Assoc Prof Timothy Cole - Researcher Profile

Biography

Timothy works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

MEDICINE, DENTISTRY & HEALTH SCIENCES

Institution: University of Melbourne

Year awarded: 1988

SCIENCE (WITH HONOURS)

Institution: University of Melbourne

Year awarded: 1983

Publications

Book Chapters

Cole, T.J., 2006, Glucocorticoid action and the development of selective glucocorticoid receptor ligands, in Biotechnology Annual Review, Volume 12, eds M Raafat El-Gewely, Elsevier, Netherlands, pp. 269-300.

Journal Articles

Caruana, G., Farlie, P.G., Hart, A.H., Bagheri-Fam, S., Wallace, M.J., Dobbie, M.S., Gordon, C.T., Miller, K.A., Whittle, B., Abud, H.E., Arkell, R.M., Cole, T.J., Harley, V.R., Smyth, I.M., Bertram, J.F., 2013, Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease, PLoS ONE [P], vol 8, issue 3, Public Library of Science, USA, pp. 1-13.

Carey, K.T., Tan, K.T., Ng, J.H.P., Liddicoat, D., Godfrey, D.I., Cole, T.J., 2013, Nfil3 Is a Glucocorticoid-Regulated Gene Required for Glucocorticoid-Induced Apoptosis in Male Murine T Cells, Endocrinology [P], vol E-pub, The Endocrine Society, USA, pp. 1-13.

McDougall, A., Hooper, S., Zahra, V., Sozo, F., Lo, C., Cole, T., Doran, T., Wallace, M., 2011, The oncogene Trop2 regulates fetal lung cell proliferation, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 301, issue 4, American Physiological Society, United States, pp. L478-L489.

Bird, A.D., Flecknoe, S.J., Tan, K.H., Olsson, P.F., Antony, N., Mantamadiotis, T., Mollard, R.A., Hooper, S.B., Cole, T.J., 2011, cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development, PLoS ONE [P], vol 6, issue 3 (Art. No: e17843), Public Library of Science, USA, pp. 1-15.

Jurado, S., Smyth, I.M., van Denderen, B.J., Tenis, N., Hammet, A., Hewitt, K., Ng, J., McNees, C.J., Kozlov, S.V., Oka, H., Kobayashi, M., Conlan, L.A., Cole, T.J., Yamamoto, K., Taniguchi, Y., Takeda, S., Lavin, M.F., Heierhorst, J., 2010, Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis, Plos Genetics [P], vol 6, issue 10, Public Library of Science, USA, pp. 1-13.

Wong, S., Tan, W., Carey, K.T., Fukushima, A., Tiganis, T., Cole, T.J., 2010, Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1, Endocrinology [P], vol 151, The Endocrine Society, USA, pp. 185-194.

Velkoska, E., Warner, F.J., Cole, T.J., Smith, A.I., Morris, M.J., 2010, Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat, Nutrition, Metabolism & Cardiovascular Diseases, vol 20, Elsevier Ltd, UK & Italy, pp. 49-55.

Zhang, Y., Schyvens, C.G., Cole, T.J., McKenzie, K.U., Vickers, J.J., Whitworth, J.A., 2010, The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice, Clinical And Experimental Pharmacology And Physiology [P], vol 37, issue 11, Wiley-Blackwell Publishing Asia, Australia, pp. 1044-1048.

Wallace, M.J., Probyn, M.E., Zahra, V.A., Crossley, K.J., Cole, T.J., Davis, P.G., Morley, C.J., Hooper, S.B., 2009, Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs, Respiratory Research, vol 10, issue 19, BioMed Central Ltd, UK, pp. 1-15.

Velkoska, E., Cole, T.J., Dean, R.G., Burrell, L.M., Morris, M.J., 2008, Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats, The Journal of Nutrition, vol 138, issue 9, American Society for Nutrition, USA, pp. 1622-1627.

Gong, H., Jarzynka, M.J., Cole, T.J., Lee, J.H., Wada, T., Zhang, B., Gao, J., Song, W., DeFranco, D., Cheng, S., Xie, W., 2008, Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase, Cancer Research, vol 68, issue 18, American Association for Canrer Research (A AC R), USA, pp. 7386-7393.

Wong, S., Brennan, F.E., Young, M.J., Fuller, P.J., Cole, T.J., 2007, A direct effect of aldosterone on endothelin-1 gene expression in vivo, Endocrinology, vol 148, issue 4, Endocine Society, Chevy Chase MD USA, pp. 1511-1517.

Denham, M., Conley, B.J., Olsson, F.P., Gulluyan, L., Cole, T.J., Mollard, R.A., 2007, A murine respiratory-inducing niche displays variable efficiency across human and mouse embryonic stem cell species, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 292, issue 5, American Physiological Society, USA, pp. 1241-1247.

Olsson, F.P., Denham, M., Cole, T.J., Hooper, S.B., Mollard, R.A., 2007, Deriving respiratory cell types from stem cells, Current Stem Cell Research & Therapy, vol 2, issue 3, Bentham Science Publishers Ltd, The Netherlands, pp. 197-208.

Anakk, S., Huang, W., Staudinger, J.L., Tan, K.H., Cole, T.J., Moore, D., Strobel, H.W., 2007, Gender dictates the nuclear receptor-mediated regulation of CYP3A44, Drug Metabolism and Disposition, vol 35, American Society for Pharmacology and Experimental Therapeutics, Bethesda USA, pp. 36-42.

Bird, A.D., Tan, K.H., Olsson, F.P., Zieba, M., Flecknoe, S.J., Liddicoat, D., Mollard, R.A., Hooper, S.B., Cole, T.J., 2007, Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development, Journal of Physiology-London, vol 585, issue 1, Blackwell Publishing, Oxford England UK, pp. 187-201.

Cole, T.J., Mollard, R.A., 2007, Selective glucocorticoid receptor ligands, Medicinal Chemistry, vol 3, issue 5, Bentham Science Publ Ltd, Sharjah UAE, pp. 494-506.

Denham, M.S., Cole, T.J., Mollard, R.A., 2006, Embryonic stem cells form glandular structures and express surfactant protein C following culture with dissociated fetal respiratory tissue, American Journal of Physiology-Lung Cellular and Molecular Physiology, vol 290, issue 6, Americal Physiological Society, Bethesda USA, pp. L1210-L1215.

Morris, M.J., Velkoska, E., Cole, T.J., 2005, Central and peripheral contributions to obesity-associated hypertension: impact of early overnourishment, Experimental Physiology, vol 90, issue 5, Blackwell Publishing, Oxford UK, pp. 697-702.

Velkoska, E., Cole, T.J., Morris, M.J., 2005, Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers, American Journal of Physiology-Endocrinology and Metabolism, vol 288, issue 6, American Physiological Society, Bethesda USA, pp. E1236-E1243.

Cole, T.J., Liddicoat, D.R., Godfrey, D.I., 2005, Intrathymic glucocorticoid production and thymocyte survival: another piece in the puzzle, Endocrinology, vol 146, issue 6, Endocrine Society, Chevy Chase USA, pp. 2499-2500.

Conley, B.J., Denham, M., Gulluyan, L., Olsson, F.P., Cole, T.J., Mollard, R.A., 2005, Mouse embryonic stem cell derivation, and mouse and human embryonic stem cell culture and differentiation as embryoid bodies, Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] [E], vol Suppl 28, issue 23.2, John Wiley & Sons, Inc., USA, pp. 1-22.

Denham, M., Conley, B.J., Olsson, F.P., Cole, T.J., Mollard, R.A., 2005, Stem cells: An overview, Current protocols in cell biology / editorial board, Juan ..., vol Suppl 28, issue 23.1, John Wiley & Sons, Inc., USA, pp. 1-18.

Cole, T.J., Solomon, N.M., Van Driel, R., Monk, J.A., Bird, D., Richardson, S.J., Dilley, R.J., Hooper, S.B., 2004, Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice, American Journal of Respiratory Cell and Molecular Biology, vol 30, issue 5, American Thoracic Society, New York USA, pp. 613-619.

Purton, J.F., Monk, J.A., Liddicoat, D.R., Kyparissoudis, K., Sakkal, S., Richardson, S.J., Godfrey, D.I., Cole, T.J., 2004, Expression of the glucocorticoid receptor from the 1A promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death, The Journal of Immunology, vol 173, issue 6, American Association of Immunologists, USA, pp. 3816-3824.

Medley, T.L., Cole, T.J., Dart, A.M., Gatzka, C.D., Kingwell, B.A., 2004, Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression, Arteriosclerosis Thrombosis And Vascular Biology [P], vol 24, issue 8, Lippincott Williams & Wilkins, USA, pp. 1479-1484.

Zhan, Y., Funda, D.P., Every, A.L., Fundova, P., Purton, J.F., Liddicoat, D., Cole, T.J., Godfrey, D.I., Brady, J.L., Mannering, S.I., Harrison, L.C., Lew, A.M., 2004, TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death, International Immunology [P], vol 16, issue 9, Oxford University Press, UK, Japan, pp. 1315-1321.

Medley, T.L., Kingwell, B.A., Gatzka, C.D., Pillay, P., Cole, T.J., 2003, Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression, Circulation Research, vol 92, issue 11, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1254-1261.

Zhan, Y., Purton, J.F., Godfrey, D.I., Cole, T.J., Heath, W.R., Lew, A.M., 2003, Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 3, National Academy Sciences, Washington USA, pp. 1197-1202.

Medley, T.L., Cole, T.J., Gatzka, C.D., Wang, W.Y., Dart, A.M., Kingwell, B.A., 2002, Fribillin-1 Genotype Is Associated With Aortic Stiffness and Disease Severity in Patients With Coronary Artery Disease, Circulation, vol 105, issue 7, Lippincott, Williams and Wilkins, Philadelphia PA USA, pp. 810-815.

Purton, J.F., Zhan, Y., Liddicoat, D.R., Hardy, C.L., Lew, A.M., Cole, T.J., Godfrey, D.I., 2002, Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice, European Journal of Immunology, vol 32, issue 12, Wiley-V C H Verlag GMBH, Weinheim Germany, pp. 3546-3555.

Cole, T.J., Myles, K., Purton, J.F., Brereton, P.S., Solomon, N.M., Godfrey, D.I., Funder, J., 2001, GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant, Molecular and Cellular Endocrinology, vol 173, Elsevier Science Ireland Ltd, Ireland, pp. 193-202.

Bhargava, A., Fullerton, M.J., Myles, K., Purdy, T.M., Funder, J.W., Pearce, D., Cole, T.J., 2001, The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action, Endocrinology, vol 142, issue 4, Endocrine Society, Chevy Chase USA, pp. 1587-1594.

Purton, J.F., Boyd, R.L., Cole, T.J., Godfrey, D.I., 2000, Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of Glucocorticoid Receptor Signaling, Immunity, vol 13, Cell Press, Cambridge USA, pp. 179-186.

Godfrey, D.I., Purton, J.F., Boyd, R.L., Cole, T.J., 2000, Stress-free T-cell development: Glucocorticoids are not obligatory, Immunologu Today, vol 21 issue 12, Elsevier Sci Ltd, Oxford England, pp. 606-611.

Krozowski, Z.S., Li, K.X., Koyama, K., Smith, R.E., Obeyesekere, V.R., Stein-Oakley, A.N., Sasano, H., Coulter, C., Cole, T.J., Sheppard, K., 1999, The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes, Journal of Steroid Biochemistry and Molecular Biology, vol 69, Pergamon-Elsevier Science Ltd., Oxford UK, pp. 391-401.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Development of new glucocorticoid-related drug therapeutic strategies for the treatment of premature.

Supervisors:

Cole, T (Main), Mcdougall, A (Associate), Wallace, M (Associate).

Completed Supervision

Student:

Bird, A.

Program of Study:

The effects of glucocorticoid and creb-mediated signalling during murine lung development. (PHD) 2008.

Supervisors:

Cole, T (Main).

Student:

Firsova, A.

Program of Study:

Treatment of neonatal mouse hyperoxia-induced lung deficit with endothelial progenitor cells from bone marrow. (PHD) 2012.

Supervisors:

Cole, T (Joint), Mollard, R (Joint-Co).

Student:

Hoong, I.

Program of Study:

EXPRESSION OF 11BETA-HYDROXYSTEROID DEHYDROGENASES IN MICE AND THE ROLE OF GLUCOCORTICOIDS IN ADIPOCYTE FUNCTION. (PHD) 2003.

Supervisors:

Cole ((Double Id)), T (Main).

Student:

Liddicoat, D.

Program of Study:

The role of glucocorticoids in lymphocyte development and function in mouse and human. (PHD) 2008.

Supervisors:

Cole, T (Joint), Godfrey, D (Joint-Co).

Student:

Moore, X.

Program of Study:

AN ANALYSIS OF THE MURINE IIB-HYDROXYSTEROID DEHYDROGENASE TYPE II GENE AND ITS INACTION IN MURINE EMBRYONIC STEM CELLS BY GENE TARGETING. (PHD) 2000.

Supervisors:

Funder, J (Main), Cole ((Double Id)), T (Associate).

Student:

Olsson, P.

Program of Study:

Interactions of glucocorticoid receptor signalling and retinoic acid receptor signalling during murine lung development. (PHD) 2011.

Supervisors:

Cole, T (Joint-Co), Mollard, R (Joint).

Student:

Purton, J.

Program of Study:

THE INFLUENCE OF GLUCOCORTICOIDS AND OTHER FACTORS IN T CELL DEVELOPMENT AND SELECTION. (PHD) 2003.

Supervisors:

Cole ((Double Id)), T (Joint), Godfrey, D (Joint-Co).

Student:

Wong, S.

Program of Study:

Characterization of corticosteroid receptor target genes regulating renal, hepatic and cardiac functions. (PHD) 2009.

Supervisors:

Cole, T (Main).