the Stephen's banded snake (Hoplocephalus stephensi), Neuropharmacology, vol 51, issue 4, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 782-788.

Clarke, C., Kuruppu, D.M.S., Reeve, S.B., Smith, A.I., Hodgson, W.C., 2006, Oxylepitoxin-1, a reversible neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus), Peptides, vol 27, issue 11, Elsevier Science Inc, New York NY USA, pp. 2655-2660.

Smith, A.I., Lew, R.A., Thomas, W.G., Tochon-Danguy, N., 2006, Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1, International Journal of Peptide Research and Therapeutics, vol 12, issue 3, Springer, New York USA, pp. 291-295.

Wilson, K.M., Smith, A.I., Phillips, D.J., 2006, Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin, Molecular and Cellular Endocrinology, vol 253, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 30-35.

Autelitano, D.J., Rajic, A., Smith, A.I., Berndt, M.C., Ilag, L.L., Vadas, M., 2006, The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities, Drug Discovery Today, vol 11, issue 7/8, Elsevier Sci Ltd, Oxford England, pp. 306-314.

McGowan, S., Buckle, A.M., Irving, J.A., Ong, P.C., Bashtannyk-Puhalovich, T.A., Kan, W., Henderson, K., Bulynko, Y.A., Popova, E.Y., Smith, A.I., Bottomley, S.P., Rossjohn, J., Grigoryev, S.A., Pike, R.N., Whisstock, J.C., 2006, X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation, The EMBO Journal, vol 25, issue 13, Nature Publishing Group, New York USA, pp. 3144-3155.

Warner, F.J., Lew, R.A., Smith, A.I., Lambert, D.W., Hooper, N.M., Turner, A.J., 2005, Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells, Journal of Biological Chemistry, vol 280, issue 47, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 39353-39362.

Paizis, G., Tikellis, C., Cooper, M.E., Schembri, J.M., Lew, R.A., Smith, A.I., Shaw, T., Warner, F.J., Zuilli, A., Burrell, L.M., Angus, P.W., 2005, Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2, Gut, vol 54, issue 12, BMJ Publishing Group, London England, pp. 1790-1796.

Buzza, M.S., Zamurs, L., Sun, J., Bird, C.H., Smith, A.I., Trapani, J.A., Froelich, C.J., Nice, E.C., Bird, P.I., 2005, Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin, Journal of Biological Chemistry, vol 280, issue 25, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 23549-23558.

Hart, A.J., Smith, A.I., Reeve, S.B., Hodgson, W.C., 2005, Isolation and characterisation of acanmyotoxin-2 and acanmyotoxin-3, myotoxins from the venom of the death adder Acanthophis sp. Seram, Biochemical Pharmacology, vol 70, issue 12, Pergamon-Elsevier Science Ltd, Kidlington England, pp. 1807-1813.

Kuruppu, D.M.S., Reeve, S.B., Smith, I.A., Hodgson, W.C., 2005, Isolation and pharmacological characterisation of papuantoxin-1, a postsynaptic neurotoxin from the venom of the Papuan black snake (Pseudechis papuanus), Biochemical Pharmacology, vol 70, issue 5, Pergamon-Elsevier Science Ltd, Kidlington England, pp. 794-800.

Kuruppu, D.M.S., Reeve, S.B., Banerjee, Y., Kini, R.M., Smith, A.I., Hodgson, W.C., 2005, Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni), Journal of Pharmacology and Experimental Therapeutics, vol 315, issue 3, The American Society for Pharmacology & Experimental Therapeutics, Bethesda USA, pp. 1196-1202.

Burrell, L.M., Risvanis, J., Kubota, E., Dean, R.G., MacDonald, P.S., Lu, S., Tikellis, C., Grant, S.L., Lew, R.A., Smith, A.I., Cooper, M.E., Johnston, C.I., 2005, Myocardial infarction increases ACE2 expression in rat and humans, European Heart Journal, vol 26, issue 4, Oxford University Press, Oxford UK, pp. 369-375.

Ahmed, N., Oliva, K.T., Barker, G., Hoffmann, P., Reeve, S.B., Smith, A.I., Quinn, M.A., Rice, G.E., 2005, Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer, Proteomics [P], vol 5, issue 17, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 4625-4636.

Lew, R.A., Hamilton, C.A., Warner, F.J., Yarski, M.A., Burrell, L.M., Smith, A.I., 2005, Soluble angiotensin converting enzyme-2 present in human plasma and urine, Febs Journal, vol 272, Blackwell Publishing, Oxford England, p. 181.

Fulton, K.F., Buckle, A.M., Cabrita, L.D., Irving, J.A., Butcher, R.E., Smith, A.I., Reeve, S.B., Lesk, A.M., Bottomley, S.P., Rossjohn, J., Whisstock, J.C., 2005, The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition, Journal of Biological Chemistry, vol 280, issue 9, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 8435-8442.

Blanchfield, J.T., Lew, R.A., Smith, A.I., Toth, I., 2005, The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide, Bio-organic & Medicinal Chemistry Letters, vol 15, issue 6, Permagon-Elsevier Science Ltd, Kidlington England, pp. 1609-1612.

Lambert, D.W., Yarski, M.A., Warner, F.J., Thornhill, P., Parkin, E.T., Smith, A.I., Hooper, N.M., Turner, A.J., 2005, Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2), Journal of Biological Chemistry, vol 280, issue 34, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 30113-30119.

O'Bryan, M.K., Foulds, L.M., Cannon, J.F., Winnall, W.R., Muir, J.A., Sebire, K.L., Smith, A.I., Keah, H.H., Hearn, M.T.W., de Kretser, D.M., Hedger, M.P., 2004, Identification of a Novel Apolipoprotein, ApoN, in Ovarian Follicular Fluid, Endocrinology, vol 145, issue 11, The Endocrine Society, USA, pp. 5231-5242.

Tikellis, C., Johnston, C.I., Forbes, J.M., Burns, W.C., Thomas, M.C., Lew, R.A., Yarski, M.A., Smith, A.I., Cooper, M.E., 2004, Identification of angiotensin converting enzyme 2 in the rodent retina, Current Eye Research [P], vol 29, issue 6, Informa Healthcare, UK, pp. 419-427.

Ahmed, N., Barker, G., Oliva, K.T., Hoffmann, P., Riley, C., Reeve, S.B., Smith, A.I., Kemp, B.E., Quinn, M.A., Rice, G.E., 2004, Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer, British Journal Of Cancer [P], vol 91, issue 1, Nature Publishing Group, UK, pp. 129-140.

Douglas, G.C., O'Bryan, M.K., Hedger, M.P., Lee, D.K.L., Yarski, M.A., Smith, A.I., Lew, R., 2004, The Novel Angiotensin-Converting Enzyme (ACE) Homolog, ACE2, Is Selectively Expressed by Adult Leydig Cells of the Testis, Endocrinology, vol 145, issue 10, The Endocrine Society, USA, pp. 4703-4711.

Smith, A.I., Turner, A.J., 2004, What's new in the renin-angiotensin system?, Cellular and Molecular Life Sciences, vol 61, issue 21, Birkhauser Verlag AG, Basel Switzerland, pp. 2675-2676.

Clavant, S.P., Greive, K.A., Nikolovski, J., Reeve, S., Smith, A.I., Comper, W.D., 2003, Albumin fragments in normal rat urine are derived from rapidly degraded filtered albumin, Nephrology, vol 8, issue 2, Blackwell Publishing Asia, Carlton Vic Australia, pp. 72-79.

Norman, M., Reeve, S.B., Dive, V., Smith, A.I., Lew, R.A., 2003, Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism, American Journal of Physiology-Heart & Circulatory Physiology, vol 284, issue 6, American Physiological Society, Bethesda USA, pp. 1978-1984.

Welss, T., Sun, J., Irving, J.A., Blum, R., Smith, A.I., Whisstock, J.C., Pike, R.N., Von Mikecz, A., Ruzicka, T., Bird, P.I., Abts, H., 2003, Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis, Biochemistry, vol 42, issue 24, American Chemical Society, Washington USA, pp. 7381-7389.

Norman, M.U., Lew, R., Smith, A.I., Hickey, M.J., 2003, Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature, American Journal of Physiology - Heart and Circulatory Physiology, vol 284, issue 6, American Physiological Society, Bethesda USA, pp. 1942-1948.

Small, D.H., Smith, A.I., 2003, Proteases and proteolytic processing in the nervous system: key targets for drug development, Journal of Neuroscience Research, vol 74, issue 3, Wiley-Liss, New York USA, pp. 339-341.

Shrimpton, C.N., Wolfson, A.J., Smith, A.I., Lew, R.A., 2003, Regulators of the neuropeptide-degrading enzyme, EC 3.4.24.15 (thimet oligopeptidase), in cerebrospinal fluid, Journal Of Neuroscience Research [P], vol 74, issue 3, John Wiley & Sons, Inc., USA, pp. 474-478.

Steer, D., Lew, R., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, Amino Acids: Versatile Peptidomimetics, Current Medicinal Chemistry, vol 9, issue 8, Bentham Science Publishing Ltd, Netherlands BR, pp. 811-822.

Steer, D., Lew, R., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of -amino acids, Biochemistry, vol 41, issue 35, American Chemical Society, Washington USA, pp. 10819-10826.

Norman, M., Smith, A.I., Hickey, M.J., 2002, Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16: potential roles in vascular physiology, Letters in Peptide Science, vol 8, Kluwer/ESCOM, Netherlands, pp. 195-199.

Shrimpton, C.N., Smith, A.I., Lew, R.A., 2002, Soluble metalloendopeptidases and neuroendocrine signaling, Endocrine Reviews, vol 23, issue 5, Endocrine Society, Chevy Chase USA, pp. 647-664.

Steer, D.L., Lew, R.A., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, The use of -amino acids in the design of protease and peptidase inhibitors, Letters in Peptide Science, vol 8, Kluwer Academic Publ., Dordrecht The Netherlands, pp. 241-246.

Greive, K.A., Eppel, G., Reeve, S., Smith, A., Jerums, G., Comper, W., 2001, Immuno-unreactive albumin excretion increases in streptozotocin diabteic rats, American Journal of Kidney Diseases, vol 38, issue 1, WB Saunders & Co, Philadelphia USA, pp. 144-152.

Sun, J., Whisstock, J.C., Harriott, P., Walker, B., Novak, A.J., Thompson, P., Smith, A., Bird, P.I., 2001, Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop, Journal of Biological Chemistry, vol 276, issue 18, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 15177-15184.

Norman, M., Lew, R., Smith, A., Denton, K.M., Evans, R.G., 2001, Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits, Clinical and Experimental Pharmacology and Physiology, vol 28, issue 10, Blackwell Science Asia, Carlton Vic Australia, pp. 836-841.

Lew, R.A., Boulos, E., Stewart, K.M., Perlmutter, P., Harte, M.F., Bond, S., Reeve, S., Norman, M., Lew, M., Aguilar, M., Smith, A.I., 2001, Substrate analogs incorporting -amino acids: potential application for peptidase inhibition, FASEB Journal, vol 15, issue 9, Federation of American Societies for Experimental Biology, Bethesda USA, pp. 1664-1666.

Gitlits, V.M., Sentry, J.W., Matthew, M.L., Smith, A., Toh, B.H., 2001, Synapsin I identified as a novel brain-specific autoantigen, Journal of Investigative Medicine, vol 49, issue 3, Lippincott Williams & Wilkins, USA, pp. 276-283.

Andrews, R.K., Gardiner, E.E., Asazuma, N., Berlanga, O., Nieswandt, B., Smith, A.I., Watson, S.P., Tulasne, D., Berndt, M.C., 2001, The viper venom metalloproteinase-disintegrin, Alborhagin, is an agonist at the platelet collagen receptor GPVI, J Biol Chem, vol 276, pp. 28092*-28097.

Smith, A.I., Lew, R.A., Shrimpton, C.N., Evans, R.G., Abbenante, G., 2000, A novel stable inhibitor on endopeptidases EC 3.4.24.15 and 3.4.24.16 potentiates bradykinin-induced hypotension, Hypertension, vol 35, American Heart Association, Dallas Texas USA, pp. 626-630.

Lew, R., Boulos, E., Stewart, K.M., Perlmutter, P.P., Harte, M.F., Bond, S., Aguilar, M., Smith, A.I., 2000, Bradykinin Analogues with beta-Amino Acid Substitutions Reveal Subtle Differences in Substrate Specificity Between the Endopeptidases Ec 3.4.24.15 and EC 3.4.24.16, Journal of Petpide Science, vol 6, John Wiley & Sons, Chichester W Sussex UK, pp. 440-445.

Steer, D., Lew, R., Perlmutter, P.P., Smith, A.I., Aguilar, M., 2000, Design and Synthesis of Inhibitors Incorporating beta-Amino Acids of Metalloendopeptidase EC 3.4.24.15, Journal of Peptide Science, vol 6, John Wiley & Sons, Chichester W Sussex UK, pp. 470-477.

Shrimpton, C.N., Abbenante, G., Lew, R., Smith, A.I., 2000, Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15, Biochemical Journal, vol 345, issue Pt 2, Portland Press Ltd, London England UK, pp. 351-356.

Gitlits, V.M., Sentry, J.W., Matthew, M.L., Smith, A.I., Toh, B.H., 1997, Autoantibodies to evolutionarily conserved epitopes of enolase in a patient with discoid lupus erythematosus, Immunology, vol 92, Blackwell Scientific Publications, UK, pp. 362-368.

Conference Proceedings

Steer, D., Aguilar, M., Smith, A.I., Perlmutter, P.P., 1998, Synthesis of beta-amino acids and their incorporation into an Inhibitor of Metalloendopeptidease 24.15, 3rd Australian Peptide Conference "From Discovery to Therapeutics", Laguna Quays The Whitsundays QLD Oct 4-9, 1998, Pink Panther Printing, Melbourne Vic Australia, p. 48.

Other

Aguilar, M., Perlmutter, P., Smith, A.I., Devi, R., 2004, Peptidomimetic drugs, Australia.

Smith, A.I., Berndt, M.C., Autelitano, D.J., Csar, X., Talbo, G.H., 2003, Method for detection of bioactive peptides.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Proteomic study of mycobacterial proteins.

Supervisors:

Coppel, R (Joint-co), Smith, A (Joint).

Completed Supervision

Student:

Chan, H.

Program of Study:

ErbB receptor signalling in Angiotensin II-simulated cardiomyocyte hypertrophy. (PHD) 2008.

Supervisors:

Thomas, W (Main), Smith, A (Associate).

Student:

Douglas, G.

Program of Study:

Proteomics Analysis of Cellular Systems Expressing Metaphaphotases. 2001.

Supervisors:

Smith ((Double Id)), A (Main).

Student:

Douglas, G.

Program of Study:

THE NOVEL ANGIOTENSIN CONVERTING ENZYME HOMOLOGUE, ACE2, IS SELECTIVELY EXPRESSED BY ADULT LEYDIG CELLS OF THE TESTIS. (Masters) 2004.

Supervisors:

Smith ((Double Id)), A (Main), Lew, R (Associate).

Student:

Lai, Z.

Program of Study:

The characterisation of ectodomain shedding of angiotensin-converting enzyme 2 (ACE2). (PHD) 2010.

Supervisors:

Smith, A (Main), Andrews, R (Associate).

Student:

Lim, F.

Program of Study:

Mechanism of neurogenesis and neuro-regeneration in the adult teleost brain. (PHD) 2011.

Supervisors:

Parhar, I (Main), Ogawa, S (Associate), Smith, A (Associate).

Student:

Norman, M.

Program of Study:

THE FUNCTION AND DISTRIBUTION OF THE ZINC METALLOENDOPEPTIDASES EC3.4.24.15 AND EC 3.4.24.16. (PHD) 2002.

Supervisors:

Smith ((Double Id)), A (Main).

Student:

Onan, D.

Program of Study:

CARDIOVASCULAR AND REGULATORY ASPECTS OF THE UROTENSIN-II RECEPTOR. (PHD) 2004.

Supervisors:

Thomas, W (Main), Smith ((Double Id)), A (Associate).

Student:

Tochon-Danguy, N.

Program of Study:

CHARACTERISATION AND CELLULAR TRAFFICKING OF ENDOTHELIN-CONVERTING ENZYME (EC 3.4.24.71). (PHD) 2003.

Supervisors:

Smith ((Double Id)), A (Main), Aguilar, M (Associate).

Student:

Zhang, K.

Program of Study:

Proteomics analysis of outer membrane proteins of Leptospira interrogans. (PHD) 2012.

Supervisors:

Adler, B (Main), Hoke, D (Associate), Smith, A (Associate).